Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 8173644 | 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses This invention relates to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to ... | 05/08/2012 |
| 8138180 | Exo-selective synthesis of himbacine analogs This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbam... | 03/20/2012 |
| 7939526 | Sulfone substituted imidazo ring ethers Imidazo ring compounds (e.g., imidazoquinolines, 6,7,8,9-tetrahydroimidazoquinolines, imidazonaphthyridines, and 6,7,8,9-tetrahydroimidazonaphthyridines) with a sulfide-, sulfinyl-, or sulfonyl-containing ether substituent at the 1-position, pharmaceutical compositi... | 05/10/2011 |
| 7906507 | Oxadiazoanthracene compounds for the treatment of diabetes The present invention provides methods of use of oxadiazoanthracene derivatives of the formula (I) and pharmaceutically acceptable salts thereof, wherein A, B, C, R, R1, R2, R3, R4 | 03/15/2011 |
| 7790714 | Oxadiazoanthracene compounds for the treatment of diabetes The present invention provides methods of use of oxadiazoanthracene derivatives of the formula (I) and pharmaceutically acceptable salts thereof, wherein A, B, C, R, R1, R2, R3, R4 | 09/07/2010 |
| 7772228 | Method for treatment of bacterial infections with once or twice-weekly administered rifalazil A method for treatment of bacterial infections with rifalazil administered once-weekly, or twice-weekly. A method for treatment of tuberculosis caused by Mycobacterium tuberculosis, infections caused by Mycobacterium avium complex, infections caused by... | 08/10/2010 |
| 7727983 | Oxadiazoanthracene compounds for the treatment of diabetes The present invention provides oxadiazoanthracene derivatives of the formula (I), wherein A, B, C, R, R1, R2, R3, R4 and R5 are as herein described, pharmaceutical comp... | 06/01/2010 |
| 7550458 | Tricycloundecane compounds useful as modulators of nuclear hormone receptor function Tricycloundecanes compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds are disclosed. ... | 06/23/2009 |
| 7494992 | Antiparasitic terpene alkaloids The present invention relates to novel terpene alkaloids and their use as antiparasitic agents. The present invention also relates to an antiparasitic agent which comprises a terpene alkaloid compound of this invention as an effective ingredient in an antiparasitic ... | 02/24/2009 |
| 7479490 | Pellet for a presurrized pipeline A system of equipment allowing addition of solid materials to a pressurized pipeline wherein said solid material is conveyed in such a way as to be readily dissolved by the liquid in said pipeline. The system includes a solid material transfer device that is used to... | 01/20/2009 |
| 7470683 | Tetracyclic compounds Compounds of formula I, of trans relative configuration: wherein: X represents an oxygen atom or an NR2 group, Y represents a group selected from —CH2 | 12/30/2008 |
| 7439239 | Tricyclic δ- opioid modulators Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows: wherein A, G, Y, R3-R5 are define... | 10/21/2008 |
| 7435733 | Mineralocorticoid receptor modulator compounds and methods, and pharmaceutical compositions containing these compounds This invention relates to compounds that bind to mineralocorticoid receptors and/or modulate activity of mineralocorticoid receptors, and to methods for making and using such compounds. Some embodiments relate to compounds of Formula I: | 10/14/2008 |
| 7432257 | Piperdinyl-phenoxazine and phenothiazine derivatives as δ-opioid modulators The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of ... | 10/07/2008 |
| 7427615 | 3-substituted-4-pyrimidone derivatives A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof having inhibitory activity against tau protein kinase 1: wherein R1 represents a C1-C12 alkyl group which may be substitu... | 09/23/2008 |
| 7384933 | Derivatives of 2-hydroxytetrahydrofuran and their use as medicaments A hydroxytetrahydrofuran of formula wherein A is with the substituents as defined in the specification, having a calpain inhibiting activity and/or an activity which traps the rea... | 06/10/2008 |
| 7361647 | Analogs of benzoquinone-containing ansamycins and methods of use thereof The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where... | 04/22/2008 |
| 7288572 | Active substance combinations having insecticidal and acaricidal properties The present invention relates to novel insecticidally and acaricidally active compound combinations of N2-[1,1-dimethyl-2-(methylsulphonyl)ethyl]-3-iodo-N1-{2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}phthalamide of the form... | 10/30/2007 |
| 7282493 | Analogs of benzoquinone-containing ansamycins and methods of use thereof The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where... | 10/16/2007 |
| 7268131 | Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma Substituted [1,4]oxazino[2,3-g]indazols for lowering intraocular pressure and treating glaucoma are disclosed. ... | 09/11/2007 |
| 7229986 | Melanin-concentrating hormone antagonist A melanin-concentrating hormone antagonist comprising a compound of the formula: wherein R is hydrogen atom or a cyclic group which may be substituted; X is a bond or a spacer having a main chain of 1 to 10 atoms... | 06/12/2007 |
