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| Number | Title | Issue Date |
| 8012954 | Chelated 8-hydroxyquinoline and use thereof in a method of treating epithelial lesions A chelation complex including 8-hydroxyquinoline and zinc mixed with a carrier demonstrates therapeutic efficacy in treating lesions including cancerous lesions, precancerous lesions, cysts and warts. ... | 09/06/2011 |
| 7919486 | Use of gallium(III) complexes for the treatment of melanomas The invention relates to the use of gallium (III) complexes for the treatment of melanomas. ... | 04/05/2011 |
| 7846919 | Chelated 8-hydroxyquinoline and use thereof in a method of treating epithelial lesions Oxinates including 8-hydroxyquinoline and a heavy metal are topically applied to epidermal lesions for therapeutic effect. The zinc oxinate compositions are shown to be therapeutically effective against The therapeutic composition demonstrates selective toxicity wit... | 12/07/2010 |
| 7803791 | Method for producing albumin conjugates containing gyrase inhibitors The present invention is directed to a Gyrase inhibitor-protein conjugate; in particular a Gyrase inhibitor-albumin conjugate. The present invention further provides methods of the treatment of inflammatory conditions and tumors. Methods of making and producing a Gy... | 09/28/2010 |
| 7608614 | Process for preparing macrocyclic compounds Intermediates of the formula QUIN: and methods for their preparation are described. The intermediate compounds are useful for preparing active agents for the treatment of hepatitis C virus (HCV) infection. ... | 10/27/2009 |
| 7423049 | Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceut... | 09/09/2008 |
| 7410959 | Therapeutic uses for aminosterol compounds A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Various pharmaceutical products may... | 08/12/2008 |
| 7375215 | Compounds for PDT A tetrakis(hydroxyphenyl)chlorin, bacteriochlorin or isobacteriochlorin, derivatised at one or more of the hydroxy groups by addition reaction with a diisocyanate, diisothiocyanate or isocyanate-isothiocyanate at one isocyanate or isothiocyanate group thereof, the o... | 05/20/2008 |
| 7214407 | Method for the prevention of barnacle attacks A method for impregnating wooden items, in particular poles situated in marine environment against attack from Teredo, where the method includes the following steps of a) forming a hole in parallel with the fibre orientation of the wood; b) then filling the hole wit... | 05/08/2007 |
| 7137358 | Amusement articles possessing microbe-inhibiting properties An amusement article for a domestic animal comprising an outer textile casing defining a shape in the form of a small article which can be carried by a domestic animal, an inner filling, and a microbe-inhibiting agent or property applied to at least one of the outer... | 11/21/2006 |
| 7138520 | Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same In part, the present invention is directed to coordination complexes comprising a therapeutic agent. In one aspect, the subject compositions comprise a platinum metal center and a covalently attached therapeutic agent. ... | 11/21/2006 |
| 7102008 | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables A, R1, R2, R3, R4, Z,... | 09/05/2006 |
| 7091351 | Vanadium compounds for treating cancer The invention provides methods for treating cancer and compounds that are useful for the treatment of tumors, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates useful for preparing the compounds. ... | 08/15/2006 |
| 7078059 | Treatment of bone diseases The invention provides a method for enhancing bone formation, inhibiting osteoclastic differentiation and/or activating osteoblastic differentiation whereby to manage, treat or achieve prophylaxis of bone disease which comprises administering to a human or animal su... | 07/18/2006 |
| 7060696 | Chelated 8-hydroxyquinoline and use thereof in a method of treating epithelial lesions A chelation complex including 8-hydroxyquinoline and zinc mixed with a carrier demonstrates therapeutic efficacy in treating lesions including cancerous lesions, precancerous lesions, cysts and warts. ... | 06/13/2006 |
| 6977257 | Aripiprazole oral solution The present invention provides for a pharmaceutical solution suitable for oral administration comprising aripiprazole, a pharmaceutically suitable solvent system, one or more taste-enhancing/masking agents and one or more agents selected from the group consisting of... | 12/20/2005 |
| 6878388 | Vanadium compounds for treating proliferative cell disorders Vanadium compounds useful to prevent and/or inhibit adhesion, migration, and invasion of proliferative cells into surrounding tissue. ... | 04/12/2005 |
| 6867217 | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety... | 03/15/2005 |
| 6809091 | Substances capable of inducing apoptosis A method for the manufacture of a substance having an apoptosis-inducing ability characterized in including a step of subjecting at least one compound selected from the following (a), (b), (c) and (d) [excluding uronic acid and/or uronic acid derivatives; and compou... | 10/26/2004 |
| 6800649 | Method for inhibiting c-jun expression using JAK-3 inhibitors The invention provides a method for inhibiting c-jun activation in mammalian or avian cells comprising contacting the cells with a substance that inhibits the activity of Janus family kinase 3 (JAK-3). The invention also provides a therapeutic method for preventing ... | 10/05/2004 |
| 6777405 | Detection and treatment of duplex polynucleotide damage Duplex polynucleotides containing damage or errors are detected with hindered intercalating compounds which are capable of intercalating only in the presence of such damage or error. Conditions characterized by the presence of polynucleotide errors or damage are tre... | 08/17/2004 |
