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Class 514/217.02 - Benzene ring bonded directly to ring carbon of the seven-membered hetero ring


Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter under 217.01 wherein a ring carbon of the
No. of patents: 36
Last issue date: 01/08/2008


NumberTitleIssue Date
7317115Mandelates salts of substituted tetracyclic tetrahydrofuran derivatives
The object of the present invention is a novel mandelate salt of a substituted tetracyclic tetrahydrofuran derivative according to Formula (I) the N-oxide forms and the stereochemically isomeric forms thereof, wh...
01/08/2008
7279468Integrin ligands
The invention relates to novel compounds which bind to integrin receptors, their use as ligands of integrin receptors, in particular as ligands of the αvβ3 integrin receptor, their use, and pharmaceutical preparations comprising these compoun...
10/09/2007
7202237Pyridylether derivatives, their preparation and use
The present invention relates to novel pyridylether derivatives which are cholinergic ligands at nicotinic Ach receptors. The compounds of the invention are useful for the treatment of conditions, disorders, or diseases involving the cholinergic system of the centra...
04/10/2007
7122538Sulfonamide derivatives as antipsychotic agents
The invention provides compounds of formula (I): wherein A and B represent the groups —(CH2)m— and —(CH2)n— respectively; R1
10/17/2006
6962924Salt and polymorphs of desloratadine hemifumarate
This invention provides a process of preparation of novel polymorphic hemifumarate salts of 8-chloro-6,11-dihyfro-11-(4-piperidylidene)-5H-benzo[5,6]-cyclohepta[1,2-b]pyridine, hereinafter called “desloratadine”. These polymorphic salt forms show much higher sol...
11/08/2005
6677332Heterocyclic analgesic compounds and methods of use thereof
One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various cellular receptors, including opiate receptors, other G-pro...
01/13/2004
6534496Thermogenic composition and benzazepine thermogenics
The object of the present invention is to provide a prophylactic and/or therapeutic drug for obesity and obesity-associated diseasestor diabetes with a reduced risk for central side effects and high universality in usage. Another object of the present inv...
03/18/2003
6495543Polycyclic azaindole compounds
The invention relates to compounds of formula (I): ##STR1## wherein: G1 represents an alkylene chain as defined in the description, A represents ##STR2## R2 and R3 represent hydrogen, alkyl, alkoxy or hydroxy or together f...
12/17/2002
64893543-alkyl substituted pyrrolidine modulators of chemokine receptor activity
The present invention is directed to pyrrolidine compounds of the formula I: ##STR1## (wherein R1, R2, R3, R4c, R4d, and R4f are defined herein) which are useful as modulators of chemokine ...
12/03/2002
6211173Use of 2,3,4,5-tetrahydro-1H-3-benzazepines for the manufacture of a pharmaceutical composition for the treatment of sleep disorders
The present invention provides novel uses of the compounds of general formula (I) wherein R3 is hydrogen, alkyl or cycloalkyl; R4 is hydrogen or R4 together with R10 represents a bridge; R7 is hydroxy...
04/03/2001
5658899Acid addition salts of 2, 3, 4, 5-tetrahydro-1H-3-benzazepine compounds
The invention provides a series of crystalline salts of (S)-8-chloro-5-(5-bromo-2,3-dihydrobenzofuran-7-yl)-3-methyl-2,3,4,5-tetra hydro-1H-3-benzazepine-7-ol, their preparation and use as therapeutic agents....
08/19/1997
54708502,3,4,5-tetrahydro-1H-3-benzazepines
2,3,4,5-Tetrahydro-1H-3-benzazepines having the general formula ##STR1## wherein R1 is Cl or Br; R3 and R4 are hydrogen, halogen, CF3, CN, NO2, or NH2. The compounds are useful in treatment...
11/28/1995
5284843Pharmacological treatment of ocular development
A method of inhibiting the abnormal postnatal axial growth of the eye of a maturing animal during conditions ordinarily leading to said abnormal growth, which comprises (1) determining the neurochemical present in the retina of said eye, eg., dopamine, th...
02/08/1994
5079243Benzazepines
Novel 2, 3, 4, 5-tetrahydro-1H-3-benzazepines, which in the 7-position have a methoxymethyloxy group, in the 8-position hydrogen, halogen, or a nitro group and in the 5-position have an optionally substituted phenyl ortho-fused ring-system, with interesti...
01/07/1992
5017571Carbamic acid ester of substituted 7-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepines
Compounds having the formula ##STR1## wherein R1, R4, R6, R7, and R8 are hydrogen or a substituent, R2 is a substituent, R5 is an optionally-substituted bicyclic ring system...
05/21/1991
5010074Novel benzazepine derivatives
Novel 2,3,4,5-tetrahydro-1H-3-benzazepines having the formula ##STR1## wherein R3 represents H, C1-3 -alkyl or C3-7 -cycloalkyl; R4 represents hydrogen or R4 together with R10 represents a ...
04/23/1991
49962021,2,4,5 tetrahydro benzazepine-3 compounds and antipsychotic use thereof
Substituted 8-amino-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines useful in treating mental disorders and which have activities of prolonged duration are disclosed. Methods for preparing these compounds and methods for their use are also described....
02/26/1991
4861771Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benz azepine as prodrugs
Prodrug carbamate derivatives of fenoldopam which provide fenoldopam plasma levels of similar magnitude and over a much longer period of time than the parent compound. An absence of a high initial peak effect associated with the parent compound is noted. ...
08/29/1989
47512222,3,4,5-tetrahydro-1H-3-benzazepines and CNS affecting use thereof
