Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 7365193 | Amino-substituted tricyclic derivatives and methods of use Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y1 and Y2 form various tricyclic cores, Xa and Xb are C, CH, or N, as defined herein, and Rx ... | 04/29/2008 |
| 7332600 | Process for the preparation of crystalline imipenem The present invention relates to a cost effective and industrially advantageous process for the preparation of imipenem of high purity, which comprises dissolving crude imipenerm in warm water to which some base has been added to obtain a solution, subjecting the re... | 02/19/2008 |
| 7026331 | Substituted beta-carbolines The subject matter of the present invention is directed to novel substituted beta-carbolines, and specifically compounds of the formula I, which are suitable for the production of pharmaceuticals for the prophylaxis and... | 04/11/2006 |
| 6680313 | Carbapenum derivatives An objective of the present invention is to provide carbapenem derivatives which have potent antibiotic activity against MRSA, PRSP, Influenzavirus, and ଲ-lactamase-producing bacteria and are stable against DHP-1. The compounds according to the pres... | 01/20/2004 |
| 6310056 | Carbapenem derivatives The carbapenem derivatives represented by the following formula (I) is disclosed. These compounds have strong anti-bacterial activities against bacteria including methicillin resistant Staphylococcus aureus, penicillin resistant Streptococcus pneumoniae, ... | 10/30/2001 |
| 5532261 | Carbapenem antibiotics, compositions containing such compounds and methods of use Compounds are disclosed represented by the formula: ##STR1## wherein Y is: ##STR2## or a pharmaceutically acceptable salt or ester thereof. ##STR3## represents an aromatic 6 membered ring; zero or one of T, U, V and W represents N... | 07/02/1996 |
| 5451579 | 1-ଲ-methyl-carbapenem, compositions containing same and methods of use A carbapenem antibiotic of the formula I ##STR1## is disclosed. The variable X.crclbar. represents a counterion. Pharmaceutical compositions and methods of use are also disclosed.... | 09/19/1995 |
| 5356889 | 2-(9-fluorenonyl)-carbapenem intermediates Disclosed are carbapenems of the formula ##STR1## which are 2-(9-fluorenonyl)-carbapenems useful as antibacterial agents. Intermediates for preparation of these compounds is also disclosed.... | 10/18/1994 |
| 5328904 | 2-phenanthridinyl carbapenem antibacterial agents The present invention relates to antibacterial agents of the carbapenem class, in which the 2-position sidechain is characterized by a phenanthridine moiety, substituted by various neutral substituents.... | 07/12/1994 |
| 5294610 | 2-(aza-9-fluorenonyl)carbapenem antibacterial agents Carbapenems of the formula ##STR1## wherein a suitably substituted aza-9-fluorenone is attached at the 2-position of the carbapenem are useful antibacterial agents.... | 03/15/1994 |
| 5240920 | 2-(substituted-dibenzofuranyl and dibenzothienyl) carbapenem antibacterial agents Carbapenems having the formula: ##STR1## where X is O or S(O)0-2 ; are useful antibacterial agents, especially with respect to activity against methicillin resistant Staphylococcus aureus (MRSA).... | 08/31/1993 |
| 5162314 | 2-benzocoumarinyl carbapenems Carbapenems of the formula ##STR1## with E as ##STR2## are useful antibacterial agents.... | 11/10/1992 |
| 5157033 | 2-phenanthridonyl carbapenems having cationizeable substituents Carbapenems of the formula ##STR1## are useful antibacterial agents.... | 10/20/1992 |
| 5153186 | 2-benzocoumarinyl-carbapenems Carbapenems of the formula ##STR1## are useful antibacterial agents.... | 10/06/1992 |
| 5153185 | 2-phenanthridonyl carbapenems Carbapenems of the formula ##STR1## are useful antibacterial agents.... | 10/06/1992 |
| 5034384 | 2-(9-fluorenonyl)-carbapenem antibacterial agents Carbapenems of the formula ##STR1## wherein either the 2-fluoren-9-one or 3-fluoren-9-one is attached at the 2-position of the carbapenem are useful antibacterial agents.... | 07/23/1991 |
| 5032587 | 2-naphthyl-carbapenem antibacterial agents Carbapenems of the formula ##STR1## are useful antibacterial agents.... | 07/16/1991 |
| 5025007 | 2-(9-fluorenonyl)-carbapenem antibacterial agents Carbapenems of the formula ##STR1## wherein either the 2-fluoren-9-one or 3-fluoren-9-one is attached at the 2-position of the carbapenem are useful antibacterial agents.... | 06/18/1991 |
| 5025008 | 2-(substituted-dibenzofuranyl and dibenzothienyl) carbapenem antibacterial agents Carbapenems having the formula: ##STR1## where Z is; ##STR2## where X is O or S(O)0-2 ; are useful antibacterial agents, especially with respect to activity against methicillin resistant Staphylococcus aureus (MRSA).... | 06/18/1991 |
| 5006519 | 2-naphthyl-carbapenem antibacterial agents Carbapenems of the formula ##STR1## are useful antibacterial agents.... | 04/09/1991 |
| 5004739 | 2-phenanthrenyl carbapenem antibacterial agents Carbapenems of the formula ##STR1## are useful antibacterial agents.... | 04/02/1991 |
| 5004740 | 2-phenanthrenyl-carbapenem antibacterial agents Carbapenems of the formula ##STR1## are useful antibacterial agents.... | 04/02/1991 |
| 4775669 | 1-carba-2-penem-3-carboxylic acid Disclosed are 1-carba-2-penem-3-carboxylic acids of the following structure: ##STR1## wherein R1, R2 and R3 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, aryl, and aralkyl. ... | 10/04/1988 |
| 4600713 | 1-, 6- and 2-substituted-1-carba-2-penem-3-carboxylic acids Disclosed are 1-, 6- and 2-substituted-1-carba-2-penem-3-carboxylic acids of the following structure: ##STR1## wherein R1, R2, R3, R4 and R5 are, inter alia, independently selected from the group... | 07/15/1986 |
