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| Number | Title | Issue Date |
| 7432274 | Acyclic nucleoside derivatives Methods and novel intermediates for the preparation of and the treatment with acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group ... | 10/07/2008 |
| 7419967 | Sulfonamide inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. T... | 09/02/2008 |
| 7388002 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases Compounds represented by the formula: A is (CH2)nR2, —CH═CH2, CH2—CH═CH2, O(CH2)nR2, CH(OH)CH3, CH(OH)... | 06/17/2008 |
| 7273864 | Compositions and methods for inducing osteogenesis The present invention provides compositions and methods for differentiating and transdifferentiating mammalian cells into cells of an osteoblast lineage, using compounds of the following formula: wherein R4 ... | 09/25/2007 |
| 7256196 | Purine cytokine inhibitors The present invention relates to 2,8,9-substituted purines which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions c... | 08/14/2007 |
| 7238700 | Aadenosine receptor antagonists Disclosed are novel A2B adenosine receptor antagonists of Formula I: A compound of the formula: wherein: R1 is... | 07/03/2007 |
| 7229961 | Compositions and methods for enhancing drug delivery across and into ocular tissues This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including into and across ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, ... | 06/12/2007 |
| 7196093 | Reversible inhibitors of SAH hydrolase and uses thereof 1. The present invention provides compositions and methods for reversibly inhibiting S-adenosyl-L-homocysteine (SAH) hydrolase. The compounds of the present invention can be used as an anti-hemorrhagic viral infection agent, an immunosuppressant, a homocysteine lowe... | 03/27/2007 |
| 7189730 | Aadenosine receptor antagonists Disclosed are novel A2A adenosine receptor antagonists of the formula: wherein: R1 is optionally substituted aryl or optionally substituted heteroaryl; | 03/13/2007 |
| 7045525 | Use of (R)-peniciclovir triphosphate for the manufacture of a medicament for the treatment of viral diseases A method of treatment of: i) HIV-1 infections in mammals, including humans; or ii) HBV infections in mammals, including humans; which method comprises the administration to the human in need of such treatment, an effective amount of the (R)-enantiomer of the triphos... | 05/16/2006 |
| 6958344 | Pyrimidine compounds and their use as modulators of chemokine receptor activity The invention provides certain heterocyclic compounds, processes, and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy; in formula (I), A is a group of formula (a) or (b). | 10/25/2005 |
| 6855736 | Molecular target of neurotoxicity The present invention relates to the fields of biology, genetics and medicine. In particular it concerns new methods for the detection, characterization and/or treatment (or management) of neuro degenerative diseases, particularly amyotrophic lateral sclerosis. ... | 02/15/2005 |
| 6770651 | A2B adenosine receptor antagonists Disclosed are novel A2B adenosine receptor antagonists of Formula I: A compound of the formula: wherein: R1 is optionally substituted alkyl or a group —Y—Z, in which Y is a covalent bond ... | 08/03/2004 |
| 6747016 | Substituted purine derivatives as inhibitors of cell adhesion The present invention relates to compounds of formula (I), in which B, D, E, G, X, Y, Z, R1, R2 and s have the meanings indicated in the claims, their physiologically tolerable salts and their prodrugs. The compounds of formula (I) are valuable... | 06/08/2004 |
| 6703394 | Acyclic nucleoside derivatives Methods and novel intermediates for the preparation of and the treatment with acyclic nucleoside derivatives of the formula: ##STR1## where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 | 03/09/2004 |
| 6696454 | Inhibitors of spermidine synthase for the treatment of osteoarthritis and cartilage rehabilitation This invention provides a method for the treatment of a subject in need of treatment for osteoarthritis comprising administering to said subject an amount of an inhibitor of spermidine biosynthesis sufficient to effect a substantial inhibition of spermidi... | 02/24/2004 |
| 6693106 | Pentoxifylline, pioglitazone and metformin are inhibitors of formation of advanced glycation endproducts (AGE's) Pentoxifylline, pioglitazone and metformin have been found to inhibit the nonenzymatic glycation of proteins which often results in formation of advanced glycation endproducts and crosslinks. The nonenzymatic glycation and crosslinking of proteins is a pa... | 02/17/2004 |
| 6683084 | Use of 2-amino purine derivatives for the treatment and prophylaxis of human herpes virus 6 infections The use of a compound of formula (A) or a bioprecursor, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the foregoing for use in the prophylactic treatment of HHV-6 infection. ##STR1##... | 01/27/2004 |
| 6613743 | Sulfonamide inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides of formula I which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and phy... | 09/02/2003 |
| 6579981 | Antiviral guanine derivatives A compound of formula (I) ##STR1## or a salt or acyl derivative thereof, in which X represents chlorine, C1-6 alkoxy, phenoxy, phenyl C1-6 alkoxy, NH2, --OH or --SH, is useful in treating viral infections.... | 06/17/2003 |
| 6576636 | Method of treating a liver disorder with fatty acid-antiviral agent conjugates The invention provides conjugates of fatty acids and antiviral agents useful in treating liver disorders.... | 06/10/2003 |
