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| Number | Title | Issue Date |
| 7465720 | Proteasome inhibiting β-lactam compounds Disclosed is a total synthesis of a biologically active β-Lactam—Compound 3, which is related to Salinosporamide A and Omuralide, both structurally and by its activity as a proteasome inhibitor. Also disclosed are protea... | 12/16/2008 |
| 7439253 | Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors The invention relates to novel heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a method for preparing these compounds, and to their use as medicaments, in p... | 10/21/2008 |
| 7291728 | Spirolactams and their synthesis The present invention is directed to a compound of formula I: wherein R1 and R2 are independently selected from H, halogen, protected or unprotected hydroxy, alkylsilyloxy, substituted or un... | 11/06/2007 |
| 7220737 | Noribogaine in the treatment of pain and drug addiction The present invention is directed to methods of treating patients for pain by administering noribogaine. Noribogaine may also be used to treat patients for the symptoms associated with withdrawal from drug dependency. In the latter case, the noribogaine treatment sh... | 05/22/2007 |
| 7125986 | Penicillanic acid derivative compounds and methods of making Compounds of formula I: wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for in... | 10/24/2006 |
| 6566355 | Bicyclic and tricyclic ଲ-lactams There are described compounds of the formula ##STR1## in which R signifies lower alkoxycarbonyl, lower alkoxy-carbonylamino, the acyl residue of an - or ଲ-amino acid or a residue of the general formula Q--X--Y-- (a) wherein Q signifies a 3- ... | 05/20/2003 |
| 6521612 | Antibiotic compounds The present invention relates to carbapenems and provides a compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2... | 02/18/2003 |
| 6514962 | Stabilized preparations of ଲ-lactam antibiotic Stabilized preparations which contain a ଲ-lactam antibiotic having an esterified carboxyl group attached directly to the mother nucleus, an oil and a phosphate.... | 02/04/2003 |
| 6468995 | Cephem compounds A compound of the formula: ##STR1## wherein R1 is amino or protected amino; R2 is hydrogen, lower alkyl or hydroxy protective group; R3 is carboxy or protected carboxy; R4 is an unsubstituted 5, 6 or 7-membered heteromono... | 10/22/2002 |
| 6395726 | 3,6-disubstituted penam sulfone derivatives Compounds are provided having the following formulae I and II: ##STR1## wherein n is 0 or 1 and when n=1, R is a 5 or 6 membered heterocyclic ring, hydroxy, halogen, oxo, carbamoyl, alkoxy, or disubstituted amino, when n=0, R is an ester, cyano or amide group;... | 05/28/2002 |
| 6369050 | Antibacterial agents The invention provides an antimicrobial agent capable of producing an excellent effect in the prevention or treatment of bacteria of two or more genera selected from among Streptococcus, Moraxella, Haemophilus, Klebsiella and the like. The agent comprises... | 04/09/2002 |
| 6348454 | Syntheses of new isodethiaazacephems and isodethiaazacephams, and use as potent antibacterial agents An isodethiaazacephem derivative having the following formula (I): ##STR1## wherein RI is hydrogen or --SO2 RIII ; RII is --CO2 RIV or --SO2 RIII in which RIII i... | 02/19/2002 |
| 6335358 | Lactacystin analogs Compounds related to lactacystin and lactacystin ଲ-lactone, pharmaceutical compositions containing the compounds, and methods of use.... | 01/01/2002 |
| 5712268 | Compositions of tricyclic ଲ-lactams and uses thereof There are described pharmaceutical compositions comprising (a) compounds of the formula ##STR1## in which R signifies lower alkoxycarbonyl, lower alkoxy-carbonylamino, the acyl residue of an - or ଲ-amino acid or a residue of the general... | 01/27/1998 |
| 5698577 | Compositions of bicyclic ଲ-lactams and uses thereof There are described pharmaceutical compositions comprising (a) compounds of the formula ##STR1## in which R signifies lower alkoxycarbonyl, lower alkoxy-carbonylamino, the acyl residue of an - or ଲ-amino acid or a residue of the general... | 12/16/1997 |
| 5683996 | 4-thia-1-aza-bicyclo4,2,0!oct-2-ene antibiotics A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## and Rb --NH--, Ra is an organic radical, Ri and Rj are individually selected from the grou... | 11/04/1997 |
| 5663164 | 1-dethia-2-thia-cephalosporanic acids Novel 1-dethia-2-thia-cephalosporanic acid derivatives of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## Ra is an organic radical, Ri and Rj are individually selected from the group consist... | 09/02/1997 |
| 5656623 | Antimicrobial lactam-quinolones Antimicrobial lactam-quinolone compounds comprising a lactam-containing moiety linked to a quinolone moiety, of the formula: ##STR1## wherein (1) A1, A2, A3, R1, R4 and R6 generally fo... | 08/12/1997 |
