Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 7947675 | Trifluoromethylbenzamide derivatives and therapeutic uses thereof Compounds of the formula (I), in which the radicals R1 to R3 and AR are as defined in the description, processes for the preparation thereof, the use thereof in the treatment of cardiovascular diseases, and pharmaceutical compositions comprisin... | 05/24/2011 |
| 7332600 | Process for the preparation of crystalline imipenem The present invention relates to a cost effective and industrially advantageous process for the preparation of imipenem of high purity, which comprises dissolving crude imipenerm in warm water to which some base has been added to obtain a solution, subjecting the re... | 02/19/2008 |
| 7041836 | Antibiotic compounds The present invention relates to carbapenems and provides a compound of the formula (I): or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 | 05/09/2006 |
| 6521612 | Antibiotic compounds The present invention relates to carbapenems and provides a compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2... | 02/18/2003 |
| 6514962 | Stabilized preparations of ଲ-lactam antibiotic Stabilized preparations which contain a ଲ-lactam antibiotic having an esterified carboxyl group attached directly to the mother nucleus, an oil and a phosphate.... | 02/04/2003 |
| 6037341 | Carbapenem derivatives Compounds having potent antimicrobial effects over Gram-positive bacteria and Gram-negative bacteria, a high stability to ଲ-lactamases and DHP-I and a high safety for the human body and a process for producing the same. Carbapenem compounds represen... | 03/14/2000 |
| 5922755 | Immunomodulator, cell adhesion inhibtor, and agent for treating, and preventing autoimmune diseases A 4H-1-benzopyran-4-one derivative of the general formura 1!, ##STR1## or a salt thereof exerts excellent effects on immunomodulation and cell adhesion inhibition, and is further expected to have the effect of relieving autoimmune diseases at a lev... | 07/13/1999 |
| 5744465 | Method of inhibiting a ଲ-lactamase enzyme by administering novel 2-thiosubstituted carbapenems Carbapenem antibiotic compounds of the general formula: ##STR1## wherein the moiety ##STR2## is a 4, 5 or 6 membered mono, di- or tri- substituted oxygen or sulfur containing ring; wherein Z is oxygen, sulfur, sulfoxide and sulfone, pharmac... | 04/28/1998 |
| 5707987 | Carbapenem derivatives A compound of the formula: ##STR1## wherein R1 is a hydrogen atom or a lower alkyl group, R2 is a hydrogen atom or a negative charge, R3 is a hydrogen atom or a lower alkyl group, Ar is a phenyl group, a naphthyl grou... | 01/13/1998 |
| 5602118 | 2-thiosubstituted carbapenems Carbapenem antibiotic compounds of the general formula: ##STR1## wherein the moiety ##STR2## is a 4, 5 or 6 membered mono, di- or tri- substituted oxygen or sulfur containing ring; wherein Z is oxygen, sulfur, sulfoxide and sulfone, pharmac... | 02/11/1997 |
| 5534510 | 2-[1-(1,3-thiazolin-2-yl)azetidin-3-yl]thio-carbapenem derivatives Novel carbapenem compounds, (1R,5S,6S)-2-[1-(1,3-thiazolin-2-yl)azetidin-3-yl]thio-6-[(R)-1-hydroxyeth yl]-1-methyl-carbapen-2-em-3 -carboxyic acid derivatives. These carbapenem compounds are represented by the following formula having a beta-coordinated m... | 07/09/1996 |
| 5496816 | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment Carbapenems of the formula: ##STR1## are disclosed as useful antibacterial agents. Pharmaceutical compositions and methods of use are also disclosed.... | 03/05/1996 |
| 5321020 | Antibacterial 2-carbapenem derivatives Antibacterial compounds of the formula ##STR1## wherein n is 0 or 1, R is hydrogen or a radical forming an ester hydrolyzable under physiological conditions, and R1 is hydrogen or methyl; the pharmaceuticallyacceptable cationic salts there... | 06/14/1994 |
| 5153188 | Piperidylthiocarbapenem derivatives A compound represented by the general formula (I): ##STR1## wherein R1 is a hydrogen atom or a methyl group; R2 and R3, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, or ta... | 10/06/1992 |
| 4925836 | Antibacterially effective methods and compositions based upon (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thi o-6-[R-1-hydroxyethyl]-1-methyl-carbapenem-3-caroxylate and salts therefore Methods and compositions are provided for controlling or preventing a bacterial infection which are based upon (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio- 6-[R-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate or a pharm... | 05/15/1990 |
| 4863916 | Substituted 6-hydroxymethyl-carbapenem antibiotics Substituted 6-hydroxymethyl-carbapenem antibiotics of the formula ##STR1## in which R1 is --OR4, ##STR2## A is a direct bond, or an alkylene and/or cycloalkylene radical, R2 is a group of the formula ##STR3#... | 09/05/1989 |
| 4757066 | Composition containing a penem or carbapenem antibiotic and the use of the same Administration of an N-acylated amino acid in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid derivative and antibiotic may be formulated to... | 07/12/1988 |
| 4717728 | Cyclic amidinyl and cyclic guanidinyl thio carbapenems Compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof wherein X is ##STR2## wherein each R is hydrogen or alkyl of 1 to 6 carbon atoms are disclosed. The compounds are useful as antibiotics.... | 01/05/1988 |
| 4698339 | Carbapenems, their production and use A compound of the general formula: ##STR1## wherein X is a lower alkylene group which may optionally be substituted by a hydroxyl group, or a lower alkenylene group, Y is (1) a lower alkyl group, (2) a cycloalkyl group containing 3 to 8 carbon atoms,... | 10/06/1987 |
| 4696923 | 6-[1-hydroxyethyl]-2-SR8 -1-methyl-1-carbadethiapen-2-em-3-carboxylic acids Disclosed are antibiotic 6-[1-hydroxyethyl]-2-SR8 -1-methyl-1-carbadethiapen-2-em-3-carboxylic acids and their pharmaceutically acceptable salts and esters (I): ##STR1## wherein: R8 is ##STR2## and ##STR3## w... | 09/29/1987 |
| 4640915 | 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives Compounds of the formula [I] ##STR1## in which R1 is hydroxy, a protected hydroxy or lower alkoxy group, R2 is carboxy or an easily eliminable esterified carboxy group and R3 is pyridyl, and pharmaceutically acceptabl... | 02/03/1987 |
| 4372965 | 6-, 1- And 2-substituted-thio-1-carbadethiapen-2-em-3-carboxylic acid S-oxides Disclosed are S-oxides of 6-, 1- and 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids having the structure: ##STR1## wherein: n is 1 or 2; and R1, R6, R7 and R8 are, inter alia, independently sel... | 02/08/1983 |
| 4323569 | ଲ-Lactam anti-bacterial, compositions containing them and a process for their preparation The compounds of the formula (II): ##STR1## and salts and esters thereof wherein R1 is a pyrimidyl group, or a pyrimidyl group substituted by one or two lower alkyl groups, or by a lower alkoxy group or by a lower acyloxy group; and R... | 04/06/1982 |