| 6569864 | Pharmaceutical agents containing acyclovir, fusaric acid and derivatives thereof Compositions and kits comprising acyclovir and fusaric acid are provided.... | 05/27/2003 |
| 6548486 | Fatty acid esters of nucleoside analogs New compounds of the general formula (I): Nu-O-Fa, wherein O represents an oxygen, Nu is a nucleoside or nucleoside analogue, and Fa is an acyl group of a mono-unsaturated C18 or 20 fatty acid. The invention also concerns anti viral pharmaceutical and vet... | 04/15/2003 |
| 6537997 | Method for diagnosing and alleviating the symptoms of chronic fatigue syndrome A method for alleviating chronic fatigue syndrome with the administration of antiviral agents. Based on clinical tests, chronic fatigue syndrome is a persistent herpes virus infection including incomplete virus multiplication and thus administration of an... | 03/25/2003 |
| 6512004 | Promoters of neural regeneration The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent protein kinase a neural cell subject to growth repulsion mediat... | 01/28/2003 |
| 6489330 | Use of penciclovir for the treatment of human herpes-virus-8 The present invention is directed to the use of a compound of Formula (A), ##STR1## or a bioprecursor, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the foregoing in the manufacture of a medicament for use in t... | 12/03/2002 |
| 6465473 | Method for treatment of reactive arthritis or bursitis An improved method for treatment of conditions in human beings associated with either or both reactive arthritis or bursitis comprising administration of a combination of L-lysine, minocycline hydrochloride, metronidazole, and valacyclovir hydrochloride. ... | 10/15/2002 |
| 6448227 | Therapeutically effective substance mixture A substance mixture, containing S-acetyl glutathione and Aciclovir, is effective as a medication against the Herpes Simplex virus and the Varicella Zoster virus.... | 09/10/2002 |
| 6440979 | Aryl isoguanines Disclosed are compounds having formula (II): ##STR1## wherein: Q3, Q6a, Q6b and Q8 are independently a bond, C1-8 alkylene, C2-8 alkenylene and C2-8 alkynylene, and R3... | 08/27/2002 |
| 6407137 | Dopamine analog amide The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the ... | 06/18/2002 |
| 6399622 | Method for diagnosing and alleviating the symptoms of chronic fatigue syndrome A method for alleviating chronic fatigue syndrome with the administration of antiviral agents. Based on clinical tests, chronic fatigue syndrome is a persistent herpes virus infection including incomplete virus multiplication and thus administration of an... | 06/04/2002 |
| 6338963 | Use of carbon monoxide dependent guanylyl cyclase modifiers to stimulate neuritogenesis Disclosed herein are methods directed generally to the control of neural activity and for selectively and controllably inducing the in vivo genetic expression of one or more naturally occurring genetically encoded molecules in mammals. More particularly, ... | 01/15/2002 |
| 6328955 | Method for regulating IL-10 with IL-9, and applications thereof The invention involves the recognition of IL-9 as a molecule involved in induction of IL-10. Administration of IL-9 leads to protection against conditions where IL-10 production is warranted, such as infections by Gram negative bacteria. Examples of such ... | 12/11/2001 |
| 6297226 | Synthesis and methods of use of 9-substituted guanine derivatives The present invention is directed to 9-substituted guanine derivatives in which the guanine moiety is linked to another moiety with physiological or pharmacological activity through a carboxamide linkage. The number of carbon atoms between the guanine moi... | 10/02/2001 |
| 6255312 | Acyclic nucleoside derivatives Compounds of the Formula I ##STR1## where one of R1 and R2 is --C(O)CH(CH(CH3)2)NH2 or --C(O)CH(CH(CH3)CH2 CH3)NH2 ; the other of R1 and R2... | 07/03/2001 |
| 6197776 | Method for treatment of reactive arthritis or bursitis An improved method for treatment of conditions in human beings associated with either or both reactive arthritis or bursitis comprising administration of a combination of acyclovir, L-lysine, minocycline hydrochloride, and metronidazole. An alternate meth... | 03/06/2001 |
| 6136814 | Aqueous acyclovir product The present invention provides a pharmaceutical product comprising an aqueous solution of acyclovir sodium contained within a sealed container constructed of an alkali resistant polymer having a CO2 permeation constant of not more than about 1... | 10/24/2000 |
| 6136813 | Pharmaceutical treatment Pharmaceutical use of a compound of formula (A): ##STR1## or a pro-drug, or a pharmaceutically acceptable salt, phosphate ester and/or acyl derivative of either of the foregoing; in the treatment of hepatitis B virus infections.... | 10/24/2000 |
| 6124304 | Penciclovir for the treatment of zoster associated pain A method for the treatment of ZAP, in particular PHN, in mammals, including humans, which method comprises administering to the mammal in need of such treatment, an effective amount of penciclovir or famciclovir, or a pharmaceutically acceptable salt ther... | 09/26/2000 |
| 6107303 | Treatment of Epstein Barr infection A method of treating Epstein Barr virus infection in humans by administering a pharmaceutically effective amount of an antiviral agent selected from a group consisting of acyclovir, famciclovir, valacyclovir and a pharmaceutically acceptable salt thereof ... | 08/22/2000 |