Class 514/232.5 - Polycyclo ring system having the additional hetero ring as one of the cyclos

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter in which the additional hetero ring is one
No. of patents: 264
Last issue date: 05/21/2013

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Number	Title	Issue Date
4746656	1,2,4,7-tetrahydro-2-oxopyrazolo[1,5-a]pyrimidine derivatives Cardiovascular activity is exhibited by compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R1 is aryl or heterocyclo; R2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, --(CH	05/24/1988
4737508	1-aryl-1-(1H-azol-1-ylalkyl)-1,3-dihydroisobenzofurans, related derivatives and pharmaceutical compositions thereof useful as antifungals Novel compounds including 1-aryl-1-(1H-imidazol-1-ylmethyl)-1,3-dihydroisobenzofurans such as 1-(4-chlorophenyl)-1-(1H-imidazol-1-ylmethyl)-1,3-dihydroisobenzofuran, and 1-aryl-1-(1H-1,2,4-trizazol-1-ylmethyl)-1,3-dihydroisobenzofurans are disclosed....	04/12/1988
4731365	5-aminoalkyl-beta-carboline derivatives, psycho tropic compositions and use Compounds of formula I ##STR1## wherein n is 0 or 1, R1 is hydrogen or lower alkyl, R2 and R3 each independently is hydrogen, optionally substituted lower alkyl, acyl or aryl, or together with the nitrogen atom form a ...	03/15/1988
4731364	Dihydrobenzo(B)thiophenes and pharmaceutical compositions thereof useful as antifungals 2-Alkyl-, 2-alkenyl- and 2-alkynyl-2,3-dihydro-2-(1H-azolyl(C1 -C2)alkyl)benzo[b]thiophenes especially 2-alkyl-, 2-alkenyl- and 2-alkynyl-2,3-dihydro-3-hydroxy-2-(1H-1-imidazolylmethyl)-4-,5-,6- and 7-halobenzo[b]thiophenes and relat...	03/15/1988
4728644	Purine derivative and pharmaceutical composition Purine derivatives of the formula: ##STR1## wherein R is hydrogen, alkyl or phenyl which may be substituted by at least one halogen, lower alkyl or lower alkoxy; each of R1 and R2 is hydrogen, alkyl, cycloalkyl, hydroxyalkyl, di...	03/01/1988
4725605	Thiazolo- and thiazino-benzimidazoles, and their use as anti-ulcer/hypersecretion agents This invention relates to a method of treating ulcers or hypersecretion in a mammal which comprises administering a compound of formula ##STR1## or a pharmaceutically acceptable salt thereof wherein --B--B1 -- represents a chain of formula...	02/16/1988
4716162	Fused 5 ring heterocyclic compounds, their preparation, and their anti-arrhythmic and diuretic use Fused ring compounds of formula (I): ##STR1## (where R1 -R4, X1 and X2 represent hydrogen or various substituents, n and m are 1-3 and 2-7 respectively, the dotted lines are double or single bonds and Y is ...	12/29/1987
4711882	Octahydro-6-azaindole compounds, compositions and use A series of novel octahydro-6-azaindole dipeptide derivatives have been prepared, including their pharmaceutically acceptable salts and bioprecursors therefor. These particular compounds are inhibitors of the angiotensin converting enzyme and are therefor...	12/08/1987
4710510	Pyrrolobenzimidazoles, pharmaceutical compositions containing them, and use of them to treat certain heart and circulatory diseases The present invention provides new pyrrolobenzimidazoles of the general formula: ##STR1## wherein R1 is a hydrogen atom or an alkyl, alkenyl or cycloalkyl radical; R2 is a hydrogen atom, cyano group or alkyl or alkenyl radi...	12/01/1987
4696939	Benzothiadiazole compounds for treating hypertension Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity....	09/29/1987
4673680	଱₂ -adrenergic receptor antagonists as modifiers of gastrointestinal motility Selective 댒 -adrenergic receptor antagonists are effective in modifying gastrointestinal motility in a manner useful in the treatment of colonic spasm, irritable bowel syndrome and constipation....	06/16/1987
4666917	Substituted acridine derivatives useful as modulators of the immune system This invention concerns novel substituted acridine compounds which are useful as modulators of the immune system in warm-blooded animals....	05/19/1987
