Class 514/228.8 - Hetero ring is six-membered and includes at least nitrogen and oxygen as ring hetero atoms (e.g., monocyclic 1,2- and 1,3-oxazines, etc.)

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter in which the hetero ring contains at least
No. of patents: 276
Last issue date: 05/01/2012

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Number	Title	Issue Date
8168631	3-(4-fluorophenyl)-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic activity Compounds according to the formula below are disclosed herein: Therapeutic methods, compositions, and medicaments related thereto are also disclosed. ...	05/01/2012
8138178	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 Disclosed is a compound represented by Formula (Im1) or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof. Also disclosed are pharmaceutical compositions comprising the compound of Formula (I...	03/20/2012
8114868	Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 Disclosed is a compound represented by Formula (Im1) or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof. Also disclosed are pharmaceutical compositions comprising the compound of Formula (I...	02/14/2012
RE42562	EPreceptor agonist, compositions and methods thereof This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in the eye of a ...	07/19/2011
7964594	Amino oxazine derivatives This invention relates to 5,6-dihydro-4H-[1,3]oxazin-2-ylamine compounds of the formula wherein R1 to R5 are as defined in the description and in the claims, as well as pharmaceutically acceptable salt...	06/21/2011
7851469	Isoxazole-imidazole derivatives The present invention is concerned isoxazole-imidazole derivatives having affinity and selectivity for GABA A α5 receptor binding site, their manufacture, pharmaceutical compositions containing them and their use for enhancing cognition or for the treatment of cogn...	12/14/2010
7700590	Antibacterial agents This invention provides compositions which are 1,3-oxazinan-2-one compounds of formulae (I) and (II), and oxazolidinone compounds of formula (III): wherein R is a hydrocarbyl group, a heterocyclic group, a hydrocarbyl group having at least one substituent, or a hete...	04/20/2010
7625891	Heterocylic antiviral compounds This invention relates to piperidine derivatives of formula I wherein R1, R2, R3 and R4 are as defined herein useful in the treatment of a variety of disorders, including those in which the modulation of CCR5 receptors is ...	12/01/2009
7598241	Carboxamide derivatives and their use as factor Xa inhibitors Novel compounds of the formula (I) in which R1, D, X, W, Y and T have the meaning indicated in Patent Claim (1), e.g. (II), are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for t...	10/06/2009
7547693	Piperidine derivative Provided are a histamine-H3 receptor antagonist; and a preventive and/or a remedy for metabolic system diseases such as obesity, diabetes, hormone secretion disorder, hyperlipemia, gout, fatty liver, circulatory system diseases, for example, stenocardia, acute/conge...	06/16/2009
7547694	Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions The present invention relates to the CGRP antagonists of general formula wherein A and R1 to R3 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the hydrates thereof...	06/16/2009
7538107	Oxazinan-2-one derivatives useful as PR modulators Compounds of the following structure are described: wherein R1-R6, m, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compou...	05/26/2009
7427614	Prostaglandin analogs Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof is disclosed herein. A, X, J, E, and Z are as described herein. These compounds are useful for treating diseases. ...	09/23/2008
7338949	Mycobacterial inhibitors The present invention relates to novel substituted quinoline derivatives according to the general formula (Ia) or the general formula (Ib) salts, quaternary amines, stereochemically isomeric forms, tautomeric forms and N-ox...	03/04/2008
7301028	Mitotic kinesin inhibitors The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which com...	11/27/2007
7279471	Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions The present invention relates to the CGRP antagonists of general formula wherein A and R1 to R3 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the hydra...	10/09/2007
7262294	Photochromatic pyrano-1,3-oxazinonaphthalene derivatives Photochromatic compounds belonging to the groups of chromenes and spiro-pyrans having general formula (I) ...	08/28/2007
7259157	N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain. ...	08/21/2007
7229988	Dialkylhydroxybenzoic acid derivatives containing metal chelating groups and their therapeutic uses The present invention provides novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups and the use of the novel compounds as therapeutics for treating and/or preventing various medical dysfunctions and diseases arising from reactive oxygen spe...	06/12/2007
