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| Number | Title | Issue Date |
| 7977337 | Quinoline derivatives and their use as 5-HT6 ligands Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, ... | 07/12/2011 |
| 7829567 | Imino-indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same Disclosed herein are novel imino-indeno[1,2-c]quinoline derivatives of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein each of the substituents is giv... | 11/09/2010 |
| 7582635 | Therapeutic agents useful for treating pain A compound of formula: wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof... | 09/01/2009 |
| 7309497 | Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. The invention relates in particular to an injectable pharmaceutical composition comprising (a) a pharmacologically active ingredient i... | 12/18/2007 |
| 7244701 | Diuretic peptide conjugate Disclosed are a variety of peptide conjugates represented by the following general formula: R1-Z-X-Z′-R2 including methods of making and using such conjugates. Also provided are antibodies that specifically bind the pepti... | 07/17/2007 |
| 7211417 | Antibiotic P175-A and semisynthetic derivatives thereof This invention relates to a new antibiotic designated P175-A, to production of fermentation of Micromonospora echinospora NRRL 30633, to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic es... | 05/01/2007 |
| 7157452 | Substituted 4,9-dihydrocyclopenta{imn}phenanthridine-5-ones derivatives thereof and their uses This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP. ... | 01/02/2007 |
| 7144843 | Pest controllers An objective of the present invention is to provide a harmful organism control agent that possesses excellent control effect against harmful organisms and can be safely used. The present invention provides a compound of formula (1) or a salt thereof. The present inv... | 12/05/2006 |
| 7053127 | Quaternized amido cyclic amine surfactant A quaternary surfactant comprising a cyclic diamine group, compositions comprising the quaternized amido cyclic amine surfactant, a gelled aqueous composition comprising the quaternized amido cyclic amine surfactant, use of the gelled aqueous well treatment applicat... | 05/30/2006 |
| 6960580 | Nitrogenous heterocyclic substituted quinoline compounds The present invention relates to nitrogen-containing heterocyclic quinoline compounds and pharmaceutically acceptable salts thereof which have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention is also r... | 11/01/2005 |
| 6936615 | Heteroaryl derivatives and their use as medicaments The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors. ... | 08/30/2005 |
| 6936610 | Heterocyclic derivatives The invention relates to heterocyclic derivatives of formula (I) A—B—X1—T1(R2)—L1—T2(R3)—X2—Q (I) or pharmaceutically-acceptable salts thereof, which ... | 08/30/2005 |
| 6838456 | Condensed pyridoindole derivatives Compounds of the general structural formula and use of the compounds and salts and solvates thereof, as therapeutic agents. ... | 01/04/2005 |
| 6800636 | Farnesyl protein transferase inhibitors Disclosed are compounds of the formula: wherein R8 represents a cyclic moiety to which is bound an imodazolylalkyl group; R9 represents a carbamate, urea, amide or sulfonamide group; and the remaini... | 10/05/2004 |
| 6642225 | Diazacycloalkanedione derivatives Compounds of formula I ##STR1## wherein R is carboxy, esterified carboxy or amidated carboxy; R1 and R3 are independently lower alkyl, (hydroxy, lower alkoxy, amino, acylamino, mono- or di-lower alkylamino or mercapto)-lower alkyl, ... | 11/04/2003 |
| 6605610 | Aryl fused azapolycyclic compounds Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such co... | 08/12/2003 |
| 6593332 | Pharmaceutically active compounds There is provided compounds of formula IA and of formula IB, ##STR1## wherein R1, R2, R3, Het1 and X have meanings given in the description, which are useful in the curative and prophylactic treatment of medical... | 07/15/2003 |
| 6586439 | Pharmaceutically active compounds There is provided compounds of formula IA and of formula IB, ##STR1## wherein R1, R2, R3, Het1 and X have meanings given in the description, which are useful in the curative and prophylactic treatment of medical... | 07/01/2003 |
| 6545011 | Substituted 4,9-dihydrocyclopenta[imn]phenanthridine-5-ones, derivatives thereof and their uses This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.... | 04/08/2003 |
| 6541483 | Acridone-derived compounds useful as antineoplastic and antiretroviral agents The present invention relates to several novel acridone-derived compounds of of formula (I) or (II). These compounds are potent anti-viral agents, useful in the treatment of viral diseases, such as Human Immunodeficiency Virus. In addition, these compound... | 04/01/2003 |
| 6444676 | Use of PARP inhibitors in the treatment of glaucoma The invention provides pharmaceutical compositions containing PARP inhibitors and methods of using these compositions to prevent, treat or ameliorate glaucomatous retinopathy and/or optic neuropathy.... | 09/03/2002 |
