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| Number | Title | Issue Date |
| 8106007 | Conjugates of a polypeptide and a pentasaccharide The present invention relates to conjugates of a polypeptide and an oligosaccharide, wherein the polypeptide is conjugated to at least one oligosaccharide-spacer residue, the oligosaccharide being a synthetic sulfated oligosaccharide comprising 4-18 monosaccharide u... | 01/31/2012 |
| 8097593 | Lipid A and other carbohydrate ligand analogs The core structure of pentaerythritol has been used as a replacement for one or both sugars in lipid A, leading to the generation of a series of lipid A analogs. These lipid A analogs may further differ from lipid A with respect to, e.g., the number, nature and loca... | 01/17/2012 |
| 8080527 | Methods and compositions for prevention and treatment of inflammatory disease, autoimmune disease, and transplant rejection The invention provides compositions and methods for reducing one or more symptoms of an autoimmune disease, inflammatory disease, and/or transplant rejection, by the administration to a subject in need thereof a pharmaceutically effective amount of a purified compou... | 12/20/2011 |
| 8071558 | Application of D-psicose to suppression of abnormal circadian increase in blood glucose level A novel use of D-psicose (for suppressing the abnormal intra-day increase of blood glucose level) is provided. A composition containing D-psicose as the active component and for use in suppressing the abnormal intra-day increase of plasma glucose concentration. The ... | 12/06/2011 |
| 8053416 | Isolation and structure of turbostatins 1-4 Described herein are novel cerebroside compounds, designated as Turbostatin 1, Turbostatin 2, Turbostatin 3, and Turbostatin 4. These compounds were extracted and isolated from the marine mollusk Turbo stenogyrus, and their structures elucidated. The new comp... | 11/08/2011 |
| 8053417 | Hexosylceramides as adjuvants and their uses in pharmaceutical compositions The present invention relates to new adjuvants and the uses in pharmaceutical compositions, like in vaccines. In particular, the present invention provides new compounds useful as adjuvants for prophylactic and/or therapeutic vaccination in the treatment of infectio... | 11/08/2011 |
| 8048860 | Butanol extract of A method of treating a Th1-mediated disorder includes administering to a subject in need of the treatment an effective amount of a compound of the formula I: wherein R1 is H, alkyl, aryl, or cyclyl; R2 | 11/01/2011 |
| 8044029 | Sulfatides for treatment of autoimmune disorders Disclosed herein are methods for the treatment of autoimmune or immune related diseases or disorders. Also disclosed are methods for treating such autoimmune or immune related diseases or disorders with the administration of sulfatides. Also disclosed herein are met... | 10/25/2011 |
| 8026221 | Method, composition and kit for antigenic binding of norwalk-like viruses A method for detecting a Norwalk-Like Virus (NLV) in a biological sample, comprising the steps of: obtaining a biological sample suspected of containing a NLV; contacting the biological sample with at least one human histo-blood group antigen to allow formation of a... | 09/27/2011 |
| 8022043 | Ceramide derivatives as modulators of immunity and autoimmunity α-Galactosylceramides and glycosylceramides (“ceramide-like glycolipids”) that modulate NK T cells. The ceramide-like glycolipids vary in the cytokines induced in NK T cells and vary in the antigen-presenting cells that are capable of efficiently presenting the... | 09/20/2011 |
| 7998935 | Quinaldine based semisquaraines and squaraine dyes, process for preparation thereof and use thereof The present invention provides quinaldine-based semisquaraines, symmetrical and unsymmetrical squaraine dyes represented by the general formulae 1, 2 and 3 and/or pharmaceutically acceptable derivatives thereof as sensitizers for photodynamic therapeutical and indus... | 08/16/2011 |
| 7994140 | Classes of compounds that interact with GPCRs The present invention relates to a method of identifying a candidate therapeutic agent. The method comprises contacting a G-Protein Coupled Receptor (GPCR) with a compound of General Formula (I), or a pharmaceutically acceptable salt thereof | 08/09/2011 |
