Class 514/203 - 3-position substituent contains pyridine ring

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein a substituent in 3-position of the
No. of patents: 193
Last issue date: 02/21/2012

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Number	Title	Issue Date
8119622	7-phenyl-substituted tetracycline compounds 7-phenyl-substituted tetracycline compounds which are substantially free of positional isomers, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described. 7-substitute...	02/21/2012
7875604	Compounds that inhibit HIV particle formation The present invention describes novel methods of identifying compounds which inhibit HIV particle formation and Rev-dependent HIV production. The present invention also provides methods and compounds for inhibiting HIV particle formation and or treating patients inf...	01/25/2011
7871997	Cephalosporin compounds This invention provides cephalosporin compounds and salts thereof. Such compounds are useful for preparing cross-linked glycopeptide-cephalosporin antibiotics. ...	01/18/2011
7419973	Phosphonocephem compound A cephem compound (particularly its crystal) represented by the formula [I], wherein X is CH3COOH, CH3CH2COOH or CH3CN, and n is 0 to 5, is useful as an antibacterial agent (particularly anti-MRSA agent) and shows superior...	09/02/2008
7384928	Broad spectrum cephem compounds A compound of the formula: (wherein, T is S, SO or O; X is halogen, CN, carbamoyl optionally substituted with lower alkyl, lower alkyl, lower alkoxy, or lower alkylthio; A is substitut...	06/10/2008
7339055	Process for the preparation of cephalosporin antibiotic A process for the preparation of cephalosporin antibiotic of the formula (I) which comprises: (i) activating the compound of formula (III) as acid halide in an organic solvent	03/04/2008
7335767	Method for preparation of ceftiofur and salts thereof A process for preparation of ceftiofur sodium of formula (Ib) possessing high stability and having purity of more than 97% and substantially free of impurities, is disclosed. The process comprises: i) reacting cef...	02/26/2008
7332471	Cross-linked glycopeptide-cephalosporin antibiotics This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacter...	02/19/2008
7282221	Antiviral product, use and formulation thereof An antiviral product is comprised of at least three dosages forms, each of which has a different release profile, with the Cmax for the antiviral product being reached in less than about twelve hours. In one embodiment, there is an immediate release dosag...	10/16/2007
6974797	Cross-linked glycopeptide-cephalosporin antibiotics This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacter...	12/13/2005
6936709	Method for purifying protected 2′-deoxycytidines and hydrated crystals thereof A protected 2′-deoxycytidine is purified by precipitating the protected 2′-deoxycytidine represented by general formula (3) in the form of a hydrated crystal from a solution containing the protected 2′-deoxycytidine and water, and by recovering the protected 2...	08/30/2005
6916801	7-Alkylidene-3-substituted-3-cephem-4-carboxylates as β-lactamase inhibitors The invention provides compounds of formula (I): wherein: R1-R4 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting β...	07/12/2005
6911543	Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is These compounds may be in the form of pharmaceutical salts or co...	06/28/2005
6911441	Prolonged release pharmaceutical composition Novel pharmaceutical compositions of a cephalosporin in a prolonged release vehicle, comprising an oil and aluminium distearate, provide a prolonged duration of effective blood-plasma concentration of the cephalosporin after injection to animals. ...	06/28/2005
6906055	Phosphonocephem compound A cephem compound (particularly its crystal) represented by the formula [I], wherein X is CH3COOH, CH3CH2COOH or CH3CN, and n is 0 to 5, is useful as an antibacterial agent (particularly anti-MRSA agent) and shows superior...	06/14/2005
6800621	Imidazo[4,5-b]-pyridiniummethyl-containing cephem compounds having broad antibacterial spectrum activity A cefem compound of the formula (I) shows wide antibacterial spectrum against various pathogenic bacteria including MRSA. wherein, X is N or CY and Y is H or halogen; R1 is amino or protected amino; R2	10/05/2004
6723716	7-acylamino-3-heteroarylthio-3-cephem carboxylic acid antibiotics and prodrugs thereof The present invention relates to a cephem prodrug having formula III or formula IV: or a pharmaceutically acceptable salt thereof, wherein R′1 is selected from the group consisting of hydrogen and —C(O)CH(...	04/20/2004
6583133	Propenyl cephalosporin derivatives and process for the manufacture thereof Disclosed are cephalosporin derivatives of the general formula ##STR1## wherein R is an organic residue with a molecular weight not exceeding 400 bonded to the adjacent sulphur atom via carbon and consisting of carbon, hydrogen, and optional oxygen, sulfu...	06/24/2003
6531465	Antibacterial cephalosporins A compound of formula ##STR1## wherein Ac, R1 and R2 have various meanings, a process for a preparation thereof and its use as a pharmaceutical, i.e. as antibacterial agent....	03/11/2003
6518263	Imidazo[4,5-b]pyridiniummethyl-containing cephem compounds having broad antibacterial spectrum A cefem compound of the formula (I) shows wide antibacterial spectrum against various pathogenic bacteria including MRSA. ##STR1## wherein, X is N or CY and Y is H or halogen; R1 is amino or protected amino; R2 is hydrogen or optiona...	02/11/2003
