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Class 514/263.32 - Nitrogen containing hetero ring in the perservative, stabilizer, or additional active ingredient


Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the preservative, stabilizer,
No. of patents: 92
Last issue date: 07/27/2010


1      
NumberTitleIssue Date
7763626Compositions and method for enhancing the therapeutic activity of opiods in treatment of pain
Compositions and methods for inhibiting opioid tolerance and opioid withdrawal-induced hyperalgesia are provided. ...
07/27/2010
7192962Xanthine phosphodiesterase V inhibitor polymorphs
Crystalline polymorphs of 1-ethyl-3,7-dihydro-8-[(1R,2R) -(hydroxycyclopentyl)amino]-3-(2-hydroxyethyl)-7-[(3-bromo-4-methoxyphenyl)methyl]-1H-Purine-2,6-dione in Form 1 and Form 2, which exhibit x-ray powder diffraction profiles substantially the same as those show...
03/20/2007
7109341Therapeutic amides
The invention provides compounds of the formula: wherein A, X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions ...
09/19/2006
7034036Inhibitors of ABC drug transporters at the blood-brain barrier
The present invention relates to inhibitors of drug transporters of the ABC protein superfamily, particularly transporters present at the blood brain barrier. ABC transporter inhibitors identified according to the invention increase brain concentrations of CNS-activ...
04/25/2006
6995164Methods of treating tumors
The invention provides a method of inhibiting tumor growth in a mammal, by administering to the mammal composition containing taurolidine, taurultam, or a biologically active derivative thereof. The composition is administered to directly contact a tumor cell at a d...
02/07/2006
6624181Synergistic combination
The invention relates to the combined administration of PDE inhibitors and 댢 adrenoceptor agonists for the treatment of respiratory tract disorders....
09/23/2003
6589941Utilization of 5' substituted nucleosides for resistance formation in cytoclastic treatment, and drug containing these nucleosides, polymers, methods of use and compositions
The invention relates to a method of producing a composition and to a composition for preventing or reducing formation of resistance in cytostatic treatment comprising combining BVDU, a salt thereof or BVDU in protected form or in prodrug form with at lea...
07/08/2003
6579895Use of a celecoxib composition for fast pain relief
There is provided a method of rapidly relieving pain in a mammalian, preferably human, subject. The method comprises orally administering to the subject an effective pain-relieving amount of a composition comprising celecoxib formulated in such a way as t...
06/17/2003
6503950Triple drug therapy for the treatment of narcotic and alcohol withdrawal symptoms
A triple drug, pharmaceutical kit, composition, and method of treatment containing a combination of effective amounts of at least one anxiolytic agent, at least one centrally acting alpha antiadrenergic agent, and at least one central nervous system stimu...
01/07/2003
6479466Compositions for treating viral infections, and methods therefor
Methods and combinations of an agent that promotes DNA synthesis in a virally-targeted cell and a nucleoside analogue having antiviral activity are provided for treating a viral infection in a subject in need thereof. Such compositions are particularly ef...
11/12/2002
6462051Composition for reducing mental fatigue, composition for maintaining and enhancing concentration, and composition for maintaining and enhancing mental vigor
The present invention is intended to provide compositions which exert excellent effects allowing improvement in the mental function of humans and animals other than humans, such as reduction of mental fatigue, maintenance and enhancement of concentration ...
10/08/2002
6440980Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
The present invention is related to antiviral compositions comprising long-chain aliphatic compounds in combination with a nucleoside analog or phosphonoformic acid, in a pharmaceutically acceptable carrier. Methods for treating viral infections using suc...
08/27/2002
6432968Combination preparation, containing cyclosporin a or FK506 or rapamycin and a xanthine derivative
Xanthines of the formula I ##STR1## are useful in producing a superadditive increase in immunosuppressive action when combined with immunosuppressive compounds such as CysA or FK506....
08/13/2002
6432966Antiviral combinations
The present invention relates to therapeutic combinations comprising (2R,cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-pyrimidin-2-one (lamivudine) and BMS-200475 which have anti-hepatitis B virus (HBV) activity. The present invention is also conce...
08/13/2002
6380267Composition and method for decreasing neurologic symptomatology
A method of decreasing the signs or symptomatology in a patient with a neurologic condition or disease, or in a patient due to effects of exposure to an exogenous substance, such as a pharmaceutical agent, comprising selecting a patient having at least on...
04/30/2002
6284765(+) naloxone and epinephrine combination therapy
A composition formulated for dose-wise delivery to a breathing passageway of a human, the composition comprising a carrier solution containing (+)naloxone and a pharmacologically effective amount of at least one adrenergic agonist, the (+)naloxone and ago...
09/04/2001
6204245Treatment of narcolepsy with immunosuppressants
The invention provides compositions and methods for treatment of narcolepsy or isolated cataplexy. Such methods entail administering a therapeutically effective regime of at least one immunosuppressive agent. The methods are particularly useful for prophy...
03/20/2001
6166025Pharmaceutical compositions containing eletriptran hemisulphate and caffeine
The present invention provides an aqueous pharmaceutical composition comprising 5 to 200 mg/ml of eletriptan hemisulfate and from 0.5 to 2.0% weight/volume of caffeine....
12/26/2000
6159953Anti-malarial composition and method of use
Anti-malarial compositions for prophylactic or therapeutic treatment of vertebrates exposed to malaria parasites are disclosed. These compositions comprise one or more pyrimidine analogue inhibitors of nucleic acid biosynthesis, e.g., 5-fluoro-orotic acid...
