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| Number | Title | Issue Date |
| 8168628 | Conjugated psychotropic drugs and uses thereof Novel chemical conjugates of psychotropic drugs and organic acids, uses thereof in the treatment of psychotic and/or proliferative disorders and diseases and as chemosensitizing agents, and their syntheses are disclosed. The organic acids are selected to reduce side... | 05/01/2012 |
| 7981885 | Compositions for treatment of diseases related to activated lymphocytes The present invention relates to inhibiting proliferation and inducing apoptosis in activated lymphocytes, including T cells and B cells. The invention also provides compositions and methods for inhibiting proliferation and inducing apoptosis in activated lymphocyte... | 07/19/2011 |
| 7414128 | Crystalline R-guanidines, Arginine or (L)-Arginine (2S)-2-Ethoxy-3-{4-[2-(10H -phenoxazin-10-yl)ethoxy]phenyl}propanoate The present invention relates to crystalline R-guanidines of (2S)-2-Ethoxy-3-{4-[2-(10H-phenoxazin-10-yl)ethoxy]phenyl}propanoate, its preparations and its use as therapeutic agents. More specifically the present invention relates to crystalline Arginine (2S)-2-Etho... | 08/19/2008 |
| 7407953 | Wound healing A phenothiazinium compound, compositions and medicaments for use in promoting wound healing and a method for promoting wound healing or cosmetic use by applying or administering a phenothiazinium compound of Formula (1) to ... | 08/05/2008 |
| 7365076 | Substituted aryl cycloalkanol derivatives and methods of their use The present invention is directed to substituted aryl cycloalkanoyl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor sym... | 04/29/2008 |
| 7335379 | Transdermal pharmaceutical formulation for minimizing skin residues This invention relates to novel transdermal or transmucosal pharmaceutical formulation which reduces the occurrences of contamination of other individuals and the transference to clothing of the user. The novel formulation includes at least one pharmacologically act... | 02/26/2008 |
| 7309497 | Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. The invention relates in particular to an injectable pharmaceutical composition comprising (a) a pharmacologically active ingredient i... | 12/18/2007 |
| 7148216 | Combinations of drugs for the treatment of neoplastic disorders The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient. ... | 12/12/2006 |
| 7119089 | Phenothiazine kinesin inhibitors Phenothiazine derivatives of formula (I) are disclosed. The compounds are inhibitors of the mitotic kinesin KSP and are useful in the treatment of cellular proliferative diseases, such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders and in... | 10/10/2006 |
| 7101916 | Exo-S-mecamylamine formulation and use in treatment A pharmaceutical composition includes a therapeutically effective amount of exo-S-mecamylamine or a pharmaceutically acceptable salt thereof, substantially free of exo-R-mecamylamine in combination with a pharmaceutically acceptable carrier. Preferably the amount is... | 09/05/2006 |
| 7060730 | Rapidly absorbed liquid compositions The present invention provides a method which provides for a faster absorption of pharmaceutically acceptable amines. The method provides a pharmaceutically acceptable amine in combination with a non-steroidal anti-inflammatory drug in a liquid form. A preferred emb... | 06/13/2006 |
| 6992082 | Phenothiazine kinesin inhibitors Phenothiazine derivatives of formula (I) are disclosed. The compounds are inhibitors of the mitotic kinesin KSP and are useful in the treatment of cellular proliferative diseases, such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders and in... | 01/31/2006 |
| 6919351 | Aza-and polyaza-naphthalenyl-carboxamides useful as HIV integrase inhibitors Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or tr... | 07/19/2005 |
| 6846816 | Combinations of drugs for the treatment of neoplastic disorders The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient. ... | 01/25/2005 |
| 6583146 | Thiazolopyrimidine compounds, its production and use Compounds represented by general formula (I): ##STR1## and salts thereof, exhibiting excellent adenosine A3 receptor antagonism: wherein A is an optionally substituted benzene ring; B may be further substituted; and R1 is an optional... | 06/24/2003 |
| 6583138 | Heterocyclic-ring condensed benzothiazine compound The invention provides a novel heterocyclic ring condensed benzothiazine compound which is effective for prevention or remedy of disease, in which histamine, leukotriene and the like participate. The heterocyclic ring condensed benzothiazine compound of t... | 06/24/2003 |
| 6566389 | Therapeutic uses of melatonin A method for treating or preventing symptoms of tardive dyskensia comprises administering melatonin to patient exhibiting or liable to develop such symptoms. The melatonin is administered in an amount effective to ameliorate or prevent symptoms of tardive... | 05/20/2003 |
| 6509335 | Benzoxazinoes/benzothiazinones as serine protease inhibitors This invention discloses benzoxazinone and benzothiazinone compounds which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts of the compounds, pha... | 01/21/2003 |
| 6468971 | Maintaining kidney function during surgery or trauma Kappa-opioid agonists prevent the impairment of renal function otherwise caused by the combination of gaseous anesthesia and surgery or severe trauma. Not only do these agents preserve renal function and maintain urine output, they also maintain plasma el... | 10/22/2002 |
| 6440961 | Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them A compound of formula (1) ##STR1## it derivatives, its analogs, its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts, or its pharmaceutically acceptable solvates, processes for its preparation and methods of use ... | 08/27/2002 |
