Bizarre Patents
A method to tenderize meat with an explosive shockwave.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8008287 | Integrase inhibitors Tricyclic compounds, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. ... | 08/30/2011 |
| 7964589 | Injectable sterile pharmaceutical formulation containing at least two active principles Mixtures of at least two active principles, of which at least one is the sodium salt, are precipitated from an organic solution containing the same active principles in salified or non-salified acid form. ... | 06/21/2011 |
| 7091197 | Beta-lactamase inhibitor prodrug Prodrugs of 6-β-hydroxymethylpenicillanic acid sulfone having the structure wherein R is H or methyl, and solvates thereof, are disclosed. Also disclosed are pharmaceutical compositions comprising a prodrug of t... | 08/15/2006 |
| 7018988 | Pharmaceutically active pyrrolidine derivatives as Bax inhibitors The present invention is related to new substituted pyrrolidine derivatives of formula (I). Said compounds are preferably for use as pharmaceutically active compounds. Specifically, pyrrolidine derivatives of formula (I) are useful in the treatment and/or prevention... | 03/28/2006 |
| 6436398 | 2 ଲ-substituted-6-alkylidene penicillanic acid derivatives as ଲ-lactamase inhibitors Compound of formula I: ##STR1## wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting ଲ-lactamase enzymes,... | 08/20/2002 |
| 6319904 | Formulation comprising antibacterial substance and antiulcer substance The present invention includes a formulation which comprises an antibacterial substance and an antiulcer substance, wherein at least either of them is formulated into a gastrointestinal mucosa-adherent solid preparation. The formulation of the present inv... | 11/20/2001 |
| 6232305 | Substituted amino bicyclic-ଲ-lactam penam and cepham derivatives as cysteine protease inhibitors The present invention provides substituted amino bicyclic-ଲ-lactam penam derivatives and substituted amino bicyclic-ଲ-lactam cepham derivatives and their diastereoisomers of formula I, as well as compositions, methods of making, and methods of... | 05/15/2001 |
| 6156745 | 2ଲ-substituted-6-alkylidene penicillanic acid derivatives as ଲ-lactamase inhibitors Compounds of formula I: ##STR1## wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting ଲ-lactamase en... | 12/05/2000 |
| 5994340 | Azetidinone derivatives as ଲ-lactamase inhibitors New 2-oxo-1-azetidine sulfonic acid derivatives with an aminoalkyl substituted "anti" (E-isomer) oxyimino group in the acylamino substituent at the 3 position of the monobactam ring. These compounds are potent inhibitors of bacterial ଲ-lactamases. T... | 11/30/1999 |
| 5840735 | Sex steroid activity inhibitors Inhibitors of sex steroid activity, for example those having the general structure ##STR1## may be used as part of a pharmaceutical composition to provide antiestrogenic effects and/or to suppress estrogen synthesis. Such pharmaceutical composit... | 11/24/1998 |
| 5686465 | Sex steroid activity inhibitors Inhibitors of sex steroid activity, for example those having the general structure ##STR1## may be used as part of a pharmaceutical composition to provide antiestrogenic effects and/or to suppress estrogen synthesis. Such pharmaceutical composit... | 11/11/1997 |
| 5681563 | 7-vinylidene cephalosporins and methods of using the same Cephalosporins with an exocyclic allene in the 7-position and their pharmaceutically active salts are potent inhibitors of ଲ-lactamases and are therefore useful in the treatment of penicillin resistant infections.... | 10/28/1997 |
| 5672600 | Antimicrobial dithiocarbamoyl quinolones Antimicrobial dithiocarbamoyl quinolone compounds of the general formula: ##STR1## wherein (1) A1, A2, A3, R1, R3, R4, and R6 form any of a variety of quinolone and related heter... | 09/30/1997 |
