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| Number | Title | Issue Date |
| 7812014 | Bicyclic 6-alkylidene-penems as β-lactamase inhibitors The present invention provides a compound of formula I wherein one of A and B is hydrogen and the other an optionally substituted fused bicyclic heteroaryl group as defined herein; X is O; R5 is H, C1-C6 alkyl, C... | 10/12/2010 |
| 7691842 | Tricyclic 6-alkylidene-penems as β-lactamase inhibitors The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof, wherein one ... | 04/06/2010 |
| 7282221 | Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag... | 10/16/2007 |
| 7250176 | Method of treating a bacterial infection Bacterial infections may be treated using a high dosage regimen of amoxicillin and potassium clavulanate. Preferably, the dosage is provided by a bilayer tablet. ... | 07/31/2007 |
| 7247622 | Pharmaceutical compositions containing oxapenem-3-carboxylic acids An oxapenem compound which is, or is capable of forming, a zwitterion of formula wherein R is a C1-C8 branched or straight chain alkyl group which is substituted by ... | 07/24/2007 |
| 7122204 | Antibiotic composition with inhibitor Antibiotic composition having four dosage forms with different release profiles providing for initial release of a beta lactam antibiotic followed by release of a beta-lactamase inhibitor, followed by release of the antibiotic followed by release of the inhibitor. I... | 10/17/2006 |
| 6979735 | Agglomerates by crystallization The present invention describes novel agglomerates in crystalline form of β-lactam compounds. Furthermore, a process for the preparation of said agglomerates, wherein a solution or suspension of at least one β-lactam compound in a solvent is mixed with one or more... | 12/27/2005 |
| 6610681 | Neurotherapeutic clavulanate composition and method Administration of clavulanic acid and related compounds at low dosages provides significant neurotropic effects in warm-blooded vertebrates evidenced inter alia by anxiolytic and anti-aggressive behavior and enhanced cognition believed to be mediated by i... | 08/26/2003 |
| 6514962 | Stabilized preparations of ଲ-lactam antibiotic Stabilized preparations which contain a ଲ-lactam antibiotic having an esterified carboxyl group attached directly to the mother nucleus, an oil and a phosphate.... | 02/04/2003 |
| 6511972 | Pharmaceutical suspension formulation comprising amoxycillin clavulanic acid and cellulose A liquid aqueous pharmaceutical suspension formulation containing as amoxycillin trihydrate, potassium clavulanate and microcrystalline cellulose filler is provided.... | 01/28/2003 |
| 6426342 | Use of ଲ-lactamase inhibitors as neuroprotectants Novel neuroprotectant methods are described. ଲ-Lactamase inhibitors are used to prevent or reduce loss of neuronal cells and neuronal cell function in patients afflicted with or susceptible to disease states or conditions known to result in or cause... | 07/30/2002 |
| 6335358 | Lactacystin analogs Compounds related to lactacystin and lactacystin ଲ-lactone, pharmaceutical compositions containing the compounds, and methods of use.... | 01/01/2002 |
| 6218380 | Pharmaceutical compositions A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulanic ac... | 04/17/2001 |
| 6051703 | Purified clavulanic acid and salts thereof A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulan... | 04/18/2000 |
| 5994342 | 3-(substituted methyl)-4-oxa-1-azabicyclo[3.2.0]heptan-7-one derivatives useful as antitumor agents The present invention is based on the discovery that certain 3-(substituted methyl)-4-oxa-1-azabicyclo[3.2.0]heptan-7-one derivatives of formula I or a pharmaceutically acceptable salt thereof are useful as antitumor agents against sensitive and resistant... | 11/30/1999 |
