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| Number | Title | Issue Date |
| 5861389 | Methods of treating androgen deficiency in men using selective aromatase inhibitors Male menopause is characterized by significant decreases in serum levels of bioavailable androgens. The administration of aromatase inhibitors to men experiencing male menopause can remedy the relative androgen deficiency in men while at the same time app... | 01/19/1999 |
| 5861391 | Use of dehydroepiandrosterone to treat primary adrenal insufficiency and Addison's disease The present invention provides a method of treating an individual with primary adrenal insufficiency, comprising the step of administering an effective amount of dehydroepiandrosterone to said individual. Also provided is a method of treating an individua... | 01/19/1999 |
| 5859000 | Method for reducing mast cell mediated allergic reactions The present invention is directed to a method for reducing mast cell mediated allergic reactions, including mast cell mediated allergy and asthma. Mast cell mediated allergic reactions, including type I hypersensitivity reasponse to allergens and asthma, ... | 01/12/1999 |
| 5855920 | Total hormone replacement therapy A hormone replenishment method particularly useful in maintaining the body's neuroendocrine clock at optimal levels and combating conditions associated with advancing age is disclosed. The method includes determining that the level of human growth hormone... | 01/05/1999 |
| 5856299 | Highly reactive esters of carboxy polysaccharides and carboxy polysaccharides derived therefrom Provided are active esters of carboxy polysaccharides and semisynthetic derivatives of carboxy polysaccharides, wherein all or part of the carboxy groups thereof are esterified with an aromatic alcohol, a substituted aromatic alcohol, an aromatic heterocy... | 01/05/1999 |
| 5854230 | Antiandrogenic agents and related pharmaceutical compositions and methods of use Novel antiandrogenic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R1 through R10, a and b are as defined herein. Pharmaceutical compositions and methods for using the compo... | 12/29/1998 |
| 5849740 | Methods for using ketoconazole and related substances in medicaments for treatment of type II diabetes The present invention is a method of using ketoconazole or molecules resembling ketoconazole with comparable biological activity for the manufacture of drugs and for medical treatment of diabetes mellitus type II as well as for counteracting the other ris... | 12/15/1998 |
| 5849729 | Use of hydrolyzed cocoa butter for percutaneous absorption The present invention relates to a pharmaceutical formulation prepared from medicaments selected from the group consisting of retinoids, corticosteroids, vitamin D or or ଲ-hydroxy acids admixed with cocoa butter or partially hydrolyzed cocoa... | 12/15/1998 |
| 5846963 | Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome The present invention is related to a method for preventing or reducing the effects of ischemia. The ischemia may be associated with injury or reperfusion injury, such as occurs as a result of infarctions, thermal injury (burns), surgical trauma, accident... | 12/08/1998 |
| 5846962 | Anti-obesity agents Anti-obesity agents which comprise 3-ketosteroid compounds as an active ingredient are provided. The anti-obesity agents of the present invention have a high anti-obesity effect with little or no side effects and toxicity. Food products which contain anti... | 12/08/1998 |
| 5843932 | Therapeutic methods and delivery systems utilizing sex steroid precursors Sex steroid precursors such as dehydroepiandrosterone and dehydroepiandrosterone sulphate, and compounds converted in vivo to either of the foregoing, are utilized for the treatment and/or prevention of vaginal atrophy, hypogonadism, diminished libido, os... | 12/01/1998 |
| 5837269 | Vaccine compositions and method for enhancing an immune response The invention relates to a vaccine which comprises an antigen and an immune response augmenting agent. The immune response augmenting agent is capable of enhancing T cell lymphokine production. Suitable immune response augmenting agents include, but are n... | 11/17/1998 |
| 5837698 | Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs The present invention relates to a pharmaceutical composition or preparation which comprises hydroxyl containing steroidal hormones and organic nitrite/nitrate or other nitric oxide donating agents.... | 11/17/1998 |
