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| Number | Title | Issue Date |
| 5001115 | Prodrugs of biologically active hydroxyaromatic compounds Prodrugs of bio-active hydroxyaromatic drugs having the structural formula: A pharmaceutically acceptable prodrug of a biologically active, therapeutically effective hydroxyaromatic drug, said prodrug being selected from the group consisting of, (A) compounds ... | 03/19/1991 |
| 4994476 | Dihydropyridin-3,5-dicarboxylates incorporating aryloxypropanolamine moieties A series of compounds useful in treating cardiovascular disorders due to the combined expression of both ଲ-block and calcium-block activity by these agents. This useful combination of actions is effected by a novel combination of structural subunits... | 02/19/1991 |
| 4990505 | Phenethanolamine compounds The invention provides compounds of the general formula (I) ##STR1## wherein the substituents are defined in the specification, and physiologically acceptable salts and solvates thereof. The compounds of formula (I) have a selective stimulant action at ... | 02/05/1991 |
| 4985425 | Dissolved composition of [benzo-1,2,4-thiadiazine]-1,1-dioxide A dissolved composition containing (A) one or more of [benzo-1,2,4-thiadiazine]-1,1-dioxide derivatives, (B) dimethyl sulfoxide, benzyl alcohol, or the mixture thereof; (C) water; and (D) one or more anionic surfactants and/or surfactants, other than anio... | 01/15/1991 |
| 4968678 | Tetrazole excitatory amino acid receptor antagonists The present invention provides novel tetrazole derivatives useful as excitatory amino acid receptor antagonists and in treating a variety of associated nervous system disorders.... | 11/06/1990 |
| 4950665 | Phototherapy using methylene blue The present invention is a method for using thiazin dyes, especially methylene blue, in combination with light to hydroxylate guanosine or deoxyguanosine at the C8 of the purine ring. The number of guanosines in a nucleic acid strand converted to 8-OH-deo... | 08/21/1990 |
| 4943570 | Benzimidazolesulfonamides and imidazopyridinesulfonamides, and their application as drugs Benzimidazole-2-sulfonamide and imidazopyridine-2-sulfonamide derivatives corresponding to the general formula: ##STR1## and their pharmaceutically acceptable salts in which: Z1 to Z4 represent a nitrogen atom or a substituted o... | 07/24/1990 |
| 4942143 | Imidazothiadiazine derivatives, and their use as medicaments The present invention relates to 1,3,6,7-Tetrahydro-7-oxoimidazo[4,5-c][1,2,6]-thiadiazine 2-oxide derivatives of the general formula (I): ##STR1## wherein R1, R2 and R4 are the same or different and represent an... | 07/17/1990 |
| 4891374 | Imidazo- and triazolothiadiazines Novel imidazo- and triazolothiadiazines of the general formula I ##STR1## in which R1 =C1 -C4 -alkyl, R2 =H or C1 -C3 -alkyl and the structural element --A--B--=--CH2 --CH2... | 01/02/1990 |
| 4873237 | 2,3-dihydro- thiazolo- and thiazino- benzimidazoles as atni-hyper secretion agents The invention relates to a method of treatment of ulcers or hypersecretion in a mammal which comprises administering a compound of formula ##STR1## or a pharmaceutically acceptable salt thereof wherein --B--B1 -- represents a chain of form... | 10/10/1989 |
| 4861773 | Heterocyclic compounds The invention relates to thiadiazinone derivatives that have utility as cardiac stimulants. A compound of the invention is 7-(1H-imidazol-1-yl)-9,9a-dihydroindeno[1,2-e][1,3,4]-thiadiazin-2(3H)-one .... | 08/29/1989 |
| 4737500 | 1-substituted-4-(thiazolyl-2-)-piperazines, -piperidines and -tetrahydropyridines useful as anxiolytic, psychogeriatric, antidepressant and antischizophrenic agents Thiazoles or pharmaceutically acceptable acid addition salts thereof are useful as anxiolytic, psychogeriatric, antidepressant and antischizophrenic agents.... | 04/12/1988 |
| 4636499 | Sulphenamides Novel compounds of the formula IIIa ##STR1## wherein R1a, R2a, R3a and R4a are the same or different and are hydrogen, an alkyl, alkoxy optionally completely or predominantly substituted by fluorine or chlo... | 01/13/1987 |
| 4616013 | Fused thiadiazines This invention relates to thiadiazinone derivatives which have inotropic and vasodilator activity. A specific compound of this invention is 7-acetamido-9,9a-dihydroindeno[1,2-e][1,3,4]thiadiazine-2(3H)-one.... | 10/07/1986 |
| 4612311 | 1,2,4-benzothiadiazine oxide derivatives 1,2,4-Benzothiadiazine oxide derivatives of the general Formula I ##STR1## in which R1 represents an unsubstituted or substituted aryl radical; R2 and R5, which may be the same or different, and represent hydrogen, halogen... | 09/16/1986 |
