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| Number | Title | Issue Date |
| 4731241 | Percutaneous pharmaceuticals preparation for external use A percutaneous pharmaceutical preparation for external use containing N-ethoxycarbonyl-3-morpholinosydnonimine (molsidomine) and an absorption promoter selected from the group consisting of aliphatic monoalcohols of 10 to 22 carbon atoms, aliphatic monoam... | 03/15/1988 |
| 4727081 | 3,4-Diazole derivatives and pharmaceutical preparations containing these compounds 3,4-Diazole derivatives corresponding to the general formula I ##STR1## which exert a highly selective action on histamine-H2 receptors are described. Processes for the preparation of these compounds and pharmaceutical preparations contain... | 02/23/1988 |
| 4696933 | Guanidine compounds useful as histamine H2-antagonists The invention relates to amide derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of the formula I: ##STR1## in which R1 is a hydrog... | 09/29/1987 |
| 4683228 | Guanidinopyrazolylamides, guanidimoimidazolylamides, compositions containing them, and method of using them to inhibit gastric acid secretion A guanidine derivative of the formula I: ##STR1## in which R1, R2, R3, R4, ring X and D are a variety of radicals defined in the specification and A is a 3-8C alkylene chain which is substituted by a hydrox... | 07/28/1987 |
| 4663323 | Tetrazole derivatives, anti-ulcer composition containing the same and method for treating ulcers Tetrazole derivatives of the formula: ##STR1## wherein R1 is an optional defined substituent; A is sulfur or a lower alkylene-thio, l is 0 or 1; B is a lower alkylene; R2 is hydroxy, a lower alkoxy, or a group: ##STR2## ... | 05/05/1987 |
| 4659721 | Alkanol derivatives, and pharmaceutical preparation containing these compounds Alkanol derivatives corresponding to the general formula I which have a highly selective action on histamine-H2 receptors are described. Due to this action, these compounds may advantageously be used for treatment of diseases caused by raised gastri... | 04/21/1987 |
| 4656180 | Diamine derivatives and pharmaceutical preparations containing these compounds Diamine derivatives corresponding to the general formula I which have a highly selective action on histamine-H2 receptors and are therefore suitable for use as anti-ulcerative agents are described. Processes for the preparation of these compounds an... | 04/07/1987 |
| 4647559 | Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of... | 03/03/1987 |
| 4640917 | 2-phenyl-hexahydro-1,2,4-triazine-3,5-diones Substituted 2-phenyl-hexahydro-1,2,4-triazine-3,5-diones of the formula ##STR1## in which n is one, two or three and the individual substituents R are independently of one another (a) hydrogen, fluorine, chlorine, bromine, iodine, trifluoromethyl, al... | 02/03/1987 |
| 4640929 | Insecticidally, acaricidally, and nematocidally 2-amino-1,3-dithiane derivatives and pesticidal compositions therefor A novel 1,3-dithiane of the formula ##STR1## wherein R1 is a di-substituted amino group; R2 and R3 are such that one of them is an electron-withdrawing group with the other being a hydrogen atom, a hydrocarbon group o... | 02/03/1987 |
| 4639447 | Azolylnitriles, and fungicides containing these compounds Compounds of the formula ##STR1## where R2 is a 5-membered or 6-membered heterocyclic structure possessing one or two hetero atoms or is phenyl which is unsubstituted or substituted by Rn, R is hydrogen, alkyl, alkoxy, alkylthio... | 01/27/1987 |
| 4639442 | Benzocyclobutene aminoalkylene ethers and thioethers, pharmaceutical compositions and use A class of benzocyclobutene aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of g... | 01/27/1987 |
| 4638001 | Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of... | 01/20/1987 |
| 4634700 | 1,3-dioxolanyl derivatives, a process for their preparation, their use and pharmaceutical preparations containing these compounds 1,3-Dioxolanyl derivatives corresponding to the general formula I ##STR1## are described. These compounds have an antimicrobial activity and may therefore advantageously be used in chemotherapy.... | 01/06/1987 |
| 4629727 | Therapeutic agents Compounds of formula I ##STR1## in which n=0 or 1; in which, when n=0, R1 is H, an alkyl, a cycloalkyl, a cycloalkylmethyl, an alkenyl or, an alkynyl group a heterocyclic ring or an optionally substituted phenyl ring or when n=1, R | 12/16/1986 |
| 4610983 | N-acyl acidic amino acid diamide derivative, a salt thereof, and an anti-ulcer agent containing the same This invention relates to a novel N-acyl acidic amino acid diamide derivative represented by the general formula or a salt thereof: ##STR1## wherein each of R1, R2, R3 and R4, which may be the same or diffe... | 09/09/1986 |
| 4600779 | Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity Histamine H2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R1 are as defined herein, and their nontoxic pharmaceutically acceptable salts, hydrates and solvates are novel anti-ulcer agents which are prepar... | 07/15/1986 |
| 4596802 | Thiadiazole derivatives active on the central nervous system and pharmaceutical compositions The invention relates to thiadiazole derivatives corresponding to the formula: ##STR1## in which R represents: a linear or branched alkyl group having from 1 to 5 carbon atoms; a cycloalkyl group having 5 or 6 carbon atoms; a phenyl group optionally ... | 06/24/1986 |
| 4593039 | 1-aryloxy-3-(substituted aminoalkylamino)-2-propanols 1-Aryloxy-3-(substituted aminoalkylamino)-2-propanols and pharmaceutically acceptable salts thereof have ଲ-adrenergic blocking activity with some cardioselectivity and hence are useful as antihypertensive, antianginal, antiarrhythmic and cardioprote... | 06/03/1986 |