| 5837700 | Therapeutic methods and delivery systems utilizing sex steroid precursors Sex steroid precursors such as dehydroepiandrosterone and dehydroepiandrosterone sulphate, and compounds converted in vivo to either of the foregoing, are utilized for the treatment and/or prevention of vaginal atrophy, hypogonadism, diminished libido, os... | 11/17/1998 |
| 5834451 | Remedy for myotonic dystrophy A remedy for myotonic dystrophy, containing dehydroepiandrosterone sulfate or a pharmacologically acceptable salt thereof, being efficacious for myotonia, adynamia and amyotrophy, and having a high safety.... | 11/10/1998 |
| 5834452 | 1- or 6-hydroxylated steroids A compound of the formula ##STR1## having progestomimetic activity, wherein the substituents are as defined in the specification and compositions of a compound of formula I and an estrogen compound.... | 11/10/1998 |
| 5830886 | Steroid sulphatase inhibitors Steroid sulphatase inhibitors and pharmaceutical compositions containing them for use in the treatment of oestrone dependent tumors, especially breast cancer. The steroid sulphatase are sulphamate esters of formula (I): ##STR1## where R1 | 11/03/1998 |
| 5827841 | Method for enhancement of production of lymphokines and applications thereof Disclosed is a method for enhancing the production of T cell lymphokines, which comprises exposing T cell lymphocytes which have a potential to make selected T cell lymphokines to an appropriate concentration of at least one particular steroid hormone pri... | 10/27/1998 |
| 5824668 | Formulation for administration of steroid compounds Disclosed are compositions including at least one 5ଲ steroid and an amorphous cyclodextrin. Also disclosed are methods for treating a condition such as obesity, diabetes syndrome, diabetes-associated hypercorticoidism, combinations thereof, and anem... | 10/20/1998 |
| 5824669 | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders Disclosed are (i) compounds of a steroid, a ଲ-agonist, an anticholinergic, a mast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linked to a NO or NO2 group or a group which stimulates endogenous production... | 10/20/1998 |
| 5824670 | 17-deoxycorticosteroid-21-O!carboxylic esters, processes for their preparation and pharmaceuticals containing these compounds 17-Deoxycorticoid-21-carboxylic esters of the formula I ##STR1## are described, in which A is CHOH and CHCl, CH2, C.dbd.O or 9(11) double bond; Y is H, F or Cl; Z is H, F or CH3 ; R(1) is aryl or hetaryl and R(2) is H or methyl.... | 10/20/1998 |
| 5824667 | Composition for contraception A combination product for oral contraception is disclosed comprising an estrogen selected from 2.0 to 6.0 mg of 17ଲ-estradiol and 0.020 mg of ethinylestradiol; and a gestagen selected from 0.25 to 0.30 mg of drospirenone and 0.1 to 0.2 mg of cyproterone aceta... | 10/20/1998 |
| 5824671 | Therapeutic methods and delivery systems utilizing sex steroid precursors Sex steroid precursors such as dehydroepiandrosterone and dehydroepiandrosterone sulphate, and compounds converted in vivo to either of the foregoing, are utilized for the treatment of vaginal atrophy, hypogonadism, diminished libido, loss of collagen or ... | 10/20/1998 |
| 5817649 | Combination therapy for the prophylaxis and/or treatment of benign prostatic hyperplasia A combination therapy for the prophylaxis and/or treatment of benign prostatic hyperplasia in susceptible warm-blooded animals which comprises administering a combination of two or more compounds selected from the group consisting of an inhibitor of 5�... | 10/06/1998 |
| 5811388 | Delivery of drugs to the lower GI tract Pharmaceutical compositions for orally delivering a therapeutically effective amount of a drug to the colon without significant release of the drug in the upper GI tract after oral administration of the composition are described. The composition is a unit... | 09/22/1998 |
| 5811418 | Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome The present invention is directed to a method for preventing or reducing ischemia following injury, such as reperfusion injury following ischemia, cellular damage associated with ischemic episodes, such as infarctions or traumatic injuries, and thus to pr... | 09/22/1998 |
| 5811417 | Process for producing a sterile prednisolone gel The invention concerns a method for producing a sterile prednisolone gel. The method is characterized in that prednisolone or its pharmaceutically acceptable ester is sterilized and incorporated into a sterile polyacrylate gel, which has been per se conve... | 09/22/1998 |