4666908	5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use The present invention relates to novel 5-substituted pyrazolo[4,3-d]pyrimidine-7-one compounds, and compositions, methods of use and processes to make therefor. The novel compounds are useful in the treatment of cardiovascular disorders, such as heart fai...	05/19/1987
4666906	Compounds for treating hypertension Compounds of the formula ##STR1## and their pharmaceutically acceptable salts, wherein the substituents are as defined herein, having antihypertensive activity....	05/19/1987
4659709	2,3-dihydrobenzofuran-5-sulfonamide derivatives useful as antihypertensive diuretic agents Highly effective diuretic antihypertensives, i.e., 2,3-dihydrobenzofuran-5-sulfonamide derivatives which is classified to loop diuretics with less adverse side-effects and can be administered orally at a daily dosage of 0.5-200 mg or parenterally of 0.01-...	04/21/1987
4652573	Calcium antagonist N-hetero ester 1,4-dihydropyridines Compounds having calcium channel antagonist activity of the formula: ##STR1## wherein R1 and R2 are each independently amino, trifluoromethyl, pentafluoroethyl, alkoxy, lower alkenyl, or lower alkynyl or branched or unbranched l...	03/24/1987
4639443	Labdane compounds, pharmaceutical compositions and use Novel labdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed....	01/27/1987
4639442	Benzocyclobutene aminoalkylene ethers and thioethers, pharmaceutical compositions and use A class of benzocyclobutene aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of g...	01/27/1987
4634701	Furan derivatives having anti-ulcer activity Compounds of formula (I): ##STR1## wherein: A represents a CH-NO2 group or a N-CN group; B represents CH2, O, S or a direct bond; R represents a bicyclic or polycyclic residue, variously substituted and functionalized; R1 ...	01/06/1987
4621082	Pyridopyrimidines, pharmaceutical compositions and use Pyridopyrimidines of the formula ##STR1## in which R1 is optionally substituted aryl or heterocyclic, exhibit circulation active properties, especially renal vasodilating and diuretic action....	11/04/1986
4617314	Benzofuran- and benzopyran-carboxamide derivatives Benzofuran- and benzopyran-carboxamide derivatives of the formula: ##STR1## wherein l is 1 or 2; X is hydrogen atom, amino group or halogen atom; Y is --S(O)m --R3 wherein R3 is lower alkyl group and m is 0, 1 or 2, o...	10/14/1986
4610983	N-acyl acidic amino acid diamide derivative, a salt thereof, and an anti-ulcer agent containing the same This invention relates to a novel N-acyl acidic amino acid diamide derivative represented by the general formula or a salt thereof: ##STR1## wherein each of R1, R2, R3 and R4, which may be the same or diffe...	09/09/1986
4599341	Substituted and bridged pyridines useful as calcium channel blockers Novel substituted and bridged pyridine compounds useful as calcium channel blockers, pharmaceutical compositions thereof, and methods of treatment are disclosed....	07/08/1986
4591587	Cyclopropyl pyridine compounds useful as calcium channel blockers Novel cyclopropyl pyridine compounds useful as calcium channel blockers, pharmaceutical compositions thereof, and methods of treatment are disclosed....	05/27/1986
4588722	N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives Novel N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives having antihistaminic properties which compounds are useful in the treatment of allergic diseases....	05/13/1986
4588723	Aminoalkyl-imidazothiadiazole-alkenecarboxylic acid amides, intermediates for their preparation and their use in medicaments The invention relates to aminoalkyl-imidazothiadiazole-alkenecarboxylic acid amides, processes for their preparation, intermediates which are used in their preparation, medicaments containing said active compounds for use as antihypertensive agents, diure...	05/13/1986
4587253	Bridged pyridine compounds useful as calcium channel blockers and analgesics Novel substituted and bridged pyridine compounds useful as calcium channel blockers and analgesics, pharmaceutical compositions thereof, and methods of treatment are disclosed....	05/06/1986
