Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 6936431 | Methods and compositions for inhibiting farnesyl transferase enzyme Disclosed are methods and compositions for the identification, characterization and inhibition of farnesyl protein transferases, enzymes involved in the farnesylation of various cellular proteins, including cancer related ras proteins such as p21ras. One ... | 08/30/2005 |
| 6932985 | Azide method and composition for controlling deleterious organisms Disclosed is both a method and composition for controlling deleterious organisms, such as insects, nematodes and weeds by applying a compound comprised of a liquid medium comprising azide and amine. The azide can be selected from the group consisting of sodium azide... | 08/23/2005 |
| 6933282 | Regulation of tyrosine hydroxylase by GPE Embodiments of this invention include methods for increasing the amount of the enzyme tyrosine hydroxylase (TH) in the central nervous system (CNS) of mammals in need of an increase in TH. Methods include the use of the tripeptide, gly-pro-glu (GPE) to increase TH i... | 08/23/2005 |
| 6933290 | 2-{N-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl}-amino}-alkylboronic acid derivatives Disclosed are derivatives of 2-{[N-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl]-amino}-alkylboronic acid, processes for the preparation of such compounds, pharmaceutical preparations, and the use of such derivatives in the preparation of pharmaceutical compo... | 08/23/2005 |
| 6927205 | Compositions and methods for treatment of psoriasis A method for treating psoriasis of the skin of a patient employs topically applying to the affected skin a composition comprising at least one peptide copper complex. In other embodiments, the present invention is directed to such a method where the composition used... | 08/09/2005 |
| 6927206 | Compositions and methods for treatment of rosacea A method for treating rosacea of the skin of a patient employs topically applying to the affected skin a composition comprising at least one peptide copper complex. In other embodiments, the present invention is directed to such a method where the composition used t... | 08/09/2005 |
| 6923955 | Presbyopia treatment by lens alteration This invention effects a change in the accommodation of the human lens affected by presbyopia through the use of various reducing agents that change accommodative abilities of the human lens, and/or by applying energy to affect a change in the accommodative abilitie... | 08/02/2005 |
| 6924286 | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 08/02/2005 |
| 6919423 | Hepatitis C inhibitor compound Compounds of formula (I): wherein B, X, R3, R21, R22, R1 and Rc are defined herein. The compounds are useful as inhibitors of HCV NS3 protease. ... | 07/19/2005 |
| 6919314 | Bioactive whey protein hydrolysate The invention relates to a partial hydrolysate of whey protein which contains bioactive peptides but does not have a bitter flavor. The hydrolysate is carried out using selective enzymes which produce the active peptides and is terminated at a degree of hydrolysis b... | 07/19/2005 |
| 6919471 | Process for preparing alkyl/aryl chloroformates Alky/aryl chloroformates are prepared directly from alcohols and triphosgene. This method is simple, mild and efficient avoids use of hazardous phosgene. It can be used for the preparation of various aryl as well as alkyl chloroformates in excellent yields. ... | 07/19/2005 |
| 6919315 | Compounds with growth hormone releasing properties Disclosed are compounds of formula I formula I wherein R1, R2, R5, R6, R7, R8, G, J, L, M, a, b, c, d, e, and f are as defined in the specification, and... | 07/19/2005 |
| 6916813 | (1-phenyl-2-heteoaryl)ethyl-guanidine compounds as inhibitors of mitochondrial F1F0 ATP hydrolase Compounds having the formula (I), and pharmaceutically acceptable salts thereof, are useful for modulating mitochondrial F1F0 ATPase activity and treating ischemic conditions including myocardial ... | 07/12/2005 |
| 6916905 | Dmt-Tic di-and tri-peptidic derivatives and related compositions and methods of use A compound of formula: wherein X is a spacer comprising one or more amino acid residues and Y comprises an aromatic group and related compositions and methods of use. ... | 07/12/2005 |
| 6914122 | Macrocyclic NS-3 serine protease inhibitors of hepatitis C virus comprising alkyl and aryl alanine P2 moieties The present invention discloses novel macrocyclic compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such macrocycles as well as... | 07/05/2005 |
| 6913761 | Bioimplant formulation A pharmaceutical and/or veterinary formulation comprising about 2-30% (w/w) (on an active basis) of at least one active agent, about 0.5-20.0% (w/w) of a pore-foaming agent and the balance stearin. Such formulations provided release of the at least one active agent ... | 07/05/2005 |
| 6911427 | No-modified hemoglobins and uses therefore S-nitrosohemoglobin (SNO-Hb) can be formed by reaction of Hb with S-nitrosothiol and by other methods described herein which do not result in oxidation of the heme Fe. Other methods can be used which are not specific only for thiol groups, but which nitrosate Hb mor... | 06/28/2005 |
| 6908901 | Hepatitis C inhibitor peptide analogs Compounds of formula (I): wherein B, Y, R3, R24, R2, R1 and RC are defined herein. The compounds are useful as inhibitors of HCV NS3 protease. ... | 06/21/2005 |
| 6908924 | N4-acylcytosine-1,3-dioxolane nucleosides for treatment of viral infections The present invention is directed to a compound, method and composition of treating or preventing viral infections, in particular, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections, in human patients or other animal hosts, comprising the admi... | 06/21/2005 |