| 7989423 | 6″-amino-6″-deoxygalactosylceramides This invention relates to galactosylceramide compounds. ... | 08/02/2011 |
| 7968522 | Treatment and prophylaxis of sepsis and septic shock A method and composition for the prophylaxis or treatment of humans or animals for septic shock and sepsis using a mixture of sophorolipids. ... | 06/28/2011 |
| 7964568 | Synthesis of high molecular weight iron-saccharidic complexes A process for preparing parenteral iron-saccharidic complexes, and the complexes produced, comprising: (1) providing an aqueous solution or dispersion including (i) Fe(III) and (OH)− ions and (ii) at least one saccharide, to form a reaction mixture, whe... | 06/21/2011 |
| 7956039 | Use of amygdalin analogues for the treatment of psoriasis The compounds of formula (I), wherein n is an integer from 0 to 4; R1 is a radical selected from the group consisting of H, CH3, CH2-CH3, C(CH3)3, COOH, CONH2 and C≡CH; R2, R3, R4 and R5 are radical... | 06/07/2011 |
| 7932232 | Cosmetic composition comprising beta-fructosyl-L-ascorbic acid for skin whitening The present invention is related to novel cosmetic composition comprising beta-fructosyl-L-ascorbic acid derivatives produced by fructose conversion reaction using by ascorbic acidskin whitening cosmetic composition as an cream, skin, lotion, pack and the like. ... | 04/26/2011 |
| 7932233 | Fungal phytotoxin fusicoccin for the treatment and diagnosis of coagulation-correlated pathologies The present invention concerns the use of tricyclic terpenes chosen from the group consisting of fusicoccin, ophyobolins or cotylenins for the therapy and diagnosis of coagulation-correlated pathologies such as Bernard-Soulier syndrome (BSS), von Willebrand disease ... | 04/26/2011 |
| 7928077 | Alpha-galactosyl ceramide analogs and their use as immunotherapies The present disclosure relates to synthetic alpha-galactosyl ceramide (α-GalCer) analogs, and their use as immunotherapies. In one aspect. a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject,... | 04/19/2011 |
| 7919470 | Glycopeptide composition with improved antibiotic activity A glycopeptide composition with improved antibiotic activity is disclosed, along with a method of preparing such a composition and a pharmaceutical composition made therefrom. ... | 04/05/2011 |
| 7915227 | Pharmaceutical formulations employing short-chain sphingolipids and their use Pharmaceutical formulations containing (i) an amphiphilic drug and (ii) a short-chain sphingolipid are described and provided herein along with methods of making and using same. ... | 03/29/2011 |
| 7902159 | Prophylactic and therapeutic treatment of infectious and other diseases with mono- and disaccharide-based compounds Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses i... | 03/08/2011 |
| 7902158 | Polysulfated glycosides and salts thereof The invention relates to polysulfated glycosides of formula (I), the pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions containing these compounds as active ingredients. Furthermore the invention provides a method of preventing, tr... | 03/08/2011 |
| 7897580 | β glycolipids as immuno-modulators The invention relates to the use of β-glycolipids as immunomodulators. More particularly, the invention relates to the use of β-glycolipids, preferably, β-lactosyl-ceramide, β-glucosylceramide, β-galactosyl-ceramide, ceramid and β-lactosyl-ceramide, as well as... | 03/01/2011 |
| 7875592 | Sulfated oligosaccharide derivatives The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the... | 01/25/2011 |
| 7851451 | Formulations for mediating inflammatory bowel disorders The invention provides formulations and methods for mediating inflammation, in particular an inflammatory bowel disorder such as necrotizing enterocolitis, and for. Further, the formulations are effective in lowering blood cholesterol and decreasing blood cholestero... | 12/14/2010 |
| 7846903 | Type II cubic liquid crystal composition A cubic liquid crystal composition comprising at least one amphiphilic compound having the following general formula (1) and having an IV/OV value of 0.65 to 0.95, and water or an aqueous medium: wh... | 12/07/2010 |