7214701	Active substance combinations having insecticidal and acaricdal properties The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ...	05/08/2007
7183238	[1,2]-oxazine-3,5-diones The present invention relates to novel [1,2]-oxazine-3,5-dione derivatives of the formula (I) in which W, X, Y, Z, G, D, A and B are as defined in the disclosure, to a pl...	02/27/2007
7179794	Multivalent macrolide antibiotics Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more proteins involved in ribosomal pro...	02/20/2007
7176209	Fungicidal formulation Adjuvants selectes from mon/ionic water/soluble mixed polyalkoxy-lated aliphatic alcohol surfactants, non ionic water soluble ethoxylated aliphatic alcohol surfactants, amine ethoxylates, and micronized polymeric waxes enhance the efficacy of fungicidal triazolopzri...	02/13/2007
7166609	Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases Pyrimidine-4,6-dicarboxylic acid diamides of the formula I are suitable for selectively inhibiting collagenase (MMP 13). The pyrimidine-4,6-dicarboxylic acid diamides can therefore be used for treating degenerati...	01/23/2007
7157078	Devices and methods for eliminating termite colonies This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to ...	01/02/2007
7148221	Vanilloid receptor ligands and their use in treatments Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular an...	12/12/2006
7148230	Quinazoline derivatives The invention concerns quinazoline derivatives of Formula I wherein R1 and R2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical composition...	12/12/2006
7115601	HIV integrase inhibitors Compounds of the present disclosure are spirocycle-substituted pyrimidinecarboxamides. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating HIV infection and AIDS. ...	10/03/2006
7094778	Heterocyclylalkylamines as muscarinic receptor antagonists This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR5, and the other substituents are...	08/22/2006
7087599	Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v...	08/08/2006
7083910	Preservation of blood platelets with citrate Methods and compositions for preserving blood platelet suspensions which can be stored and preserved for extended periods of time are provided herein. The methods and compositions employ a mixture comprising blood platelets and one or more citrate salts. Such blood ...	08/01/2006
7084151	5-(1',1'-cycloalkyl/alkenyl)methylidene 1,2-dihydro--chromeno[3,4-ƒ]quinolines as selective progesterone receptor modulator compounds The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions. ...	08/01/2006
7070968	DNA damaging agents in combination with tyrosine kinase inhibitors The present invention relates to the signalling pathways connecting DNA damage, such as that induced by ionizing radiation or alkylating agents, and phosphorylation by tyrosine kinases. ...	07/04/2006
7053085	EP receptor agonist, compositions and methods thereof This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in the eye of a ...	05/30/2006
7030110	Cyclic oxyguanidine pyrazinones as protease inhibitors Cyclic oxyguanidine pyrazinone compounds are described, including compounds of the Formula I: wherein R3, R4, R5, W, and A are as set forth in the specification, as well as hydrates, sol...	04/18/2006
7008903	Pesticide The present invention provides a composition comprising synergistic amounts of a compound of the formula (I) wherein X, E, R, A and Z are as defined herein, and at least one fungicidal active compound as defined herein...	03/07/2006
7001912	HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use Beta-carboline hydroxamic acid compounds represented by formula (I) are described. The beta-carboline hydroxamic acid compounds and compositions containing those compounds may be used to inhibit or modulate the activity...	02/21/2006
6995162	Substituted alkylamine derivatives and methods of use Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical composit...	02/07/2006
6987129	Compounds and methods for the treatment of urogenital disorders The present invention provides methods for treating a variety of urogenital disorders, such as, for example, vaginismus, dyspareunia, vulvodynia (including vulvar vestibulitis), interstitial cystitis, nonspecific urethriris (i.e., nonspecific pain and/or burning of ...	01/17/2006
6972288	4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases The present invention relates to bicyclic heterocycles of general formula wherein Ra to Rd, A to G and X are defined as in claim 1, the tautomers, the steroisome...	12/06/2005

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Class 514/228.8 - Hetero ring is six-membered and includes at least nitrogen and oxygen as ring hetero atoms (e.g., monocyclic 1,2- and 1,3-oxazines, etc.)