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| Number | Title | Issue Date |
| 8101622 | Pyridopyrimidinone inhibitors of PI3Kα and mTOR The invention is directed to Compounds of Formula I: optionally as a single stereoisomer or mixture of stereoisomers thereof, and additionally optionally as a pharmaceutically acceptable salt thereof; as well as methods of ... | 01/24/2012 |
| 8076345 | 2-cyanophenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine compounds, compositions and uses thereof Fused heterocyclic compounds are provided according to formula 1: where R1, R2, R3, and m are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the... | 12/13/2011 |
| 8058283 | 7H-pyrido[3,4-D]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing the... | 11/15/2011 |
| 8044062 | Substituted pyrido[2,3-d]pyrimidin-7(8H)-one inhibitors of phospatidylinositol 3-kinase alpha The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds. ... | 10/25/2011 |
| 8030318 | Fused bicyclic inhibitors of HCV Substituted fused bicyclic pyrimidine compounds having an amide-substituted pyridylamine group at C-4 of the pyrimidine ring are useful in the treatment of conditions associated with HCV. ... | 10/04/2011 |
| 8008310 | Derivatives of pyrido[2,3-d]pyrimidine, the preparation thereof, and the therapeutic application of the same Derivatives of pyrido[2,3-d]pyrimidine are provided having formula (I) with Ar1, Ar2 and R1 as defined herein, which are useful for treating cell proliferative conditions, and to the prepara... | 08/30/2011 |
| 7923450 | Modulators for amyloid beta The invention relates to compounds of formula wherein R1, R2, R3, R4, X and Y are as defined herein and to pharmaceutically active acid addition salts thereof. The compounds can b... | 04/12/2011 |
| 7910595 | Anti-viral compounds Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or t... | 03/22/2011 |
| 7879866 | Inhibition of the activity of the capsaicin receptor in the treatment of obesity or obesity-related diseases and disorders The present invention provides a method of treating diseases or disorders benefiting from inactivating or down regulating the activity of the capsaicin receptor in a mammal by inhibiting the activity of the capsaicin receptor. The present invention also provi... | 02/01/2011 |
| 7842698 | Pyridine methylene azolidinones and use thereof phosphoinositide inhibitors The present invention relates to pyridine methylene azolidinone compounds of Formula (I) for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative ... | 11/30/2010 |
| 7750016 | Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones Compounds of the Formula: where X1, Ar1, R1, and R2 are as defined herein, and compositions comprising the same. Also provided are methods for using compounds of Formula I in trea... | 07/06/2010 |
| 7745451 | Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds and compositions thereof useful in the treatment of conditions associated with neurological and inflammatory disorders and dysfunctions Fused heterocyclic compounds are disclosed that have formula 1: where A, B, L, N, R1, R3, R4′, Y and Z are as defined herein. The compounds and pharmaceutical compositions thereof are usef... | 06/29/2010 |
| 7696213 | 4-methylpyridopyrimidinone compounds The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-Kα). ... | 04/13/2010 |
| 7662828 | Substituted 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2-yl compounds and 5,6,7,8-tetrahydroquinazoline-2-yl compounds Substituted 5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-yl and 5,6,7,8-tetrahydro-quinazolin-2-yl compounds, corresponding to formula I processes for the production thereof, pharmaceutical preparations containing these comp... | 02/16/2010 |
| 7645764 | Kinase inhibitors and methods for using the same Compounds of formula I: wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds, pharmaceutical compositions, methods of using the comp... | 01/12/2010 |
| 7582643 | Heterocyclic compounds useful in treating diseases and conditions The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of su... | 09/01/2009 |
| 7531545 | 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives useful as inhibitors of β-secretase (BACE) The present invention is directed to novel 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhib... | 05/12/2009 |
| 7524852 | Bicyclic pyrimidine derivatives [wherein m and n may be the same or different and each represents an integer of 1 to 3 wherein m+n is 4 or less; R1 represents —NR4R5 (wherein R4 and R5 may be the same or d... | 04/28/2009 |
| 7504406 | Derivatives of pyrido[2,3-d]pyrimidine, the preparation thereof, and the therapeutic application of the same The invention relates to derivatives of pyrido[2,3-d]pyrimidine, to the preparation thereof, and to the therapeutic application of the same. ... | 03/17/2009 |
