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| Number | Title | Issue Date |
| 4505896 | Method of treating acne vulgaris and composition An improved method of treating acne vulgaris comprising administering a therapeutically effective amount of nicotinic acid or nicotinamide and compositions useful in said method.... | 03/19/1985 |
| 4474751 | Ophthalmic drug delivery system utilizing thermosetting gels This invention describes the application of selected polymers as novel drug delivery systems which use the body temperature and pH to induce a liquid to gel transition of the polymer which contains a drug or therapeutic agent therein. The goal of such a d... | 10/02/1984 |
| 4470976 | Poly-cation salt of 4-O-polyhexaose-thio-arylene sulfates Poly-cation salts of 4-O-polyhexaose-thio-arylene sulfate derivatives, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and products.... | 09/11/1984 |
| 4468385 | Poly-cation salts of 4-O-poly-hexaose-thio-alkylene sulfate derivatives and method of use Poly-cation salts of 4-O-polyhexaose-thio-alkylene sulfate derivatives, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and products.... | 08/28/1984 |
| 4459295 | Method of increasing oral absorption of glycosidic and related antibiotics A method and drug form are provided for increasing the oral absorption of glycosidic and related antibiotics such as macrolide, aminoglycoside, lincomycin and anthracycline antibiotics and related chemical species by the oral administration of said glycos... | 07/10/1984 |
| 4459293 | Method of modulating the complement system by administering bis-[ଲ-D-glucopyranosyl-1-thio (or sulfinyl or sulfonyl)]-aryline sulfate derivatives and the cation salts thereof Bis-[ଲ-D-glucopyranosyl-1-thio (or sulfinyl or sulfonyl)]-arylene sulfate derivatives, the cation salts thereof, useful as modulators of the complement system, the intermediates thereof and the process for the preparation of such intermediates and e... | 07/10/1984 |
| 4454123 | O-xylopyranoside series compounds and methods of use Disclosed is a D-xylopyranoside series compound represented by the following general formula: ##STR1## in which R1 represents a benzyl group, ##STR2## (X, Y and p are as defined in the specification), ##STR3## --S--R2 | 06/12/1984 |
| 4444762 | Vehicle composition containing 1-substituted azacyclopentan-2-ones Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein ... | 04/24/1984 |
| 4435387 | Poly-cation salts of bis (or tris) 4-O-polyhexose-thio-arylene sulfate derivatives Poly-cation salts of bis (or tris) 4-O-polyhexose-thio-arylene sulfate derivatives, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.... | 03/06/1984 |
| 4431636 | Bis(4-O-polyhexaose-thio)-phenyl ureas and method of use Poly-cation salts of bis (4-O-polyhexaose-thio)-phenyl urea sulfate derivatives, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.... | 02/14/1984 |
| 4431638 | Poly-cation salts of bis(or tris)[4-0-monohexose-thio]-arylene sulfate derivatives Poly-cation salts of bis(or tris)[4-O-monohexose-thio]-arylene sulfate derivatives useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.... | 02/14/1984 |
| 4424210 | Vehicle composition containing 1-substituted azacycloalkan-2-ones Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein ... | 01/03/1984 |
| 4423040 | Vehicle composition containing 1-substituted azacyclohexan-2-ones Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein ... | 12/27/1983 |
| 4415563 | Vehicle composition containing 1-substituted azacyclononan-2-ones Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein ... | 11/15/1983 |
| 4404195 | Poly cation salts of monohexosethio (or oxy) alkyl diamides N,N'-Bis[4-[(2,3,4,6-tetra-O-sulfo-(or ଲ)-D-glucopyranosyl)thio(or oxy)]phenyl]alkyl diamides, the cation salts thereof, useful as modulators of the complement system, the intermediates thereof and the process for the preparation of such ... | 09/13/1983 |
| 4399126 | Modulators of the complement system N,N'-Bis[4-[2,3,6,-tri-O-sulfo-4-O-(2,3,4,6-tetra-O-sulfo-(and ଲ)-D-glucopyranosyl)-(and ଲ)-D-glucopyranosylthio or sulfinyl or sulfonyl]phenyl]alkyldiamides and alkyldiamines, the cation salts thereof, useful as modulators of th... | 08/16/1983 |
| 4397845 | Lincomycin 3-(5'-adenylate) as anesthetic The 3-(5'-adenylate) of lincomycin- and clindamycin-type compounds in which the propyl hygric acid moiety has been replaced by different cyclic amino acids can be used as a local anesthetic in humans and animals.... | 08/09/1983 |
| 4368193 | Process for treating malaria A process for treating a protozoan disease, for example, malaria, by the systemic administration to a subject hosting a malarial parasite of the 3-(5'-ribonucleotide) of a novel analog of the well-known antibiotics lincomycin and clindamycin. The analogs ... | 01/11/1983 |
| 4316893 | Vehicle composition containing 1-substituted azacycloalkan-2-ones Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein ... | 02/23/1982 |
| 4310660 | Lincomycin compounds Novel useful analogs of the well known antibiotics lincomycin and clindamycin. These analogs are prepared by condensing a cyclic acid with a sugar amine.... | 01/12/1982 |
| 4293547 | Method of treating malaria A process for treating a protozoan disease, for example, malaria, by the systemic administration to a subject hosting a malarial parasite of a novel analog of the well-known antibiotics lincomycin and clindamycin. These analogs are prepared by condensing ... | 10/06/1981 |
