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| Number | Title | Issue Date |
| 7001601 | Ganglioside-KLH conjugate vaccine plus QS-21 This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of ganglioside or oligosaccharide portion thereof conjugated to an immuno... | 02/21/2006 |
| 7001888 | Compositions and methods for treating cancer Methods and compositions are provided for the treatment of cancer that take advantage of the increased uptake of glucose-anti-neoplastic agent conjugates in cancer cells relative to normal cells. ... | 02/21/2006 |
| 6998392 | Formulation to treat or prevent parasitic infection The invention provides a formulation for treatment or prevention of a parasitic infection such as a protozoan or helminths infection, for example: Giardia. The formulation comprises at least one ganglioside, which may be selected from the group consisting of:... | 02/14/2006 |
| 6998470 | Process for large-scale isolation and purification of hypothalamic inhibitory factor The present invention relates to a method of isolating and/or purifying hypothalamic inhibitory factor (HIF) from a sample (e.g., tissue fluid) containing HIF. The present invention provides for isolation of large amounts of HIF using diafiltration, solid phase extr... | 02/14/2006 |
| 6992037 | Precious metal catalyst for debenzylation One aspect of the invention relates to catalyst composite containing a metal catalyst and a specifically defined carbon support containing a carbonaceous material. For example, the carbon support may have a total pore surface area of about 800 m2/g or mor... | 01/31/2006 |
| 6989162 | Hepatoprotective agent of plant origin and a process thereof A process of isolation of pure Acteoside of high hepatoprotection from plant Colerbrookea oppositifolia, said process comprising steps of drying aerial parts of the plant, grounding the dried parts into powder, percolating the powder with water or ethanol for... | 01/24/2006 |
| 6987094 | Optimized formulation of tobramycin for aerosolization The invention provides a tobramycin formulation for delivery by aerosolization in the form of additive-free, isotonic solution whose pH has been optimised to ensure adequate shelf-life at room temperature. Said formulation can be advantageously used for the treatmen... | 01/17/2006 |
| 6987098 | Health supplement Compositions enriched with natural phyto-oestrogens or analogues thereof selected from Genistein, Daidzein, Formononetin and Biochanin A. These may be used as food additives, tablets or capsules for promoting health in cases of cancer, pre-menstrual syndrome, menopa... | 01/17/2006 |
| 6987092 | Indigoid bisindole derivatives The present invention relates to novel indigoid binsindole derivatives which can be used for the manufacture of a medicament for the treatment of solid cancers. ... | 01/17/2006 |
| 6984630 | Endofucanases and method using same for preparing fuco-oligosaccharides from fucanes, bacterium producing endofucanases and uses of fuco-oligosaccharides for plant protection The invention concerns endofucanases suitable for preparing fuco-oligosaccharides by enzymatic hydrolysis of fucanes. It also concerns a bacterium producing endofucanases and the preparation of said enzyme from the bacterium. It further concerns endofucanase genes a... | 01/10/2006 |
| 6979675 | Treatment of cancer with 2-deoxyglucose The compound 2-deoxyglucose can be used to treat cancer and to improve patient outcome when administered at a therapeutically effective dose, and, optionally, co-administered with other anti-cancer drugs, or in combination with surgical resection or radiation therap... | 12/27/2005 |
| 6977294 | Process for isolation of eupalitin from Boerhavia diffusa The present invention relates to a process of isolation of bioactive eupalitin (3-O-O-D-galactopyranoside) of formula 1 possessing anti-osteoporosis activity by extraction of powdered leaves of Boerhaavia diffusa, with better yield: | 12/20/2005 |
| 6974801 | Inhibitors and methods of use thereof New triterpenoid derivatives with various substituents at the C-17 position of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) were synthesized. Among them, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile (CNDDO), 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-... | 12/13/2005 |
