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| Number | Title | Issue Date |
| 5098889 | Method for preventing or inhibiting loss of cognitive function employing a combination of an ace inhibitor and a drug that acts at serotonin receptors A method is provided for imhibiting loss of cognitive functon, including memory, which may or may not be associated with Alzheimer's disease, by administering an ACE inhibitor, such as captopril, fosinopril, zofenopril or ceranapril in combination with a ... | 03/24/1992 |
| 5043327 | Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives, compositions and use The present invention relates to novel positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives having positive inotropic and lusitropic properties which are useful in the treatment of warm-blooded animals suffering from... | 08/27/1991 |
| 5032578 | Method for preventing or treating depression employing a combination of an ace inhibitor and a drug that acts at serotonin receptors A method is provided for inhibiting onset of or treating depression by administering an ACE inhibitor, such as captopril, fosinopril, zofenopril or ceranapril in combination with a drug that acts at serotonin receptors such as zacopride, over a prolonged ... | 07/16/1991 |
| 5015646 | Pharmaceutically useful polymorphic modification of buspirone "Buspirone hydrochloride can exist in two polymorphic forms and the newly discoverd lower melting form, which is thermodynamically favored at pharmaceutically relevant temperatures, offers advantage in manufacture of buspirone pharmaceutical compositions"... | 05/14/1991 |
| 4994455 | Anti-anxiety agents Anti-anxiety agents; namely, 1-(heterocyclylcarbonyl)-3-[4-(2-pyrimidinyl)-1-piperazinyl]propanes and 1-(heterocyclylsulfonyl)-3-[4-(2-pyrimidinyl)-1-(piperazinyl)]propanes; and methods for their preparation and use.... | 02/19/1991 |
| 4883795 | Piperazinyl-heterocyclic compounds Arylpiperazinyl-ethyl (or butyl)-heterocyclic compounds and their pharmaceutically acceptable acid addition salts are neuroleptic agents. They are useful in the treatment of psychotic disorders.... | 11/28/1989 |
| 4871738 | Use of 2-pyrimidinyl-1-piperazine derivatives in the treatment of dependence on nicotine A method of treating warm-blooded animals to reduce their dependency upon nicotine comprising administering to such animals a medicament containing a 2-pyrimidinyl-1-piperazine derivative of the formula ##STR1## in which n stands for 2, 3, 4, 5 or 6 ... | 10/03/1989 |
| 4826846 | Arylpiperazinylalkoxy derivatives of cyclic imides to treat anxiety There are disclosed compounds of the formula ##STR1## wherein the group A is ##STR2## where R1 and R2 are each independently or loweralkyl, or R1 +R2 =(CH2)m, m being 2 to 6, p is... | 05/02/1989 |
| 4788189 | Method to treat smoking withdrawal symptoms by potentiated central noradrenergic blocking Administering divided dose of oral Clonidine potentiated by an intramuscular tricyclic antidepressant alleviates the abstinence syndrome resulting from withdrawal of nicotine by smoking cessation. Patient response to the Clonidine/tricyclic serves as the ... | 11/29/1988 |
| 4780466 | Arylpiperazinylalkoxy derivatives of cyclic imides There are disclosed compounds of the formula ##STR1## wherein the group A is ##STR2## where R1 and R2 are each independently hydrogen or loweralkyl, or R1 +R2 =(CH2)m, m being 2 t... | 10/25/1988 |
| 4777173 | Method for treatment of alcohol abuse Buspirone and its pharmaceutically acceptable salts are useful in the treatment of alcohol abuse.... | 10/11/1988 |
| 4696927 | 4-(2-pyrimidinyl)-1-piperazinyl heterocyclic carbonyl derivatives This invention relates to 4-(2-pyrimidinyl)-1-piperazinyl heterocyclic carbonyl derivatives, to a process for their preparation, and to their use as anxiolytic agents.... | 09/29/1987 |
| 4640921 | Treatment of sexual dysfunction with buspirone Buspirone and its pharmaceutically acceptable salts are useful in treating patients of both sexes suffering from sexual dysfunction.... | 02/03/1987 |
| 4639453 | Substituted 1-(4-amino-6,7-dialkoxyquinazolinyl)-4 cyclohexenyl derivatives of piperazine and homopiperazine, processes for their preparation and their use, formulations containing these compounds and intermediates New substituted 1-(4-amino-6,7-dialkoxyquinazolinyl)-4-cyclohexenyl derivatives of piperazine and homopiperazine, of the general formula I ##STR1## in which R1, R2, R3, R4 and R5, which can be id... | 01/27/1987 |
| 4634703 | Method for alleviation of panic disorders Buspirone and its pharmaceutically acceptable salts are useful in alleviation of panic disorders which can take the form of clinical syndromes comprising, for example, panic attacks, agoraphobia and phobic anxiety.... | 01/06/1987 |
| 4581357 | Antipsychotic 5-fluoro-pyrimidin-2-yl piperazine compound 8-[4-[4-(5-Fluoro-pyrimidin-2-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decan e-7,9-dione and its pharmaceutically acceptable salts demonstrate antipsychotic activity.... | 04/08/1986 |
| 4543355 | Substituted succinimides, compositions and method of use Succinimide derivatives representable by the following formula: ##STR1## wherein X and Y are combined to form a group of the formula: ##STR2## (wherein A is an oxygen atom, a methylene group or an ethylene group and a full line accompanying a br... | 09/24/1985 |
| 4438119 | Method for alleviation of extrapyramidal motor disorders Buspirone and its pharmaceutically acceptable salts are useful in alleviation of extrapyramidal motor disorders which can take the form of clinical syndromes such as Parkinsonism and neuroleptic-induced extrapyramidal symptoms (EPS).... | 03/20/1984 |
| 4182763 | Buspirone anti-anxiety method Buspirone hydrochloride is an effective anti-anxiety agent for the palliative treatment of neurotic patients in which symptoms of anxiety are predominant at doses which are without observable effect in either normal individuals or psychotic patients.... | 01/08/1980 |
| 3976776 | Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones The present invention concerns the class of heterocyclic carbon compounds comprised of N-(heteroarcyclic)piperazinylalkyl derivatives of azaspiroalkanediones which have potent and specific tranquilizing action and anti-emetic properties. Typical embodimen... | 08/24/1976 |