6407091	ଲ-lactamase inhibiting compounds The invention provides compounds of formula I and IV: ##STR1## wherein R1 -R11 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting ଲ-lactamase enzyme...	06/18/2002
6294527	Cephem compounds An antibacterial compound ##STR1## wherein ##STR2## represents benzene ring, pyridine ring, pyrazine ring or 5-membered aromatic neterocycle (having one oxygen or sulfur atom as ring-constituting atom), there being no R4 where ##STR3#...	09/25/2001
6265394	Bis quaternary MRSA cephem derivatives Provided by the present invention are cephem derivatives represented by the general formula ##STR1## wherein Ar is an optionally substituted lipophilic phenyl, naphthyl or pyridyl group; L1 and L2 are (C1 -C6)al...	07/24/2001
6214818	Cephem compounds and pharmaceutical compositions containing the same A cephem compound, wherein the cephem ring has a substituent at the 3-position, which substituent is shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of...	04/10/2001
6159961	Cephem compounds A compound of the formula: ##STR1## wherein R1 is amino or protected amino, R2 is hydrogen or hydroxy protective group, R3 is carboxy or protected carboxy, R4 is hydrogen, lower alkenyl, acyloxy(lower)alkenyl, option...	12/12/2000
6159706	Application of enzyme prodrugs as anti-infective agents The present invention provides a method for targeting toxic antimetabolites to gram negative infections. It provides a means of taking advantage of a key disease resistance mechanism to activate these drugs locally, and to overcome the resistance phenotyp...	12/12/2000
6093712	Cephalosporin derivatives Provided are cephem derivatives represented by the general formula ##STR1## wherein Ar, R1, R2, R3, R9 and R10 are as defined in the application. The derivatives are gram-positive antibacterial agents...	07/25/2000
6066630	Cephalosporin antibiotics The present invention includes novel compounds of formula ##STR1## where R99 is selected from the group consisting of sulfur, SO, SO2, NH, N-alkyl, oxygen, C.dbd.C (cis or trans), and C.tbd.C, and R12 is ##STR2##...	05/23/2000
6057312	Cephalosporin antibiotics The present invention includes novel compounds of formula ##STR1## where G, H, J, L and M are carbon or nitrogen, R99 is selected from the group consisting of sulfur, SO, SO2, NH, N-alkyl, oxygen, C.dbd.C (cis or trans), and C.t...	05/02/2000
6034076	Stable hydrates of a cephalosporin chloride salt The cephalosporin compound [6R, 7R]-7-[2-(2-Amino-4-thiazolyl)-2-(Z)-(methoxyimino)acetamido]-3-[1-(methyl amino)pyridinium-4-thiomethyl]-ceph-3-em-4-carboxylic acid chloride hydrochloride is provided as a mono-, di- or tri-hydrate. The hydrates are p...	03/07/2000
6025352	Cephalosporin antibiotics The present invention includes novel compounds of formula ##STR1## where G, H, J, L and M are carbon or nitrogen, R99 is selected from the group consisting of sulfur, SO, SO2, NH, N-alkyl, oxygen, C.tbd.C (cis or trans), and C.t...	02/15/2000
5994340	Azetidinone derivatives as ଲ-lactamase inhibitors New 2-oxo-1-azetidine sulfonic acid derivatives with an aminoalkyl substituted "anti" (E-isomer) oxyimino group in the acylamino substituent at the 3 position of the monobactam ring. These compounds are potent inhibitors of bacterial ଲ-lactamases. T...	11/30/1999
5981519	Vinyl-pyrrolidinone cephalosporins The present invention relates to compounds having the formula ##STR1## wherein X, R1, R2, R3, R4, R5, R6, and R7 are as defined herein as well as readily hydrolyzable esters ...	11/09/1999
5948774	Cephem compounds, their production and use Cephem compounds of the formula: ##STR1## wherein R1 is an optionally protected amino group; R2 is a fluoro-lower alkyl group; and the ring A may have further substituent(s), or their esters or salts, show broad and excellent an...	09/07/1999
5945414	Process for the preparation of new intermediates useful in the synthesis of cephalosporins Cefazolin, cefazedone, cefoperazone, cefamandole, cefatrizine or ceftriaxone is prepared by reacting glutaryl 7-ACA of the formula: ##STR1## with a compound of formula (II): R--SH (II) wherein R is 5-me...	08/31/1999
5935950	Cephalosporin pyridinium derivatives Compounds of formula I ##STR1## wherein R1 is hydrogen, lower alkyl, cycloalkyl or acetyl; x is CH or N; n is 0, 1 or 2; m is 0 or 1; R2 is hydrogen, lower alkyl, ω-hydroxy alkyl, benzyl or lower alkyl-heterocyclyl, the benzyl and t...	08/10/1999
5834458	Heterocyclic compounds and their use The present invention relates to therapeutically active heterocyclic compounds and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating diseases in the central nervous system caused by malfunctioning of the m...	11/10/1998
5728691	Quinolonylcarboxamidocephalosporin derivatives and pharmaceutical compositions containing them Derivatives of 7-aminoceph-3-em-4-carboxylic acid with 6-fluoroquinolone derivatives in which the cephem and 6-fluoroquinolone moieties are bound to each other through a carboxamido bond as well as the pharmaceutical compositions containing them are descr...	03/17/1998
5714469	Method of treating sepsis The invention relates to the method of preventing and treating sepsis using (S)-5-oxo-L-prolyl-L-଱-glutamyl-L-଱-aspartyl-N8 -(5-amino-1-carboxypentyl)-8-oxo-N7 -N-N-(5-oxo-L-prolyl)-L-଱-glutamyl!-L-଱-aspar...	02/03/1998
5698547	Cephalosporin antibiotics The present invention includes novel (7R)-7-(acylamino)-3-(arylthio)-3-cephem-4-carboxylic acids or their pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms including organisms which are resistan...	12/16/1997

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Class 514/203 - 3-position substituent contains pyridine ring