Did You Know...
...that when IBM conducted a market study of Chester Carlson's invention in 1959, the company concluded that it would take only 5000 units of his new product to saturate the market? IBM therefore declined to be part of the new product introduction. Too bad for IBM. Carlson's invention was the xerography process, and his new product was the beginning of the Xerox Corporation. It is estimated that every day, worldwide, 3,000,000,000 copies are made!!
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| Number | Title | Issue Date |
| 8053425 | Use of oxandrolone in the treatment of burns and other wounds The subject invention provides a method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone to the patient. The invention also provides a method of treating a wound in a patient su... | 11/08/2011 |
| 8003628 | Methods of inhibiting osteoclast activity Methods of inhibiting osteoclastogenesis and the activity of osteoclasts are disclosed. Methods of treating patients who have diseases characterized bone loss are disclosed. According to the methods, an amount of a TRANCE/RANK inhibitor effective to inhibit osteocla... | 08/23/2011 |
| 7981875 | 2″ oxo-voruscharin and derivatives thereof Compounds and pharmaceutical compositions which include 2″ oxo-voruscharin and derivatives are disclosed. The compounds and pharmaceutical compositions are useful in methods of treating cancer, particularly pancreatic cancer. ... | 07/19/2011 |
| 7867988 | Macrocyclic lactone compounds and methods for their use A method of inhibiting smooth muscle cell proliferation or cytokine production in a subject, comprising administering a compound disclosed herein to the subject, is provided. The compound can be administered systemically, locally, or a combination thereof. For examp... | 01/11/2011 |
| 7749988 | Triterpenoid derivatives The present invention relates to the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in therapy. Prefereably, the compound may be used for treating a patient suffering from leukaemia, cancer or other proliferative disorder. A further... | 07/06/2010 |
| 7645749 | Sterol/stanol nitroderivatives and use thereof Sterol and stanol nitro derivatives and their use in treating or preventing cardiovascular disease, its underlying conditions and other disorders are disclosed. The disclosed nitro derivatives are synthesized by ester linkage of a nitric oxide (NO)-releasing moiety ... | 01/12/2010 |
| 7645748 | Sterol/stanol phosphorylnitroderivatives and use thereof Sterol and stanol phosphorylnitro derivatives and their use in treating or preventing cardiovascular disease, its underlying conditions and other disorders are disclosed. The disclosed compounds include a phosphate linker, at least one moiety that releases nitric ox... | 01/12/2010 |
| 7625885 | Cytotoxin compound and method of isolation A compound or groups of compounds, present in an active principle, derived from tunicates of the species Synoicum adareanum, as well as to pharmaceutical compositions comprising these compounds. Extracts from tunicates show selective toxicity against several ... | 12/01/2009 |
| 7579334 | Compounds with anti-inflammatory activity The present invention relates to new compounds represented by Formula I: wherein M represents a macrolide subunit of the substructure II: L represents the chain of the substructur... | 08/25/2009 |
| 7417038 | Methods of treating cachexia A method of treating weight loss due to underlying disease in a patient the method comprising administering to the patient an effective amount of an agent which reduces sympathetic nervous system activity. A method of treating weight loss due to underlying disease i... | 08/26/2008 |
| 7405206 | Anti-inflammatory androstane derivatives There are provided compounds of formula (I) wherein R1 represents O, S or NH; R2 represents —C(═O)-aryl or —C(═O)-heteroaryl; R3 represents hyd... | 07/29/2008 |
| 7387800 | Sesquiterpenoid derivatives having adipocyte differentiation inhibitory effect The objective of the present invention is to identify compounds having an inhibitory effect on adipocyte differentiation, and to provide pharmaceutical compositions and food compositions for prevention, improvement, or treatment of obesity or obesity related disease... | 06/17/2008 |