Novel 2,3,4,5-tetrahydro-1H-3-benzazepines which in the 5-position have furyl, thienyl, pyridyl, or ring systems consisting of phenyl ortho condensed with a benzen, cyclohexan, cyclohexen, cyclopentan or cyclopenten ring wherein one of the carbon atoms ma...
06/14/1988
4600714Fenoldopam 4',8-bis-hydrogen sulfate and dopaminergic use thereof
Fenoldopam 4',8-bis-hydrogen sulfate and its salts are useful prodrugs to obtain extended dopaminergic activity. A useful species is the monoammonium salt....
07/15/1986
4514394Anti-hypertensive use of 1-(4'-branched alkylsulfonylphenyl)-6-chloro-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benz azepines
6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines whose structures have an isopropylsulfonyl, isopropylthio, isobutylsulfonyl or isobutylthio group substituted at the 4-position of the 1-phenyl substituent have potent renal dopaminergic...
04/30/1985
4469690Synergistic compositions of renal dopaminergic agent and ଲ-blocker
Compositions useful for improving kidney function and treating hypertension are comprised of a 6-chloro, 6-fluoro or 6-methyl-7,8-dihydroxy-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzaze pine combined with a ଲ-adrenergic blocking agent known to ...
09/04/1984
43594643-Furylmethyl-6-halo-7,8-dihydroxy-1-p henyl-2,3,4,5-tetrahydro-1H-3-benzazepines and antihypertensive use thereof
3-Furylmethyl-6-halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzaze pines have potent dopaminergic activity. As such they have utility as antihypertensive and especially anti-Parkinsonism agents....
11/16/1982
42859387,8-Dihydroxy-1-(sulfamylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
New 7,8-dihydroxy-1-(sulfamylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines having pharmaceutical activity together with new intermediates and methods of synthesis for preparing them. The lead compound is 6-chloro-7,8-dihydroxy-1-(p-sulfamylphenyl)-2,3,4,5-...
08/25/1981
42658896-Lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
A series of 6-lower alkyl-7,8-dihydroxyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines having dopaminergic activity together with intermediates and processes for their preparation are disclosed....
05/05/1981
42554226-Halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
7,8-Dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines having a halo substituent at the 6-position have potent dopaminergic activity. The 6-chloro congeners are most active....
03/10/1981
42515253-Allyl-7,8-dihydroxy-6-halo-1-(4-hydr oxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-be nzazepine derivatives are prepared by N-allylation of 7,8-dimethoxy-6-halo-1-(4-methoxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepi ne using an allyl halide in acetonitrile in the pres...
02/17/1981
4206210Alkylthio-7,8-dihdroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines having dopaminergic activity
A new series of lower alkylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines having potent central dopaminergic activity of utility in treating Parkinson's disease. The 6-and 9-methylthio compounds are particularly of use....
06/03/1980
41972976-Halo-7,8-d ihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines
6-Halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines whose structures have a hydroxy group substituted on the 1-phenyl ring have potent and specific antihypertensive activity by means of their peripheral dopaminergic effect. The lead compoun...
04/08/1980
41928726-Halo-3-lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
6-Halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines whose structures have a lower alkyl substituted at the 3 or N-position have potent and often specific anti-Parkinsonism activity by means of their central dopaminergic effect. The lead com...
03/11/1980
4171359Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
A group of 6,9-disubstituted-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepi nes have dopaminergic activity. Examples of leading species of the invention are 6,9-dichloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and 6,9...
10/16/1979
41653726-Carboxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds and use as dopaminergic agents
A group of 1-phenyl-3-benzazepines with structures characterized by having a carboxy derived substituent at position 6 which are dopaminergic agents or are intermediates for preparing other dopaminergic agents. Particular illustrative species include ...
08/21/1979
4163798Stabilized aqueous amide antimicrobial composition
Aqueous antimicrobial compositions which comprise a halogenated amide antimicrobial, such as 2,2-dibromonitrilopropionamide, a water miscible organic solvent such as a straight chain polyalkylene glycol (e.g., polyethylene glycol 200) or an ether thereof ...
08/07/1979
4104379Substituted 1-alkylthiophenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
A group of 1-phenyl-1H-3-benzazepines whose structures are characterized by having a functional thio containing group on the 1-phenyl moiety and which have pronounced peripheral and diminished central dopaminergic activity. This activity is manifested in ...
08/01/1978
4052506Pharmaceutical compositions and method of producing anti-Parkinsonism activity
Pharmaceutical compositions and method of producing anti-Parkinsonism activity by administering internally a nontoxic effective quantity of a benzazepine derivative to an animal....
10/04/1977
4011319Pharmaceutical compositions and methods involving benzazepine derivatives
Pharmaceutical compositions and a method of stimulating peripheral dopamine receptors by administering internally a nontoxic effective quantity of a benzazepine derivative to an animal. Renal vasodilator and diuretic methods are also disclosed....
03/08/1977
 
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