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| Number | Title | Issue Date |
| 5250535 | Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent Compounds useful as antiviral agents are defined by the following formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R1 is hydrogen or --C(O)R7 wherein R7 is hydrogen, alkyl of o... | 10/05/1993 |
| 5216142 | Anti-virals Anti-virals wherein a linoleyl, gamma-linolenyl or other unsaturated long chain fatty acyl group is borne directly on a hydroxy or amino group of the sugar/sugar analogue or heterocyclic moiety of a nucleoside or nucleoside analogue.... | 06/01/1993 |
| 5166140 | Use of certain nucleoside analogs to attenuate cancer cell resistance to DNA damaging chemotherapy A method involving the administration of nucleoside analogs to circumvent resistance attributable to the enhanced DNA repair capacity of cancer cells is described. The nucleoside analogs function as suicide substrates for DNA repair enzymes. A method of s... | 11/24/1992 |
| 5098906 | Purine derivatives Novel purine derivatives are described as agents for treating autoimmune diseases as well as a method of manufacture and pharmaceutical compositions as well as novel intermediates in the manufacture thereof.... | 03/24/1992 |
| 5079252 | Therapeutic compounds The present invention relates to the valeryl ester of acyclovir and pharmacologically acceptable salts thereof and their use in medical therapy particularly in the treatment of viral infections. Also provided are processes for the preparation and pharmace... | 01/07/1992 |
| 5077296 | Method for treating equine navicular disease with pentoxifylline, and composition containing pentoxifylline for administrating to horses A method of treating a horse suffering from navicular disease which involves administering an amount of a composition including pentoxifylline in a daily dose for a sufficient period of time effective to alleviate lameness in horses resulting from navicul... | 12/31/1991 |
| 5061708 | Therapeutic guanine esters The present invention relates to certain amino acid esters of the purine nucleoside acyclovir, pharmaceutically acceptable salts thereof and their use in the treatment and prophylaxis of herpes virus infections. The invention also includes pharmaceutical ... | 10/29/1991 |
| 5043339 | Antiviral compounds The present invention relates to amino acid esters of pyrimidine and purine nucleosides containing an acyclic side chain, and their use in medical therapy, particularly the treatment of herpes virus infections. Also provided are pharmaceutical formulation... | 08/27/1991 |
| 4965270 | Purine derivatives Compounds of formula (I), and pharmaceutically acceptable salts thereof: ##STR1## wherein R1 is hydrogen or CH2 OH; R2 is hydrogen or, when R1 is hydrogen, hydroxy or CH2 OH; R3 is CH2 | 10/23/1990 |
| 4963555 | Formulations of heterocyclic compounds A topical pharmaceutical formulation for use in treating virus infections of the skin or mucosa and containing 9-(2-hydroxyethoxymethyl) guanine or a salt or ester thereof which comprises a dispersed oil phase and a continuous aqueous phase containing the... | 10/16/1990 |
| 4957924 | Therapeutic valine esters of acyclovir and pharmaceutically acceptable salts thereof The present invention relates to certain amino acid exters of the purine nucleoside acyclovir, pharmaceutically acceptable salts thereof and their use in the treatment of herpes virus infections. The invention also includes pharmaceutical formulations and... | 09/18/1990 |
| 4942166 | Crystalline purine compounds A crystalline monohydrate of the compound of formula (A) or a crystalline sodium salt monohydrate of the compound of formula (A): ##STR1## having antiviral activity, processes for their preparation and their use as pharmaceuticals.... | 07/17/1990 |
| 4921859 | Purine derivatives Novel purine derivatives are described as agents for treating autoimmune diseases as well as a method of manufacture and pharmaceutical compositions as well as novel intermediates in the manufacture thereof.... | 05/01/1990 |
| 4829055 | Method of treatment for herpes infections of external tissues A method of treatment is disclosed for herpes infections of external tissues and method of preventing the occurrence of blisters and ulcerations in herpes disease in humans. The method consists of directly injecting small treatment amounts of suitable ant... | 05/09/1989 |
| 4798833 | Guanine derivative Antivirally active compounds of the formula ##STR1## wherein A is ##STR2## wherein m is 1 or 2, n is 1 or 2, whereby m is 1 when n is 2 and m is 2 when n is 1, Ra ' is (CH2)p OH, NHCONH2 or CORa ... | 01/17/1989 |
| 4755516 | Antiviral compounds 4-(Guanin-9-yl)butanals and their 3-oxa, 3-thia, and 2-ene counterparts and derivatives thereof, wherein the aldehyde is protected, which have antiviral activity, and are useful in treating viral infections, particularly herpes viral infections, such as h... | 07/05/1988 |