| 5925633 | 3-Substituted-4-oxa-1-azabicyclo 3,2,0!heptan-7-one as cysteine protease inhibitors The use of certain 3-substituted-4-oxa-1-azabicyclo3,2,0! heptan-7-one derivatives of general formula I, ##STR1## or physiologically acceptable salts thereof or isomers thereof, as active ingredients for the preparation of pharmaceutical compositio... | 07/20/1999 |
| 5905076 | 6-substituted amino-4-oxa-1-azabicyclo 3,2,0! heptan-7-one derivatives as cysteine protease inhibitors Novel 6-substituted amino-4-oxa-1-azabicyclo3,2,0!heptan-7-one compounds, as well as the pharmaceutically acceptable salts thereof and diastereoisomers thereof, of formula I, ##STR1## are disclosed, which exhibit excellent cysteine protease inhibit... | 05/18/1999 |
| 5726170 | Clavulanic acid salts The salts are prepared by reacting a benzhydrylamine of the formula I (or a salt thereof) with clavulanic acid (or a salt thereof) in solvent, and isolating the resulting salt. In formula I, each of R1 and R2 is hydrogen (preferred) ... | 03/10/1998 |
| 5652234 | 3-(7-oxo-1-aza-4-oxabicyclo[3.2.0]hept-3-yl)alanine derivative as antitumor agent The present invention relates to the use of 3-(7-oxo-1-aza-4-oxabicyclo[3.2.0]hept-3-yl)alanine derivatives of formula (I) or a pharmaceutically acceptable salt thereof, as antitumor agents. ##STR1## Wherein R is: hydrogen or COOR2 wherein... | 07/29/1997 |
| 5585373 | 3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0]-hept-3'-YL)propionic acid derivative as antitumor agent A derivative of 3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0 ]hept-3'-yl)propionic acid represented by the formula ##STR1## wherein R1 is a hydrogen atom, a lower alkyl group optionally having one or more cycloalkyl groups, a lower acyl group, a b... | 12/17/1996 |
| 5561126 | 4-oxa-1-azabicyclo [3,2,0] heptan-7-one derivatives as antitumor agents The present invention relates to the use of 4-oxa-1-azabicyclo [3,2,0] heptan-7-one derivatives of formula (I) or a pharmaceutically acceptable salt thereof, as antitumor agents. ##STR1## Wherein R is --OCOR1 group wherein R1 is... | 10/01/1996 |
| 5096899 | Oxapenem-3-carboxylic acids Compounds of the structural formulae ##STR1## and their pharmaceutically acceptable salts, esters and amide derivatives, in which R1 and R2, independently of one another, denote hydrogen or pharmaceutically acceptable groups whi... | 03/17/1992 |
| 5059596 | Azabicyclo compounds A compound selected from the group consisting of a compound of the formula ##STR1## wherein R1 and R2 are individually selected from the group consisting of hydrogen, alkyl and hydroxyalkyl of 1 to 5 carbon atoms and amino, n is... | 10/22/1991 |
| 4797396 | ଲ-Lactam derivatives as anti-inflammatory and antidegenerative agents ଲ-Lactam derivatives and analogs are found to be potent elastase inhibitors and thereby useful anti-inflammatory/antidegenerative agents.... | 01/10/1989 |
| 4652560 | A-deoxy-a-aza derivatives of clavulanic acid, a process for their preparation and their use The compounds of the formula (II): ##STR1## or pharmaceutically acceptable salts or esters thereof wherein A is a hydrogen atom or an esterifying radical; X is an alkyl group of 1-12 carbon atoms optionally substituted by a hydroxy, amino, acylamino ... | 03/24/1987 |
| 4650795 | Amine salts of clavulanic acid as antibacterial agents The present invention provides the salts of the formula (II): ##STR1## wherein R1 is a hydrogen atom or a lower alkyl, aralkyl, phenyl or inertly substituted lower alkyl, aralkyl or phenyl group; R2 is a hydrogen atom or a lower... | 03/17/1987 |
| 4584291 | 9-deoxy-9-tetrazolyl-derivatives of clavulanic acid, their preparation and their use Tetrazolyl derivatives of clavulanic acid are described, having the formula: ##STR1## wherein X is an optionally substituted tetrazolyl group attached via a nitrogen atom. These compounds are useful as antibiotics and ଲ-lactamase inhibitor... | 04/22/1986 |
