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| Number | Title | Issue Date |
| 8183233 | Stable pharmaceutical formulations Stable pharmaceutical formulations and methods of making same are provided. In a general embodiment, the present disclosure provides a method of making a stable pharmaceutical formulation comprising adding one or more vitrifying additives to an aqueous pharmaceutica... | 05/22/2012 |
| 8173633 | Protein kinase C activity enhancer containing alkyl ether derivative or salt thereof Disclosed is a protein kinase C enhancer characterized by containing a benzothiophene alkyl ether derivative represented by the general formula below or a salt thereof. (In the formula, R1 and R2 may be ... | 05/08/2012 |
| 7683049 | Carbapenem antibacterials with gram-negative activity and processes for their preparation The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions, wherein the compounds are generally of th... | 03/23/2010 |
| 7632828 | Gram-positive carbapenem antibacterials and processes for their preparation The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions, wherein the compounds are generally of th... | 12/15/2009 |
| 7470678 | Diphenylazetidinone derivatives for treating disorders of the lipid metabolism Compounds of formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as cholesterol absorption inhibitors for the treatment of hyperlipidaemia are described. ... | 12/30/2008 |
| 7468364 | Carbapenem compounds Carbapenem compounds represented by the general formula [1] or pharmaceutically acceptable salts thereof: wherein R1 is C1-C3 alkyl or hydroxylated C1-C3 alkyl, R is hy... | 12/23/2008 |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7205291 | Carbapenem compounds A compound or its pharmaceutically acceptable salt represented by the following formula: The invention is a carbapenem compound which has a potent antibacterial activity over a broad range of Gram negative and Gr... | 04/17/2007 |
| 7157095 | Multiple-delayed release antifungal product, use and formulation thereof An anti-fungal product is comprised of at least three delayed release dosages forms, each of which has a different release profile, with the Cmax for the anti-fungal product being reached in less than about twelve hours after initial release of anti-funga... | 01/02/2007 |
| 7122204 | Antibiotic composition with inhibitor Antibiotic composition having four dosage forms with different release profiles providing for initial release of a beta lactam antibiotic followed by release of a beta-lactamase inhibitor, followed by release of the antibiotic followed by release of the inhibitor. I... | 10/17/2006 |
| 7115595 | Carbapenem compounds Carbapenem compounds having a substituted phenyl or a substituted thienyl directly attached to the 3-position of carbapenem nucleus as represented by the formula: wherein Ring E is benzene ring or thiophen... | 10/03/2006 |
| 7105174 | Multiple-delayed release anti-neoplastic product, use and formulation thereof An anti-neoplastic product is comprised of at least three delayed release dosages forms, each of which has a different release profile, with the Cmax for the anti-neoplastic product being reached in less than about twelve hours after initial release of an... | 09/12/2006 |
| 7074417 | Multiple-delayed release anti-viral product, use and formulation thereof An anti-viral product is comprised of at least three delayed release dosage forms, each of which has a different release profile, with the Cmax for the anti-viral product being reached in less than about twelve hours after initial release of anti-viral fr... | 07/11/2006 |
| 7071330 | Process for carbapenem synthesis A process for synthesizing a compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein deprotection is conducted using a prereduced metal catalyst is disclosed. ... | 07/04/2006 |
| 7025989 | Multiple-delayed released antibiotic product, use and formulation thereof An antibiotic product is comprised of at least three delayed release dosages forms, each of which has a different release profile, with the Cmax for the antibiotic product being reached in less than about twelve hours. ... | 04/11/2006 |
| 6979735 | Agglomerates by crystallization The present invention describes novel agglomerates in crystalline form of β-lactam compounds. Furthermore, a process for the preparation of said agglomerates, wherein a solution or suspension of at least one β-lactam compound in a solvent is mixed with one or more... | 12/27/2005 |
| 6929804 | Anti-fungal composition An anti-fungal product for delivering at least two different anti-fungals that is comprised of three dosage forms with different release profiles with each anti-fungal being present in at least one of the dosage forms. ... | 08/16/2005 |
| 6924376 | Compounds, compositions and methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. ... | 08/02/2005 |
| 6908913 | Carbapenem derivatives An objective of the present invention is to provide carbapenem derivatives which have strong antibiotic activity also against MRSA, PRSP, Influenzavirus, and β-lactamase producing bacteria and are stable to DHP-1. The carbapenem derivatives according to the present... | 06/21/2005 |
| 6825187 | Carbapenem derivatives of quarternary salt type An objective of the present invention is to provide carbapenem derivatives which have potent antibiotic activity against MRSA, PRSP, Influenzavirus, and β-lactamase-producing bacteria and are stable against DHP-1. The compounds according to the present invention ar... | 11/30/2004 |
