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| Number | Title | Issue Date |
| 8173627 | Neuroprotective effect of solubilized UDCA in focal ischemic model The present disclosure provides compositions and methods for treating, ameliorating, or relieving at least one symptom associated with loss of blood flow to the brain including, without limitation, ischemic stroke. Compositions of the disclosure may comprise a bile ... | 05/08/2012 |
| 8173628 | Steroidal antiestrogens and antiandrogens and uses thereof The present invention comprises the design, synthesis and development of a new class of chemotherapeutic agents for prophylactic and therapeutic treatments in a mammal, particularly a human, believed to be at risk of suffering from a hormone-responsive disorder. In ... | 05/08/2012 |
| 8168621 | 6-substituted estradiol derivatives and methods of use A compound having the structure: wherein R1, R2, R, R, X, Y and Z are as defined herein. The compounds are estrogen receptor modulators useful for the treatment of proliferative disorders. ... | 05/01/2012 |
| 8158614 | Therapeutic treatment of cancer and dysplasia of the cervix or vagina using estrogen antagonists A method for treatment of cervical or vaginal cancer and their associated dysplasia, including the steps of identifying a human cervical or vaginal cancer and/or dysplasia patient, administering an effective amount of an estrogen antagonist therapy to the patient, w... | 04/17/2012 |
| 8148355 | Phophylactic and therapeutic use of hydroxysteroids 3-Hydroxy-7-hydroxy steroids and 3-oxo-7-hydroxy steroids, especially the 7β-isomers thereof, and pharmaceutically acceptable esters thereof are useful for protection against ischaemia-induced damage to peripheral organs, such as the heart or kidneys, as well as tr... | 04/03/2012 |
| 8114862 | TGR5 modulators and methods of use thereof The invention relates to compounds of Formula A: or a salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inf... | 02/14/2012 |
| 8110564 | Bile acid or bile salt fatty acid conjugates The present invention relates to the use of a bile acid or bile salt fatty acid conjugate of general formula II W—X-G in which G is a bile acid or bile salt radical, which, if desired, is conjugated in position 24 with a suitable amino acid, W ... | 02/07/2012 |
| 8106037 | Identification and treatment of estrogen responsive prostate tumors The present invention is directed to specific chromosomal rearrangements that are associated with prostate tumors that respond to compounds acting at estrogen receptors. Patients having the TMPRSS2-ERG fusion, may be treated with agonists of the estrogen beta recept... | 01/31/2012 |
| 8101593 | Formulations of deoxycholic acid and salts thereof The present application is directed to an aqueous pharmaceutical formulation comprising less than about 5% w/v sodium deoxycholate maintained at a pH sufficient to substantially inhibit precipitation of the sodium deoxycholate. Also disclosed herein, are methods for... | 01/24/2012 |
| 8093233 | Agent for inhibiting visceral fat accumulation To reduce amounts of fat accumulated in abdominal cavity and to prevent or ameliorate visceral fat type obesity, considered to be a main factor of metabolic syndrome, the present invention provides an agent or a food or drink which contains a compound having a lophe... | 01/10/2012 |
| 8084446 | Use of DHEA derivatives for enhancing physical performance A method is disclosed for administering a DHEA derivative or a physiologically acceptable salt, ester or ether thereof for one of decreasing body weight, reducing adipose tissue, increasing endurance, as an anti-aging compound and generating production of red blood ... | 12/27/2011 |
| 8058267 | Steroids as agonists for FXR The invention relates to compounds of formula (I): wherein R is ethyl and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR... | 11/15/2011 |
| 8030298 | 17β-HSD1 and STS inhibitors The present invention relates to novel substituted steroid derivatives which represent selective inhibitors of the 17β-hydroxysteroid dehydrogenase type I (17β-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their sa... | 10/04/2011 |
| 8022053 | Oral solid dosage forms containing a low dose of estradiol The present invention relates to oral solid dosage forms containing a very low dose of estradiol. The dosage forms are formulated in a manner so as to avoid degradation of the estradiol and to minimise the content of polyvinylpyrrolidone, while still achieving simil... | 09/20/2011 |
| 8012952 | Cationic 17 α-substituted-estradiol derivatives useful as anti-cancer agent The present invention provides a novel series of cationic, lipid-based, 17α-substituted-estradiol derivatives. The present invention further provides a process for the preparation of a novel series of 17α-substituted-estradiol derivatives. The invention also provi... | 09/06/2011 |
| 8003629 | 21-substituted progesterone derivatives as new antiprogestational agents A compound having the general formula: in which: R1 is a member selected from the group consisting of —OCH3, —SCH3, —N(CH3)2, —NHCH3, —CHO, —COCH... | 08/23/2011 |
| 7994157 | Method for dispersing plant sterol for beverage and a plant sterol-dispersed beverage, of which particle size is nanometer-scale in dispersed beverage Disclosed are a method for dispersing plant sterol for beverage and a plant sterol-dispersed beverage, of which particle size is nanometer-scale in dispersed beverage. The dispersion of plant sterols starts with the admixing of plant sterol to at least one emulsifie... | 08/09/2011 |
| 7994158 | Method for inhibiting tumor growth with dehydrosulphurenic acid extracted from The present invention relates to a method for inhibiting tumor growth, in particular to the method using dehydrosulphurenic acid to inhibit the growth of leukemia cell or pancreatic cancer cell by a compound extracted and purified from Antrodia cinnamomea. De... | 08/09/2011 |
| 7981877 | Stabilized steroid composition and method for its preparation Stabilized, 17-substituted hydrocortisone containing compositions and methods of manufacture are disclosed. Isomerization of the hydrocortisone component of topical steroid compositions is markedly reduced by including an omega-6 acid component in the form of a free... | 07/19/2011 |