| 7442710 | Substituted phenyl methanones The present invention relates to compounds of general formula IA or IB wherein X1 and X2 are each independently N or C—R″ and R1, R2,R3, R... | 10/28/2008 |
| 7423042 | Compounds This invention relates to a novel group of 8-Alkyl/Aryl-4-aryl-2-N-(alkylamino)-N″-substituted-N′-cyanoguanidino-8H-pyrido[2,3-d]pyrimidin-7-one compounds, processes for the preparation thereof, the use thereof in treating CSBP/p38 kinase mediated diseases and p... | 09/09/2008 |
| 7361662 | Pyridopyrimidinone compounds, method for production thereof and medicaments comprising the same A compound of formula (I): wherein: R1, R2, R3, R4 are defined in the description, its enantiomers, diastereoisomers, tautomers and also addition salts thereof with a phar... | 04/22/2008 |
| 7348331 | Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones Compounds of the Formula: where X1, Ar1, R1, and R2 are as defined herein, and compositions comprising the same. Also provided are methods for using compounds of Formula I in trea... | 03/25/2008 |
| 7334538 | Topical medicants for aquatic animals A topical medicant for fishes, amphibians, reptiles, and aquatic macroinvertebrates applied in a site-specific manner for the localized treatment of skin wounds, lesions and diseases. The medicant comprises a hydrophilic carrier with an antimicrobial therapeutant fo... | 02/26/2008 |
| 7329664 | Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with ... | 02/12/2008 |
| 7323472 | 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds The present invention is directed to the novel use of a CSBP/p38 inhibitor for the treatment, including prophylaxis of inflammation enhanced cough in a mammal in need thereof. ... | 01/29/2008 |
| 7320987 | 6-Alkoxy-pyrido-pyrimidines The present invention provides compounds of the Formula I: wherein R1 is alkyl, cycloalkyl, cycloalkylalkyl, or —CH2-alkenyl, X1 is O, NH, N(alkyl), S or —C(═O), Z is N or C... | 01/22/2008 |
| 7314881 | 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors. ... | 01/01/2008 |
| 7312330 | Bicycloheteroarylamine compounds as ion channel ligands and uses thereof Amine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of condi... | 12/25/2007 |
| 7279484 | Heterocyclic compounds The inventive subject matter relates to compounds, pharmaceutical compositions, and kits containing a heterocyclic compound represented by the formula (I) wherein R is an alkyl group optionally having substituent... | 10/09/2007 |
| 7253284 | Chemical compounds Compounds of the formula I, Wherein X is N, n is 1 and R2and R3 together form a ring, R, R1 and R4 are as defined in the specifications. ... | 08/07/2007 |
| 7235551 | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases Novel substituted pyrimidol[4,5-d]pyrimidin-2-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors. ... | 06/26/2007 |
| 7208489 | 2-(pyridin-2-ylamino)-pyrido [2,3-d]pyrimidin-7-ones The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders. The novel compounds of the present invention are potent inhibitors of cyclin-dependent kinases 4 (cdk4) ... | 04/24/2007 |
| 7202249 | Antagonists of chemokine receptors Compounds are provided which are antagonists of chemokine receptor activity. The compounds thereof have the structure including enantiomers, diastereomers, tautomers, pharmaceutically acceptable salts and ... | 04/10/2007 |
| 7196097 | 6-alkoxy-pyrido-pyrimidines The present invention provides compounds of the Formula I: wherein R1 is alkyl, cycloalkyl, cycloallkylalkyl, or —CH2-alkenyl, X1 is O, NH, N(alkyl), S or —C(═O), Z is N or ... | 03/27/2007 |
| 7189732 | Pyrido[2,3-d]pyrimidine dichloro-phenyl derivatives The invention describes compounds of the general formula I a process for their manufacture, compositions containing them and their manufacture as well as the use of these compounds as pharmaceutically active agen... | 03/13/2007 |
| 7189731 | Substituted 7-azaquinazoline compounds useful as p38 kinase inhibitors Compounds having the formula (I) or (II), are useful as p38 kinase inhibitors, wherein R is an optionally substituted alkyl, cycloalkyl, or aryl; R6 is hydrogen or lower alkyl; R7 is hydroge... | 03/13/2007 |
| 7173136 | 3-Cyano-quinoline derivatives The invention concerns quinoline derivatives of Formula (I) wherein each of Z1, m, R1, n, R3, Z2 and R14 have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmac... | 02/06/2007 |
| 7163941 | Pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents The invention describes compounds of the general formula I a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agent... | 01/16/2007 |
| 7157466 | Quinazoline ditosylate salt compounds Ditosylate salts of 4-quinazolineamines are described as well as methods of using the same in the treatment of disorde4rs characterized by aberrant erbB family PTK activity. ... | 01/02/2007 |