| 7335753 | Bifunctional heterocyclic compounds and methods of making and using same The invention provides a family of bifunctional heterocyclic compounds useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using... | 02/26/2008 |
| 7320971 | 2″ oxo-voruscharin and derivatives thereof 2″ oxo-voruscharin compound and derivatives thereof are disclosed as well as pharmaceutical compositions which include 2″ oxo-voruscharin compound or derivatives thereof. The disclosed 2″ oxo-voruscharin compound and its derivatives are useful for cancer treat... | 01/22/2008 |
| RE40000 | Method of treatment for decreasing mortality resulting from congestive heart failure A method of treatment using a compound of Formula I: wherein: R1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; R | 01/08/2008 |
| 7238507 | 11 alpha hydroxylase and oxidoreductase The present invention relates to a novel cytochrome P450-like enzyme (Aspergillus ochraceus 11 alpha hydroxylase) and an oxidoreductase (Aspergillus ochraceus oxidoreductase) isolated from cDNA library generated from the mRNA of Aspergillus ochraceu... | 07/03/2007 |
| 7235655 | Processes to prepare eplerenone The present invention involves intermediates, including a 7α-substituted steroid (II), and processes which are used to prepare eplerenone, a useful pharmaceutical agent. ... | 06/26/2007 |
| 7196208 | Processes for preparing 7-carboxy substituted steroids This invention relates to processes for the preparation of 7-carboxy substituted steroid compounds of Formula I, wherein R1 is selected from H or COR4; R4 is C | 03/27/2007 |
| 7157101 | Micronized eplerenone compositions The invention relates to oral pharmaceutical compositions useful as aldosterone receptor blockers comprising the active agent micronized eplerenone in an amount of about 10 mg to about 1000 mg and one or more carrier materials. ... | 01/02/2007 |
| 7119082 | 11β-long-chain-substituted 19-nor-17α-pregna-1,3,5(10)-trien-17β-ols with a 21,16α-lactone ring This invention relates to new 19-nor-17α-pregna-1,3,5(10)-trien-17β-ols with a 21,16α-lactone ring with a long-chain substituent in 11β-position of general formula II in which R11 means a straight-... | 10/10/2006 |
| 7112670 | Crystal form The present invention involves a novel crystal form of 17β-hydroxy-7α-(5′-methyl-2′-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid, γ-lactone, having the formula which is an intermediate useful in pre... | 09/26/2006 |
| 7091196 | Bifunctional heterocyclic compounds and methods of making and using same The invention provides a family of compounds useful as anti-infective agents and/or anti-proliferative agents, for example, chemotherapeutic agents, anti-fungal agents, anti-bacterial agents, anti-parasitic agents, anti-viral agents, and/or anti-inflammatory agents,... | 08/15/2006 |
| 7087591 | 21-substituted progesterone derivatives as new antiprogestational agents A compound having the general formula: in which: R1 is a member selected from the group consisting of —OCH3, —SCH3, —N(CH3)2, —NHCH3, —C... | 08/08/2006 |
| 7074778 | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders This invention relates to methods for treating asthma or allergy in a mammal by administering a 3-aminosteroid compound to a mammal in need thereof. The 3-aminosteroid compound being capable of down regulating the IL-9 pathway and alleviating asthmatic responses to ... | 07/11/2006 |
| 7033807 | Aspergillus ochraceus 11 alpha hydroxylase and oxidoreductase The present invention relates to a novel cytochrome P450-like enzyme (Aspergillus ochraceus 11 alpha hydroxylase) and an oxidoreductase (Aspergillus ochraceus oxidoreductase) isolated from cDNA library generated from the mRNA of Aspergillus ochraceu... | 04/25/2006 |
| 7015210 | Methods of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists A method for treating or preventing ophthalmic disorders comprising the administration of one or more aldosterone receptor antagonists that contain a 9,11-epoxy moiety, such as eplerenone is disclosed. The method results in a reduction of intraocular pressure which ... | 03/21/2006 |
