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Class 514/224.8 - Phenothiazines (including hydrogenated)


Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter in which the polycyclo ring system has the
No. of patents: 109
Last issue date: 05/29/2012


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NumberTitleIssue Date
8188074Biologically active methylene blue derivatives
The present invention relates to a composition which includes a moiety of formula wherein R1, R2, R3 and R4 each represent n-pentyl, and to a method of sterilizing a su fluid using same.
05/29/2012
8097615Neurofibrillary labels
Disclosed are in vitro methods for identifying ligands capable of labeling aggregated PHF tau protein, the methods comprising the steps of: (i) providing a first agent suspected of being capable of labeling aggregated PHF tau protein, (ii) contacting (a) a tau prote...
01/17/2012
8088762Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
The invention describes novel nitrosated nonsteroidal anti-inflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or r...
01/03/2012
7915254Biologically active methylene blue derivatives
The present invention relates to a method of photodynamic therapy and to a method of inducing a photocytoxic effect which comprises applying to an area to be treated an effective amount of a compound of formula in which R
03/29/2011
7893054Materials and methods relating to protein aggregation in neurodegenerative disease
The present invention is directed to methods for the treatment or prophylaxis of a tauopathy comprising administering to a patient in need thereof a medicament comprising a phenothiazine. ...
02/22/2011
7855197Biologically active methylene blue derivatives
A phenothiazinium compound of Formula (I) wherein: A and B each independently is in which R′ and R″ each independently is a linear, branched or cycl...
12/21/2010
7737138Methods of treatment of a tauopathy condition comprising the use of thioninium compounds
This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7-diaminophenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) inclu...
06/15/2010
7732439Biologically active methylene blue derivatives
The present invention relates to a pharmaceutical composition which contains a compound of formula in which R1, R2, R3 and R4 are each n-butyl, where XP− is a counter...
06/08/2010
7713962Neurofibrillary labels
A method for determining the Braak stage of neurofibrillary degeneration associated with a tauopathy in a subject having neurofibrillary degeneration is disclosed. The method comprises the steps of (i) administering to the subject a conjugated, chelated or detectabl...
05/11/2010
7696197Use of a phenothiazine derivative for preventing and/or treating hearing loss
The invention concerns the use of a phenothiazine derivative of formula (I), wherein: R represents the hydrogen atom, an alkyl radical, arylalkyl, or —C(O)R′, for preparing a medicine for preventing and/or treating hearing loss. ...
04/13/2010
7534786Inhibition of tau-tau association
The present invention relates to methods for the detection of substances capable of modulating or inhibiting pathological tau-tau protein association. The methods of the present invention are particularly useful in screening substances for the prophylaxis and treatm...
05/19/2009
7371744Biologically active methylene blue derivatives
A phenothiazinium compound of Formula (I): wherein: A and B each independently is in which R′ and R″ each independently is a linear, branched or cyclic...
05/13/2008
7335652Neurofibrillary labels
Disclosed are methods for determining the stage of neurofibrillary degeneration associated with a tauopathy in a subject believed to suffer from the disease, by (i) introducing into the subject a ligand capable of labeling aggregated paired helical filament (PHF) ta...
02/26/2008
7323461Use of methylene blue and related compounds to prevent or reverse an exaggerated hemodynamic reaction
The present invention relates to the use of the dye methylene blue (MB) or a related compound to prevent or reverse an exaggerated hemodynamic reaction in animals in need thereof, including humans. More specifically, the present invention concerns the use of MB or a...
01/29/2008
7241760Heteroaryl-substituted imidazole derivatives
The present invention relates to imidazole derivatives of the general formula wherein R1, R2, R3 and R4 are described hereinbelow. These compounds can be used in the tr...
07/10/2007
7232832Antibacterial agents
Quinoline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans. ...
06/19/2007
7186730Bicyclic nitrogen-containing heterocyclic derivatives for use as antibacterials
Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man. ...
03/06/2007
7169798Inhibitors of c-Jun N terminal kinases (JNK) and other protein kinases
The present invention provides compounds of formula I: where R1 is H, CONH2, T(n)-R, or T(n)-Ar2, n may be zero or one, and G, XYZ, and Q are as described be...
01/30/2007
7148216Combinations of drugs for the treatment of neoplastic disorders
The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient. ...
12/12/2006
7122544Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
Compounds having activity as inhibitors of IKK are disclosed, particularly IKK-2. The compounds of this invention are anilinopyrimidine derivatives having the following structure: wherein R1 and R6
10/17/2006
7119198Tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
Novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the formula (I) and compositions containing them. The compounds have hypolipidemic, antihyperglycemic uses. ...