| 5180719 | Antimicrobial quinolonyl lactam esters Antimicrobial quinolonyl lactam esters comprising a lactam-containing moiety linked, by an ester group, to the 3-carboxy group of a quinolone moiety. These compounds are of the formula: ##STR1## wherein (1) R3, R4, and R5 | 01/19/1993 |
| 5126335 | Penicillins containing an acrylamide side chain Compounds of formula (I) and pharmaceutically acceptable salts and in-vivo hydrolysable esters thereof: ##STR1## wherein X is hydrogen or a group NHR1, wherein R1 is hydrogen or an amino protecting group, and R is an optionally ... | 06/30/1992 |
| 5114929 | Pharmaceutical formulation An unpressurized container containing a palatable pharmaceutical formulation comprising a homogeneous, non-aqueous suspension of an orally active medicament, an edible oily vehicle, an edible emulsifier and a finely particulate sugar having no oily after ... | 05/19/1992 |
| 5069899 | Anti-thrombogenic, anti-microbial compositions containing heparin Anti-thrombobenic, anti-microbial compositions containing heparin reacted with quaternary ammonium components and bound with water-insoluble polymers are disclosed. Such compositions may also contain additional quaternary ammonium compounds not reacted wi... | 12/03/1991 |
| 4954489 | Penicillins having a substituted acrylamido side chain Compounds of formula (I) and their salts and esters: ##STR1## wherein X is hydrogen or a group NHR1, wherein R1 is hydrogen or an amino protecting group, and R is optionally substituted C5-8 cycloalkyl or cycloalkenyl... | 09/04/1990 |
| 4918067 | Heterocyclic substituted penicillin antibiotics The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt or in-vivo hydrolysable ester thereof: ##STR1## wherein R1 is a 5 or 6 membered sulphur and/or nitrogen containing heterocyclic group substitute... | 04/17/1990 |
| 4898731 | Antibiotic combinations of penicillins An antibacterial synergistic composition consisting essentially of a mixture of a penicillin or cephalosporin derivative of the formula ##STR1## and a penicillin of the formula ##STR2## preferably in association with a pharmaceutical carrier.... | 02/06/1990 |
| 4861768 | 2 ଲ-substituted thiomethylpenicillin derivatives and their preparation and use Disclosed is a penicillin derivative of the formula: ##STR1## wherein n is an integer of 0, 1 or 2; Y is a cyano group, a lower acyl group, a mono- or di-lower alkylthiocarbamoyl group, ##STR2## wherein R1 is a hydrogen atom, a lower ... | 08/29/1989 |
| 4820701 | Penam derivatives Antibacterial agents have the formula (I) or are pharmaceutically acceptable salts or in vivo hydrolysable esters thereof: ##STR1## wherein R3 is phenyl, substituted phenyl, cyclohexenyl, cyclohexadienyl or an optionally substituted 5- or ... | 04/11/1989 |
| 4816452 | Aminothiazole substituted penicillins and antibacterial compositions thereof The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt or in-vivo hydrolysable ester thereof: ##STR1## wherein R1 is hydrogen or an amino protecting group and R is substituted methyl; optionally subs... | 03/28/1989 |
| 4757066 | Composition containing a penem or carbapenem antibiotic and the use of the same Administration of an N-acylated amino acid in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid derivative and antibiotic may be formulated to... | 07/12/1988 |
| 4748163 | Novel ଲ-lactam antibiotics Antibacterially active and animal growth-promoting novel ଲ-lactam compounds of the formula ##STR1## in which R1 represents the radical ##STR2## Y representing N or CR9, or Y--R7 representing >C.dbd.O or ... | 05/31/1988 |
| 4734407 | Alpha-aminoacyl-penicillins and cephalosporins Antibacterially active and animal growth-regulating novel ଲ-lactam compounds of the formula ##STR1## in which R1 represents an optionally substituted radical of the formula ##STR2## Z represents oxygen, sulphur or --N--R | 03/29/1988 |
