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| Number | Title | Issue Date |
| 8153600 | Direct application of non-toxic crosslinking reagents to resist progressive spinal deformity A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous tissue with an effective amount of a crosslinking reagent. Methods and ... | 04/10/2012 |
| 8148321 | Bioconjugates as therapeutic agent and synthesis thereof The present disclosure relates to a novel enzymatic approach according to the invention using an unprecedented sortase-catalyzed transpeptidation reaction between a substrate comprising LPXTG (SEQ ID NO: 11) peptide motif and biomolecules such as aminosugars, hydrox... | 04/03/2012 |
| 8143226 | Tyrosine kinase receptor antagonists and methods of treatment for breast cancer A method of treatment is disclosed whereby cancer cells are brought into contact with a formulation comprising an inhibitor of tyrosine kinase receptors. The formulation may be comprised of an injectable carrier and two or more tyrosine kinase receptor inhibitors wh... | 03/27/2012 |
| 8138157 | Antibiotic formulation and method of treatment A formulation comprised of particles which may be in groups and are comprised of a biocompatible polymer and an antimicrobial drug for controlled release of the drug is disclosed. The particles may be in an aqueous solution comprising thrombin and be dispersed in a ... | 03/20/2012 |
| 8133870 | Therapeutic furopyrimidines and thienopyrimidines The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of formula I, II, and ... | 03/13/2012 |
| 8124589 | Use of ketogenic compounds for treatment of age-associated memory impairment This invention relates to the field of therapeutic agents for the treatment of Age-Associated Memory Impairment (AAMI). In particular, the present invention utilizes compositions comprising at least one compound capable of elevating ketone body concentrations in a m... | 02/28/2012 |
| 8119607 | Bicyclic nucleosides and nucleotides as therapeutic agents The present disclosure relates to the use and methods of manufacture of bicyclic nucleosides and nucleotides for the treatment and prevention of infectious and proliferative diseases, including microbial infections and cancer. ... | 02/21/2012 |
| 8110555 | 7-hydroxy chromones as potent antioxidants The present invention describes the identification and purification of 7-hydroxychromes that exhibit potent antioxidant activity. In one embodiment the present invention includes a method for providing an antioxidant to a host in need thereof, comprising administeri... | 02/07/2012 |
| 8106021 | Benzylbenzene derivatives and methods of use Provided are compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently... | 01/31/2012 |
| 8101581 | Use of D-ribose to treat cardiac arrhythmias D-ribose, given in doses of five to 15 grams daily, reduces or prevents the occurrence of atrial fibrillation in persons experiencing atrial fibrillation. ... | 01/24/2012 |
| 8097591 | Polysialic acid derivatives, methods of production, and uses in enhancing cancer antigen production and targeting The present invention relates to compositions and methods of their production and use, including use in increasing de-N-acetyl sialic acid antigen of a mammalian cell and methods that exploit the increase in deNAc sialic acid antigen on such cells. ... | 01/17/2012 |
| 8097592 | Cocrystal of C-glycoside derivative and L-proline A cocrystal of (1S)-1,5-anhydro-1-[3-(1-benzothien-2-ylmethyl)-4-fluorophenyl]-D-glucitol and L-proline. It is a cocrystal of known compound A, which has a constant quality, is superior in storage stability, has no moisture absorptivity, and is suitable as a crystal... | 01/17/2012 |
| 8088743 | Methods for treating obesity employing an SGLT2 inhibitor Methods are provided for treating obesity or causing weight loss in a mammalian subject or patient, wherein a therapeutically effective amount of an SGLT2 inhibitor alone or optionally in combination with another anti-obesity agent, is administered to a mammalian su... | 01/03/2012 |
| 8088742 | Polyol-glycoside compositions for the skin The disclosure discusses polyol-glycoside compositions for topical use. The invention provides compositions containing an efficient amount of polyol-glycoside obtained from the acetalization of a polyol with a reducing sugar. Applications for the composition include... | 01/03/2012 |
| 8071557 | Treatment of pulmonary hypertension with carbonic anhydrase inhibitors This disclosure relates generally to methods and pharmaceutical compositions useful in treating pulmonary hypertension. In one embodiment, for example, the disclosure provides a method for treating pulmonary hypertension comprising administering a therapeutically ef... | 12/06/2011 |
| 8067359 | Composition for nutritionally improving glucose control and insulin action Disclosed is a method and composition for nutritionally improving glucose and insulin balance in an individual. The invention further provides a method for treating a comorbidity of diabetes. In one embodiment, the invention provides a nutritional formulation compri... | 11/29/2011 |
| 8058246 | Method and composition to achieve stable color of artificially colored hair The present invention relates to a composition comprising at least one amylose-containing starch, and its use in extending or improving the color durability and stability of artificially colored hair. Such compositions may be applied either as a leave-on or as a rin... | 11/15/2011 |
| 8058245 | Fused heterocycle derivative, medicinal composition containing the same, and medicinal use thereof The present invention provides fused heterocyclic derivatives represented by the following general formula (I) or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an inhibitory activity in human SGLT and are useful as agents for the prev... | 11/15/2011 |
| 8039441 | Glucopyranosyl-substituted cyclopropylbenzene derivatives, pharmaceutical compositions containing such compounds, their use as SGLT inhibitors and process for their manufacture Glucopyranosyl-substituted cyclopropyl-benzene derivatives defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of... | 10/18/2011 |