10/10/2006
7087614Pyrimidine inhibitors of phosphodiesterase (PDE) 7
Pyrimidine phosphodiesterase 7 (PDE 7) inhibitors of the following formula wherein R1, R2, Z, J and L are described herein, and analogs thereof are provided which are useful in treating T-ce...
08/08/2006
7084158Substituted propargylamines
The present invention relates to the use of substituted aryl- and heteroarylpropargylamines of the formula (I) where a) R1 is heteroaryl or aryl, unsubstituted or mono- or polysubstituted ...
08/01/2006
7074782Carbamate caspase inhibitors and uses thereof
This invention provides caspase inhibitors of formula I: wherein Z is oxygen or sulfur; R1is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; Y is an electron...
07/11/2006
7067324Photon reducing agents for fluorescence assays
The present invention provides a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon reducing agents). The present invention further provides a method fo...
06/27/2006
6977075Photosensitizer conjugates for targeting intracellular pathogens
The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention features methods for treating a subject who has a disorder that is assoc...
12/20/2005
6953794Inhibition of tau-tau association
A composition and use thereof for the prophylaxis or treatment of Alzheimer's disease, motor neurone disease, Lewy body disease, Pick's disease or progressive supranuclear palsy. The composition includes an agent which modulates or inhibits tau-tau association and w...
10/11/2005
6939550Stabilized antihistamine syrup
An antihistaminic syrup is stabilized against degradation of the active ingredient, by the addition of and about 0.05 to about 5 mg/mL of an aminopolycarboxylic acid such as a salt of ethylenediaminetetraacetic acid. ...
09/06/2005
6846816Combinations of drugs for the treatment of neoplastic disorders
The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient. ...
01/25/2005
6747024Heterocyclic compounds and their use as medicines
The present invention relates to new heterocyclic derivatives having an inhibitory activity on calpains and/or a trapping activity on reactive oxygen species, of formula in which A, X, Y, R1, R2 and Het repres...
06/08/2004
6743817Substituted fused pyrroleimines and pyrazoleimines
Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein R, Ar, A, n, R1 and R2 are defined herein. These compounds are highly selective agonists, antagonists...
06/01/2004
6706707Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles
This invention relates to a compound and the use of the compound of the formula wherein R1, R2, R3, R4 and R5 are as defined in the description, A signifies —CH═...
03/16/2004
6703401Compounds, their preparation and use
The present invention relates to compounds of the general formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by clear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR)....
03/09/2004
6583138Heterocyclic-ring condensed benzothiazine compound
The invention provides a novel heterocyclic ring condensed benzothiazine compound which is effective for prevention or remedy of disease, in which histamine, leukotriene and the like participate. The heterocyclic ring condensed benzothiazine compound of t...
06/24/2003
6485750Phenothiazine in prill form and method for making the same
Phenothiazine and its derivatives products are provided with a minimal level of fines or dust as a result of forming such products in prill form. The prills are generally spherical. Also provided is a method for reducing the level of powder in phenothiazi...
11/26/2002
6482822N-(iminomethyl)amines derivatives, their preparation, their use as medicines and compositions containing them
The invention concerns novel N-(iminomethyl)amine derivatives comprising in their skeleton the aminophenylamine, oxodiphenylamine, carbazole, phenazine, phenoxazine or oxodiphenyl motif, their use as medicines and pharmaceutical compositions containing th...
11/19/2002
6468971Maintaining kidney function during surgery or trauma
Kappa-opioid agonists prevent the impairment of renal function otherwise caused by the combination of gaseous anesthesia and surgery or severe trauma. Not only do these agents preserve renal function and maintain urine output, they also maintain plasma el...
10/22/2002
6436437Covalent polar lipid conjugates with neurologically active compounds for targeting
This invention herein describes a method of facilitating the entry of drugs into cells and tissues at physiologically protected sites at pharmicokinetically useful levels and also a method of targeting drugs to specific organelles within the cell. This po...
08/20/2002
6420405Pharmaceutical composition for angiotensin II-mediated diseases
This invention relates to a pharmaceutical composition for angiotensin II-mediated diseases, which comprises a compound having angiotensin II antagonistic activity of the formula ##STR1## wherein R1 is H or an optionally substituted hydrocarbon...
07/16/2002
6365586Compounds, their preparation and use
The present invention relates to compounds of the general formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR)....
04/02/2002
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