| 6974818 | 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain A compound of formula: (wherein X is O or S and R1, R3, R4, and R5 are disclosed herein) or a pharmaceutically acceptable salt thereof (a “Thiadiazolylpiperazine Compoundâ€... | 12/13/2005 |
| 6972283 | Glucopyranosyloxypyrazole derivatives, medicinal compositions containing the same and intermediates in the production thereof The present invention relates to glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R1 represents a hydrogen atom or a lower alkyl group; one of Q1 and T1 | 12/06/2005 |
| 6967022 | Ganglioside-KLH conjugate vaccines plus QS-21 This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of ganglioside or oligosaccharide portion thereof conjugated to an immuno... | 11/22/2005 |
| 6962930 | Compounds, compositions and method suitable for amelioration of withdrawal syndromes and withdrawal-induced brain damage Compounds, composition and method for ameliorating alcohol or drug dependency withdrawal syndromes and withdrawal-induced brain damage are disclosed. In particular, a series of N-substituted-4-uredo-5,7-dihalo-2-carboxy quinoline compounds are disclosed having combi... | 11/08/2005 |
| 6960344 | Use of imine-forming polysaccharides as adjuvants and immunostimulants The present invention relates to polysaccharide conjugates that comprise: a polysaccharide that binds to surface-receptors present on Antigen Presenting Cells, conjugated to one or more compounds having stable carbonyl groups covalently attached, either directly or ... | 11/01/2005 |
| 6960566 | Compositions and methods for treatment of cancer Compositions containing one or more peptido-mimetics or modified peptido-mimetics of a carbohydrate ligand of an adhesion molecule in a physiologically acceptable carrier are useful for methods of reducing metastasis in a mammal and for inhibiting inflammatory respo... | 11/01/2005 |
| 6958326 | Cyclodextrin-drospirenone inclusion complexes Pharmaceutical compositions comprising low doses of sensitive complexes between an estrogen and a cyclodextrin are provided with improved stability. In specific embodiments the composition comprises a complex between ethinyl estradiol and β-cyclodextrin in a granul... | 10/25/2005 |
| 6958395 | Method for producing water-soluble saccharide conjugates and saccharide mimetics by Diels-Alder reaction The present invention relates to a method by which saccharide compounds can be prepared in a very easy way. This method comprises the steps of: (a) attaching at least one saccharide to a cyclic or acyclic diene, (b) reacting the saccharide-... | 10/25/2005 |
| 6958315 | Amphoteric surfactants based upon alkyl polyglucoside The invention relates to a series of polyglycoside derivatives that contain water-soluble groups introduced into the molecule by reaction with the hydroxyl groups present in the starting polyglycoside molecule. The preferred products have more than one water-soluble... | 10/25/2005 |
| 6956109 | Ceramide analogs, process for their preparation and their use as antitumor agents The present invention is directed to ceramide analog compounds of general formula (I) the process for their preparation and use for the preparation of pharmaceutical formulations for the treatment of tumors. ... | 10/18/2005 |
| 6953781 | Compounds and their uses Compounds having a mimetic or antagonistic property of an inositol phosphoglycan, and the uses of these compounds are disclosed, together with the use, e.g. to treat a condition ameliorated by administration of an IPG second messenger or an IPG antagonist thereof. I... | 10/11/2005 |
| 6953797 | Use of phenylheteroalkylamine derivatives There is disclosed the use of a compound of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates thereof, in the manufacture of a medicament, for the ... | 10/11/2005 |
| 6949521 | Therapeutic azide compounds Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and hydroxy substituents are converted in vivo to the corresponding drugs... | 09/27/2005 |
| 6949517 | Method of treating inflammatory, tissue repair and infectious conditions The present invention relates to a method of treating inflammatory, tissue repair and infectious conditions in a mammal suffering therefrom which comprises administering to a mammal in need thereof an effective amount of a cyclic compound selected from the group con... | 09/27/2005 |
