Did You Know...
...that it was melting ice cream that inspired the invention of the outboard motor? It was a lovely August day and Ole Evinrude was rowing his boat to his favorite island picnic spot. As he rowed, he watched his ice cream melt and wished he had a faster way to get to the island. At that moment the idea for the outboard motor was born!
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| Number | Title | Issue Date |
| 8119641 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors Furo[3,2-c]pyrazole derivatives of formula (I) as defined in the description, and pharmaceutically acceptable salts thereof, wherein A is an aryl or heteroaryl ring, —NHZR5 is at the ortho position to the CONH linker; —R1 and R2 ... | 02/21/2012 |
| 8053437 | Furo[3. 2-B] pyrrol derivatives The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein: R3 is tert-butylmethyl, sec-butyl or tert-butyl; X is CH or N; and R4 is optionally substituted C1-8 alkyl or optional... | 11/08/2011 |
| 8039474 | 2,3,4,9-tetrahydro-1-carbazole derivatives as CRTH2 receptor antagonists The invention relates to novel tetrahydro-1H-carbazole derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceut... | 10/18/2011 |
| 7846935 | Furo[3,2-B]pyrrol-3-one derivatives and their use as cysteinyl proteinase inhibitors The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein: X is CH or N; and R4 is optionally substituted C3-8 alkyl or optio... | 12/07/2010 |
| 7846934 | Furo[3,2-B] pyrrol-3-one derivatives and their use as cysteinyl proteinase inhibitors The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof (I), wherein: R3 is cyclopentyl or cyclohexyl; X is CH or N; and R4 is optionally substituted C1-8 alkyl or optionally substitut... | 12/07/2010 |
| 7803803 | Tetrahydrofuro[3,2-B] pyrrol-3-ones as cathepsin K inhibitors The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein: X is CH or N; one of R1 and R2 is H, and the other is select... | 09/28/2010 |
| 7737150 | Furo[3, 2-b] pyrrol derivatives The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein: R3 is tert-butylmethyl, sec-butyl or tert-butyl; X is CH or N; and R4 is optionally substituted C1-8 alkyl or optional... | 06/15/2010 |
| 7456183 | Guanidino compounds Compounds having the general structure I are provided. X and Y are independently selected from the group consisting of CH2, N, NR9, C═O, C═S, S═O, SO2, S, O, (CR6R7)n, C(═O)—(CR6R... | 11/25/2008 |
| 7297711 | Arylalkyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them The present invention relates to novel tetracyclic arylalkyl indoles, their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel interm... | 11/20/2007 |
| 7256188 | 3-aminoalkyl-2-aryl-indole derivatives and their use as GnRH antagonists The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use of a compound of the present invention in the manufacture of a medicam... | 08/14/2007 |
| 7238695 | Imidazolyl derivatives The present invention is directed to imidazolyl derivatives or pharmaceutically acceptable salts thereof which are useful as agonists or antagonists of somatostatin receptors, having the following formula (I), wh... | 07/03/2007 |
| 7223765 | 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives The present invention relates to substituted 4-phenyl-1-piperazinyl derivatives having the formula I wherein W is C, CH or N, and the dotted line emanating from W indicates a bo... | 05/29/2007 |
| 7153848 | Inhibitors of HCV replication Indole compounds of Formula I are described. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV. Different forms and compositions comprising the compounds are also described as well as methods of preparing ... | 12/26/2006 |
| 7144883 | Bicyclic sulfonamide compounds The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obe... | 12/05/2006 |
| 7141568 | Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them Pyrrolo[3,4-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be usefu... | 11/28/2006 |
| 7091229 | Tricyclic lactam and sultam derivatives and their use as histone deacetylase inhibitors A compound of formula (I) wherein A and B are optionally substituted cyclohexenyl or phenyl groups, X is carbonyl or sulfonyl, and Y is 5–7 atoms-linker, is useful as histone deacetylase inhibitors, particularl... | 08/15/2006 |
| 7074796 | 4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives The present invention relates to substituted 4-phenyl-1-piperazinyl derivatives having the formula I wherein W is C, CH or N, and the dotted line emanating from W indicates a bond when W is C and no bond when W i... | 07/11/2006 |
| 7074782 | Carbamate caspase inhibitors and uses thereof This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; Y is an electron... | 07/11/2006 |
| 7005439 | Compounds The invention provides compounds of general formula (I) wherein m, n, Z1, Z2, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the specification, process... | 02/28/2006 |
| 6998403 | Benzoindoline compounds A compound of formula (I): wherein: R1 and R2 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amin... | 02/14/2006 |
| 6953801 | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors i... | 10/11/2005 |
