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| Number | Title | Issue Date |
| 8178533 | 2-oxo-1-pyrrolidine derivatives, processes for preparing them and their uses The present invention concerns 2-oxo-1-pyrrolidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals. ... | 05/15/2012 |
| 8178534 | cMET inhibitors Compounds of the following formula are provided for use with cMET: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; meth... | 05/15/2012 |
| 8173655 | Bicyclic anilide heterocyclic CGRP receptor antagonists Compounds of formula I: (wherein variables A1, A2, B, m, n, J, R4, G1, G2, G3 and Y are as described herein) which are antagonists of CGRP receptors and whic... | 05/08/2012 |
| 8173654 | Triazolopyridazine compounds The invention is directed to triazolopyridazine compounds of Formula I: where R1, R5, R6, R7, R8, and A are as defined herein, the use of such compounds as protein tyro... | 05/08/2012 |
| 8168636 | Polycyclic heteroaryl substituted triazoles useful as Axl inhibitors Polycyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditio... | 05/01/2012 |
| 8168635 | Modulators of central nervous system neurotransmitters Disclosed are agents having pharmacological activity against cellular receptors and intracellular signaling, particularly receptors and signaling pathways of central nervous system (CNS) neurotransmitters. Also disclosed are related methods and compositions for the ... | 05/01/2012 |
| 8163749 | Six-membered heterocycles useful as serine protease inhibitors The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, R3 and R11 are as defined her... | 04/24/2012 |
| 8153632 | Oxygen linked pyrimidine derivatives The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to oxygen linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions con... | 04/10/2012 |
| 8143253 | Organic compounds Compounds of formula I in free or salt or solvate form, where R1, R2 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical c... | 03/27/2012 |
| 8129381 | Caspase inhibitors and uses thereof The present invention relates to compounds of formula I: useful as inhibitors of caspases. The present invention also provides pharmaceutically acceptable compositions comprising said compounds, processes for preparing the ... | 03/06/2012 |
| 8129382 | Compounds, methods and pharmaceutical compositions for inhibiting PARP The present invention provides compounds which inhibit poly(ADP-ribose) polymerase (“PARP”), compositions containing these compounds and methods for using these PARP inhibitors to treat, prevent and/or ameliorate the effects of the conditions described herein. | 03/06/2012 |
| 8129380 | Phthalazinone derivatives A compound of the formula (I): wherein: A and B together represent an optionally substituted, fused aromatic ring; X and Y are selected from CH and CH, CF and CH, CH and CF and N and CH respectively; RC | 03/06/2012 |
| 8119635 | Diazabicyclic central nervous system active agents Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals. ... | 02/21/2012 |
| 8114874 | Substituted acetylenic imidazo[1,2-B]pyridazine compounds as kinase inhibitors This invention relates to compounds of the general formula: in which the variable groups are as defined herein, and to their preparation and use. In particular, the compounds include embodiments in ... | 02/14/2012 |
| 8101612 | Phthalazine compounds and methods of use The present invention comprises a new class of compounds useful for the prophylaxis and treatment of p38 kinase mediated diseases and related inflammatory conditions. The compounds have a general Formula II wherein L1 | 01/24/2012 |
| 8097627 | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents The invention relates to multiply-substituted tetrahydronaphthalene derivatives of formula (I) process for their production and their use as anti-inflammatory agents. ... | 01/17/2012 |
| 8093247 | Heteroaryl sulfonamides and CCR2 Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in... | 01/10/2012 |
| 8088773 | Therapeutic compositions and methods The present invention relates in general to therapeutic compositions and methods of use. In preferred embodiments, the invention relates to the field of eye health. In some embodiments, the invention relates to the prevention and treatment of macular degeneration by... | 01/03/2012 |
| 8076336 | Triazolopyridazines as PAR1 inhibitors, production thereof, and use as medicaments The invention relates to novel compounds of formula I where R1, R2, R3, R4, R5, R6, R7, R8, Q1, Q2 and Q3 are each as defined below. The compounds of formula I have antithrombotic activity and inhibit especially protease-ac... | 12/13/2011 |
| 8063049 | Inhibitors of MEK This invention concerns to N-(2-aylamino)aryl sulfonamides, which are inhibitors of MEK, methods of using such compounds in the treatment of hyperproliferative diseases, and to pharmaceutical compositions containing such compounds. ... | 11/22/2011 |