| 6946484 | Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype Methods and formulations for inhibiting and preventing a malignant cell phenotype by administering to cells a low dose of a nitric oxide mimetic are provided. ... | 09/20/2005 |
| 6946121 | Composition in particular cosmetic or dermatological composition, containing oligosaccharides and preparation method and cosmetic treatment method The invention concerns a composition comprising at least a first constituent which is an oligosaccharide of formula (I) containing 3 to 5 oside units and having at least a D-galactose unit bound by an α[1-6] bond with a sucrose unit. The invention is characterized ... | 09/20/2005 |
| 6946451 | Insulin secretion promoter Provided are a method for promoting insulin secretion, a method for suppressing the elevation of a blood glucose level, a method for ameliorating diabetes mellitus, a method for promoting growth of an animal, and a method for increasing an insulin level in breast mi... | 09/20/2005 |
| 6942876 | Analgesic compositions comprising anti-epileptic compounds and methods of using same The present invention is directed to novel combinations of anti-epileptic compounds that demonstrate pain alleviating properties, with compounds selected from the group consisting of analgesics, NMDA receptor antagonists, and NSAIDs and pharmaceutical compositions c... | 09/13/2005 |
| 6939856 | Method for preparing dexchlor tannate The invention pertains to a method for preparing dexchlorpheniramine (“dexchlor”) tannate by reacting dexchlorpheniramine free base at a temperature of about 75 to about 150° C. with tannic acid neat or as an aqueous slurry containing up to about 20 wt. % water... | 09/06/2005 |
| 6939945 | Synthetic peptides, conjugation reagents and methods The invention provides methods and compositions useful for making synthetic peptide conjugates. In one embodiment, the invention provides compositions comprising the structure: wherein R is selected from lower substitu... | 09/06/2005 |
| 6939857 | Compounds and their uses Compounds having a mimetic or antagonistic property of an inositol phosphoglycan, and the uses of these compounds are disclosed, together with the use, e.g. to treat a condition ameliorated by administration of an IPG second messenger or an IPG antagonist thereof. P... | 09/06/2005 |
| 6939858 | Malto-oligosaccharide derivatives and use thereof The present invention provides a substance which strongly inhibits human α-amylase and is effective for the prevention and treatment of hyperglycemia, for example, diabetes and the diseases caused thereby, and an α-amylase inhibitor and a prophylactic or therapeut... | 09/06/2005 |
| 6936253 | Ganglioside-KLH conjugate vaccines plus QS-21 This invention provides a vaccine for stimulating or enhancing in a subject to which the vaccine is administered, production of an antibody which recognizes a ganglioside, comprising an amount of ganglioside or oligosaccharide portion thereof conjugated to an immuno... | 08/30/2005 |
| 6936590 | C-aryl glucoside SGLT2 inhibitors and method A method is provided for treating diabetes and related diseases employing an SGLT2 inhibiting amount of a compound of the formula alone or in combination with one or more other antidiabetic agent(s) or other therapeuti... | 08/30/2005 |
| 6936605 | Pharmaceutical composition A liquid pharmaceutical composition is described comprising from about 7.5 mg/mL to about 12.5 mg/mL of midazolam in the form of midazolam maleate in solution in an aqueous liquid medium comprising ethanol and a polyhydroxy solvent. This composition can be administe... | 08/30/2005 |
| 6936589 | Parenteral delivery systems Hypertonic sugar compositions administered by other than ingestion and swallowing or intravascular injection, such as by intranasal spray or drops, intraocular drops or ointment, oral spray, intraotic spray or drops, lozenges, chewable tablet, chewing gum, or gargle... | 08/30/2005 |
| 6932962 | Aerosol drug formulations containing hydrofluoroalkanes and alkyl saccharides Aerosol formulations suitable for use in pressurised metered dose inhalers comprise a hydrofluoroalkane propellant, an medicament for inhalation and a surfactant which is a a C8–C16 fatty acid or salt thereof, a bile salt, a phospholipid, or ... | 08/23/2005 |