| 6774124 | Chelated 8-hydroxyquinoline and use thereof in a method of treating epithelial lesions A chelation complex including 8-hydroxyquinoline and zinc mixed with a carrier is effective in treating the bite of the brown recluse spider. ... | 08/10/2004 |
| 6753317 | Dmt-Tic di- and tri-peptide derivatives and related compositions and methods of use A compound of formula: comprising the Dmt-Tic pharmacophore and related compositions and methods of use in the inhibition of the binding of an opioid receptor-binding compound with a P-glycoprotein, specifically hMDR-... | 06/22/2004 |
| 6743786 | Vanadium compounds for treating cancer The invention provides methods for treating cancer and compounds that are useful for the treatment of tumors, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates useful for preparing the compounds. ... | 06/01/2004 |
| 6689771 | Amide derivatives as inhibitors of matrix metalloproteinases, TNF-, and aggrecanase The present application describes novel amides and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein these compounds are useful as inhibitors of matrix metalloproteinases, TNF-, and aggrecana... | 02/10/2004 |
| 6685958 | Quinolone carboxylic acid compositions and related methods of treatment The present invention relates to the use of quinolone carboxylic acid formulations in the treatment of ocular and periocular infections. The present invention also relates to sustained release compositions comprising specific quinolone carboxylic acid com... | 02/03/2004 |
| 6667339 | Vanadium (IV) complexes containing catecholate ligand and having spermicidal activity Vanadium (IV) complexes containing a substituted or unsubstituted catecholate ligand, and the spermicidal activity of such compounds. Preferred compounds are vanadocene (IV) complexes containing alkyl substituted catecholate ligands.... | 12/23/2003 |
| 6534493 | - and ଲ-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors - and ଲ-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 03/18/2003 |
| 6476014 | Chelated 8-hydroxyquinoline for the treatment of epithelial lesions Oxinates including 8-hydroxyquinoline and a heavy metal are topically applied to epidermal lesions for therapeutic effect, wherein said epithelial lesions selected from the croup consisting of cancerous lesions, precancerous lesions, cysts and warts; and ... | 11/05/2002 |
| 6475505 | Biocide-polyester concentrates and biocidal compositions prepared therefrom Concentrates of various classical biocides in a polyester carrier resin when incorporated into a substrate resin, preferably a polyolefin such as polypropylene or polyethylene, provide the substrate polymer which biocidal activity with superior resistance... | 11/05/2002 |
| 6465450 | Vanadium (IV) complexes containing catecholate ligand and having spermicidal activity Vanadium (IV) complexes containing a substituted or unsubstituted catecholate ligand, and the spermicidal activity of such compounds. Preferred compounds are vanadocene (IV) complexes containing alkyl substituted catecholate ligands.... | 10/15/2002 |
| 6444661 | Detection and treatment of duplex polynucleotide damage Duplex polynucleotides containing damage or errors are detected with hindered intercalating compounds which are capable of intercalating only in the presence of such damage or error. Conditions characterized by the presence of polynucleotide errors or dam... | 09/03/2002 |
| 6432941 | Vanadium compounds for treating cancer The invention provides methods for treating cancer and vanadium compounds that are useful for the treatment of tumors, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates useful for preparing the compou... | 08/13/2002 |
| 6410592 | Aminomethylcarboxylic acid derivatives The present invention relates to aminomethylcarboxylic acid derivatives general formula (I), wherein Z is (CH2)n, O, S, SO, SO2 or N--R5 ; n is 0, 1 or 2; X represents 1-3 substituents independently selected fro... | 06/25/2002 |
| 6350740 | Transplatinum complexes as cytotoxic and anticancer agents The invention provides a method for enhancing the water solubility of cytotoxic trans-platinum complexes. The present invention also provides a method for killing tumor cells, and a method for the treatment of tumors by the administration of a cytotoxic p... | 02/26/2002 |
| 6329360 | Hetero-linked phenylglycinolamides The hetero-linked phenylglycinolamides are prepared by reaction of the corresponding hetero-linked phenylacetic acids with appropriate phenylglycinols. The hetero-linked phenylglycinolamides are suitable as active compounds in medicaments.... | 12/11/2001 |
| 6306846 | Anti-inflammatory and anti-ulcer compounds and process Disclosed herein are anti-inflammatory and anti-ulcer copper coordination compounds and a process for using them in the treatment of arthritis and gastrointestinal ulcers in animal bodies. The copper coordination compounds utilized are the reaction produc... | 10/23/2001 |
| 6232340 | Vanadium complexes and derivatives thereof and methods related thereto Organovanadium complexes, and more specifically hydroxyoxovanadium(V), μ-oxo dimeric oxovanadium(V) and cis-dioxovanadium(V) complexes, are provided. The complexes may be formulated into a pharmaceutical composition. The complexes and/or compositions may... | 05/15/2001 |
| 6037326 | Reduction of hair growth Mammalian hair growth is reduced by applying to the skin an inhibitor of a DNA topoisomerase.... | 03/14/2000 |
| 6015659 | Inducement of thermotolerance with benzoquinonoid ansamycins Thermotolerant phenotypes are developed in cells, tissues, organs and organisms by the administration of benzoquinonoid ansamycins such as herbimycin A and any of various analogs. The general stress tolerance resulting from this inducement offers benefits... | 01/18/2000 |