| 4745119 | Method for using purine derivatives The novel 2-aminopurine derivatives disclosed herein which have a hydrogen atom in the 6-position and an acyclic chain ##STR1## in the 9-position [wherein X=O or S, Y=H or CH2 OR and R=H or ##STR2## wherein R°=H, C1-16 alk... | 05/17/1988 |
| 4612314 | Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent Compounds useful as antiviral agents are defined by the following formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R1 and R2 are both --C(O)R7 wherein R7 is 1-adamantyl; ... | 09/16/1986 |
| 4609662 | Method for using purine derivatives The novel 2-aminopurine derivatives disclosed herein which have a hydrogen atom in the 6-position and an acyclic chain ##STR1## in the 9-position [wherein X=O or S, Y=H or CH2 OR and R=H or ##STR2## wherein R°=H, C1-16 alk... | 09/02/1986 |
| 4579849 | N-alkylguanine acyclonucleosides as antiviral agents Disclosed are compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof wherein R1 and R2 are independently alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl or haloalkynyl, each having 1 to 19 carbon at... | 04/01/1986 |
| 4567182 | Compounds endowed with immunomodulating activity The invention relates to a series of purine derivatives of formula (I) ##STR1## wherein R is hydrogen or NH2, n is an integer from 1 to 6, R1 is one of the following chains: ##STR2## wherein R2 is the residue of ... | 01/28/1986 |
| 4565868 | Process for preparing guanine derivatives 1-Monophosphate esters, 1,3-bisphosphate esters and cyclic phosphate esters of 9-(1,3-dihydroxy-2-propoxymethyl)guanine are useful as antiviral agents.... | 01/21/1986 |
| 4556659 | Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents Compounds useful as antiviral agents are defined by the following formula: ##STR1## wherein R1 is hydrogen, --C(Y)OR7 or --C(O)NHR7 wherein R7 is alkyl of one to twelve carbon atoms, alkenyl of two to twelve ... | 12/03/1985 |
| 4548819 | Derivatives of 9-(2-hydroxyethoxymethyl) guanine Compounds of the general formula ##STR1## (wherein X represents an oxygen or sulphur atom, R1 represents a hydroxy or amino group, R2 represents a hydrogen atom or a group of formula --CH2 OR3a a... | 10/22/1985 |
| 4544634 | Method of producing acyclovir The novel compound 6-deoxyacyclovir is enzymatically converted to acyclovir by xanthine oxidase/dehydrogenase or aldehyde oxidase in vivo, i.e. within the body of the animal being treated. The enzymatic conversion may also be effected ex vivo (i.e. in vit... | 10/01/1985 |
| 4507305 | 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent The compound 9-(1,3-dihydroxy-2-propoxymethyl)guanine and the pharmaceutically acceptable salts thereof are useful as antiviral agents.... | 03/26/1985 |
| 4495190 | Derivatives of guanine for combating herpes virus infections Novel antiviral compounds of the formula ##STR1## wherein each of R1 and R2, which are the same or different is hydrogen, hydroxy or fluoro; provided that R1 or R2 is hydrogen when R1 and R2... | 01/22/1985 |
| 4423050 | 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent The compound 9-(1,3-dihydroxy-2-propoxymethyl)guanine and the pharmaceutically acceptable salts thereof are useful as antiviral agents.... | 12/27/1983 |
| 4360522 | Purine derivatives 9-Hydroxyethoxymethyl (and related) derivatives of certain 6-, and 2,6-substituted purines have been discovered to have potent anti-viral activities. Novel compounds and their pharmaceutically acceptable salts, pharmaceutical formulations containing the c... | 11/23/1982 |
| 4355032 | 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent The compound 9-(1,3-dihydroxy-2-propoxymethyl)guanine and the pharmaceutically acceptable salts thereof are useful as antiviral agents.... | 10/19/1982 |
| 4294831 | Purine derivatives 9-Hydroxyethoxymethyl (and related) derivatives of certain 6-, and 2,6-substituted purines have been discovered to have potent anti-viral activities. Novel compounds and their pharmaceutically acceptable salts, pharmaceutical formulations containing the c... | 10/13/1981 |
| 4199574 | Methods and compositions for treating viral infections and guanine acyclic nucleosides 9-Hydroxyethoxymethyl (and related) derivatives of certain 6-, and 2,6-substituted purines have been discovered to have potent anti-viral activities. Novel compounds and their pharmaceutically acceptable salts, pharmaceutical formulation containing the co... | 04/22/1980 |
| 4060616 | Purine derivatives with repeating unit 9-[2-(2-Hydroxyethoxy)ethoxymethyl] and related derivatives of certain 2-amino-6-substituted purines have been discovered to have potent anti-viral activities. Novel compounds and their pharmaceutically acceptable salts, pharmaceutical formulations contai... | 11/29/1977 |