| 5637580 | Antimicrobial penem-quinolones Compounds of structure: ##STR1## as well as their pharmaceutically-acceptable salts and biohydrolyzables esters, and hydrates thereof, are effective antiinfective agents, useful in treating and preventing infection.... | 06/10/1997 |
| 5578591 | 2-isocephem and oxacephem derivatives, and use as antibacterial agents Compounds of the formula: ##STR1## wherein R1 is hydrogen, methoxy or formamido; R2 is an acyl group, in particular that of an antibacterially active cephalosporin; CO2 R3 is a carboxy group or a carboxylate ani... | 11/26/1996 |
| 5538963 | Cephalosporins The syn isomer of a compound of the formula ##STR1## in the R or S form or a mixture of R and S forms wherein selected from the group consisting of ##STR2## and their non-toxic, pharmaceutically acceptable acid addition salts wherein the su... | 07/23/1996 |
| 5510343 | Bicyclic and tricyclic ଲ-lactams There are described compounds of the formula ##STR1## in which R signifies lower alkoxycarbonyl, lower alkoxycarbonylamino, the acyl residue of an - or ଲ-amino acid or a residue of the general formula Q--X--Y-- ... | 04/23/1996 |
| 5446038 | 5-thia-1,4-diazabicyclo[4.2.0]octane-3,8-dioxo analogs of ଲ-lactam, processes for the preparation thereof and the use thereof 5-Thia-1,4-diazabicyclo[4.2.0]octane-3,8-dioxo analogs of ଲ-lactam, processes for the preparation thereof and the use thereof Disclosed are novel 5-thia-1,4-diazabicyclo[4.2.0]octane-3,8-dioxo ଲ-lactam analogs of the general formula I ##STR1##... | 08/29/1995 |
| 5385897 | 4-thia-1-aza-bicyclo[4,2,0]oct-2-ene derivatives A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## and Rb --NH--, Ra is an organic radical, Ri and Rj are individually selected from the grou... | 01/31/1995 |
| 5378697 | Cephalosporins The syn isomer of a compound of the formula ##STR1## in the R or S form or a mixture of R and S forms and their non-toxic, pharmaceutically acceptable acid addition salts wherein the substituents are defined as in the specification having antibacteri... | 01/03/1995 |
| 5262411 | Isocephem derivatives, and antimicrobial composition containing the derivatives There is provided a cephalosporin derivative represented by the general formula (1): ##STR1## wherein R101, R102, R103 and Y101 are as difined; the general formula (2): ##STR2## wherein R201 | 11/16/1993 |
| 5132300 | Beta-lactam elastase inhibitors Novel beta lactam compounds having potent elastrase inhibition activity are disclosed. These compounds are characterized by the general structural formulae I, II, and III: ##STR1## These compounds are further characterized such that X and Y are each ... | 07/21/1992 |
| 5059596 | Azabicyclo compounds A compound selected from the group consisting of a compound of the formula ##STR1## wherein R1 and R2 are individually selected from the group consisting of hydrogen, alkyl and hydroxyalkyl of 1 to 5 carbon atoms and amino, n is... | 10/22/1991 |
| 4908359 | 1-dethia-2-thia-cephalosporanic acids 1-dethia-2-thia-cephalosporanic acids of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## Rb --NH--and ##STR3## Ra is an organic radical Ri and Rj are individually ... | 03/13/1990 |
| 4576939 | Penem derivatives What are disclosed are penem compounds of the formula ##STR1## wherein R is hydrogen, a cation, or an esterifying group and R1 is alkyl or aryl, methods for making such compounds, methods for using the compounds as a ଲ-lactamase inhi... | 03/18/1986 |
| 4476124 | 2-Amino-4-thiazolyl-2-oxyimino-acetamido-bicyclooctene-carboxylic acids Novel syn isomers of optically active isomers and racemates of 7-[2-(2-amino-4-thiazolyl)-2-oxyimino-acetamido]-bicyclooctene-carboxylic acid derivatives of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, optionally ... | 10/09/1984 |
| 4431658 | Aza penem compounds Described is a novel process for the preparation of penems and carbapenems useful as antibacterial agents which comprises the reaction of an appropriate 4-substituted-azetidine-2-one with an acid halide in the presence of a tertiary amine and an alkaline ... | 02/14/1984 |
| 4339449 | Analogous compounds of cephalosporins, and pharmaceutical composition comprising the same A compound of high antimicrobial activity of the formula: ##STR1## in which R1 is amino or a substituted amino group and R2 is hydrogen or lower alkoxy, or R1 and R2 are combined together to form a group of the formu... | 07/13/1982 |
| 4126692 | Substituted 3-oxo-6-thia-2-azabicyclo [2.2.0] hexanes Disclosed is the antibiotic 5-methyl-2-(1-carboxyl-2-methyl-propen-1-yl)-3-oxo-6-thia-2-azabicyclo [2.2.0] hexane (I): ##STR1## Also disclosed are processes for preparing I and its pharmaceutically acceptable salts and esters; pharmaceutical com... | 11/21/1978 |