| 8063047 | Pyridazine compounds and methods The invention relates to novel chemical compounds of Formula I compositions and methods of using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions com... | 11/22/2011 |
| 8063048 | Acetylenyl-pyrazolo-pyrimidine derivatives The present invention relates to compounds of formula (I): wherein R1 to R3, A, M, L, E, G, and J are as defined in the description and claims. The invention also relates to a process for the manufactu... | 11/22/2011 |
| 8058274 | Heterocycles as potassium channel modulators Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides heterocycles, compositions and methods... | 11/15/2011 |
| 8044050 | Imidazo[1,2-a]azines and their use as pharmaceuticals The present invention relates to derivatives of imidazo[1,2-a]azines of formula I, in which R, R1 to R3, X, Y and n have the meanings indicated in the claims, which modulate the transcription of endothelial nitric oxide (NO... | 10/25/2011 |
| 8044049 | Fused heterocyclic derivative and use thereof The present invention provides a fused heterocyclic derivative having a potent kinase inhibitory activity and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the specifica... | 10/25/2011 |
| 8034812 | Imidazopyridazine derivative having kinase inhibitory activity and pharmaceutical agent thereof The present invention provides an imidazopyridazine derivative compound having a potent kinase inhibitory activity and a pharmaceutical agent thereof useful for treatment or prevention of cancer and the like. One such compound is represented by the formula: | 10/11/2011 |
| 8030305 | Triazolopyridazines as kinase modulators The invention is directed to triazolopyridazine compounds of Formula I: where R1, R5, R6, R7, R8, and A are as defined herein, the use of such compounds as protein tyro... | 10/04/2011 |
| 8030306 | Azabicyclic heterocycles as cannabinoid receptor modulators The present application describes CB-1 inverse agonists according to Formula (I) and (Ia), pharmaceutical compositions comprising at least one compound according to Formula (I) or (Ia), and optionally one or more additional therapeutic agents and methods of treatmen... | 10/04/2011 |
| 8003647 | (Aza)indole derivative and use thereof for medical purposes The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to (aza)indole derivatives represented by... | 08/23/2011 |
| 8003646 | Substituted triazolo-pyridazine derivatives This invention relates to novel substituted triazolo-pyridazines, their derivatives, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treat... | 08/23/2011 |
| 7994167 | Pentafluorosulphanyl-substituted compound and its use for producing medicaments The present invention relates to pentafluorosulphanyl-substituted compounds, methods for their production, medicaments containing such compounds and the use of such compounds for producing medicaments. ... | 08/09/2011 |
| 7989452 | Stable hydrazalazine pharmaceutical compositions The present invention relates to stable and highly purified stable hydralazine hydrochloride compositions and stable hydralazine-containing pharmaceutical compositions. A sterile aqueous injectable pharmaceutical composition suitable for parenteral administration is... | 08/02/2011 |
| 7981889 | Phthalazinone derivatives Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X═NRX then n is 1 or 2 and if X═CR | 07/19/2011 |
| 7981892 | Disubstituted phthalazine hedgehog pathway antagonists The present invention provides novel 1,4-disubstituted phthalazine hedgehog pathway antagonists useful in the treatment of cancer. ... | 07/19/2011 |
| 7981890 | Phthalazinone derivatives A compound of the formula (I): wherein RH represents one or more optional substituents on the fused cyclohexene ring; R1 is selected from H and halo; RN is selected from H and optionally sub... | 07/19/2011 |
| 7981891 | Aurora kinase modulators and method of use The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediate... | 07/19/2011 |
| 7977333 | Substituted pyridines and pyridazines with angiogenesis inhibiting activity Substituted and pyridines and pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X... | 07/12/2011 |
| 7977334 | Beta-agonists, methods for the preparation thereof and their use as pharmaceutical compositions The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 to R7 have the meanings given in the claims and specification, the tautomers, the enantiomers, the diaste... | 07/12/2011 |
| 7943615 | Fused aminopiperidines as dipeptidyl peptidase-4 inhibitors for the treatment or prevention of diabetes The present invention is directed to novel substituted fused aminopiperidines of structural formula (I) which are inhibitors of the dipeptidyl peptidase-4 enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-4 enzy... | 05/17/2011 |
| 7932253 | Immunomodulating oxopyrrazolocinnolines as CD80 inhibitors N-(1-Aza-bicyclo[2.2.2]oct-3-yl)-4-(6,9-difluoro-3-oxo-1,3-dihydro-pyrazolo[4,3-c]cinnolin-2-yl)-benzamide is a CD80 antagonist, useful in the treatment of diseases which benefit from immuno-inhibition. ... | 04/26/2011 |