| 4578459 | Heterocyclic alkylaminoheterocycles Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-4-pyrimidone.... | 03/25/1986 |
| 4558044 | 1,2,4-Benzothiadiazines Disclosed are compounds of the formula wherein R1 is guanidino or substituted guanidino, Ar is furandiyl, thiophendiyl, phenylene, pyridinediyl, pyrimidinediyl, thiazolediyl, thiadiazolediyl or imidazolediyl; a is 0, 1 or 2; b is 2, 3, 4 or 5; and ... | 12/10/1985 |
| 4544655 | Antiinflammatory, analgesic, and antirheumatic 4-hydroxy-2-methyl-n-(2-pyridyl)-6-trifluoromethyl-2H-thieno[2,3-e]-1,2- thiazine-3-carboxamide 1,1-dioxide, corresponding compositions, and 3-carboxylic acid lower alkyl ester intermediates 4-Hydroxy-2-methyl-3-(2-pyridylcarbamoyl)-6-trifluoromethyl-2H-thieno[2,3-e ]-1,2-thiazine 1,1-dioxide of the formula ##STR1## and its pharmaceutically acceptable salts which possess valuable pharmacodynamic properties are described. More particularly... | 10/01/1985 |
| 4443445 | Imidazo- and pyrimido-1,3,5-thiadiazin-4-ones The invention relates to novel substituted imidazo- and pyrimido-1,3,5-thiadiazin-4-ones of the formula ##STR1## wherein each of R1, R2 and R3 independently of one another is hydrogen, halogen, C1 -C4 | 04/17/1984 |
| 4390536 | Piperidine derivatives New piperidine derivatives which have a useful pharmacological activity such as hypotensive activity are prepared.... | 06/28/1983 |
| 4344945 | Piperidine derivatives New piperidine derivatives which have a useful pharmacological activity such as hypotensive activity are prepared.... | 08/17/1982 |
| 4221790 | Substituted 2,2-dioxo-1,2,3-benzoxathiazines The invention relates to novel 2,2-dioxo-1,2,3-benzoxathiazines substituted in the benzene nucleus, as well as the 3,4-dihydro analogs thereof, useful as anti-inflammatory, antipyretic, analgesic agents.... | 09/09/1980 |
| 4219541 | Novel oral composition for the care of the mouth and teeth An oral composition for the care of the mouth and teeth which contains as an active ingredient, a compound of the formula: ##STR1## wherein R1 and R2, which may be the same or different, are hydrogen atoms, alkyl groups having 1... | 08/26/1980 |
| 4171361 | 1-Substituted-3-amino-6,7-dialkoxy-1H-1,2,4-benzothiadiazine-1-oxides 1-Substituted-3-amino-6,7-dialkoxy-1H-1,2,4-benzothiadiazine-1-oxides, useful as hypotensive agents.... | 10/16/1979 |
| 4100280 | 1,3-Dialkyl-6,7-methoxy-1H-1,2,4-benzothiadiazine-1-oxides 1,3-Dialkyl-6,7-methoxy-1H-1,2,4-benzothiadiazine-1-oxides, useful as hypotensive agents.... | 07/11/1978 |
| 4069325 | 3-Carbalkoxyamino-1H-2,1,4-benzothiadiazine derivatives 3-Carbalkoxyamino-1H-2,1,4-benzothiadiazine derivatives are disclosed as well as a process for their manufacture. The compounds are suitable for combatting helminths and especially gastrointestinal Strongylides and liver flukes.... | 01/17/1978 |
| 4042693 | Derivatives of 1,2,4-thiadiazine This invention relates to new derivatives of 1,2,4-thiadiazine having anti-inflammatory properties. The new derivatives of 1,2,4-thiadiazine may be represented by the following general formula: ##STR1## in which R1 and Z each represent an ... | 08/16/1977 |
| 4018920 | 3-Halohydrocarbylthio-1,2,3-benzoxathiazin-4-(3H)-one 2-oxides Compounds of the formula ##STR1## wherein R is an alkyl group or an alkenyl group, each substituted with 1 to 5 halogen atoms of atomic number 9 to 35, and X is halogen of atomic number 9 to 35, nitro, cyano, lower alkyl, lower alkoxy or trifluoromet... | 04/19/1977 |
| 3954972 | Antibiotic A-26771 factor Antibiotic mixture A-26771, comprising microbiologically active factors A, B and C, produced by fermentation of Penicillium turbatum Westling NRRL 5630, and isolation and separation of the individual factors thereof by extraction, chromatography and cryst... | 05/04/1976 |
| 3954981 | Triazolocycloalkylhydrothiadiazine derivatives Novel triazolocycloalkylhydrothiadiazines and their preparation, which are useful as antisecretory agents, central nervous system stimulants, and central nervous system depressants, are disclosed.... | 05/04/1976 |
| 3954984 | Triazolocycloalkylthiadiazine derivatives Novel triazolocycloalkylthiadiazines, their preparation, and use as antisecretory agents and central nervous system depressants.... | 05/04/1976 |
| 3954983 | Triazolobenzocycloalkylthiadiazine derivatives Novel triazolobenzocycloalkylthiadiazines, their preparation, and use as central nervous system antidepressants.... | 05/04/1976 |
