Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| RE43431 | Quinazoline derivatives and pharmaceutical compositions containing them A compound of general formula I wherein: Ra is a benzyl, 1-phenylethyl, or 3-chloro-4-fluorophenyl group; Rb is a dimethylamino, N-methyl-N-ethylamin... | 05/29/2012 |
| 8106061 | Use of phosphodiesterase inhibitors in the treatment of prostatic diseases The present invention pertains to the use of inhibitors of phosphodiesterase I, IV and V for the prophylaxis and treatment of prostatic diseases, in particular the use of a) 2-(2-propoxy-phenyl)-8-azapurin-6-one (zaprinast); ... | 01/31/2012 |
| 8080557 | Quinazolinedione derivatives as PARP inhibitors The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, L1, L2, X, Y... | 12/20/2011 |
| 7994182 | Quinazolinone-derivatives and their use for preparation of pharmaceutical compositions having PARP enzyme inhibitory effect The subject of the present invention are quinazoline derivatives and their pharmaceutically acceptable salts of general formula (I), that inhibit a DNA-repairing enzyme, poly(ADP-ribose) polymerase (PARP), enabling them to be used for the preparation of pharmaceutic... | 08/09/2011 |
| 7875621 | Substituted 2-alkyl quinazolinone derivatives as PARP inhibitors The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions containing compounds of formula (I) wherein R1, R3, L, X, Y and Z have defin... | 01/25/2011 |
| 7863281 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof The present invention relates to bicyclic heterocycles of general formula wherein Ra, Rb, Rc, A, B, C, D, E and X are defined as in claim 1, the tautomers, the stereoisomers... | 01/04/2011 |
| 7838530 | Quinazoline derivatives as antiproliferative agents The invention concerns quinazoline derivatives of Formula (I), wherein each of R1a, R1b, R2, R3 and a have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions contai... | 11/23/2010 |
| 7772244 | Therapeutic agents for the treatment of migraine The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods... | 08/10/2010 |
| 7705005 | Bicyclic heteroaromatic compounds The invention disclosed herein relates to compounds of formula (I) where the various groups are defined herein, and which are useful for treating inflammatory diseases such as atherosclerosis. ... | 04/27/2010 |
| 7635700 | 5-Substituted quinazolinone derivatives and compositions comprising and methods of using the same Provided are 5-substituted quinazolinone compounds, for example, of formula (I), and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use for treating angiogenesis or cytokine related disorders, and pharmaceuti... | 12/22/2009 |
| 7585869 | Substituted heterocylces for the treatment of abnormal cell growth The invention relates to compounds of formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R3, R4, R11, N, Z, A, m and p are as defined h... | 09/08/2009 |
| 7569578 | Heterocyclic anti-migraine agents The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods... | 08/04/2009 |
| 7569577 | Quinazoline derivatives as tyrosine kinase inhibitors The invention concerns quinazoline derivatives of the Formula (I); wherein each of R1, R2, W, X1, X2, Z, a and b are as defined in the description; processes for their preparation; pharmaceutical compositions containing th... | 08/04/2009 |
| 7538115 | Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof The present invention relates to substituted piperidines of general formula wherein R, R2 to R5, A, X, Z and n are defined as in claim 1, the tautomers, diastereomers, enantiomers, mixtures and salts t... | 05/26/2009 |
| 7429597 | Substituted nitrogen-containing heterobicycles, the preparation thereof and their use as pharmaceutical compositions The present invention relates to new substituted nitrogen-containing heterobicyclic compounds of general formula wherein B, X1 to X3 and R1 to R5 are defined as in claim 1,... | 09/30/2008 |
| 7407963 | Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof A compound of general formula (I) wherein R and R1 are as defined herein, or a tautomer, diastereomer, enantiomer, or salt thereof, particularly the physiologically acceptable salts thereof, which have valuable p... | 08/05/2008 |
| 7384940 | Method of treating cancer using kinase inhibitors Described herein are methods for treating cancer and other disease conditions in individuals who have either developed a resistance to conventional tyrosine kinase inhibitor (TKI) therapy or who are non-responsive ab initio to conventional TKI therapy. In various em... | 06/10/2008 |
| 7358256 | ATP competitive kinase inhibitors The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 th... | 04/15/2008 |
| 7348341 | Chemical compounds The invention concerns compounds of formula (I), and their use in therapy, particularly in the modulation of CCR3 activity. ... | 03/25/2008 |