| 4571392 | 6-Substituted derivatives of clavulanic acid The present invention provides the compounds of the formula (II): ##STR1## and salts and esters thereof wherein R1 is a hydrogen atom or an alkyl group of 1-4 carbon atoms and R2 is a hydrogen atom or an alkyl group of 1-4 carbo... | 02/18/1986 |
| 4562182 | Compounds containing beta-lactams A compound of formula (I) or a salt or ester thereof: ##STR1## Pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt or pharmaceutically acceptable ester thereof are also disclosed.... | 12/31/1985 |
| 4529720 | Antibiotic from Streptomyces clavulicerus A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulonic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potancy, clavulan... | 07/16/1985 |
| 4524073 | ଲ-Lactam compounds A compound of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof: ##STR1## wherein R represents an alkyl or aralkyl group, substituted on an alkyl carbon atom other than that adjacent to --NH-- group, with one or ... | 06/18/1985 |
| 4505915 | 6-N-Heterocyclyl penicillins This invention relates to a new class of penicillins (I) and their pharmaceutically acceptable salts and esters which are useful as antibiotics: ##STR1## wherein the stylized radical (hereafter referred to as R'): ##STR2## attached to the 6... | 03/19/1985 |
| 4463010 | 1-Aza-[3.2.0]-bicycloheptane-2-carboxylic acid, ester or salt thereof A 1-aza[3.2.0]bicycloheptan-2-carboxylic acid or salt or ester thereof having a substituent at position 7 of the formula: wherein R1 and R2 are independently hydrogen, halogen or an organic group.... | 07/31/1984 |
| 4455314 | Penicillin derivatives The preparation and use of 6,-methoxy-6,ଲ-[2-(2-methylphenoxycarbonyl)-2-(thien-3-yl) acetamido] penicillanic acid of formula (II): ##STR1## or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof.... | 06/19/1984 |
| 4428958 | Therapeutic compounds containing ଲ-lactams Compounds of the formula ##STR1## wherein X is S, SO or SO2 and R is an organic group of up to 20 carbon atoms and A is a group such that CO2 A represents a carboxylic acid group or a salt or ester thereof, are useful for their ... | 01/31/1984 |
| 4427689 | Clavulanic acid 9-deoxy-9-thia derivatives their preparation and use The compounds of the formula (I): ##STR1## and salts and esters thereof wherein R1 is a hydrogen atom or a lower alkyl, aryl or aralkyl group, R2 and R3 are independently hydrogen, aryl, aralkyl, lower alkyl or substi... | 01/24/1984 |
| 4427690 | Esters of clavulanic acid A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): ##STR1## In addition to being a broad spectrum antibiotic of medium potency, clavulan... | 01/24/1984 |
| 4426389 | Derivatives of clavulanic acid, a process for their preparation and their use The compounds of the formula (II): ##STR1## pharmaceutically acceptable salts thereof, esters thereof and acid addition salts thereof wherein X is a C1-6 alkylene group, a C3-8 cycloalkylene group or a C3-8 cycloalkyl... | 01/17/1984 |
| 4343806 | Benzylamino clavulanates and their production The compounds of the formula (II): ##STR1## wherein R3 and R4 are as defined in relation to formula (I) and R7 is a nitro, cyano, amino or aminomethyl group, are antibacterial agents and ଲ-lactamase inhibitors. ... | 08/10/1982 |
| 4343807 | Derivatives of clavulanic acid, a process for their preparation and their use The compounds of the formula (II): ##STR1## and pharmaceutically acceptable salts and esters thereof wherein X is a C1-6 alkylene group; m is 1, 2 or 3; n is 1, 2 or 3; A is oxygen, sulphur, --CH2 -- or --NR3 -- where... | 08/10/1982 |