| 7141566 | Benzoxazine and benzothiazine derivatives and the use thereof in medicaments The invention relates to compounds of formula (I), the tautomeric and isomeric forms and salts thereof, in addition to a method for production and use thereof in medicaments. ... | 11/28/2006 |
| 7135468 | Antibacterial compounds Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, salts of prodrugs, and metabolites thereof, processes for making the compounds and intermediates in the processes, composit... | 11/14/2006 |
| 7135499 | Active substance combinations having insecticidal and acaricidal properties The present invention relates to novel insecticidally and acaricidally active compound combinations of N2-[1,1-dimethyl-2-(methylsulphonyl)ethyl]-3-iodo-N1-{2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}phthalamide of the form... | 11/14/2006 |
| 7115624 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 The present invention provides a method of inhibiting a member of a family of Protein Tyrosine Phosphatases (PTPases, PTPs) such as PTP1B, TC-PTP, CD45, SHP-1, SHP-2, PTPα, PTPε, PTPμ, PTPδ, PTPσ, PTPζ, PTPβ, PTPD1, PTPD2, PTPH1, PTP-MEG1, PTP-LAR, and HePTP ... | 10/03/2006 |
| 7084138 | Active ingredient combinations with insecticidal and acaricidal properties The invention relates to novel active compound combinations having very good insecticidal and acaricidal properties and containing (a) cyclic ketoenols having the formula in which the gro... | 08/01/2006 |
| 7081457 | Cyclothiocarbamate derivatives as progesterone receptor modulators Methods of using compounds which are progesterone receptor agonists for contraception and the treatment of progesterone-related maladies alone or in combination with an estrogen receptor agonist or progesterone receptor antagonist are provided. These compounds have ... | 07/25/2006 |
| 7060294 | Compressed tablet formulation This invention relates to a 50% drug loaded compressed tablet formulation for efavirenz. Efavirenz is a non-nucleoside reverse trancriptase inhibitor being studied clinically for use in the treatment of HIV infections and AIDS. ... | 06/13/2006 |
| 7015219 | 3-aryl-hydroxybenzoxazines and 3, 4-dihydro-3-aryl-hydroxybenzoxazines as selective estrogen receptor beta modulators Substituted benzoxazine and 3,4-dihydrobenzoxazine derivatives possessing activity as estrogen receptor beta (ERβ) modulators are provided which have the structure of formula I wherein the subs... | 03/21/2006 |
| 6992092 | Anti-diabetic agents The present invention provides compounds of formula (I) the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs; wherein R1, R2 | 01/31/2006 |
| 6936606 | Cyanoamido-containing heterocyclic compounds useful as reversible inhibitors of cysteine proteases Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R1, R2, R3, R4, R5, R6, R8, R9 and X are defined herein. The co... | 08/30/2005 |
| 6919090 | Active substance combinations with insecticidal and acaricidal properties The invention relates to novel active combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties. ... | 07/19/2005 |
| 6914059 | Benzoxazine and benzothiazine derivatives and the use thereof in medicaments Compounds of formula I, their tautomeric and isomeric forms and salts, as well as the process for their production and their use in pharmaceutical agents are described. ... | 07/05/2005 |
| 6897199 | Pharmaceutically acceptable salts of phenoxazine and phenothiazine compounds The present invention relates to pharmaceutically acceptable salts of compound of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable solvates and pharmaceuticall... | 05/24/2005 |
| 6861442 | PYK2 and inflammation The present invention relates generally to the fields of immunology and medicine, and more specifically to the field of cellular signal transduction. The present invention relates, inter alia, to methods for diagnosis, treatment, and identification of therapeutics f... | 03/01/2005 |
| 6858607 | 7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I: or pharmaceutically acceptable salts or prodrugs thereof, wherein: wherein A, R1 | 02/22/2005 |
| 6841550 | Benzoxazine and benzothiazine derivatives and their use in medicines The invention relates to compounds of formula (I) and their tautomeric and isomeric forms and salts, as well as to a method for producing said compounds and their use in medicines. ... | 01/11/2005 |
| 6794384 | Hydroxylation activated drug release The present invention concerns prodrugs whose aromatic oxidation, particularly their enzymatic aromatic hydroxylation, results in their activation by the release of a drug moiety. It particularly concerns anti-tumor prodrugs and those which are specifically activate... | 09/21/2004 |
| 6703401 | Compounds, their preparation and use The present invention relates to compounds of the general formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by clear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).... | 03/09/2004 |
| 6630465 | Synergistic insecticidal compositions The present invention provides a synergistic insecticidal composition comprising as essential active ingredients a neuronal sodium channel antagonist and an arylpyrrole insecticide. Also provided are methods for synergistic insect control and crop protect... | 10/07/2003 |
