Quotables
"Radio has no future."
Lord Kelvin, British mathematician and physicist ; 1897
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8183234 | Tricyclic guanidine derivatives as sodium-proton exchange inhibitors Guanidine derivatives having a condensed tricyclic ring of formula 1: are disclosed, wherein U is C(O), CRaRb, O, NRa or S(O)m; V is CRaRb or NRa;... | 05/22/2012 |
| 7834001 | Tricyclic guanidine derivatives as sodium-proton exchange inhibitors Guanidine derivatives having a condensed tricyclic ring of formula 1: are disclosed, wherein U is C(O), CRaRb, O, NRa or S(O)m; V is CRaRb or NRa;... | 11/16/2010 |
| 7807663 | Therapeutic agents for diabetes A pharmaceutical composition for preventing and/or treating diabetes, diabetic complication, hyperinsulinemia, disorders of glucose metabolism or obesity, comprising a combination of the following compound, analogues or pharmaceutically acceptable salts thereof with... | 10/05/2010 |
| 7625888 | Fused triazole derivatives as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes The present invention is directed to novel fused triazole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is ... | 12/01/2009 |
| 7429577 | Augmentation of atypical antipsychotic agent pharmacotherapy with chromium supplementation The present invention relates to pharmaceutical compositions comprising an antipsychotic agent in combination with a chromium salt, which are used for minimizing side effects in a patient taking an antipsychotic agent. ... | 09/30/2008 |
| 7348355 | Triamide-substituted heterobicyclic compounds The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for prep... | 03/25/2008 |
| 7320973 | Dihydrodiaryloxazepine derivative and pharmaceutical composition containing the same The present invention provides dihydrodiaryloxazepine derivative represented by the following formula [1], analogs thereof and pharmaceutical compositions containing them. Those compounds have an excellent effect of improving functional diseases of gastrointestinal ... | 01/22/2008 |
| 7235541 | Neurokinin antagonists for use as medicaments The present application relates to internally cyclized naphthamide compounds of the formula Ia (wherein R1a, R1b, R1c, R2, R3, R4, R5, R6, R7, R8, X1 | 06/26/2007 |
| 7229984 | Dibenzoxazepinone derivatives and uses thereof Compounds of the Formula I: wherein m, n, k, A, X, Y, Z, Ar, R1, R2, R3, and R4 are as defined herein. The compounds are useful as 5-HT6 receptor antagonists. Also prov... | 06/12/2007 |
| 7208522 | Methods and compositions for the prevention and treatment of Syndrome X Methods and compositions for preventing or treating Syndrome X are provided. The method includes administering a therapeutically effective amount of conjugated linoleic acid. ... | 04/24/2007 |
| 7202213 | Combination therapy using a dual PPAR-α/PPAR-γ activator and a GLP-1 derivative for the treatment of metabolic syndrome and related diseases and disorders The present invention relates to a pharmaceutical composition comprising a dual Peroxisome Proliferator-Activated Receptor-alpha/Peroxisome Proliferator-Activated Receptor-gama activator (PPAR-α/PPAR-γ) and a Glucagon Like Peptide-1 (GLP-1) derivative for treating... | 04/10/2007 |
| 7041661 | Use of thiazolobenzoheterocycles for treating multiple sclerosis The invention relates to the use of compound of Formula I in treating patients for inflammatory or neuropathic pain as well as various symptoms of multiple sclerosis ... | 05/09/2006 |
| 6989379 | Selective NPY (Y5) antagonists This invention is directed to triazine derivatives, bicyclic compounds and tricyclic compounds which are selective antagonists for a NPY (Y5) receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of... | 01/24/2006 |
| 6979692 | Triamide-substituted heterobicyclic compounds The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for... | 12/27/2005 |