| 5807849 | Therapeutic methods and delivery systems utilizing sex steroid precursors Sex steroid precursors such as dehydroepiandrosterone and dehydroepiandrosterone sulphate, and compounds converted in vivo to either of the foregoing, are utilized for the treatment and/or prevention of vaginal atrophy, hypogonadism, diminished libido, os... | 09/15/1998 |
| 5807848 | Use of dehydroepeiandrosterone-3-carboxylates to control body weight Method of prophylactically averting weight gain, promoting weight loss and treating obesity with a family of thermogenic steroids. Such steroids include substantially pure Ɗ5 Androstene-17-ones having an ester of a saturated, unbranched C2-24 ... | 09/15/1998 |
| 5804576 | Derivatives of 5-androsten-17-ones and 5-androstan-17-ones Steroids of the formula: ##STR1## useful as cancer preventive agents, anti-obesity agents, anti-hyperglycemic agents, anti-aging agents, and anti-hypercholesterolemic agents and anti-auto-immune agents.... | 09/08/1998 |
| 5798348 | Fatty-acid monoesters of estrogens for the treatment of obesity and/or overweight The pharmaceutical and/or cosmetic compositions for treatment of obesity and/or overweight contain an effective amount of a fatty-acid monoester of an estrogen and a fatty acid wherein the estrogen is estrone, diethylstilbestrol, estriol, estradiol or eth... | 08/25/1998 |
| 5798347 | Therapeutic methods and delivery systems utilizing sex steroid precursors Sex steroid precursors such as dehydroepiandrosterone and dehydroepiandrosterone sulphate, and compounds converted in vivo to either of the foregoing, are utilized for the treatment and/or prevention of vaginal atrophy, hypogonadism, diminished libido, os... | 08/25/1998 |
| 5795884 | 3-keto-nor-pregnenes substituted in the 6-position and treatment of menopause A 3-keto-19-nor-pregnene of the formula ##STR1## wherein R is selected from the group consisting of hydroxy, acyloxy of an organic carboxylic acid, lower alkoxy, halogen and lower alkyl, R' is selected from the group consisting of hydrogen and haloge... | 08/18/1998 |
| 5795880 | Method and composition for treating obesity and related disorders in animals comprising dehydroepiandrosterone (DHEA), or a derivative thereof, and an anorectic agent The invention describes a method and composition for treating obesity or related disorders in animals using an anorectic agent and dehydroepiandrosterone (DHEA). The composition effectively diminishes caloric intake, may alter metabolism, weight gain, or ... | 08/18/1998 |
| 5792757 | 19-nor-pregnane steroids as neurochemical initiators of change in human hypothalamic function The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a 19-nor pregnane steroid, or a pharmaceutical composition containing a vomeropherin, such that the... | 08/11/1998 |
| 5789442 | Treatment of urinary incontinence with nitric oxide synthase substrates and/or nitric oxide donors alone or in combination with estrogen or progesterone and/or other agents The invention provides a method for the treatment and prevention of urinary incontinence in mammals, e.g., human males and females, especially nonpregnant female mammals, by administering a nitric oxide synthase substrate and/or nitric oxide donor, alone ... | 08/04/1998 |
| 5783571 | Method of altering hypothalamic function by nasal administration of estrene steroids The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human semiochemical, e.g. an Estrene steroid, or a pharmaceutical composition containing an Estrene steroid, such that the l... | 07/21/1998 |
| 5780444 | Compositions and methods for cell transformation The present invention relates to methods and compositions for the transformation of cells. In particular, compositions and methods are disclosed which include combinations of the nucleic acid of interest and polyhydroxylated or polyglycosylated steroid mo... | 07/14/1998 |
| 5780460 | Therapeutic methods and delivery systems utilizing sex steroid precursors Sex steroid precursors such as dehydroepiandrosterone and dehydroepiandrosterone sulphate, and compounds converted in vivo to either of the foregoing, are utilized for the treatment of vaginal atrophy, hypogonadism, diminished libido, loss of collagen or ... | 07/14/1998 |
| 5776923 | Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone Sex steroid precursors such as dehydroepiandrosterone and dehydroepiandrosterone sulphate, and compounds converted in vivo to ether of the foregoing, are utilized for the treatment and/or prevention of vaginal atrophy, hyprogonadism, diminished libido, os... | 07/07/1998 |
