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| Number | Title | Issue Date |
| 7678798 | Piperazinylpiperidine derivatives as chemokine receptor antagonists The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the... | 03/16/2010 |
| 7557105 | N-oxides of N-phenyl-2-pyrimidine-amine derivatives The invention relates to N-phenyl-2-pyrimidine-amine derivatives in which at least one nitrogen atom carries an oxygen atom to form the corresponding N-oxides, to processes for the preparation thereof, to pharmaceutical compositions comprising those compounds, and t... | 07/07/2009 |
| 7521452 | Preparation of pharmaceutical salts of piperazine compounds The present invention is generally directed to a process to directly prepare pharmaceutically acceptable salts enriched with respect to selected rotameric salts of a basic compound, by creative choice of an acid and a solvent medium. The process is particularly usef... | 04/21/2009 |
| 7470691 | Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein A, L, D a... | 12/30/2008 |
| 7365069 | Pyrimidone derivatives The present invention relates to novel pyrimidones of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and pharmaceutical... | 04/29/2008 |
| 7361691 | Method of treating cancers using β-lapachone or analogs or derivatives thereof Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint activator, which is preferably β-lapachone, or a derivative or analog thereof, combined with an oncogenic kinase modulator, preferably imatinib. This combination of the cell cyc... | 04/22/2008 |
| 7354924 | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives This invention provides Compounds I having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral acti... | 04/08/2008 |
| 7345046 | Heteroaryl-fused pyrimidinyl compounds as anticancer agents Heteroaryl-fused pyrimidinyl compounds, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the heteroaryl-fused pyrimidinyl compounds, either alone or in combination with at lea... | 03/18/2008 |
| 7335663 | Heteroaryl compounds which inhibit leukocyte adhesion mediated by αintegrins Disclosed are compounds which bind α4 integrins, where the α4 integrin is preferably VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by α4 integrins, where the α | 02/26/2008 |
| 7329671 | 2,4-pyrimidinediamine compounds and their uses The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a... | 02/12/2008 |
| 7329661 | N-phenyl-3-pyrimidine-amine derivatives The invention relates to N-phenyl-2-pyrimidine-amine derivatives of formula I wherein the substituents are defined as indicated in the description, to processes for the preparation thereof, to medicaments compris... | 02/12/2008 |
| 7329672 | 2,4-pyrimidinediamine compounds and their uses The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a... | 02/12/2008 |
| 7326699 | 4-Amino-5-phenyl-7-cyclobutyl-pyrrolo(2,3-d)pyrimidine derivatives The invention relates to new 4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives, processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof-alone or in combination with o... | 02/05/2008 |
| 7312216 | N-phenyl-2-pyrimidine-amine derivatives The invention relates to N-phenyl-2-pyrimidine-amine derivatives of formula I wherein the substituents are defined as indicated in the description, to processes for the preparation thereof, to medicaments compris... | 12/25/2007 |
| 7307081 | Piperidine derivatives useful as CCR5 antagonists The present invention provides a compound of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein the various moieties are as defined in the specification. The present invention also provides pharma... | 12/11/2007 |
| 7300937 | Derivatives of cyano-aryl (or cyanoheteroaryl)-carbonyl-piperazinyl-pyrimidines, their preparation and application as medication New derivatives of cyanoaryl (or cyanoheteroaryl)-carbonyl-piperazinyl-pyrimidines (I), where R1 represents an OR3 radical, where R3 represents a radical derived from a saturated hydrocarbon, with a linear or branched chain of 1 to 4... | 11/27/2007 |
| 7300938 | Polymorphs of imatinib mesylate The present invention relates to novel polymorphs of imatinib mesylate, to processes for their preparation and to pharmaceutical compositions containing them. ... | 11/27/2007 |
| 7297694 | Pyridylfurans and pyrroles as Raf kinase inhibitors Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. ... | 11/20/2007 |
| 7285545 | Cytokine inhibitors Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as... | 10/23/2007 |
| 7244748 | Pyridines for treating injured mammalian nerve tissue The invention provides novel pyridines, pharmaceutical compositions comprising such pyridines, and the use of such compositions in treating injured mammalian nerve tissue, including but not limited to an injured spinal cord. In one embodiment, the compounds, composi... | 07/17/2007 |