| 7981876 | Polymorphic and amorphous salt forms of squalamine dilactate The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More specifically, this application is directed to various forms of the dilactate salt... | 07/19/2011 |
| 7943604 | Method of treating human skin and a skin care composition for use in such a method The invention relates to cosmetic methods of treating human skin. The method includes applying to the skin a composition containing an estrogenic component and a cosmetically acceptable vehicle. Other aspects of the invention relate to therapeutic methods of treatin... | 05/17/2011 |
| 7932243 | Bile preparations for gastrointestinal disorders The present disclosure relates to methods and compositions to offset, ameliorate and/or alleviate one or more unwanted and/or adverse gastrointestinal effects. For example, in some embodiments, the present disclosure relates to compositions that include a bile acid,... | 04/26/2011 |
| 7932244 | Bile acid derivatives as FXR ligands for the prevention or treatment of FXR-mediated diseases or conditions The present invention relates to compounds of formula (I): wherein R is hydrogen or alpha-hydroxy, the hydroxyl group in position 7 is in the alpha or beta position; | 04/26/2011 |
| 7915244 | Methods for the treatment of a traumatic central nervous injury Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in ne... | 03/29/2011 |
| 7897588 | Agents and methods for enhancing bone formation The present invention discloses agents and methods for inducing osteoblastic cellular differentiation, as well as the use of such agents and method to treat patients to maintain bone mass, enhance bone formation and/or bone repair. Exemplary agents include oxysterol... | 03/01/2011 |
| 7893044 | Composition and method for altering levels of or sensitivity to adenosine with analogs of dehydroepiandrosterone A method of treating adenosine depletion in a subject in need of such treatment is disclosed. The method comprises administering to the subject folinic acid or a pharmaceutically acceptable salt thereof in an amount effective to treat adenosine depletion. A method o... | 02/22/2011 |
| 7867990 | Steroid hormone products and methods for preparing them The present invention relates to steroid hormone products, such as oral contraceptive products, including at least one steroid active ingredient mixed with an excipient and having improved dissolution and release rate properties. The invention further relates to met... | 01/11/2011 |
| 7863261 | Breast and prostate cancer treatment method The invention provides methods to treating conditions such as prostate cancer, or for ameliorating one or more symptoms associated with prostate cancer, or for agents that modulate the biological activity of the androgen receptor. The invention also provides methods... | 01/04/2011 |
| 7858608 | Bile acid derivatives as FXR ligands for the prevention or treatment of FXR-mediated diseases or conditions The present invention relates to compounds of formula (I) wherein: R1 is hydrogen or an alkyl group; R2 is hydrogen or a halogen, nitro, alkyloxy, amino or carboxy group; ... | 12/28/2010 |
| 7838516 | 15 β-substituted steroids having selective estrogenic activity The invention provides 15β-substituted steroidal compounds having selective estrogen receptor activity according to Formula I: wherein, R1 is H, C1-5 alkyl, C1-... | 11/23/2010 |
| 7812012 | Agent for inhibiting visceral fat accumulation To reduce amounts of fat accumulated in abdominal cavity and to prevent or ameliorate visceral fat type obesity, considered to be a main factor of metabolic syndrome, the present invention provides an agent or a food or drink which contains a compound having a lophe... | 10/12/2010 |
| 7812011 | Steroid agonist for FXR The invention relates to a FXR agonist of formula (I) and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. ... | 10/12/2010 |
| 7799771 | Oral pharmaceutical products containing 17β-estradiol-3-lower alkanoate, method of administering the same and process of preparation A pharmaceutical dosage unit for oral administration to a human female comprising a therapeutically effective amount of 17β-estradiol-3-lower alkanoate, most preferably 17β-estradiol-3-acetate, and a pharmaceutically acceptable carrier is disclosed. Also disclosed... | 09/21/2010 |
| 7795241 | Derivative prodrugs of ethinyl estradiol The present invention is a prodrug derivative of ethinyl estradiol according to Formula I: ... | 09/14/2010 |
| 7790706 | Treatment of inflammation with 5α reduced metabolites The present invention relates to the modulation of glucocorticoid metabolism. In particular the invention relates to the modulation of the functional activity of the glucocorticoid receptor by 5α reduced metabolic breakdown products of glucocorticoids. ... | 09/07/2010 |
| 7786102 | Steroids as agonists for FXR The invention relates to compounds of formula (I): wherein R is ethyl, and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FX... | 08/31/2010 |
| 7786101 | Cardiovascular protection using anti-aldosteronic progestins A composition comprises drospirenone as the sole therapeutically active agent. ... | 08/31/2010 |
| 7763600 | Hormone-based nitrogen monoxide donor compounds and use thereof in obstetrics and gynecology The invention concerns compounds capable of being fixed on hormone receptors and having a nitrogen monoxide donor group and their use for preventing premature births, increasing cervical dilatation, for use in hormone substitution therapy as anti-hypertensive drug a... | 07/27/2010 |
| 7754705 | Cationic steroid antimicrobial compositions and methods of use The invention provides methods for decreasing or inhibiting poxvirus infection or pathogenesis of a cell in vitro, ex vivo or in vivo, a symptom or pathology associated with poxvirus infection or pathogenesis in vitro, ex vivo or in vivo, or an adverse side effect o... | 07/13/2010 |
| 7718640 | Methods and pharmaceutical compositions for reliable achievement of acceptable serum testosterone levels The present invention relates to pharmaceutical compositions, formulated for injectable administration, which comprises a testosterone ester, in particularly testosterone undecanoate, in a vehicle comprising castor oil and a co-solvent. Upon injecting the compositio... | 05/18/2010 |