| 7011844 | Formulations for the administration of fluoxetine Composition of matter for application to a body surface or membrane to administer fluoxetine by permeation through the body surface or membrane, the composition comprising fluoxetine to be administered, at a therapeutically effective rate, alone or in combination wi... | 03/14/2006 |
| 7002028 | 5-androsten-3β-ol steroid intermediates and processes for their preparation The present invention provides 5-androsten-3β-ol steroid intermediates and processes for their preparation. ... | 02/21/2006 |
| 6984633 | Method to treat cardiofibrosis with a combination therapy of an angiotensin II antagonist and epoxymexrenone A therapeutic method is described for treating cardiofibrosis or cardiac hypertrophy using a combination therapy comprising a therapeutically-effective amount of an angiotensin II receptor antagonist and a therapeutically-effective amount of expoxymexrenone. ... | 01/10/2006 |
| 6979454 | Biologically active composition A biologically active stick composition comprising a biologically active agent dissolved in a carrier system including an unsaturated fatty acid alcohol in mutual dissolution with an alkylene glycol as a solvent for said biologically active agent and a stiffening ag... | 12/27/2005 |
| 6908626 | Compositions having a combination of immediate release and controlled release characteristics Disclosed are compositions exhibiting a combination of immediate release and controlled release characteristics. The compositions comprise at least one poorly soluble active ingredient having a nanoparticulate particle size, at least one surface stabilizer adsorbed ... | 06/21/2005 |
| 6878699 | Taccalonolide microtubule stabilizing agents In accordance with the present invention, there have been identified extracts from a tropical plant that initiate paclitaxel-like microtubule bundling. Bioassay-directed purification yields the steroid taccalonolide A. Taccalonolide, like paclitaxel, initiates the f... | 04/12/2005 |
| 6863902 | Immediate release eplerenone compositions The invention relates to oral pharmaceutical compositions useful as aldosterone receptor blockers comprising the active agent micronized eplerenone in an amount of about 10 mg to about 1000 mg and one or more carrier materials. ... | 03/08/2005 |
| 6828313 | Use of oxandrolone in the treatment of burns and other wounds The subject invention provides a method of treating burn-induced weight loss in a burn patient which comprises administering a therapeutically effective amount of an oxandrolone to the patient. The invention also provides a method of treating a wound in a patient su... | 12/07/2004 |
| 6759399 | Use of antimineralocorticoid compounds against narcotic withdrawal syndrome The method of treating narcotic withdrawal symptoms in warm-blooded animals comprising administering to warm-blooded animals in need thereof an amount of a compound having anti-mineralocorticoid activity sufficient to treat narcotic withdrawal symptoms. ... | 07/06/2004 |
| 6747020 | Methods of treating heart failure and hypertension using combinations of eplerenone and an angiotensin converting enzyme inhibitor Methods of using eplerenone, an angiotensin converting enzyme inhibitor and optionally a diuretic are described for treatment of heart failure and hypertension. ... | 06/08/2004 |
| 6716829 | Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders Combinations of aldosterone blockers and Cyclooxygenase-2 inhibitors useful in the treatment of inflammation are disclosed. ... | 04/06/2004 |
| 6713464 | Derivatives of 3,3-diphenylpropylamines The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodr... | 03/30/2004 |
| 6699846 | Mono- and disaccharides for the treatment of nitric oxide related disorders Methods for treating diseases or conditions modulated or ameliorated by nitric oxide, particularly ischemia and reperfusion injury, are provided, using glycolipids structurally related to monophosphoryl lipid A but with notable reduction in proinflammator... | 03/02/2004 |
| 6670347 | 19-nor-17-pregna-1,3,5(10)-trien-17ଲ-ols with a 21,16-lactone ring This invention relates to new 19-nor-17-pregna-1,3,5(10)-trien-17ଲ-ols with a 21,16-lactone ring of formula II, ##STR1## process for their production and pharmaceutical preparations that contain these compounds as well as 17³... | 12/30/2003 |