| 7345049 | Phenylalanine derivatives Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin. ... | 03/18/2008 |
| 7329665 | Quinazolinone derivative An optically active form of the quinazolinone derivatives represented by the general formula (1): [wherein Y represents a phenyl group or C2-C7 alkyl group; E represents —CH═ or nitrogen atom; and R represent... | 02/12/2008 |
| 7312212 | Aminopiperidine derivatives Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man. ... | 12/25/2007 |
| 7304059 | Substituted quinazolin-4-ylamine analogues Substituted quinazolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activati... | 12/04/2007 |
| 7285557 | Pyrimidinones as melanin concentrating hormone receptor 1 A compound of formula (Ia) comprising a pharmaceutically acceptable salt or solvate thereof, formulations, processes of preparing, and methods of administering to mammals are provided ... | 10/23/2007 |
| 7271260 | 3,4-dihydroquinazoline derivatives as T-type calcium channel blockers and method of preparing the same The present invention relates to 3,4-dihydroquinazoline derivatives as T-type calcium channel blockers and a method of preparing the same. The present invention further relates to a composition comprising the same. The composition comprising the 3,4-dihydroquinazoli... | 09/18/2007 |
| 7268142 | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline The invention pertains to substituted quinazoline and isoquinoline compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE-10. The invention also relates to in... | 09/11/2007 |
| 7268230 | Quinazoline compounds The invention relates to compounds of the formula (I): wherein ring C is as defined herein, for example indolyl, indazolyl or azaindolyl; Z is —O—, —NH— or —S—; n is 0-5; m is 0-3; R1 and R2 are defined herein including groups: (i) ... | 09/11/2007 |
| 7265125 | Neuropeptide Y antagonists Quinoline and quinazoline derivatives can be used in the form of pharmaceutical preparations as Neuropeptide Y antagonists for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity. ... | 09/04/2007 |
| 7232824 | Quinazoline derivatives as medicaments Quinazoline derivatives have the formula: or the pharmaceutically acceptable salts thereof; wherein each of Z5, Z6, Z7 and Z8 ... | 06/19/2007 |
| 7232832 | Antibacterial agents Quinoline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans. ... | 06/19/2007 |
| 7230000 | Methods and compositions utilizing quinazolinones Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity ... | 06/12/2007 |
| 7230001 | Arylalkane, arylalkene and aryl azaalkane, medicaments containing said compounds and method for the production thereof The present invention relates to compounds of general formula R—Z1—Z2—Z3—R1, (I) wherein R, R1 and Z1 to Z3 are defined as in claim 1, ... | 06/12/2007 |
| 7223756 | Quinazoline compounds with therapeutic use The invention concerns the use of the quinazoline derivatives of Formula (I) wherein each of m, R1, Z, n and R3 have any of the meanings defined in the description in the manufacture of a medicament for use in the prevention or treatment of T c... | 05/29/2007 |
| 7220750 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them The present invention relates to bicyclic heterocycles of general formula wherein Ra to Rc, A to E and X are defined as in claim 1, the tautomers, stereoisomers and salts thereof, pa... | 05/22/2007 |
| 7214674 | Heterocyclymethylpiperidines and -piperazines possessing affinity at 5ht-1 type receptors Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein: A is optionally substituted phenyl, naphthyl, indolyl, quinolinyl, quinazolinyl, indazolyl, isoquinolinyl or benzofur... | 05/08/2007 |
| 7211580 | Compounds, compositions, and methods Compounds, compositions and methods useful for treating cellular proliferative diseases and disorders, for example, by modulating the activity of KSP, are disclosed. ... | 05/01/2007 |
| 7205408 | Quinolines and nitrogenated derivative thereof substituted in 4-position by a piperidine-containing moiety and their use as antibacterial agents Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man. ... | 04/17/2007 |
| 7189733 | Compositions and methods for inhibiting TGF-β This invention provides compounds that are useful for treating patients having a TGF-β-mediated disease, particularly an ALK5-mediated disease. The compounds are represented by formula I: wherein: a-b is CH... | 03/13/2007 |
| 7186730 | Bicyclic nitrogen-containing heterocyclic derivatives for use as antibacterials Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man. ... | 03/06/2007 |
| 7183274 | Piperidine-2,6-diones heterocyclically substituted in the 3-position Piperidine-2,6-diones heterocyclically substituted in the 3-position corresponding to formula I Also the production and use of such compounds in pharmaceutical formulations and related methods of treatment. ... | 02/27/2007 |