| 6677331 | Carbapenem derivatives Disclosed is a novel carbapenem derivative having a substituted imidazo[5,1-b]thiazole group at the 2-position on the carbapenem ring have high anti microbial activities against ଲ-lactamase producing bacteria, MRSA, resistant-Pseudomonas aeruginosa,... | 01/13/2004 |
| 6620785 | Treatment of Mycobacterial diseases by administration of bactericidal/permeability-increasing protein products The present invention relates to methods for treating a subject suffering from infection with Mycobacteria, such as M. leprae or M. tuberculosis comprising administering to the subject a composition comprising a bactericidal/permeability-inducing (BPI) pr... | 09/16/2003 |
| 6602864 | Sulfonic acid or sulfonylamino N-(heteroaralkyl)-azaheterocyclylamide compounds The compounds of formula I herein exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More specifically, they are inhibit... | 08/05/2003 |
| 6521612 | Antibiotic compounds The present invention relates to carbapenems and provides a compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2... | 02/18/2003 |
| 6514962 | Stabilized preparations of ଲ-lactam antibiotic Stabilized preparations which contain a ଲ-lactam antibiotic having an esterified carboxyl group attached directly to the mother nucleus, an oil and a phosphate.... | 02/04/2003 |
| 6458780 | Carbapenem derivatives Disclosed is a novel carbapenem derivative having a substituted imidazo[5,1-b]thiazole group at the 2-position on the carbapenem ring have high anti-microbial activities against ଲ-lactamase producing bacteria, MRSA, resistant-Pseudomonas aeruginosa,... | 10/01/2002 |
| 6399597 | 1,8-naphthosultamylmethyl carbapenem antibacterial compounds, compositions containing such compounds and methods treatment Compounds of formula I are disclosed. ##STR1## as well as pharmaceutically acceptable salts thereof. The naphthosultam is substituted with various substituent groups including at least one cationic group --A--Q--L--B. The carbapenems of the invention are ... | 06/04/2002 |
| 6346526 | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment Compounds of formula I: ##STR1## as well as pharmaceutically acceptable salts thereof useful as carbapenem antibacterial agents are disclosed wherein X is CH2 or C.dbd.O.... | 02/12/2002 |
| 6346525 | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment Compounds of formula I: ##STR1## as well as pharmaceutically acceptable salts thereof and compositions useful as carbapenem antibacterial agents are disclosed.... | 02/12/2002 |
| 6310055 | Halophenoxy substituted carbapenem antibacterial compounds The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2 -position with a iodophenoxy linked through a group --Z--CH2 --; The compound is further substituted with various substitue... | 10/30/2001 |
| 6294528 | Carbapenem antibacterial compounds, compositions containing such compounds and method of treatment Compounds of formula I: ##STR1## as well as pharmaceutically acceptable salts therefor and compositions useful as carbapenem antibacterial agents are disclosed.... | 09/25/2001 |
| 6291448 | Carbapenem antibacterial compounds, compositions containing such compounds and method of treatment Compounds of formula I: ##STR1## as well as pharmaceutically acceptable salts thereof useful as carbapenam antibacterial agents are disclosed wherein X is CR2 R2, NR2, or O.... | 09/18/2001 |
| 6288054 | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment The present invention relates to tricyclic carbapenem antibacterial agents in which the carbapenem nucleus is fused to a 6 membered carbocyclic ring. The compound is further substituted with various substituent groups including at least one cationic group... | 09/11/2001 |
| 6284744 | Peritoneal induced medicaments A solution of hyaluronic acid and water-soluble salts thereof in a pharmaceutically acceptable media in which the hyaluronic acid concentration is at least about 0.4% by weight based on the weight of the solution and the solution having a viscosity at 25Â... | 09/04/2001 |
| 6284753 | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment The present invention relates to tricyclic carbapenem antibacterial agents wherein X is CH2, CHRa, CHRb, C.dbd.CHRa, C.dbd.CHRb, O, S, SO, SO2, CO, COO | 09/04/2001 |
| 6281199 | Method of treatment of heart disease caused by Chlamydia pneumoniae A method of combatting atherosclerosis by administering an effective amount of a macrolide antibiotic, for example an azalide such as azithromycin, optionally together with one or more pharmaceutically acceptable carriers or excipients, to a subject.... | 08/28/2001 |
| 6274575 | Isolation of clavulanic acid from fermentation broth by ultrafiltration Provided is a process for preparation and/or purification of clavulanic acid or a pharmaceutically acceptable salt or ester thereof including removing solids from a clavulanic acid containing fermentation broth by microfiltration to form a first filtrate,... | 08/14/2001 |
| 6265395 | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment Compounds of formula I: ##STR1## as well as pharmaceutically acceptable salts thereof useful as carbapenem antibacterial agents are disclosed.... | 07/24/2001 |
| 6255300 | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with an iodo-substituted phenyl linked through a CH2 --O-- group. The compounds of the invention are represented b... | 07/03/2001 |
| 6251890 | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment The present invention relates to carbapenem antibacterial agents of formula I: ##STR1## or a pharmaceutically acceptable salt thereof, wherein: R2 represents: ##STR2## in formula I, in which the carbapenem nucleus is substituted at the 2-p... | 06/26/2001 |