| 4259324 | Immunologic adjuvant thio glycoside compounds and compositions Compounds of the formulae Y--R wherein Y is 1-thio-ଲ-L-fucose, 1-thio-ଲ-D-galactose or 1-thio-ଲ-lactose and R is 2-(1-adamantyl)ethyl, 3-[(p-tetrafluorophenethyl)phenyl]propyl, 6-(5-cholesten-3ଲ-yloxy)hex-3-ynl, oleyl, or hexadecyl... | 03/31/1981 |
| 4229441 | Immunologic adjuvant Glycolipid compounds of the formulae ##STR1## wherein R is ##STR2## are useful immunologic adjuvants in vaccines.... | 10/21/1980 |
| 4201775 | Bis[triethylphosphine)aurio]sulfonium sugars A new series of gold containing sugars having anti-arthritic activity are characterized by the presence of a bis[(triethylphosphine)aurio]sulfonium salt moiety at the 1-position of the glucopyranoside. The compounds are prepared by reacting a 1-S-triethyl... | 05/06/1980 |
| 4189471 | Immunologic glycolipid adjuvants Glycolipid compounds of the formulae ##STR1## are useful immunologic adjuvants in vaccines.... | 02/19/1980 |
| 4175123 | Amino-sugar derivatives, process for their preparation and pharmaceutical composition thereof The present invention provides amino-sugar derivatives of the general formula ##STR1## in which n and m independently of each other represent an integer from 0 to 8 and the sum n+m has a value of 0 to 8, and X designates a group --OR, --SH, --SR, --N... | 11/20/1979 |
| 4122170 | Physiological vehicle compositions containing higher alkyl substituted azacyclopentan-2-ones There is disclosed an improved method for topically administering a physiologically active agent to a human or animal by dissolving an effective amount of the agent in a carrier containing suitable amounts of 1-alkyl substituted-azacyclopentan-2-one, as d... | 10/24/1978 |
| 4100276 | Fusidic acid derivatives The invention relates to a new series of fusidic acid derivatives, to salts and easily hydrolyzable esters thereof, to the preparation of these compounds and to pharmaceutical compositions containing the compounds, the new compounds having the general for... | 07/11/1978 |
| 4096247 | Gold thio glucopyranoside compounds and method of use A new series of lower alkyl ethers of S-tri-lower-alkylphosphinegold 1-thio-ଲ-D-glucopyranoside has been prepared and found to have anti-arthritic activity and, in particular, are of use in the treatment of rheumatoid arthritis.... | 06/20/1978 |
| 4096250 | Tri-substituted phosphinegold(I) 1-thio-ଲ-D-glucopyranosides The compounds are tri-substituted phosphinegold(I) 1-thio-ଲ-D-glucopyranosides which have antiarthritic activity and, in particular, are of use in the treatment of rheumatoid arthritis. Of the three substituents on the phosphine one is optionally su... | 06/20/1978 |
| 4096249 | Trialkylphosphinegold(I)-lower alkyl carbamoyl glucopyranosides The compounds are trialkylphosphinegold(I)2,3,4,6-tetra-O-(N-loweralkylcarbamoyl)-1-thio-.be ta.-D-glucopyranosides which have antiarthritic activity and, in particular, are of use in the treatment of rheumatoid arthritis.... | 06/20/1978 |
| 4096248 | Sulfonyl containing organic gold glycoside compounds and method of use A new series of lower alkyl sulfonyl esters of S-tri-lower-alkylphosphinegold 1-thio-ଲ-D-glucopyranosides has been prepared and found to have anti-arthritic activity and, in particular, are of use in treating rheumatoid arthritis.... | 06/20/1978 |
| 4034100 | Antihypertensive agents Compounds of the formula ##STR1## possess antihypertensive activity. Also provided are methods for the preparation of the compounds as well as pharmaceutical formulations and methods for their use as antihypertensive agents.... | 07/05/1977 |
| 4018918 | Topical clindamycin preparations Disclosed is an anti-inflammatory compound, 6,9-di-fluoro-11ଲ,17,21-trihydroxy-16ଲ-meth ylpregna-1,4-diene-3,20-dione 17,21-diacetate, and topical pharmaceutical formulations which include antimicrobial agents.... | 04/19/1977 |
| 3991203 | Vehicle composition containing 1-substituted azacyclopentan-2-ones There is disclosed an improved method for topically administering a physiologically active agent to a human or animal by dissolving an effective amount of the agent in a carrier containing suitable amounts of 1-substituted azacyclopentan-2-one, as defined... | 11/09/1976 |
| 3989816 | Vehicle composition containing 1-substituted azacycloheptan-2-ones There is disclosed an improved method for topically administering a physiologically active agent to a human or animal by dissolving an effective amount of the agent in a carrier containing suitable amounts of 1-substituted-azacycloheptan-2-one, as defined... | 11/02/1976 |
| 3989815 | Novel N-bis-azacyclopentan-2-onyl alkanes There is disclosed an improved method for topically administering a physiologically active agent to a human or animal by dissolving an effective amount of the agent in a carrier containing suitable amounts of N-bis-azacyclopentan-2-onyl alkanes, as define... | 11/02/1976 |
| 3969516 | Composition and method for treatment of acne There is disclosed a method for topical treatment of acne. The method involves topical treatment of a human suffering from acne with an effective amount of an antibiotic of the lincomycin family.... | 07/13/1976 |
| 3957983 | Prevention of toxicity accompanying administration of 3,7-disubstituted bile acids A method for reducing or preventing toxicity in mammals which comprises administering to said mammal a small but effective amount of an antibiotic either prior to or concurrently with the administration to said mammal of a compound of the formula ##S... | 05/18/1976 |