12/12/2000
6140324Use of a tachykinin antagonist and a muscarinic antagonist and/or an antihistamine to treat motion sickness
The present invention relates to the use of a tachykinin antagonist and a muscarinic antagonist and/or an antihistamine for the treatment or prevention of motion sickness. There is also provided pharmaceutical compositions and products comprising a tachyk...
10/31/2000
6110955Metabolically stabilized oxyalkylene esters and uses thereof
This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating cutaneous ulcers, treating gastrointestinal disorders, treating b...
08/29/2000
6093389Methods and compositions for attracting and controlling termites
The present invention provides a composition for attracting termites containing a steroid derivative of formula I ##STR1## The present invention also provides a method for attracting or controlling termites with the composition....
07/25/2000
6037347Combination preparation for use in dementia
The invention relates to a composition which is a pharmaceutical combination preparation comprising a compound which has an acetylcholinesterase-inhibitory action or exhibits muscarinergic action and a compound which increases the endogenous extracellular...
03/14/2000
5990103Combination preparation for use in immunological diseases
A combination preparation comprising a compound which has a phosphodiesterase-inhibiting action, and a compound which reduces the biologically effective intracellular Ca2+ content, is suitable for the treatment of immunological diseases....
11/23/1999
5981536Use of xanthine derivatives for the modulation of apoptosis
Compounds of the formula I ##STR1## where one of the radicals R1 and R3 is a radical of the formula II --(CH2)n --A--CH3 (II) in which A is a covalent bond,--C(O)-- or --C(R4)(OH)--, a...
11/09/1999
5916895Compositions and methods for controlling pest insects
Compositions of a purine, a xanthine oxidase inhibitor and/or a dihydrofolate reductase inhibitor, and methods of using same, for controlling the growth of pest insects which salvage, store, or excrete their nitrogenous wastes via the purine metabolic pat...
06/29/1999
5900416Aqueous caffeine dosage forms
Aqueous caffeine solutions containing a co-solubilizing agent selected from niacinamide, nicotinic acid and mixtures thereof present at a level up to the maximum concentration soluble in water and in a weight ratio to caffeine less than 1.50:1, wherein th...
05/04/1999
5874439Compositions and methods for controlling pest insects
Compositions of a purine, a xanthine oxidase inhibitor and/or a dihydrofolate reductase inhibitor, and methods of using same, for controlling the growth of pest insects which salvage, store, or excrete their nitrogenous wastes via the purine metabolic pat...
02/23/1999
5869479Treatment of upper airway allergic responses
Relief from the symptoms of rhinitis is obtained by treatment with: (a) an antihistaminic effective amount of a histamine H1 receptor antagonist; together with (b) a sufficient amount of a histamine H3 receptor antagonist to provide ...
02/09/1999
5856330Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin
Compounds of the formula I ##STR1## where one of the radicals R1 and R3 is a radical of the formula II --(CH2)n --A--CH3 (II) in which A is a covalent bond, --C(O)-- or --C(R4)(OH)--, ...
01/05/1999
5852025Compositions and methods for controlling pest insects
Compositions of a purine, a xanthine oxidase inhibitor and/or a dihydrofolate reductase inhibitor, and methods of using same, for controlling the growth of pest insects which salvage, store, or excrete their nitrogenous wastes via the purine metabolic pat...
12/22/1998
5811423Benzoxazinones as inhibitors of HIV reverse transcriptase
Certain benzoxazinones are useful in the inhibition of HIV reverse transcriptase (including its resistant varieties), the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharma...
09/22/1998
5795897Oxohexyl methylxanthine compounds
There is disclosed a pharmaceutical composition comprising 1-(5-oxohexyl)-3-methylxanthine in admixture with a pharmaceutically acceptable excipient, wherein the pharmaceutical composition is useful for treating an immune disorder. There is also disclosed...
08/18/1998
5731304Potentiation of temozolomide in human tumour cells
The toxicity of temozolomide, an anti-tumour agent useful in the treatment of various mammalian neoplasms, can be potentiated by the prior administration of an ATase inhibiting agent, i.e., O6 -benzylguanine....
03/24/1998
5726180Stabilized solid pharmaceutical preparation and method of producing the same
To stabilize the active ingredients, a caffeine is incorporated into a solid pharmaceutical preparation comprising a dextromethorphan and a phenylpropanolamine. The pharmaceutical preparation may further comprise ibuprofen. The active ingredients may be f...
03/10/1998
56913381,2-dithiole-3 thiones for the treatment of reverse transcriptase-dependent viral infections
This invention provides a method of inhibiting the replication of a reverse transcriptase-dependent virus in cells which comprises contacting infected cells with an effective amount of a 1,2-dithiole-3-thione. A composition for inhibiting reverse transcri...
11/25/1997
5668132HIV Protease inhibitors useful for the treatment of AIDS
Compounds of formula ##STR1## where R1 and R2 are independently hydrogen or optionally-substituted C1-4 alkyl or aryl, and R1 also forms a heterocycle or heterocycle-C1-4 alkyl, are HIV protease ...
09/16/1997
5665720Benzoxazinones as inhibitors of HIV reverse transcriptase
Certain benzoxazinones are useful in the inhibition of HIV reverse transcriptase (including its resistant varieties), the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharma...
09/09/1997
5663175Prodrugs of herpes TK inhibitors
Certain prodrugs such as ##STR1## are useful in the inhibition of herpes virus thymidine kinase, the prevention or treatment of recurrent infection by herpes virus, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ...
09/02/1997
5648358Compositions and methods for treating respiratory disorders
The present invention relates to compositions and methods for providing improved treatment, management or mitigation of cold, cold-like, allergy, sinus and/or flu symptoms by administering a safe and effective amount of a composition comprising caffeine a...
07/15/1997
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