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| Number | Title | Issue Date |
| 7534782 | Crystal of 1-methylcarbapenem solvate A 1-methylcarbapenem compound ethanolate of the formula (I-1) in the crystalline form that shows main peaks at interplanar spacings d=7.60, 6.69, 6.33, 6.14, 5.15, 4.58 and 4.48 in the X-ray powder diffraction pattern obtained with Cu Kα irradiation ... | 05/19/2009 |
| 7439253 | Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors The invention relates to novel heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a method for preparing these compounds, and to their use as medicaments, in p... | 10/21/2008 |
| 7342005 | Antibiotic compounds The present invention relates to carbapenems and provides a compound of the formula (I): or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 ... | 03/11/2008 |
| 7332600 | Process for the preparation of crystalline imipenem The present invention relates to a cost effective and industrially advantageous process for the preparation of imipenem of high purity, which comprises dissolving crude imipenerm in warm water to which some base has been added to obtain a solution, subjecting the re... | 02/19/2008 |
| 7205291 | Carbapenem compounds A compound or its pharmaceutically acceptable salt represented by the following formula: The invention is a carbapenem compound which has a potent antibacterial activity over a broad range of Gram negative and Gr... | 04/17/2007 |
| 7157576 | Crystalline acid salts of cefdinir and process for preparing cefdinir using same High purity cefdinir is prepared in a high yield by a process comprising the steps of: treating a crystalline salt of a cefdinir intermediate with a formic acid-sulfuric acid mixture or a formic acid-methanesulfonic acid mixture to obtain a crystalline salt of cefdi... | 01/02/2007 |
| 7041836 | Antibiotic compounds The present invention relates to carbapenems and provides a compound of the formula (I): or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 | 05/09/2006 |
| 7041660 | Crystalline 1-methylcarbapenem derivatives This invention provides crystalline forms of a 1-methylcarbapenem derivative of formula (I-1), (I-2) or (I-3) The crystalline forms of the 1-methylcarbapenem derivative exhibit excellent antibiotic activity against vari... | 05/09/2006 |
| 6924279 | Crystalline 1-methylcarbapenem derivatives This invention provides crystalline forms of a 1-methylcarbapenem derivative of formula (I) or of pharmaceutically acceptable salts thereof. The crystalline forms of the 1-methylcarbapenem derivative exhibit excellent ... | 08/02/2005 |
| 6548492 | Process for formulation of carbapenem antibiotic compositions A novel process for preparing a stabilized, lyophilized carbapenem, antibiotic formulation suitable for intravenous administration to patients in need thereof, wherein the active ingredient is of formula II: ##STR1## The process entails compounding a unst... | 04/15/2003 |
| 6521612 | Antibiotic compounds The present invention relates to carbapenems and provides a compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2... | 02/18/2003 |
| 6486150 | Process for formulation of antibiotic compounds The present invention involves a process for preparing a stable final formulation product of a compound of formula I, ##STR1## or its pharmaceutically acceptable salt, hydrate or solvate by incorporating a suitable carbon dioxide source to an unstable mon... | 11/26/2002 |
| 6436921 | Carbapenem derivatives and a preparation method thereof The present invention relates to carbapenem derivatives of Formula I, wherein X is carbonyl or sulfonyl, and a preparation method thereof. The carbapenem derivatives of the invention have excellent antibacterial properties and are thus useful as antibioti... | 08/20/2002 |
| 6410525 | Carbapenem derivatives, utilization thereof and intermediate compounds of the same A carbapenem compound of the formula (I) ##STR1## wherein R1 is a group hydrolyzable in the living body, R2 and R3 are the same or different and each is a lower alkyl, R is a group of the formula (B) or (C) ##STR2## w... | 06/25/2002 |
| 6342494 | Carbapenem compounds, use thereof, and intermediate compounds of the same A carbapenem compound of the formula (I) ##STR1## wherein R1 is a group hydrolyzable in the body, R2 is selected from the group consisting of aryl groups optionally substituted by 1-3 alkyl groups having 1-4 carbon atoms, 1-alkanoylo... | 01/29/2002 |
| 6297231 | Stabilized carbapenem antibiotic compositions and method of making The present invention relates to a novel stabilized form of carbapenem antibiotics of formula II: ##STR1## compositions and methods thereof wherein the antibiotics and compositions are stabilized degradation and dimer formation. The compounds can be used ... | 10/02/2001 |
| 6180622 | Imidazo[5,1-b]thiazol-3-yl carbapenem antimicrobials Compounds of formula (I) and compounds of formula (II) which have potent antimicrobial activity against a wide range of bacteria including Gram-positive bacteria and Gram-negative bacteria as well as heve potent antimicrobial activity against various �... | 01/30/2001 |
| 6090802 | 1- Methylcarbapenem derivatives A 1-methylcarbapenem compound represented by the following formula (I): ##STR1## wherein R1 represents hydrogen or C1 -C4 alkyl; R2 represents hydrogen or an ester residue; and A represents a group of the f... | 07/18/2000 |
