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| Number | Title | Issue Date |
| 7049293 | Peptide and osteogenetic accelerator A peptide has any one of the sequences SEQ ID NO.1 to SEQ ID NO.8, or has a sequence derived from any one of the sequences SEQ ID NO.1 to SEQ ID NO.8 by substitution, deletion or addition of one or several amino acids therein and having an osteogenetic activity.... | 05/23/2006 |
| 7045502 | Use of melagatran for the manufacture of a medicament for the treatment of Type 1 diabetes mellitus According to the invention there is provided the use of melagatran, or a pharmaceutically-acceptable derivative thereof, for the manufacture of a medicament for the treatment of Type I diabetes. ... | 05/16/2006 |
| 7045518 | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, rela... | 05/16/2006 |
| 7041639 | Depsipeptide and congeners thereof for use as immunosuppressants Depsipeptides and congeners thereof are disclosed having the following structure: wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, ... | 05/09/2006 |
| 7041651 | Cellular uptake of bioactive agents Provided is a composition and a method for increasing cellular uptake of bioactive agents, particularly those compounds termed “small molecules” into the cells of mammalian tissue, such as the epithelial cells of the mucosa. ... | 05/09/2006 |
| 7041692 | Methods of treating factor VIIa-associated conditions with compounds having an amine nucleus Methods of treating Factor VIIa-associated conditions in a mammal are described, comprising administering to the mammal in need of treatment thereof an effective amount of at least one compound having the formula (I), ... | 05/09/2006 |
| 7041314 | GPE analogs and peptidominetics This invention relates to analogs and peptidomimetics of glycyl-L-prolyl-L-glutamic acid (GPE). In particular, this invention relates to GPE analogs and peptidomimetics that are anti-apoptotic and anti-necrotic, to methods of making them, to pharmaceutical compositi... | 05/09/2006 |
| 7037898 | Tumor-activated prodrug compounds and treatment The compound (W-Z-M) according to the invention comprises a component (M) chosen from the group consisting of markers and therapeutic agents possessing an intracellular active site (A.S.), linked to a ligand (W-Z) comprising an arm (Z) linked to a terminal group (W)... | 05/02/2006 |
| 7037941 | Alpha-and Beta-amino acid hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors Certain Alpha- and Beta-amino acid hydroxyethylamino sulfamic acid derivatives represented by the following formula are useful as retroviral protease inhibitors: ... | 05/02/2006 |
| 7038084 | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 05/02/2006 |
| 7034007 | Low adenosine anti-sense oligonucleotide, compositions, kit & method for treatment of airway disorders associated with bronchoconstriction, lung inflammation, allergy(ies) & surfactant depletion An in vivo method of selectively delivering a nucleic acid to a target gene or mRNA, comprises the topical administration, e.g. to the respiratory system, of a subject of a therapeutic amount of an oligonucleotide (oligo) that is anti-sense to a mRNA complementary t... | 04/25/2006 |
| 7034004 | Peptides and methods for the control of obesity The subject invention provides novel peptides for use in treating mammals to control appetite and obesity. Disclosed is a peptide derivative having the formula: X1-Z-Q-arg-trp-NH12 wherein: X1 | 04/25/2006 |
| 7034002 | Angiotensin converting enzyme inhibitor The present invention provides an angiotensin converting enzyme inhibitor having strong activity of inhibiting angiotensin converting enzyme, good hue and easily to take in which is a composition containing peptides obtained by digesting a fish meat with thermolysin... | 04/25/2006 |
| 7030084 | Drug-oligomer conjugates with polyethylene glycol components The present invention relates generally to hydrolyzable drug-oligomer conjugates, pharmaceutical compositions comprising such conjugates, and to methods for making and using such conjugates and pharmaceutical compositions. For example, a conjugate of insulin, PEG, a... | 04/18/2006 |
| 7030089 | Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione Compounds which are α-halogenoacryloyl distamycin derivatives of formula (I) wherein R1 is a bromine or chlorine atom; R2 is a distamycin or distamycin-like framework as set forth in the specification; or a pharmaceutically acceptable salt the... | 04/18/2006 |
| 7030161 | α-and β-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 04/18/2006 |
| 7029695 | Therapeutic compositions containing glutathione analogs Pharmaceutical compositions and methods of using them. Lipid formulations of a glutathione analog and methods of manufacturing them. Their use to stimulate hematopoiesis, protect hematopoietic cells from damage caused by radiation or chemotherapy, or potentiate the ... | 04/18/2006 |
| 7030213 | Conformationally stabilized cell adhesion peptides Novel synthetic Arg-Gly-Asp containing peptides which have high affinity and specificity for their receptors by virtue of restrictions on their stereochemical conformation. Such restrictions can be provided by cyclization, by inclusion into a constraining conformati... | 04/18/2006 |
| 7030214 | Ureins derived from α, ω, diamino acids and process for their preparation Ureins are obtained by reaction, in basic medium, between an Nω-(aryloxycarbonyl)diamino acid and a compound containing a free amino group. The chirality of the compounds is outstandingly well preserved. ... | 04/18/2006 |