| 6951860 | Calcium channel blockers The invention involves the identification of a family of compounds which block calcium channels. The compounds can be formulated in pharmaceutical carriers and administered to subjects. The compounds are useful for treating disorders associated with calcium channel ... | 10/04/2005 |
| 6949572 | Triamide-substituted heterobicyclic compounds The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for... | 09/27/2005 |
| 6943156 | Dibenzoxazepine αv integrin receptor antagonist The present invention relates to a novel dibenzoxazepine derivative, its synthesis, and its use as an αv integrin receptor antagonist. More particularly, the compound of the present invention is an antagonist of the integrin receptors αvβ3 and αvβ5 and therefor... | 09/13/2005 |
| 6939853 | Combined use of a GLP-1 compound and another drug for treating dyslipidemia Methods and uses for treatment of dyslipidemia comprising administration of a GLP-1 compound and another antidyslipidemic drug. ... | 09/06/2005 |
| 6908926 | Substituted imidazoles, their preparation and use Disclosed is a novel class of substituted imidazole compounds, pharmaceutical compositions containing them and uses of these compounds in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, these compoun... | 06/21/2005 |
| 6900315 | 2-amino-9H-purin-9-yl compounds and methods for inhibiting/treating HIV infections and AIDS related symptoms The present invention relates to novel compounds, compositions and methods for inhibiting the growth, elaboration and/or replication of HIV in human patients and to the prevention and treatment of human acquired immunodeficiency syndrome (AIDS) and other diseases ca... | 05/31/2005 |
| 6846814 | Neurokinin antagonists for use as medicaments Compounds having the general formula wherein R1a, R1b, R1c, R2, R3, R4, R5, R6, R7, R8, X1, X | 01/25/2005 |
| 6831077 | Augmentation of atypical antipsychotic agent pharmacotherapy with chromium supplementation The present invention relates to pharmaceutical compositions comprising an atypical antipsychotic agent in combination with a chromium salt, which are used for treating atypical depression, as well as minimizing side effects in a patient taking an atypical antipsych... | 12/14/2004 |
| 6710041 | Pyrrolo[2,1-B][3,1] benzothiazepines and their use for the preparation of medicaments with antipsychotic activity A compound of formula (I): where: R=H, Cl, Br, F, I, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkyl, or C5-C6 cycloalkyl; R1 = | 03/23/2004 |
| 6642222 | Pyrano, piperidino, and thiopyrano compounds and methods of use ##STR1## The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.... | 11/04/2003 |
| 6638938 | Method for preventing tissue injury from hypoxia There is disclosed a method for preventing tissue injury caused by tissue hypoxia and reoxygenation, comprising administering a compound that inhibits signal transduction by inhibiting cellular accumulation of linoleoyl phosphatidic acid (PA) through an i... | 10/28/2003 |
| 6537987 | 4,1-benzoxazepines or 4,1-benzothiazepines and their use as squalene synthetase inhibitors This invention relates to certain benzoxazepinones and benzothiazepinones useful as hypocholesterolemic agents, hypotriglyceridemic agents, antiatherosclerosis agents, antifungal agents, anti-Alzheimer's agents or anti-acne agents.... | 03/25/2003 |
| 6528504 | Oxazepine derivatives and medicine containing the same The present invention provides (R)-5,11-dihydro-5-[1-(4-methoxyphenethyl)piperidine-2-ylmethyl]dibenzo[b, e][1,4]oxazepine, (R)-5,11-dihydro-5-[1-(4-dimethylaminophenethyl)piperidine-2-ylmethyl]dibe nzo[b,e][1,4]oxazepine, compounds analogous to them a... | 03/04/2003 |