| 4731360 | Acylcarnitines as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal compartments Acylcarnitine used as a nasal, buccal, sublingual and vaginal drug absorption enhancing vehicle for poorly absorbed drugs.... | 03/15/1988 |
| 4729989 | Enhancement of absorption of drugs from gastrointestinal tract using choline ester salts Choline ester salts are used as drug absorption enhancing agents for orally and rectally administered drugs.... | 03/08/1988 |
| 4707474 | Veterinary composition of cloxacillin for eye treatment Compositions comprising a cloxacillin salt and liquid paraffin, arachis oil or fractionated coconut oil are useful in treating infectious keratoconjunctivitis in cattle and domestic animals.... | 11/17/1987 |
| 4692441 | Chorine esters as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal cavities Choline esters are used as drug absorption enhancing agents for drugs which are poorly absorbed from the nasal, oral, and vaginal cavities.... | 09/08/1987 |
| 4684664 | Derivatives of ଲ-(4-isocyano-1,2,3,4-diepoxycyclopentyl) acrylic acid Disclosed herein are derivatives of ଲ-(4-isocyano-1,2,3,4-diepoxycyclopentyl)acrylic acid, the derivatives showing an antibacterial activity, an antifungal activity and an antimycoplasmal activity.... | 08/04/1987 |
| 4647457 | Penicillanic acid derivatives ଲ-lactams of the formula ##STR1## wherein R1 signifies hydrogen or a group readily cleavable by hydrolysis, A signifies the group R2 --N.dbd.C(CH3)--CH.dbd.C< or O.dbd.C(CH3)--CH2 --C(R | 03/03/1987 |
| 4629726 | Penem carboxylic acids A 2-substituted or unsubstituted-6-(2-oxo-1, 3-dioxolan-4-yl)-2-penem-3-carboxylic acid derivative represented by the following formula (Ia) and: ##STR1## wherein R is hydrogen, a light metal or a carboxy-protecting group, R1 is an al... | 12/16/1986 |
| 4623644 | Acylation of tirandamycic, streptolic and sorbic acids to cephalosporin and penicillin nuclei This invention relates to the hybridization of streptolydigin, tirandamycin and sorbic acid to penicillin and cephalosporin nuclei.... | 11/18/1986 |
| 4623643 | Penem derivatives Penem derivatives are disclosed characterized by a substituted pyridiniomethyl group in the 2-position of the penem nucleus. The compounds of the present application exhibit better antibacterial activity than other known penem derivatives.... | 11/18/1986 |
| 4612337 | Method for preparing infection-resistant materials An infection-resistant polymeric material, such as polytetrafluoroethylene, for use on or within a human or animal body, for example, in the form of a vascular graft, can be prepared by an improved method which comprises the following sequence of steps: (... | 09/16/1986 |
| 4598074 | ଲ-lactam antibiotics Alpha-carboxy-3-thienylmethyl penicillin having either the R- or the S- configuration at C-10 is obtained in cyrstalline form. The isomers show improved stability and higher biological activity as compared to the amorphous RS material.... | 07/01/1986 |
| 4591459 | Intermediates for 6-(aminoacyloxymethyl) penicillanic acid 1,1-dioxides beta-Lactamase inhibitors which are aminoacid esters of 6-alpha- and 6-beta-(hydroxymethyl)pencillanic acid 1,1-dioxides; pharmaceutically-acceptable salts thereof; conventional esters thereof which are hydrolyzable in vivo; bis-methanediol esters thereof... | 05/27/1986 |
| 4540688 | ଲ-Lactam antibiotics Compounds of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof have antibacterial activity: ##STR1## wherein R is hydrogen, C1-6 alkylcarbonyl or C1-6 alkyl; R1 is hydrogen or hyd... | 09/10/1985 |
| 4540689 | Penicillin derivative A penicillin derivative having an antibacterial activity similar to a penicillin antibiotic in a living body without affecting the intestinal bacterial colonies, a process for preparing the derivative and a pharmaceutical composition in a dosage unit form... | 09/10/1985 |