| 7022349 | Antihistamine composition An extraction process and composition produced thereby for use as an antihistamine is disclosed. The composition comprises an extraction of Loranthus, which is derived from a species of Loranthus known to possess quantities of quercetin and avicularin,... | 04/04/2006 |
| 7022676 | Peptide having angiotensin converting enzyme inhibitory effect A peptide Met-Lys-Pro, which is obtained by chemical synthesis ot hydrolysis of casein, is used as the active ingredient of angiotensin converting enzyme inhibitors or hypotensive drugs. ... | 04/04/2006 |
| 7022737 | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses Mammals are treated for infections or for conditions associated with pathologically proliferating mammalian cell growth by administration of a manipulator of nitrosative stress to selectively kill or reduce the growth of the microbes or helminths causing the infecti... | 04/04/2006 |
| 7018650 | Preparation of aqueous clear solution dosage forms with bile acids Compositions for pharmaceutical and other uses comprising clear aqueous solutions of bile acids which do not form any detectable precipitates over selected ranges of pH values of the aqueous solution and methods of making such solutions. The compositions of the inve... | 03/28/2006 |
| 7015196 | Basic monocyclic compounds having Nk2 antagonist action, processes for their preparation, and formulations containing them Basic monocyclic compounds having general formula (I) useful as NK-2 antagonists are described, processes for their preparation and pharmaceutical compositions containing them are also described. ... | 03/21/2006 |
| 7015199 | Treatment of psoriasis through down-regulation of the EGF-receptor with topically-applied EGF Topical agent formulations for the treatment of psoriasis containing epidermal growth factor (EGF) as the active agent. EGF precursors or biological equivalents can be used. The formulation can also contain an anti-inflammatory. The formulation can contain sulfadiaz... | 03/21/2006 |
| 7015305 | Process for preparing glycopeptide derivatives Disclosed are processes for preparing glycopeptide antibiotic derivatives having an amino-containing side chain. The multi-step process is conducted in a single reaction vessel without isolation of intermediate reaction products. ... | 03/21/2006 |
| 7012066 | Peptides as NS3-serine protease inhibitors of hepatitis C virus The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of us... | 03/14/2006 |
| 7008928 | Tetrapeptide derivative TZT-1027 crystal The invention provides crystals of N2-(N,N-dimethyl-L-valyl)-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-1-pyrrolidinyl]-1-[(S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide or salts thereof which p... | 03/07/2006 |
| 7005418 | Method for the therapeutic management of extrauterine proliferation of endometrial tissue, chronic pelvic pain and fallopian tube obstruction The present inventions provides a method for therapeutic management of extrauterine proliferation of endometrial tissue, chronic pelvic pain and fallopian tube obstruction by short term induction treatment with an LH-RH antagonist for 4 to 12 weeks. According to ano... | 02/28/2006 |
| 7001887 | Peptide derivatives A compound of Formula (1): wherein R1 represents an amidinophenyl group, etc.; R2 represents a hydrogen atom, etc.; R3 repr... | 02/21/2006 |
| 7001921 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them fo... | 02/21/2006 |
| 7001984 | Di-, tri-, and tetra-peptides having antiangiogenic activity Compounds having the formula (SEQ ID NO:1), which are useful for treating conditions that arise from or are exacerbated by angiogenesis, are described. Also disclosed are pharmaceutical compositions comprising these compounds, methods of treatment using these compou... | 02/21/2006 |
| 7001907 | Peptide-containing α-ketoamide cysteine and serine protease inhibitors This invention relates to peptide-containing α-ketoamide inhibitors of cysteine and serine proteases, methods for making these compounds, and methods for using the same. ... | 02/21/2006 |
| 6998423 | Prevention of loss and restoration of bone mass by certain prostaglandin agonists Prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disorders includ... | 02/14/2006 |
| 6994987 | Process for producing tripeptides A process for efficiently, easily and stably producing tripeptides Val-Pro-Pro and Ile-Pro-Pro, which are useful as hypotensive drugs, anti-stress drugs, etc., by an enzymatic method. This process involves the step of cleaving a milk casein-containing material with ... | 02/07/2006 |
| 6995238 | Cyclopeptide derivatives Disclosed herein is a process for promoting the integration of a biocompatible device or implant into a tissue of a subject. The process comprises covalently bonding to the surface of the device or implant a compound of the formula I R-Q-X I ... | 02/07/2006 |
| 6995141 | Interleukin 1β protease and interleukin 1β protease inhibitors There is disclosed an isolated polypeptide and derivatives thereof having protease biological activity for human precursor IL-1β and for a substrate comprising: R1—Asp—R2—R3 wherein R1 and R | 02/07/2006 |
| 6995142 | Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compoun... | 02/07/2006 |
| 6995174 | Hepatitis C virus inhibitors Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Composit... | 02/07/2006 |
| 6992064 | N-alkylglycine trimeres capable of protecting neurons against excitotoxic aggressions and compositions containing such trimeres N-alkylglycine trimeres, their stereoisomers, racemic mixtures and salts of formula (I) below, where R1, R2 and R3, independent of one another, are chosen from amongst cyclopropyl, sec-butyl, 2-methoxyethyl, 3-methylbutyl, cyclohexyl... | 01/31/2006 |