| 6951874 | Compounds The invention provides compounds of general formula (I) wherein Q, R, R2, R4, R5, R6, R7 and R8 are as defined in the specification, processes for their preparation, pharmaceutical compositions contai... | 10/04/2005 |
| 6916822 | Phenoxyalkylamine derivatives useful as opioid δ receptor agonists A medicament useful for preventive and/or therapeutic treatment of nerve system diseases which comprises, as an active ingredient, a compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof: | 07/12/2005 |
| 6916812 | Alpha-aminoamide derivatives as melanocortin agonists Novel piperazine and homopiperazine derivatives are agonists of melanocortin receptor(s) and are useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of the melanocortin receptors. The compounds of the present inven... | 07/12/2005 |
| 6914064 | 1,4-Disubstituted piperazine derivatives useful as uro-selective α1-adrenoceptor blockers The present invention relates to a novel 1,4-disubstituted piperazine derivatives of Formula I, and their pharmaceutically acceptable acid addition salts having excellent uro-selective α1-adrenoceptor antag... | 07/05/2005 |
| 6903085 | Substituted piperidine compounds useful as modulators of chemokine receptor activity The invention provides compounds of formula (I) wherein R1, R2, R3, R6, Z, Q, m, n, X1, X2, X3, X4 and T are as defined in the specification, processes for their preparation, pha... | 06/07/2005 |
| 6890921 | Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia This invention relates to a series of arylsubstituted piperazines, of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibi... | 05/10/2005 |
| 6861432 | Piperazine derivatives that destabilize androgen receptors This invention relates to new piperazine derivatives of general formula I, in which V, W, n, R, R′, i, j, Y and Z have the meaning that is indicated in the description. The compounds according to the inventio... | 03/01/2005 |
| 6852725 | Imidazolyl derivatives The present invention is directed to imidazolyl derivatives of the formula: where the substituents are defined in the specification, or a pharmaceutically acceptable salt thereof. The derivatives bind selectively to th... | 02/08/2005 |
| 6849631 | Semicarbazides and their uses The present invention relates to the synthesis of a new class of indeno [1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the ca... | 02/01/2005 |
| 6841552 | 3a,4,5,9b-tetrahydro-1H-benz[e]indol-2-yl amine-derived neuropeptide Y receptors ligands useful in the treatment of obesity and other disorders Compounds of the formula: are disclosed as ligands for neuropeptide Y receptors and as such are useful in the treatment of obesity and disorders of the central nervous system. ... | 01/11/2005 |
| 6784183 | Diphenylurea compounds Compounds of formula (I): and medicinal products containing the same which are useful as dual α2/5-HT2c antagonists. ... | 08/31/2004 |
| 6740636 | Non-peptide CCR1 receptor antagonists in combination with cyclosporin A for the treatment of heart transplant rejection This invention is directed to pharmaceutical compositions useful in treating heart transplant rejection in mammals comprising a pharmaceutically acceptable excipient, a therapeutically effective amount of a non-peptide CCR1 receptor antagonist and a sub-nephrotoxic ... | 05/25/2004 |
| 6713473 | Tricyclic compounds A compound represented by the formula (I) [A represents a 5- to 7-membered hydrocarbon ring group; L represents —NR3—CO—, —CO—NR3— and the like (R3 represents a hydrogen atom, a lower alkyl group, a lower acyl group and t... | 03/30/2004 |
| 6689784 | Carbamate caspase inhibitors and uses thereof This invention provides caspase inhibitors of formula I: ##STR1## wherein Z is oxygen or sulfur; R1 is hydrogen, --CHN2, R, CH2 OR, CH2 SR, or --CH2 Y; Y is an electronegative leaving group; R2 | 02/10/2004 |
| 6676931 | Buccal, polar and non-polar spray or capsule Buccal aerosol sprays or capsule using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the in... | 01/13/2004 |
| 6664258 | Spirocyclic dopamine receptor subtype ligands This invention relates to novel, pharmaceutically active compounds of formula (I) wherein a, b and R1 through R6 are as defined in the specification ##STR1## These compounds exhibit central dopaminergic activity and are useful in the... | 12/16/2003 |
| 6555537 | Piperazine derivatives and their use as anti-inflammatory agents This invention is directed to acyl piperazine derivatives, for example, of the following formula (Ia): ##STR1## wherein R1a, R2, R3, R4, R5, and R6 are described herein. These derivatives a... | 04/29/2003 |
| 6498251 | Tetrahydrobenzindole derivatives Compounds containing tetrahydrobenzindole which bind to serotonin receptor and are useful in treatment or prevention of disease induced by abnormality of central peripheral serotonin controlling functions.... | 12/24/2002 |
| 6407112 | Optically active tetrahydrobenzindole derivative Optically active tetrahydrobenzindole type compounds having affinity for a 5-HT receptor, useful for prevention and treatment of mental diseases. A species compound is (S)-2a-4-(4-(2-methoxyphenyl)piperazinyl)butyl)-2a,3,4,5,-tetrahydro 1 H-benz[cd]i... | 06/18/2002 |