| 5977097 | 1-methylcarbapenem derivatives A 1-methylcarbapenem compound represented by the following formula: ##STR1## [wherein R1 represents a hydrogen atom or a lower alkyl group, R2 represents a hydrogen atom or a lower alkyl group, R3 represents a hydroge... | 11/02/1999 |
| 5952323 | Carbapenem antibiotic A pharmaceutical composition is disclosed which contains a compound of formula I: ##STR1## or a pharmaceutically acceptable salt, prodrug or hydrate thereof, in the stabilized form and/or in combination with a carbon dioxide source.... | 09/14/1999 |
| 5866564 | Carbapenem derivatives, their preparation and their use as antibiotics Compound of formula (I): ##STR1## wherein R1 is hydrogen, C1 -C6 alkyl, C2 -C6 alkenyl, C2 -C6 alkynyl or --C(.dbd.NH)R0 where R0 is hydrogen or C... | 02/02/1999 |
| 5856321 | Antibiotic compounds The present invention relates to carbapenems and provides a compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R | 01/05/1999 |
| 5712267 | Carbapenem derivatives, their preparation and their use as antibiotics Compounds of formula (I): ##STR1## wherein R1x is hydrogen or methyl, R2x is hydrogen optionally substituted aliphatic hydrocarbon or acylimidoyl, R3x is hydrogen or an ester group, and Qx is cyclic or acyc... | 01/27/1998 |
| 5652233 | Antibiotic compounds The present invention relates to carbapenems and provides a compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R | 07/29/1997 |
| 5571805 | Antibiotic compounds The present invention relates to carbapenems and provides a compound of the formula (I) ##STR1## wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxyethyl; R2 is hydrogen or C1-4 alkyl; R3 is hydrogen or C | 11/05/1996 |
| 5554606 | Antibiotic compounds The present invention provides a compound of the formula (I) ##STR1## wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4 alkyl; R3 and R4 are ortho with respect to one an... | 09/10/1996 |
| 5541178 | Carbapenem antibiotic compounds A carbapenem compound of the formula (I) ##STR1## wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4 alkyl; R3 is hydrogen or C1-4 alkyl; R4 is hydroxy or carb... | 07/30/1996 |
| 5527793 | Antibiotic carbapenem compounds The present invention relates to carbapenems and provides a compound of the formula (I) ##STR1## wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4 alkyl; R3 is hydrogen or C | 06/18/1996 |
| 5527791 | Carbapenem antibiotic compounds The present invention provides a compound of the formula: ##STR1## or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: A is a group of the formula (IA) or (IB): ##STR2## R1 is 1-hydroxyethyl, 1-fluoroe... | 06/18/1996 |
| 5519015 | Carbapenem antibiotic compounds The present invention relates to carbapenems and provides a compound of the formula (I) ##STR1## wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4 alkyl; R3 is hydrogen or C | 05/21/1996 |
| 5478820 | Antibiotic compounds The present invention relates to carbapenems and provides a compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R | 12/26/1995 |
| 5444057 | Carbapenem-antibiotic compounds The present invention relates to carbapenems and provides a compound of the formula (I) ##STR1## wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4 alkyl; R3 is hydrogen or C | 08/22/1995 |
| 5441949 | Carbapenem antibiotic compounds The present invention relates to carbapenems and provides a compound of the formula (I) ##STR1## wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4 alkyl; R3 is hydrogen or C | 08/15/1995 |
| 5420119 | Carbapenem derivatives having antibiotic activity, their preparation and their use Carbapenem compounds of formula (I): ##STR1## [in which: A is a fully saturated heterocyclic group, of which at least one ring atom is nitrogen; R1 is hydrogen or methyl; R2 is hydrogen or alkyl; R3 is hydrogen or a n... | 05/30/1995 |
| 5317016 | Pyrrolidylthiocarbapenem derivative A pyrrolidylthiocarbapenem derivative represented by Formula I is provided: ##STR1## wherein R1 is hydrogen or lower alkyl; R2, R3 and R4 are hydrogen, lower alkyl which can be substituted or an amino protecting... | 05/31/1994 |
| 5310735 | Carbapenem derivatives having antibiotic activity, their preparation and their use Carbapenem compounds of formula (I): ##STR1## in which: A is a fully saturated heterocyclic group, of which at least one ring atom is nitrogen; R1 is hydrogen or methyl; R2 is hydrogen or alkyl; R3 is hydrogen or a ne... | 05/10/1994 |
| 5215983 | Carbapenem compounds Novel carbapenem compounds of the formula: ##STR1## in which R1 is carboxy or protected carboxy, R2 is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl, R3 is hydrogen or lower alkyl, R4 is unsaturated bicyclic h... | 06/01/1993 |
| 5100888 | Cyclic amidinylthiocarbapenem derivatives A compound represented by formula (I): ##STR1## wherein R1 represents a hydrogen atom or a methyl group; R2 and R3, which may be the same or different, each represents a hydrogen atom or a lower alkyl group; and R | 03/31/1992 |
| 5093328 | Beta-lactam compounds A beta-lactam compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, which is useful as an anti-microbial agent or an intermediate in the synthesis of anti-microbial agents.... | 03/03/1992 |
| 4983596 | 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid derivatives and their preparation The invention relates to a compound of antimicrobial activity, of the formula: ##STR1## in which R1 is carboxy or protected carboxy, R2 is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl, R3 is hydrogen or lower alkyl... | 01/08/1991 |
