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| Number | Title | Issue Date |
| 8188094 | Inhibitors of glutaminyl cyclase Compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof wherein: ... | 05/29/2012 |
| 8188095 | Gyrase inhibitors and uses thereof The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the p... | 05/29/2012 |
| 8188096 | Protein kinase targeted therapeutics The present invention relates to compositions and methods useful in treating diseases and disorders related to protein kinases. In particular, the present invention relates to compositions and methods useful for targeting protein kinases related to mitogen activated... | 05/29/2012 |
| 8178540 | Pyrimidylmethyl-sulfonamide compounds The present invention relates to novel pyrimidylmethyl-sulfonamide compounds and to their N-oxides, their agriculturally acceptable salts and their veterinarily acceptable salts and also to agricultural compositions comprising at least one such compound as active co... | 05/15/2012 |
| 8168642 | Dihydropyrimidine compounds and their uses in preparation of medicaments for treating and preventing antiviral diseases The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, to a process for preparing the compound of formula (I), and to use of the compound of formula (I) or a pharmaceutically acceptable salt or hydrate th... | 05/01/2012 |
| 8148382 | Compounds for the treatment of hepatitis C The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV. ... | 04/03/2012 |
| 8148381 | Potentiator of radiation therapy A radiation therapy potentiator, which, when employed in combination with cancer radiation therapy, can reduce radiation dose and can mitigate adverse effects, the radiation therapy potentiator containing, as an effective ingredient, a uracil derivative represented ... | 04/03/2012 |
| 8143260 | Tricyclic amine compound A compound represented by the following general formula (I): [wherein R1 represents hydrogen atom or a C1-6 alkyl group, A and B represent —(CH2)2—, —(CH2)3 | 03/27/2012 |
| 8133896 | Pyrimidine derivatives which are antagonist of the vitronectin receptor A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparatio... | 03/13/2012 |
| 8129396 | 2-[1H-benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides as kinase inhibitors 2-[1H-benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and their salts are kinase inhibitors, useful in the treatment of cancer. ... | 03/06/2012 |
| 8129395 | 4,5-disubstituted-2-aryl pyrimidines 4,5-disubstituted-2-arypyrimidines of Formula I and Formula II are provided: wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a ... | 03/06/2012 |
| 8119645 | Fungicide hydroximoyl-tetrazole derivatives The present invention relates to hydroximoyl-tetrazole derivatives of formula (I) wherein T represent a tetrazolyl substituent, A represents a carbo- or heterocycle, L1 and L2 represent various linking groups and Q represents a 5-membered heter... | 02/21/2012 |
| 8119646 | Fungicide hydroximoyl-tetrazole derivatives The present invention relates to hydroximoyl-tetrazole derivatives of formula (I) wherein T represent a tetrazolyl substituents, A represents a carbo- or heterocycle, L1 and L2 represent various linking groups and Q represents a carbocycle, the... | 02/21/2012 |
| 8114882 | (1H-indol-7-yl)-(pyrimidin-2-ylamino)methanone derivatives and related compounds as IGF-R1 inhibitors for the treatment of cancer The invention relates to compounds of the formula (I), in which Ar denotes a mono- or bicyclic aromatic homo- or heterocycle having 1 to 4 N, O and/or S atoms and 5 to 10 skeleton atoms, which may be unsubstituted or mono-, di- or trisubstituted by carbonyl oxygen, ... | 02/14/2012 |
| 8101621 | Aminopyridine derivatives having aurora a selective inhibitory action The present invention relates to a compound of general formula I: wherein: n1 and n2 are the same or different, and are 0 or 1; R is aryl, heteroaryl, etc.; Re | 01/24/2012 |
| 8097630 | Pinane-substituted pyrimidinediamine derivatives useful as Axl inhibitors Pinane-substituted pyrimidinediamine derivatives and pharmaceutical compositions containing the derivatives are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the derivatives in treating diseases or... | 01/17/2012 |
| 8093253 | Leukotriene Binhibitors Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositi... | 01/10/2012 |
| 8084457 | Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, i... | 12/27/2011 |
| 8080552 | Pyrimidyl derivatives as protein kinase inhibitors Objects of the present invention are the compounds of formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the ... | 12/20/2011 |
| 8076343 | Benzimidazoles useful as inhibitors of protein kinases The present invention relates to compounds useful as inhibitors of Aurora, FLT-3, or PDK1 protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various... | 12/13/2011 |
| 8067423 | Polymorphs of dasatinib isopropyl alcohol and process for preparation thereof The invention provides crystalline forms of isopropyl alcohol solvate of dasatinib, methods for their preparation, and pharmaceutical compositions thereof. ... | 11/29/2011 |
