Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 8163724 | Glucocorticosteroids, processes for their preparation, pharmaceutical compositions containing them and their use in therapy The present invention provides compounds of formula (I) wherein n, p, R1, R2, X1, X2, X3, X4, X5, R3a, R3b, R4, R... | 04/24/2012 |
| 8088758 | 17β-hydroxysteroid dehydrogenase type I inhibitors 3,15-substituted estrone compounds which act as inhibitors of 17β-hydroxysteroid dehydrogenase type I (17β-HSD1), salts thereof, pharmaceutical preparations containing such compounds, processes for preparing such compounds, and therapeutic uses of such compounds, ... | 01/03/2012 |
| 8080540 | Therapeutically active triazoles and their use Estratrien-triazoles corresponding to formula (I) (shown below) which are useful in therapy, especially for the treatment and/or prevention or inhibition of a steroid hormone dependent disorder, preferably a steroid hormone dependent disease or disorder requiring th... | 12/20/2011 |
| 8067401 | Compounds and compositions for treating infection Compounds from 14 Kenyan plants, including from the root of Dovyalis abyssinica and Clutia robusta have been characterized and isolated, and their uses are disclosed. ... | 11/29/2011 |
| 7947668 | Aminoalkyl sterol compounds having an anti-tumoral and neuroprotective activity Sterol derivatives of formula (I) and a method for the production of the compounds, a medicament using one of the compounds and a pharmaceutical composition comprising the medicament. ... | 05/24/2011 |
| 7875599 | C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens, in vitro biological activities, pharmacokinetics and antitumor activity Described are steroidal C-17 benzoazoles, pyrimidinoazoles (azabenzoazoles) and diazines. Methods for their synthesis are also described, which include methods having a step of nucleophilic vinylic “addition-elimination” substitution reaction of 3β-acetoxy-17-c... | 01/25/2011 |
| 7838515 | Formulations of quaternary ammonium neuromuscular blocking agents Muscle relaxant formulations which include one or more quaternary ammonium neuromuscular blocking agents have a reduced tendency for hydrolytic degradation, and therefore a longer shelf life stability, when combined with one or more organic anions having at least si... | 11/23/2010 |
| 7727976 | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs Disclosed are compounds that exhibit high transport across the intestinal wall of an animal. The compounds may optionally be linked to drugs that are poorly absorbed or poorly transported across the intestinal wall after oral administration to provide for enhanced t... | 06/01/2010 |
| 7691836 | Progesterone receptor modulators The subject invention provides a compound according to Formula I, wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable salt and/or hydrate f... | 04/06/2010 |
| 7687486 | Selective estrogen receptor modulators Compositions and methods for treating a cancer in mammals by administering selective estrogen receptor modulators particularly compounds represented by: or any other of the structures contained herein, or of a stereoisomer,... | 03/30/2010 |
| 7671045 | 17-phosphorous steroid derivatives useful as progesterone receptor modulators The present invention is directed to novel 17-phosphorous steroid derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by a progesterone or glucocorticoid receptor. ... | 03/02/2010 |
| 7557097 | Structural, behavioral characterization, and synthesis of attractants for migratory lamprey Compounds that function as lamprey attractants and methods. ... | 07/07/2009 |
| 7517870 | Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization The present invention concerns the use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization. Particularly, the above-me... | 04/14/2009 |
| 7407947 | Amphoteric sterols and the use thereof An amphoteric compound based on a sterol skeleton, the 3-position of the sterol ring system being substituted by one or more amphoteric groups having an isoelectric point of between about 4 and 9, together with liposomes containing such compounds and their uses.... | 08/05/2008 |
| 7396827 | Pharmaceutical compositions and treatment methods The invention provides compositions comprising formula 1 steroids, e.g., 16α-bromo-3β-hydroxy-5α-androstan-17-one hemihydrate and one or more excipients, typically wherein the composition comprises less than about 3% water. The compositions are useful to make imp... | 07/08/2008 |
| 7381718 | Method for preparing oestrogen derivatives A process for the preparation of compounds of formula (I) in which R1, R2, R3 and n are defined as indicated in the description, use of said compoun... | 06/03/2008 |
| 7375098 | 8β-vinyl-11β-(ω-substituted)alkyl-estra-1,3,5(10)-trienes This invention relates to 8β-vinyl-11β-(ω-substituted)alkyl-estra-1,3,5(10)-trienes of general formula I with ERβ-antagonistic activity, process for their production, their intermediate products, pharmaceutical preparat... | 05/20/2008 |
| 7345034 | Azacyclosteroid histamine-3 receptor ligands Azacyclosteroid histamine-3 receptor ligands, pharmaceutical compositions comprising such compounds, and methods for using such compounds and compositions are described herein. ... | 03/18/2008 |
| 7312206 | Sterol derivatives, liposomes comprising sterol derivatives and method for loading liposomes with active substances Disclosed is a sterol derivative having a pKa value of 3.5-8 according to the general formula cation-spacer 2-Y-spacer 1-X-sterol, wherein Y and X represent bonding groups. The invention also relates to liposomes containing said sterol derivatives. ... | 12/25/2007 |
| 7265099 | Use of chemical chelators as reversal agents for drug-induced neuromuscular block The invention relates to the use of chemical chelators for the preparation of a medicament for the reversal of drug-induced neuromuscular block, to a kit for providing neuromuscular block and its reversal, and to cyclophane derivatives having general formula (A) whe... | 09/04/2007 |