| 6476017 | Compounds activating pharmacological effect of retinoids A compound represented by the formula (I) or (II) or a salt thereof wherein R1 represents hydrogen atom or a C1-6 alkyl group; R2 and R3 independently represent a hydrogen atom or a C1-6 alkyl group, ... | 11/05/2002 |
| 6436922 | 5,11-dihydrobenzo[b,e][1,4]oxazepine derivatives and pharmaceutical compositions containing the same Disclosed are 5,11-Dihydrodibenzo[b,e][1,4]oxazepine derivatives such as (R)-(+)-5,11-dihydro-5-[1-(4-methoxyphenethyl)-2-pyrrolidinylmethyl]dibenz o[b,e][1,4]oxazepine and (R)-(+)-5,11-dihydro-5-[1-(4-fluorophenethyl)-2-pyrrolidinylmethyl]dibenzo [b,e... | 08/20/2002 |
| 6417180 | Zinc finger-reactive antimicrobial compounds The invention relates to antimicrobial compounds which interact with zinc in a zinc finger of a bacterial DNA polymerase, methods of screening for such compounds, and methods of using such compounds to inhibit polymerase activity or bacterial growth.... | 07/09/2002 |
| 6362176 | Compositions, methods and kits for treating rheumatoid arthritis Disclosed are methods of treating rheumatoid arthritis by coadministering synergistic effective amounts of pentostatin and methotrexate to a host in need thereof, and kits and compositions that include pentostatin and methotrexate.... | 03/26/2002 |
| 6235730 | 3-piperidyl-4-oxoquinazoline derivatives and pharmaceutical compositions comprising the same 3-piperidyl-4-oxoquinazoline derivatives are provided, which is represented by the formula (I): ##STR1## wherein R represents an amino group or a cyclic amino group such as dibenzoazepine, each of which is substituted with a substituted or unsubstitu... | 05/22/2001 |
| 6214820 | Compounds, their preparation and use The present invention relates to compounds of formula (I) ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, R8, A, X, T, Q, Z, U, Y, Ar, p and n are as defined in the speci... | 04/10/2001 |
| 6191140 | Pyrano, piperidino, and thiopyrano compounds and methods of use The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.... | 02/20/2001 |
| 6127361 | 5,11-dihydrodibenzo[b,e][1,4]oxazepine derivatives and pharmaceutical compositions containing the same Disclosed are 5,11-Dihydrodibenzo[b,e][1,4]oxazepine derivatives such as (R)-(+)-5,11-dihydro-5-[1-(4-methoxyphenethyl)-2-pyrrolidinylmethyl]dibenz o[b,e][1,4]oxazepine and (R)-(+)-5,11-dihydro-5-[1-(4-fluorophenethyl)-2-pyrrolidinylmethyl]dibenzo [b,e... | 10/03/2000 |
| 6127362 | 9,10-diazatricyclo[4,4,1,12,5 ] decane and 2,7-diazatricyclo [4,4,0,03,8 ] decane derivatives having analgesic activity 9,10-DIAZATRICYCLO[4,4,1,12,5 ]DECANE (la) AND 2,7-DIAZATRICYCLO[4,4,0,03,8 ]DECANE (1b) DERIVATIVES HAVING ANALGESIC ACTIVITY. ##STR1##... | 10/03/2000 |
| 6063779 | 5-(4-piperidinyl)dibenzothiazepine derivatives and 5-(4-piperidinyl)dibenzoxazepine derivatives, and antiarrhythmic agents An objective of the present invention is to provide a compound that has antiarrhythmic activity. The present invention provides a compound of formula (I): ##STR1## wherein R1 and R2 each represent H, halogen or lower alkyl which... | 05/16/2000 |
| 6024977 | Covalent polar lipid conjugates with neurologically active compounds for targeting This invention herein describes a method of facilitating the entry of drugs into cells and tissues at physiologically protected sites at pharmicokinetically useful levels and also a method of targeting drugs to specific organelles within the cell. This po... | 02/15/2000 |
| 6008213 | Integrin receptor antagonists Compounds of formula (I) ##STR1## wherein A1 is C or N; E is a five- or six-membered heteroaromatic or six-membered aromatic ring optionally substituted by R3 or R4 ; X1 --X2 is CHR1 -... | 12/28/1999 |
| 6004983 | N-substituted azaheterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic carboxcylic acids of the general formula wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the description, or salts thereof, to methods for thei... | 12/21/1999 |
