Class 514/223.2 - 1,2,4 - Benzothiadiazine - 1,1 - dioxides (including hydrogenated)

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter in which the polycyclo ring system has the
No. of patents: 116
Last issue date: 09/29/2009

«First «Previous1 2 3 Next»Last»

Number	Title	Issue Date
7595313	Nitric oxide donating diuretic compounds, compositions and methods of use The invention describes novel compositions and kits comprising at least one nitric oxide enhancing diuretic compound, or pharmaceutically acceptable salts thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. T...	09/29/2009
7582626	5,6-dihydro-1-pyridin-2-one compounds The invention is directed to 5,6-dihydro-1H-pyridin-2-one compounds of Formula I and pharmaceutical compositions containing such compounds that are useful in treating hepatitis C virus infections: w...	09/01/2009
7572789	Salts of potassium ATP channel openers and uses thereof Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment...	08/11/2009
7524841	4,4-disubstituted piperidine derivatives having CCR3 antagonism The invention provides low molecular compounds having activity which inhibits binding of CCR3 ligands to CCR3 on target cells, i.e. CCR3 antagonists. The invention also provides 4,4-(disubstituted)piperidine derivatives represented by formula (I) below, pharmaceutic...	04/28/2009
7517875	Piperidine derivatives having CCR3 antagonism The invention provides low molecular compounds having activity which inhibits binding of CCR3 ligands to CCR3 on target cells, i.e. CCR3 antagonists. The invention also provides compounds represented by formula (I) below, pharmaceutically acceptable acid adducts the...	04/14/2009
7517876	Anti-infective agents Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermedia...	04/14/2009
7425552	Pyridazinone compounds The invention is directed to pyridazinone compounds of Formula I and pharmaceutical compositions containing compounds of Formula I wherein R1 and R2 are independently H, alkyl, cycloalkyl, aryl, or het...	09/16/2008
7423034	Benzothiazine and benzothiadiazine compounds Compounds of formula (I): wherein: R1 represents hydrogen, a halogen or alkyl, R1a represents hydrogen or alkyl, R2 represents hydrogen, a halogen or h...	09/09/2008
7396829	Nitric oxide enhancing diuretic compounds, compositions and methods of use The invention describes novel compositions and kits comprising at least one nitric oxide enhancing diuretic compound, or pharmaceutically acceptable salts thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. T...	07/08/2008
7378414	Anti-infective agents Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermedia...	05/27/2008
RE40000	Method of treatment for decreasing mortality resulting from congestive heart failure A method of treatment using a compound of Formula I: wherein: R1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; R	01/08/2008
7279497	Benzopyran derivatives substituted with secondary amines including imidazole, their preparation and pharmaceutical compositions containing them The present invention relates to benzopyran derivatives substituted with secondary amines including imidazole, their preparation, and pharmaceutical compositions containing them. The present invention is pharmacologically useful for the treatment of cancer, rheumato...	10/09/2007
7268130	Benzothiadiazine compounds The invention relates to compounds of formula (I): wherein: R1 represents alkyl substituted by one or more halogen atoms, R2 represents hydrogen, halogen or hydroxy...	09/11/2007
7268129	Fluorinated benzothiadiazine compounds Compounds of formula (I): wherein: RF represents monofluoro- or polyfluoro-alkyl or monofluoro- or polyfluoro-cycloalkylalkyl, R1 represents hydrogen or a group sel...	09/11/2007
7262191	Benzothiadiazine compounds The invention relates to compounds of formula (I): wherein: X represents oxygen or sulphur, R1 represents linear or branched (C1-C6	08/28/2007
7262190	Benzothiazine and benzothiadiazine compounds The invention relates to compounds of formula (I): wherein: R1 represents hydrogen, alkyl or cycloalkyl, R2 represents hydrogen, halogen or hydroxy, A ...	08/28/2007
7250411	Benzothiazine and benzothiadiazine compounds Compounds of formula (I): wherein: R1 represents hydroxy or RCO—O—, R2 represents hydrogen, halogen, hydroxy or R′CO—O, R, R′, which may be i...	07/31/2007
7235548	Compounds and their use as positive AMPA receptor modulators The invention provides novel compounds represented by the general formula compound represented by the formula: wherein the bond represented by the broken line may be a single, a...	06/26/2007
7091200	Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists This invention relates to compounds which are generally alpha-1A/B adrenoceptor antagonists and which are represented by Formula I: wherein Z is —C(O)— or —S(O)2—, X is...	08/15/2006
7026317	Pyrazolotriazines as CRF antagonists The present invention relates to pyrazolotriazines according to formula (I) and stereoisomers, isomers and salts thereof wherein R1-R5 are selected from certain alkyl, aryl and heteroaryl species ...	04/11/2006
7001907	Peptide-containing α-ketoamide cysteine and serine protease inhibitors This invention relates to peptide-containing α-ketoamide inhibitors of cysteine and serine proteases, methods for making these compounds, and methods for using the same. ...	02/21/2006