| 6906199 | Process for preparing distamycin derivatives It is described a process for preparing, in high yields and purity and without the need of carrying out several steps and/or isolating many intermediates which could lead to undesired by-products, a distamycin derivative of formula | 06/14/2005 |
| 6903136 | Food supplements containing 4-hydroxyisoleucine and creatine The present invention provides a dietary or food supplement for healthy humans that includes a combination of 4-hydroxyisoleucine and creatine, or nutraceutically acceptable derivatives of these two compounds. The supplement may include additives such as carbohydrat... | 06/07/2005 |
| 6903128 | Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases There is disclosed a genus of non-peptidyl compounds, wherein said compounds are VLA-4 inhibitors useful in treating inflammatory, autoimmune, and respiratory diseases, and wherein said compounds comprise a compound of Formula (1.0.0): | 06/07/2005 |
| 6902721 | Inhibitors of proteasomal activity for stimulating bone growth The present invention relates to compounds that inhibit the activity of the proteasome or the production of proteasomal proteins and promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyro... | 06/07/2005 |
| 6903075 | Heterocyclic amide compounds as cell adhesion inhibitors Compounds of Formula I are antagonists of VLA-4 and/or α4β7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions an... | 06/07/2005 |
| 6900176 | Pest control agents/depsipeptides The present invention relates to the use of 24-membered cyclodepsipeptides of the formula (1) in which R1 and R2 are as defined in the description, for controlling animal pests in veteri... | 05/31/2005 |
| 6896899 | Pharmaceutical preparations of glutathione and methods of administration thereof A method of increasing glutathione levels in mammalian cells comprising administering an oral bolus of encapsulated pharmaceutically stabilized glutathione in a rapidly dissolving formulation to a mammal on an empty stomach. Pharmaceutical formulations including glu... | 05/24/2005 |
| 6894028 | Use of KPV tripeptide for dermatological disorders The present invention is directed to a prevention and treatment for dermatological disorders. One aspect of this invention involves a dermatological treatment comprising one or more polypeptides with an amino acid sequence including KPV (SEQ. ID. NO. 1), MEHFRWGKPV ... | 05/17/2005 |
| 6890898 | Method of regulating glucose metabolism, and reagents related thereto The present invention provides methods and compositions for modification and regulation of glucose and lipid metabolism, generally to reduce insulin resistance, hyperglycemia, hyperinsulinemia, obesity, hyperlipidemia, hyperlipoprotein-emia (such as chylomicrons, VL... | 05/10/2005 |
| 6890904 | Anti-tumor agents A method for treating subjects with abnormal cell proliferation is provided. The method involves administering to subjects in need of such treatment an effective amount of an agent of Formula I, to inhibit cell proliferation such as that associated with tumor growth... | 05/10/2005 |
| 6884869 | Pentapeptide compounds and uses related thereto Pentapeptide compounds are disclosed. The compounds have biological activity, e.g., cytotoxicity. Prodrugs having targeting groups and pentapeptide moieities, as well as precursors thereof are also disclosed. For example, precursors having a reactive linker that can... | 04/26/2005 |
| 6875609 | Methods for the early diagnosis of ovarian cancer The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. Specifically, the present invention relates to expression of hepsin protease. The de... | 04/05/2005 |
| 6875743 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them fo... | 04/05/2005 |
| 6872805 | Hepatitis C virus inhibitors The present invention relates to tripeptide compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. In particular, the present invention provides novel tripeptide analogs, pharmaceutical compositions containing such analogs and me... | 03/29/2005 |
| 6870028 | Biologically active peptides and compositions, their use This invention relates to derivatives of hemiasterlin or Geodiamolide G having anti-mitotic activities and useful in treating cancer. These derivatives are represented by general formula I, whe... | 03/22/2005 |
| 6867184 | Methods of treating diabetic cardiomyopathy using glycogen phosphorylase inhibitors The present invention provides methods of treating diabetic cardiomyopathy, the methods comprising administering to a patient having or at risk of having diabetic cardiomyopathy a therapeutically effective amount of a glycogen phosphorylase inhibitor. The present in... | 03/15/2005 |
| 6867192 | Compounds useful in the treatment of inflammatory diseases There are provided according to the invention, novel compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification, pro... | 03/15/2005 |
| 6861506 | Compositions and methods for the treatment and diagnosis of breast cancer Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccine... | 03/01/2005 |
| 6858587 | Use of tissue factor agonist or tissue factor antagonist for treatment of conditions related to apoptosis The present invention relates to use of FVII and/or FVIIa and/or another TF agonist and/or FVIIai and/or another TF antagonist in therapeutic treatment of pathological conditions increased or decreased cell apoptosis is required. ... | 02/22/2005 |
| 6858577 | Indole peptidomimetics as thrombin receptor antagonists The invention is directed to novel indole peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosc... | 02/22/2005 |
| 6858396 | Positively charged non-natural amino acids, methods of making and using thereof in peptides This invention relates to positively charged non-natural amino acids, methods of making thereof, and utilization thereof in peptides. ... | 02/22/2005 |