| 7244762 | Antitumoral d-homoestra-1,3,5 (10)-trien-3-yl 2-substituted sulfamates This invention relates to 2-substituted D-homo-estra-1,3,5(10)-trien-3-yl sulfamates of general formula I (I), in which R3 means a C1-C5-alkyl or C1-C5-alkyloxy group as well as their use for the production of a pharmaceutical agent for treating tumor diseases, whic... | 07/17/2007 |
| 7229835 | Amine detection method and materials A compound linked to a solid support (R) through a divalent linker moiety (X) and which is represented by the following formula: is disclosed. In particular, the 1-hydroxybenzotriazole-6-carboxylic acid is direct... | 06/12/2007 |
| 7205415 | Process for the preparation of simvastatin A process for manufacturing simvastatin is provided using novel intermediates. Thus, for example, lovastatin is reacted with methoxyethylamine, alpha methylated 2-methylbutyryl side chain of the amide formed, hydrolyzed and lactonized to produce finally simvastatin ... | 04/17/2007 |
| 7182942 | Vaccine immunotherapy for immune suppressed patients A method of immunotherapy to treat cancer or a synergistic anti-cancer treatment by administering an effective amount of a natural cytokine mixture (NCM), an effective amount of cyclophosphamide (CY), or an effective amount of indomethacin (INDO), wherein the NCM, C... | 02/27/2007 |
| 7176221 | Low dose pharmaceutical composition having uniform drug distribution and potency A method for manufacturing a pharmaceutical composition having uniform drug distribution and potency is described which utilizes silicon dioxide to reduce the loss of active ingredient during the manufacturing process. The method is particularly useful for the manuf... | 02/13/2007 |
| 7161008 | Optically active β-aminoketones, optically active 1,3-amino alcohols and processes for preparing them The invention relates to chiral Mannich bases of formula (I), chiral 1,3-amino alcohols of formula (II) derived therefrom, wherein R1, R2, R3, R4 and R5 are as defined herein, and to processes for preparing Mann... | 01/09/2007 |
| 7153930 | Peptide transport The present invention relates to improving and/or increasing the bioavailability of a biologically active substance, such as a peptide. In particular, the present invention relates to the conjugation of the biologically active substance to a bile acid. The conjugate... | 12/26/2006 |
| 7153844 | Estrogen-linked platinum (II) complexes as anticancer agents wherein X may be —CH2—O—CH2— or —CH2—, wherein n may be 1, 2, 3, 4 or 5 when X is —CH2—O—CH2—, wherein n may be 2, 3, 4, 5, 6, 7, 8, 9 or 10 when X is ... | 12/26/2006 |
| 7135581 | Antiangiogenic agents Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering derivatives of 2-methoxyestradiol of the general formula: wherein the variables are defined in th... | 11/14/2006 |
| 7078396 | Method of treating disorder related to high cholesterol concentration A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): Also disclosed are methods, kits, combinations, and co... | 07/18/2006 |
| 7074778 | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders This invention relates to methods for treating asthma or allergy in a mammal by administering a 3-aminosteroid compound to a mammal in need thereof. The 3-aminosteroid compound being capable of down regulating the IL-9 pathway and alleviating asthmatic responses to ... | 07/11/2006 |
| 7074779 | Estrieno[3,2-b]/[3,4-c]pyrrole derivatives useful as modulators of the estrogen receptors The present invention is directed to novel estrieno[3,2-b]/[3,4-c]pyrrole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and diseases mediated by an estrogen receptor. ... | 07/11/2006 |
| 7067503 | 17-aryl linker derivatised estrogen 3-sulphamates as inhibitors of steroid sulphatase There is provided a compound comprising a steroidal ring system and a group R1 selected from any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the D ring of the steroidal ring ... | 06/27/2006 |
| 7056906 | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women The present invention provides compositions, therapeutic combinations and methods including: (a) at least one hormone replacement therapy composition; and (b) at least one sterol absorption inhibitor which can be useful for treating vascular conditions in post-menop... | 06/06/2006 |
| 7053076 | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs Disclosed are compounds that exhibit high transport across the intestinal wall of an animal. The compounds may optionally be linked to drugs that are poorly absorbed or poorly transported across the intestinal wall after oral administration to provide for enhanced t... | 05/30/2006 |
| 7053074 | Prevention of ovarian cancer by administration of a Vitamin D compound The present invention relates to methods for preventing the development of epithelial ovarian cancer by administering a Vitamin D compound in an amount capable of increasing apoptosis in non-neoplastic ovarian epithelial cells of the female subject. ... | 05/30/2006 |
| 7049305 | Bile-acid conjugates providing for sustained systemic concentration of drugs This invention is directed to compounds that provide for sustained systemic concentrations of therapeutic or prophylactic agents following administration to animals. This invention is also directed to pharmaceutical compositions including and methods using such comp... | 05/23/2006 |
| 7045513 | DHEA composition and method Disclosed are improved pharmaceutical formulations comprising dehydroepiandrosterone (DHEA), enriched in selected polymorphic forms, for therapeutic applications. In one embodiment, the formulation comprises, in solid form, DHEA, at least 85% of which is present as ... | 05/16/2006 |
| 7040756 | Process for surface modifying substrates and modified substrates resulting therefrom The present invention generally relates to a method of modifying the surface of substrates such as contact lenses and other biomedical articles by at least partially coating the surfaces of such substrates with a polymeric tie layer having reactive sites. Various ot... | 05/09/2006 |
| 7037907 | Estradiol conjugates and uses thereof A conjugated prodrug of an estradiol compound conjugated to a biological activity modifying agent. ... | 05/02/2006 |