6979698	Method of treating cognitive deficits in learning and memory The treatment of learning, memory, and age-related memory disorders includes administration of a nicotine antagonist. The preferred nicotine antagonists are mecamylamine, a mecamylamine analog, or a mecamylamine stereoisomer. The effective amount of the nicotine ant...	12/27/2005
6962922	Alkynylated quinazoline compounds A compound selected from those of formula (I): wherein W1 represents O, S, or —NR3 in which R3 represents hydrogen, alkyl, OH or CN; W2 represe...	11/08/2005
6949651	Fused bicyclic metalloproteinase inhibitors The present invention relates to fused bicyclic metalloproteinase inhibitors of the formula wherein A, B, X, Y, and R1 are as defined in the specification, and to pharmaceutical compositions and methods of t...	09/27/2005
6943159	Compounds and their use as positive AMPA receptor modulators The invention provides novel compounds represented by general formula (I) wherein the bond represented by the broken line may be a single, double bond or absent; and if the bond is absent, then the nitrogen is substitu...	09/13/2005
6939870	Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression A compound represented by the formula I: wherein A represents the following heterocycles: and R1-9 are as defined herein, a composition containing this compoun...	09/06/2005
6919331	Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides heterocyclic substituted 2-methylbenzimidazole derivatives for the treatm...	07/19/2005
6894043	Benzothiadiazine derivatives, preparation method and pharmaceutical compositions containing same Compound selected from those of formula (I): wherein: X represents flourine, bromine, iodine or methyl, each of R1 and R2, which may be identica...	05/17/2005
6858228	Solid oral dosage forms of valsartan The present invention is concerned with solid oral dosage forms of comprising a) an active agent selected from valsartan and optionally HCTZ, and b) Pharmaceutically acceptable additives suitable for the preparatio...	02/22/2005
6737427	Mucin synthesis inhibitors The claimed invention relates to methods of modulating mucin synthesis and the therapeutic application of compounds in controlling mucin over-production associated with diseases such as chronic obstructive pulmonary diseases (COPD) including asthma and chronic bronc...	05/18/2004
6730668	6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula:	05/04/2004
6656932	Benzo thiadiazine matrix metalloproteinase inhibitors Selective MMP-13 inhibitors are benzo thiadiazines of the Formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein R2 is hydrogen or alkyl; R1 and R3 include hydrogen, alkyl, and aryl, with the proviso that ...	12/02/2003
6620808	Endocrine modulation with positive modulators of AMPA type glutamate receptors Methods for modulating the endocrine system of a mammal are provided. In the subject methods, a positive allosteric modulator of AMPA receptors of the hypothalamus are administered to the host. The subject methods find use in applications where it is desi...	09/16/2003
6608051	Compositions and methods for treating blood A blood collection system and method are disclosed in which taurolidine, a neutralizing agent for pathogens is added to the blood collected in standard blood bags. The taurolidine agent may be prepositioned in the collection bag prior to the collection of...	08/19/2003
6605627	Modulators of peroxisome proliferator activated receptor-gamma, and methods for the use thereof In accordance with the present invention, there is provided a class of compounds which are capable of modulating processes mediated by peroxisome proliferator activated receptor-gamma (PPAR-γ). The identification of such compounds makes it possible to in...	08/12/2003
6521617	Treatment of apoptotic cell death New methods are provided for treating against apoptotic cell death, including apoptotic cardiac and neuronal cells. Therapies of the invention include administration of a mitochondrial oxidizer compound to a subject in need thereof, such as a subject suff...	02/18/2003
6498157	Coatings and soaks for medical prosthetic devices comprising taurinamide derivatives and carboxylic acids and/or salts thereof The present invention relates to a method of inhibiting or preventing infection and blood coagulation in or near a medical prosthetic device after said device has been inserted in a patient comprising administering to the device a pharmaceutically effecti...	12/24/2002
6485745	Solid oral dosage forms of valsartan The present invention is concerned with solid oral dosage forms of comprising a) an active agent selected from valsartan and optionally HCTZ , and b) Pharmaceutically acceptable additives suitable for the preparation of solid oral dosage forms by compression m...	11/26/2002
6436927	IL-8 receptor antagonists The present invention involves certain 8-ureido and 8-thioureido, 1,2-benzothiazines, 1,2,4-benzothioxazines and 1,2,4-benzothiodiazines useful in the treatment of disease states mediated by the chemokine, Interleukin-8....	08/20/2002
6423706	Antimicrobial locks comprising taurinamide derivatives and carboxylic acids and/or salts thereof The present invention relates to a method of inhibiting or preventing infection and blood coagulation in or near a medical prosthetic device after said device has been inserted in a patient comprising administering to the device a pharmaceutically effecti...	07/23/2002

«First «Previous1 2 3 Next»Last»

PatentStorm

Quotables

PatentStorm News

Class 514/223.2 - 1,2,4 - Benzothiadiazine - 1,1 - dioxides (including hydrogenated)