| 7825094 | Method of treatment for cancers associated with elevated HER 2 levels Novel methods of treating proliferative disorders characterized by elevated Her-2, and the patient is then administered an effective amount of an HSP90 inhibitor. ... | 11/02/2010 |
| 7820627 | Lipid A and other carbohydrate ligand analogs The core structure of pentaerythritol has been used as a replacement for one or both sugars in lipid A, leading to the generation of a series of lipid A analogs. These lipid A analogs may further differ from lipid A with respect to, e.g., the number, nature and loca... | 10/26/2010 |
| 7820629 | Galactose derivative, drug carrier and medicinal composition The object of the present invention is to provide a novel and useful galactose derivative, which is a component of a drug carrier by which a medicine can be efficiently transferred into the liver, a drug carrier comprising the derivative, and a pharmaceutical compos... | 10/26/2010 |
| 7820628 | Tumor lesion regression and conversion in situ into autologous tumor vaccines by compositions that result in anti-Gal antibody binding The present invention discloses that an intratumoral injection of: i) glycolipids with α-gal epitope; ii) gene vectors comprising an α1,3galactosyltransferase gene; or iii) a mixture of α1,3galactosyltransferase, neuraminidase, and uridine diphosphate galactose r... | 10/26/2010 |
| 7816329 | Therapeutic use for a group of sulphated polysaccharides The present invention relates to the use of a sulphated polysaccharide in acid form or as a physiologically acceptable salt thereof, selected from the group constituting of inulin sulphate, gellan sulphate, pullulan sulphate, curdlan sulphate, alginiq acid sulphate,... | 10/19/2010 |
| 7811996 | Methods and compositions for prevention and treatment of inflammatory disease, autoimmune disease, and transplant rejection The invention provides compositions and methods for reducing one or more symptoms of an autoimmune disease, inflammatory disease, and/or transplant rejection, by the administration to a subject in need thereof a pharmaceutically effective amount of a purified compou... | 10/12/2010 |
| 7795230 | Derivative of glucose and of vitamin F, compositions comprising it, uses and preparation process An O-acyl product derived from glucose which may be obtained by partial or total esterification of glucose and of vitamin F, comprising a mixture of esters, for example, monoesters, of glucose and of at least one acid chosen from linoleic acid, oleic acid, palmitic ... | 09/14/2010 |
| 7795229 | Serum cholesterol lowering agent or preventative or therapeutic agent for atherosclerosis A serum cholesterol lowing agent or a preventive or therapeutile agent for atherosclerosis, which each comprises a combination of a compound represented by the following general formula (I) or pharmaceutical acceptable salts thereof with a cholesterol biosynthesis i... | 09/14/2010 |
| 7790689 | Monosaccharide derivatives The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bron... | 09/07/2010 |
| 7781408 | Formulations for mediating inflammation and for reducing blood cholesterol The invention provides formulations for mediating inflammation and for lowering blood cholesterol. For example, inflammation of the intestine, retina or neural tissues, may be mediated. Further the formulations are effective in decreasing blood cholesterol absorptio... | 08/24/2010 |
| 7781410 | Compositions containing chalcones and use thereof The present invention features composition comprising a chalcone and the use thereof for treating acne and reducing the appearance of oil or pores on the skin, hair and scalp. ... | 08/24/2010 |
| 7781409 | Composition for external use A composition for external use, comprising 2-O-(β-D-glucopyranosyl)ascorbic acid represented by the formula (I): or a salt or ester thereof which is safe to the human body, and a koji mold or a processed koji. The composit... | 08/24/2010 |
| 7772192 | Compositions and methods for treatment of disease with acetylated disaccharides Compositions and methods for treatment of disease with acetylated disaccharides and analogs thereof are provided. ... | 08/10/2010 |