4579847	Amino derivatives of benzylidene-pyrrolo[2,1-b]quinazolines useful for treating conditions of allergic origin Amino derivatives of benzylidene-Pyrrolo[2,1-b] Quinazolines are provided, together with pharmaceutical compositions containing them. The compounds and the compositions have pharmaceutical utility and are particularly useful as anti allergy agents....	04/01/1986
4572910	Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings 1,2,4-Triazolo[1,5-c]pyrimidines substituted at the 5 or 7 positions through a nitrogen atom which is part of a heterocyclic ring have been found to have potent bronchodilator activity. Methods for inducing bronchodilation, pharmaceutical compositions and...	02/25/1986
4564613	Pyridoindole derivatives, compositions and use Pyridoindoles of the formula ##STR1## in which R1 represents hydrogen or C1 -C4 -alkyl, which is optionally substituted by the radical ##STR2## R2 and R3 represent H or form a bond, or R	01/14/1986
4564610	Substituted 5H-pyrimido[5,4-b]indoles Substituted 5H-pyrimido[5,4-b]indoles of Formula I ##STR1## wherein R2 is halogen; the oxadiazolyl group ##STR2## wherein R" is lower alkyl with up to 3 carbon atoms; C1-5 -alkyl, cycloalkyl, aralkyl, or aryl; ORI	01/14/1986
4560685	2-Piperazino-pteridines useful as antithrombotics and antimetastatics Compounds of the formula ##STR1## wherein R1 is phenylalkylamino, alkylamino, dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxido-thiomorpholino; R2 is dialkylamino, piperidino, morpholino, thiomorpholino or 1-oxido-...	12/24/1985
4556649	Substituted malonic acid diamide insecticides, compositions and use Insecticidally active novel substituted malonic acid diamide insecticides of the formula ##STR1## wherein R1 represents aryl or heteroaryl, each of which can optionally be substituted, R2 represents hydrogen or trialkylsilyl, an...	12/03/1985
4556654	Antimicrobial substituted anthra[1,9-cd]pyrazol-6(2H)-ones Substituted anthra[1,9-cd]pyrazol-6(2H-ones have antimicrobial activity. Methods for their preparation, use and pharmaceutical compositions are disclosed....	12/03/1985
4555512	Circulation-active novel chromone- and thiochromone-substituted 1,4-dihydropyridine-lactones Dihydropyridines of the formula ##STR1## in which R1, R2, R5 and R6 can be hydrogen or various halogen or organic radicals, R4 is an optionally substituted hydrocarbon radical, A is a direct bond, a C...	11/26/1985
4551459	Method of treating heart failure using (2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolinyl)oxyalkylamides Compounds according to the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein: n is an integer of 1 to 6; R1 is hydrogen or alkyl of 1 to 4 carbon; R2 is hydrogen or R1 and R2	11/05/1985
4550118	Heterocyclic compounds Compounds of Formula I are described ##STR1## in which X and Y are independently --NH--, --O-- or --S--; Z may be a pyrimidine, triazine, triazole, thiazole, thiadiazole ring. The methods of preparation are described. The compounds are useful as anti...	10/29/1985
4544667	2-Sulfamoylbenzo[b]furan derivatives for the treatment of elevated intraocular pressure Novel 2-sulfamoylbenzo[b]furans and derivatives thereof are shown to be useful for the treatment of elevated intraocular pressure in compositions including opthalmic drops and inserts....	10/01/1985
4530924	Phthalocyanine compounds and anti-microbial use A process for combating micro-organisms in or on organic or inorganic substrates and for protecting the said substrates against attack by micro-organisms, which comprises treating the substrates with a water-soluble phthalocyanine derivative, in the prese...	07/23/1985
4518596	Antithrombotic use of 2-(perhydro-1,4-diazino)-pyrimido (5,4,D)-pyrimidines Compounds of the formula ##STR1## wherein R1 is a substituted alkoxy group, or an optionally substituted mercapto or amino group, R2 is a cyclic imino group, R3 is hydrogen, phenyl, alkyl or acyl, and n is 2 or 3, and non-...	05/21/1985

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Class 514/232.5 - Polycyclo ring system having the additional hetero ring as one of the cyclos