| 4593026 | Anti-hypoxic disubstituted polymethylene imine derivatives, compositions, and method of use therefor Disubstituted polymethylene imines of the formula: ##STR1## in which: A is a straight or branched chain (C3 -C5) hydrocarbon containing radical optionally containing one or two double bond and optionally substituted by one or mo... | 06/03/1986 |
| 4588719 | Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of... | 05/13/1986 |
| 4571394 | Heterocyclic derivatives The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which Q represents a benzene ring in which incorporation into the rest of the molecule is through bond... | 02/18/1986 |
| 4570000 | Nitrogen heterocycles The invention relates to nitrogen heterocycles which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention there is provided a guanidine derivative of the formula I:- ##STR1## in which R1 and R | 02/11/1986 |
| 4569933 | Antihypertensive substituted derivatives of 2,5-diamino 1,4-diazole This invention relates to new chemical compounds which are derivatives of 2,5-diaminodiazoles. It relates more particularly to new 2-amino 5-(aralkylamino piperidino alkyl) diazoles. These compounds and the acid addition salts thereof have interesting the... | 02/11/1986 |
| 4568677 | 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents 1,4-Dihydropyridine derivatives of the formula: ##STR1## wherein R is aryl or heteroaryl; R1 and R2 are each independently C1 -C4 alkyl or 2-methoxyethyl; X is a 5 or 6 membered nitrogen-containing heterocy... | 02/04/1986 |
| 4562186 | (1,2,4-Oxadiazol-3-yl)arylmethanones, compositions and pharmaceutical use There are disclosed novel compounds having the formula ##STR1## where X is hydrogen, halogen (F, Cl, Br or I), loweralkyl or loweralkoxy; and R is --CH, --CONH2, --COOCH(CH3)2, --COOH, --COO(CH2)4 | 12/31/1985 |
| 4562185 | Five-membered nitrogen-containing hetero-cyclic compounds and their use as pest-combating agents The present invention relates to combating pests with five-membered nitrogen-containing heterocyclic compounds of the formula (I) ##STR1## in which R1, R2, R3, X and Y have the meaning given in the description. Many o... | 12/31/1985 |
| 4562184 | Substituted-aminohydroxypropoxy-thiadiazoles, ଲ-blocking compositions and use Novel substituted-aminohydroxypropoxy-thiadiazoles and pharmaceutically acceptable salts thereof exhibit ଲ-adrenergic blocking activity.... | 12/31/1985 |
| 4560553 | Use of eucalyptol for enhancing skin permeation of bio-affecting agents Eucalyptol is used to enhance skin permeation of bio-affecting agents.... | 12/24/1985 |
| 4557934 | Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one Improved topical pharmaceutical compositions containing a pharmaceutically-active agent and the penetration enhancing agent 1-dodecylazacycloheptan-2-one are disclosed. This agent is used at selected levels in combination with certain C3 -C | 12/10/1985 |
| 4556649 | Substituted malonic acid diamide insecticides, compositions and use Insecticidally active novel substituted malonic acid diamide insecticides of the formula ##STR1## wherein R1 represents aryl or heteroaryl, each of which can optionally be substituted, R2 represents hydrogen or trialkylsilyl, an... | 12/03/1985 |
| 4551469 | Antifungal triazole ethanol derivatives Antifungal and plant growth regulatory compounds of the formula ##STR1## in which R1 is alkyl, cycloalkyl or optionally substituted phenyl, and R2 is optionally substituted phenyl or benzyl.... | 11/05/1985 |
| 4549900 | Combating fungi with substituted 1-azolyl-butan-2-ones and -2-ols Substituted 1-azolyl-but-2-ones and -2-ols of the formula ##STR1## in which B is --CO-- or --CH(OH)-- Az represents a 1,2,4-triazol-1-yl or -4-yl or imidazol-1-yl radical, R1 represents a hydrogen atom, an alkyl, alkenyl, alkinyl, optionally su... | 10/29/1985 |
| 4548935 | Dihydropyridine anti-ischaemic and anti-hypertensive agents, compositions and use Dihydropyridine anti-ischaemic and anti-hypertensive agents of the formula: ##STR1## and their pharmaceutically acceptable salts; wherein R is aryl or heteroaryl; R1 and R2 are each independently C1 -C4 or ... | 10/22/1985 |
| 4543352 | Naphthalene aminoalkylene ethers and thioethers, and their pharmaceutical uses A class of naphthalene aminoalkylene ether and thioether compounds exhibiting pharmacological activity including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastroi... | 09/24/1985 |
| 4539318 | Tertiary aminohydroxypropoxy substituted thiadiazoles, pharmaceutical compositions and use Novel tertiary aminohydroxypropoxy substituted thiadiazole compounds exhibit 댑 -adrenoceptor and serotonin antagonism and are also useful as antihypertensive agents.... | 09/03/1985 |
| 4536508 | Triazoleamine derivatives having histamine H2 -antagonist properties The invention relates to compounds of the general formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, which show pharmacological activity as selective histamine H2 -antagonists.... | 08/20/1985 |
| 4529723 | Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of ... | 07/16/1985 |
| 4528377 | Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity Histamine H2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R1 are as defined herein, and their nontoxic pharmaceutically acceptable salts, hydrates and solvates are novel anti-ulcer agents which are prepar... | 07/09/1985 |
| 4521414 | Ophthalmic compositions and their use for treating elevated intraocular pressure and glaucoma Antiglaucoma compositions that contain enriched R-(+)-1-tert-butylamino-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-prop anol compared to the S-(-)-isomer and the ophthalmologically acceptable acid addition salts thereof are useful in methods for treatin... | 06/04/1985 |