| 6423707 | Nitroimidazole ester analogues and therapeutic applications Novel nitroimidazole compounds are provided that have a substituent linked via an ester linkage. The ester linkage may be obtained by derivation of the hydroxyl group of metronidazole. These nitroimidazole ester analogs have anti-microbial activity, with ... | 07/23/2002 |
| 6333322 | Nitrogen-containing tricyclic compounds and drugs containing the same A phenothiazine, acridan, acridone oxime, acridone hydrazone and dibenzodiazepine derivative represented by formula (I) ##STR1## effective against diseases in which histamine, leukotrienes, etc. participate and effective in preventing or treating diseases... | 12/25/2001 |
| 6159966 | Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them A compound of formula (I) ##STR1## its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts or its pharmaceutically acceptable solvates, wherein R3, R4, R5, and R6 are ... | 12/12/2000 |
| 6054453 | Tricyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them Novel ଲ-aryl--oxysubstituted alkylcarboxylic acids of the formula (I) and compositions containing them. ##STR1## The compounds have hypolipidemic, antihyperglycemic uses.... | 04/25/2000 |
| 6034079 | Nicotine antagonists for nicotine-responsive neuropsychiatric disorders Nicotine-responsive neuropsychiatric disorders can be treated by administering a nicotine antagonist, particularly mecamylamine. Combination therapy of mecamylamine with a neuroleptic drug also is disclosed. The neuropsychiatric disorders include Tourette... | 03/07/2000 |
| 5902609 | Composition for the control of wound scar production This invention pertains to a composition for controlling wound scar production containing a calcium antagonist and a protein synthesis inhibitor. The method can be used to minimize wound scars, such as hypertrophic wound healing disorders keloids and burn... | 05/11/1999 |
| 5863912 | Method of treatment of hormone-unresponsive metastiatic prostate cancer Prostate cancer particularly hormone-unresponsive metastatic prostate cancer, is treated by cyclophosphamide or other normally substantially inactive agent. Potentiation of the anti-cancer activity and amelioration of cyclophosphamide-associated toxicity ... | 01/26/1999 |
| 5837701 | Composition and method for treating conditions associated with symptoms of unspecified retarded maturation Compositions and method for treating conditions in humans associated with symptoms of unspecified retarded maturation due to chromosomal abnormalities cerebral atrophy, Huntington's Chorea, Alzheimer's disease and the like wherein the composition comprise... | 11/17/1998 |
| 5663167 | Antipsychotic composition and method of treatment A method for treating a serious psychotic mental illness includes the step of administering to a patient in need of such treatment a combination of (i) an 댒 -adrenergic receptor antagonist and (ii) a D2 dopamine receptor antag... | 09/02/1997 |
| 5607955 | Tricyclic compounds on angiotensin II receptor antagonists A tricyclic compound represented by the following formula (I): ##STR1## exhibits antagonism to angiotensin II receptors.... | 03/04/1997 |
| 5602105 | Cardiotropic formulation The invention provides a cardiotropic formulation comprising a cardiac glycoside, a beta-adrenergic receptor stimulant nicotinamide adenine dinucleotide, cytochrome C and inosine for use in conditions of heart failure.... | 02/11/1997 |
| 5569678 | Control of wound scar production This invention pertains to a method for controlling wound scar production by administering a calcium antagonist, alone or in a combination with or followed by a steroid, to the wound site. The method can be used to minimize wound scars, such as hypertroph... | 10/29/1996 |
| 5552162 | Method for improvement of scar size and appearance A method for improving the size and appearance of a scar associated with a fibromatosis, a keloid, or a hypertrophic wound healing disorder comprises stimulating collagenase activity in the scar. Preferably, stimulating collagenase activity is accomplishe... | 09/03/1996 |
| 5496818 | Stable emulsion suitable for pharmaceutical administration, the production thereof and emulsion for pharmaceutical use A stable active substance emulsion of the oil-in-water type with a phospholipid as emulsifier is described, where the active substance dissolved in the lipid phase has one or more basic groups, is hydrophobic and oil-soluble, and has a pKa of at least 7.5... | 03/05/1996 |
| 5492907 | Antipsychotic composition and method of treatment A method for treating a serious psychotic mental illness includes the step of administering to a patient in need of such treatment a combination of (i) an 댒 -adrenergic receptor antagonist and (ii) a D2 dopamine receptor antag... | 02/20/1996 |
| 5432168 | Method of treatment of hormone-unresponsive metastatic prostate cancer Prostate cancer particularly hormone-unresponsive metastatic prostate cancer, is treated by cyclophosphamide or other normally substantially inactive agent. Potentiation of the anti-cancer activity and amelioration of cyclophosphamide-associated toxicity ... | 07/11/1995 |
| 5254546 | Fused aryl substituted imidazole angiotensin II receptor inhibitors Substituted imidazoles such as ##STR1## which are useful as angiotensin II receptor inhibitors. These compounds have activity in treating hypertension and congestive heart failure.... | 10/19/1993 |
| 5238936 | Trisubstituted triazines The compounds are trisubstituted triazines and pyrimidines useful for the suppressing the resistance of tumour cells to anti-cancer agents and for suppressing the resistance of parasites to anti-parasitic agents. A compound disclosed is 2,4-diallylamino-6... | 08/24/1993 |
| 5166145 | Antiemetic therapy A dosage form is disclosed comprising an antiemetic and antinausea drug for treating vomiting and nausea.... | 11/24/1992 |
| 5086052 | Substituted 1,4,5,6-tetrahydro-2H-pyridazin-3-one and -3-thione compounds having lipoxygenase inhibitory activity Pyridazinone, triazinone and oxapyridazinone compounds which are useful in inhibiting lipoxygenase enzymes, particularly 5-lipoxygenase.... | 02/04/1992 |