| 8034788 | Composition and methods for skin care Compositions useful in the treatment of skin atrophy and improvement of skin appearance and texture are disclosed. The methods include the topical administration of vitamin D3 or specific vitamin D3 analogs as an essential ingredient either on its own or in combinat... | 10/11/2011 |
| 8026220 | C-linked glucuronide of N-(4-hydroxybenzyl) retinone, analogs thereof, and method of using the same to inhibit neoplastic cell growth Compounds of the formula: are described, along with pharmaceutical compositions containing these compounds, and methods of using the compounds to prevent and to treat cancer in mammals, including humans. ... | 09/27/2011 |
| 8022042 | Composition and methods for the treatment of cancer The present invention discloses anti-cancer compositions, and associated methods, including an anti-cancer composition comprising: a cellular energy inhibitor having the structure according to formula I ... | 09/20/2011 |
| 8012941 | Carba-nucleoside analogs for antiviral treatment Provided are imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof. The compounds, compositions, and methods provided are useful for the treatment of Flavivi... | 09/06/2011 |
| 8012940 | Utilization of anti-neuropathic pain effect of D-allose and D-psicose To control neuropathic pain produced by various mechanisms. Disclosed is a composition for elimination, relief or reduction of neuropathic pain comprising, as an active ingredient, at least one substance selected from the group consisting of D-allose, a derivative o... | 09/06/2011 |
| 8012942 | Carba-nucleoside analogs for antiviral treatment Provided are thieno[3,4-d]pyrimidin-7-yl and furo[3,4-d]pyrimidin-7-yl ribosides, riboside phosphates and prodrugs thereof as well as intermediates and methods of preparation. The compounds, compositions, and methods provided are useful for the treatment of Flavivir... | 09/06/2011 |
| 8008264 | 1′-substituted carba-nucleoside analogs for antiviral treatment Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1′ position of the nucleoside sugar is subs... | 08/30/2011 |
| 7994138 | Microbial biosurfactants as agents for controlling pests Biosurfactants produced by microbes are used to control pests. The biosurfactants can be produced by cultivating a biosurfactant-producing microbe, producing a fermentation broth, and obtaining the biosurfactant from the fermentation broth. Alternately, the biosurfa... | 08/09/2011 |
| 7994139 | Antiviral therapeutic agents The invention provides compounds of Formula I: as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The c... | 08/09/2011 |
| 7985737 | Compositions and methods for the regulation of homocysteine levels within the body Described herein is a method for reducing levels of the harmful metabolic waste product of S-adenosylmethionine (SAMe), homocysteine, and provide vitamin and other nutritional co-factors that reduce the production of homocysteine and either re-methylate homocysteine... | 07/26/2011 |
| 7977318 | Derivative of glucose and of vitamin F, compositions comprising it, uses and preparation process An O-acyl product derived from glucose which may be obtained by partial or total esterification of glucose and of vitamin F, comprising a mixture of esters, for example, monoesters, of glucose and of at least one acid chosen from linoleic acid, oleic acid, palmitic ... | 07/12/2011 |
| 7977319 | Ultra-high fiber supplement and method of reducing weight, cardiovascular risks and ingested toxins An improved ultra-high fiber supplement that promotes satiety, caloric reduction, and weight loss. The supplement comprises guar, oat, psyllium, locust bean gum, pectin, green tea, multi-anthocyanadins, pyridoxine, and folic acid. The supplement can exist as a liqui... | 07/12/2011 |
| 7973012 | C-phenyl glycitol compound Provided is a novel C-phenyl glycitol compound that may serve as a prophylactic or therapeutic agent for diabetes by inhibiting both SGLT1 activity and SGLT2 activity, thereby exhibiting a glucose absorption suppression action and a urine glucose excretion action. A... | 07/05/2011 |
| 7973013 | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 2′ position of the nucleoside sugar is subs... | 07/05/2011 |
| 7968521 | Stable cystal of protected pseudouridine A stable and high-purity protected pseudouridine in crystal form is provided represented by the following structural formula: wherein M represents a trityl group or a derivative thereof, which is a useful material for produ... | 06/28/2011 |
| 7960351 | Method for producing pectin hydrolysis products Methods for the production of pectin hydrolysis products, the pectin hydrolysis products produced in this manner, as well as their use are described. ... | 06/14/2011 |
| 7947656 | Processes for producing cellooligosaccharide A process of producing cellooligosaccharide, comprising enzymatically decomposing, in the presence of cellulase, a water-insoluble natural cellulosic material having an average degree of polymerization not greater than 700, an average particle size not greater than ... | 05/24/2011 |
| 7943582 | Crystalline form of 1-(β-D-glucopyransoyl)-4-methyl-3-[5-(4-fluorophenyl)-2- thienylmethyl]benzene hemihydrate A novel crystal form of 1-(β-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene hemihydrate, and having favorable characteristics, is characterized by its x-ray powder diffraction pattern and/or by its infra-red spectrum. ... | 05/17/2011 |
| 7906487 | Method of utilizing physiological activity of rare saccharide and composition containing rare saccharide A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which... | 03/15/2011 |
| 7906488 | Sphingolipids in treatment and prevention of steatosis and of steatosis or of hepatotoxicity and its sequelae The present invention relates to the use of sphingolipids for the preparation of a food item, a food supplement and/or a medicament for the prevention and/or treatment of elevated blood levels of cholesterol and triglycerides related to steatosis and hepatotoxic eff... | 03/15/2011 |
| 7902157 | Azetidine and azetidone derivatives useful in treating pain and disorders of lipid metabolism Disclosed are compounds of the formula wherein Z1 is —CH2—or —C(O)—, R4 and R5 are carbon chains (and optionally, together can form a C2 bridge), u and v are in... | 03/08/2011 |