| 6410550 | Aryl fused azapolycyclic compounds Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein R1, R2, and R3 are defined as in the specification, intermediates in the synthesis of such compounds. pharmaceutical compositions conta... | 06/25/2002 |
| 6362188 | Farnesyl protein transferase inhibitors Disclosed are compounds of the formula: ##STR1## wherein R.sup.8 represents a cyclic moiety to which is bound an imodazolylalkyl group; R.sup.9 represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein.... | 03/26/2002 |
| 6358967 | Ergoline amine derivatives with blood pressure lowering effect The invention relates to novel derivatives of ergoline of the general formula 1 ##STR1## in which R1 together with the two adjacent N atoms is the residue of a diamine and R4 together with the two adjacent carbonyl groups is the ... | 03/19/2002 |
| 6300330 | Heterocycle derivatives which inhibit factor Xa The invention relates to heterocyclic derivatives of the formula (I): A--B--X1 --T1 (R2)--L1 --T2 (R3)--X2 --Q or pharmaceutically acceptable salts thereof, which possess antithr... | 10/09/2001 |
| 6221870 | Ergoline derivatives and their use as somatostatin receptor antagonists The invention provides compounds of formula I ##STR1## wherein R1 to R6 are as defined in the description, and a process for preparing them. The compounds of formula I are useful as pharmaceuticals.... | 04/24/2001 |
| 6204273 | 16-substituted-4-aza-androstane 5--reductase isozyme 1 inhibitors Compounds of the Formula I ##STR1## are inhibitors of the 5-reductase 1 isozyme, and are useful alone, or in combination with a 5-reductase 2 inhibitor, for the treatment of androgenic sensitive disorders such as acne vulgaris, seborrhea, fe... | 03/20/2001 |
| 6187775 | Acridone-derived compounds useful as antineoplastic and antiretroviral agents The present invention relates to several novel acridone-derived compounds of of formula (I) or (II). These compounds are potent anti-viral agents, useful in the treatment of viral diseases, such as Human Immunodeficiency Virus. In addition, these compound... | 02/13/2001 |
| 6156754 | Glycoconjugates of modified camptothecin derivatives (A-or B-ring linkage) The present invention relates to glycoconjugates of camptothecin derivatives in which at least one carbohydrate component is linked via suitable spacers with the A or B ring of a camptothecin derivative. The invention furthermore relates to processes for ... | 12/05/2000 |
| 6133280 | Androgen synthesis inhibitors This invention relates to novel inhibitors of androgen synthesis that are useful in the treatment of prostate cancer and benign prostatic hypertrophy. The present invention also provides methods of synthesizing these novel compounds, pharmaceutical compos... | 10/17/2000 |
| 6127368 | Anellated ଲ-carbolines Compounds of formula I ##STR1## are described, as well as the process for their production and their use in pharmaceutical agents.... | 10/03/2000 |
| 6004962 | Rapid opioid detoxification Rapid opioid detoxification procedures are provided which include sedating a patient with a rapid-acting, safely reversible intravenous anesthetic agent having a very short full recovery period. The patient is administered an opioid antagonist while sedat... | 12/21/1999 |
| 5880125 | 4-spiroindoline piperidines promote release of growth hormone The present invention is directed to certain novel compounds identified as 4-spiroindoline piperidines of the general structural formula: ##STR1## wherein R1, R1a, R2a, R3a, R3b, R4, R... | 03/09/1999 |
| 5814642 | Tetracyclic condensed heterocyclic compounds their production, and use A novel compound of the formula ##STR1## wherein Ar represents a tetracyclic fused heterocyclic group which may be substituted; R1 represents H or a hydrocarbon group which may be substituted; Y represents an amino acid or nitrogen-contain... | 09/29/1998 |
| 5756512 | Treatment of non-small cell lung carcinoma A method of treating non-small cell lung carcinoma in a human afflicted therewith which comprises administering to such human an effective amount of a compound of the water soluble camptothecin analog class.... | 05/26/1998 |
| 5741795 | 16-substituted-6-aza-androsten-4-ene-3-ones as 5--reductase inhibitors Compounds of the formula I ##STR1## are inhibitors of 5-reductase, and are useful for the treatment of hyperandrogenic disorders such as acne vulgaris, seborrhea, female hirsutism, male pattern baldness, prostatic carcinoma, prostatitis and ... | 04/21/1998 |
| 5696127 | Steroid receptor modulator compounds and methods Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions f... | 12/09/1997 |
| 5693646 | Steroid receptor modulator compounds and methods Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions f... | 12/02/1997 |
| 5674872 | Treatment of ovarian cancer A method of treating ovarian cancer in a human afflicted therewith which comprises administering to such human an effective amount of a compound of the water soluble camptothecin analog class.... | 10/07/1997 |
| 5670500 | Water soluble camptothecin analogs The present invention provides water soluble camptothecin analogs of Formula I: ##STR1## which are particularly useful as antineoplastic agents; pharmaceutical compositions thereof; and a method of treating cancer in an animal in need thereof, i... | 09/23/1997 |