| 7238525 | Strategy for leukemia therapy The chimeric Bcr-Abl oncoprotein is the molecular hallmark of chronic myelogenous leukemia (CML). In the cytoplasm, the protein transduces a growth signal that is responsible for overexpansion of cells. In the nucleus, the protein induces apoptosis. The invention is... | 07/03/2007 |
| 7235538 | Heterocyclic compounds, which are inhibitors of the enzyme DPP-IV The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV, which are of formula I wherein each n is one or two independently and R1, R2, R3 | 06/26/2007 |
| 7232825 | Phenylaminopyrimidine derivatives and methods of use The present invention relates to phenylaminopyrimidine derivatives, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment of disease states such as cancers associated with tyrosine kinases, espec... | 06/19/2007 |
| 7196080 | Phenylpyridinecarbonylpiperazinederivative The present invention relates to a compound which is represented by the following general formula and has type 4 phosphodiesterase inhibitory action, and uses and an intermediate compound thereof. (wherein ... | 03/27/2007 |
| 7186723 | Tyrosine kinase inhibitors The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogen... | 03/06/2007 |
| 7173025 | Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents Compounds of formula (I), wherein G1 is CH or N; G2 is CH or N; R1 is a variety of optional substituents; L1 is (1-4C)alkylene; T1 is CH or N; R2 and R3 are independently hydrogen or (1-4C)... | 02/06/2007 |
| 7166597 | Fused pyrazole derivatives being protein kinase inhibitors Compounds of Formula (I): salts or solvates or physiologically functional derivatives thereof, wherein Z is CH or N, and R1, R2, and R4 are various substituent groups, are protein kinase inhibitors | 01/23/2007 |
| 7163940 | Pyrazolopyridinyl pyrimidine therapeutic compounds The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceuti... | 01/16/2007 |
| 7157455 | 4-Aminopyrimidine-5-one derivatives Novel 4-aminopyrimidine-5-one derivatives are disclosed. These compounds inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are ... | 01/02/2007 |
| 7157462 | Therapeutic agents useful for treating pain A compound of formula: wherein Ar, Ar1, Ar2, R3–R6, R13, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Hydroxyiminopip... | 01/02/2007 |
| 7153855 | Pyrazolopyridinyl pyrimidine therapeutic compounds The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents. ... | 12/26/2006 |
| 7144914 | 3,7-diazabicyclo[3.3.0]octanes and their use in the treatment of cardiac arrhythmias There is provided compounds of formula (I) wherein R1 to R4, Ra to Rf, A and B have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventr... | 12/05/2006 |
| 7141569 | Antiviral pyrazolopyridine compounds The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents. ... | 11/28/2006 |
| 7135477 | Heterocyclic compounds which inhibit leukocyte adhesion mediated by αintegrins Disclosed are compounds which bind α4 integrins, preferably VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by α4 integrins, preferably VLA-4. Such compounds are useful in the ... | 11/14/2006 |
| 7122544 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto Compounds having activity as inhibitors of IKK are disclosed, particularly IKK-2. The compounds of this invention are anilinopyrimidine derivatives having the following structure: wherein R1 and R6 | 10/17/2006 |
| 7119203 | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metallop... | 10/10/2006 |
| 7109197 | N-phenyl-4-(4-pyridyl)-2-pyrimidineamine derivatives The present invention relates to a method of protecting plants against attack or infestation by phytopathogenic organisms, such as nematodes or especially microorganisms, preferably fungi, bacteria and viruses, or combinations of two or more of these organisms, by a... | 09/19/2006 |
| 7098213 | CCR5 antagonists useful for treating AIDS Compounds of the formula or a pharmaceutically acceptable salt or isomer thereof, wherein: Q, X and Z are CH or N; R, R4–R7 and R13... | 08/29/2006 |
| 7094784 | High affinity ligands for nociceptin receptor ORL-1 Novel compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein: the dotted line represents an optional double bond; X1 | 08/22/2006 |
| 7094785 | Method of treating polycythemia vera The invention is directed to the use of imatinib mesylate for treating polycythemia vera. Imatinib mesylate is surprisingly effective at controlling the symptoms of polycythemia vera and reducing the need for phlebotomy. ... | 08/22/2006 |