| 8067421 | Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α Solvates and crystalline forms of imatinib mesylate are described. Further, methods for preparing such solvates and crystalline forms of imatinib mesylate are described. ... | 11/29/2011 |
| 8067422 | Crystal form of phenylamino pyrimidine derivatives The present invention relates to a particular form of the (3,5-bis trifluoromethyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide (formula I), processes for the preparation thereof, pharmaceutical compositions containing this crystal form, and t... | 11/29/2011 |
| 8058279 | Insecticidal pyrimidinyl aryl hyrdrazones Pyrimidinyl aryl hydrazones are effective at controlling insects. ... | 11/15/2011 |
| 8053439 | Benzophenone derivatives useful for inhibiting formation of microtubule Disclosed herein are novel benzophenone derivatives represented by formula I, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, a pharmacological composition containing the same, and a use of the composition as therapeutic drugs. Th... | 11/08/2011 |
| 8048887 | Compounds for the treatment of hepatitis C The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV. ... | 11/01/2011 |
| 8026243 | [4,5′]Bipyrimidinyl-6,4′-diamine derivatives as protein kinase inhibitors The invention provides a novel class of compounds of the Formula I: in which the symbols have the meanings given in the description and claims, to pharmaceutical compositions comprising such compounds and methods of using s... | 09/27/2011 |
| 8012985 | Compounds with antiparasitic activity and medicines containing same The invention relates to compounds having an anti-parasitic, in particular antimalarial activity, characterized in that they correspond to general formula (I) Applications in particular as compounds with anti-parasitic acti... | 09/06/2011 |
| 8012986 | Pyridine and pyrimidine derivatives as MGLUR2 antagonists The present invention relates to compounds of formula (I) wherein A, B, Q, X, Y, R1, and R2 are as defined herein; pharmaceutical compositions containing them; a process for their manufacture; and meth... | 09/06/2011 |
| 8008307 | Heteroaryl compounds useful as inhibitors of E1 activating enzymes This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including ca... | 08/30/2011 |
| 8003655 | Substituted sulphoximines as TIE2 inhibitors and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same The invention relates to substituted sulphoximines according to the general formula (I): in which A, E, G, X, R1, R2, R3, R4, R5, R6, R7, R8 | 08/23/2011 |
| 7989458 | Pyrimidine derivatives as alk-5 inhibitors Compounds of formula (I) in free or salt or solvate form, where T1, T2, Ra and Rb have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pu... | 08/02/2011 |
| 7989457 | Glucagon receptor antagonists, preparation and therapeutic uses The present invention discloses novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention d... | 08/02/2011 |
| 7981900 | 2-phenyl pyrimidines which are tubulin inhibitors Compounds of general formula (I), (II) (III) and (V) are described for use in modulating microtubule polymerisation and in the treatment of associated disease states. Use of compounds (I), (III) and (V) in the treatment of kinase-associated disease states is also de... | 07/19/2011 |
| 7981899 | Use of compatible solutes for inhibiting the release of ceramides Disclosed are the use of compatible solutes for inhibiting the release of ceramides or for the prophylaxis and protection of human skin against premature skin aging and for the prophylaxis and protection of human skin against wrinkling. ... | 07/19/2011 |
| 7977341 | Substituted isoxazoles as fungicides The present invention provides compounds of formula I: (I) along with methods of making the same, compositions thereof, and methods of use thereof, particularly methods of use as fungicides. ... | 07/12/2011 |
| 7973045 | Anhydrous form of dasatinib and process for preparation thereof The invention provides anhydrous forms of dasatinib, methods for their preparation, and pharmaceutical compositions thereof. ... | 07/05/2011 |
| 7973044 | Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4 Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, su... | 07/05/2011 |
| 7968552 | Oxadiazolidinedione compound A compound which can be used as a pharmaceutical, particularly a insulin secretion promoter or a agent for preventing/treating disease in which GPR40 is concerned such as diabetes or the like, is provided. It was found that an oxadiazolidinedione compound whi... | 06/28/2011 |
| 7960393 | Pyrimidine derivatives useful for the treatment of diseases mediated by CRTH2 The present invention relates to a pyrimidine derivative of the formula (I) and salts thereof which is useful as an active ingredient of pharmaceutical preparations. The pyrimidine derivative of the present invention has excellent CRTH2 (G-protein-coupled chemoattra... | 06/14/2011 |
