Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 8178519 | Pharmaceutical manufacturing process for heat sterilized glucocorticoid suspensions The present invention provides a method for preparing a sterile suspension of a glucocorticosteroid. The glucocorticosteroids used in the invention are preferably antiinflammatory glucocorticosteroids. By making the last stage of product preparation be the steriliza... | 05/15/2012 |
| 8124597 | Method of treating gaucher disease Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as pharmacological chaperones for mutant forms of the beta-glucocerebrosidase. Methods of treatment involve pro... | 02/28/2012 |
| 7524834 | Sterile powders, formulations, and methods for producing the same The invention provides sterile glucocorticosteroids and sterile formulations containing glucocorticosteroid and use thereof in the treatment of an allergic and/or inflammatory condition of the nose or the lungs. ... | 04/28/2009 |
| 7468362 | Carbonate and carbamate modified forms of glucocorticoids in combination with βadrenergic agonists Compositions containing β2 adrenergic agonists in combination with carbonates and carbonates of the formula and in combination with related steroid carbonates and carbonates are disclosed. The compositions are u... | 12/23/2008 |
| 7368442 | Nitrate esters of corticoid compounds and pharmaceutical applications thereof Compounds of the formula and use of the compounds as medicaments. ... | 05/06/2008 |
| 7354570 | Chinese preparation for treating enteritis ulcer colitis and preparation method thereof This invention provides a preparation of traditional Chinese medicinal materials for the treatment of ulcerative colitis and the processed method thereof. The preparation of present invention is prepared from Sanguis Draxonis, etc. The processed method of the prepar... | 04/08/2008 |
| 7329402 | Methods of imaging and treatment Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultrasound. The... | 02/12/2008 |
| 7267813 | Inhalation particles incorporating a combination of two or more active ingredients Crystalline spherical inhalation particles incorporating a combination of two or more different active ingredients and a process for the preparation thereof. The particles have a narrow particle size distribution, rough surfaces and improved stability. The inhalatio... | 09/11/2007 |
| 7250408 | Glucocorticoid receptor antagonists for prophylaxis and therapy of glucocorticoid-mediated hypogonadism, of sexual dysfunction and/or infertility The novel glucocorticoid receptor antagonists are 11β-substituted steroid compounds of formula (I): wherein R1 denotes a methyl group, a methoxy group, or an ethoxy group; wherein R2 denote... | 07/31/2007 |
| 7223748 | Pharmaceutical formulations for dry powder inhalers in the form of hard-pellets The invention provides a formulation to be administered as a dry powder for inhalation suitable for efficacious delivery of active ingredients into the low respiratory tract of patients suffering from a pulmonary disease such as asthma. In particular, the invention ... | 05/29/2007 |
| 7225024 | Sensors having protective eluting coating and method therefor A cardiac management implantable device that has an intravascular device body, and one or more chemical sensors coupled with the intravascular device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near th... | 05/29/2007 |
| 7208485 | Crystalline forms of halobetasol propionate The present invention provides a crystalline halobetasol propionate selected from the group consisting of halobetasol propionate having crystalline Form I characterized by power X-ray diffraction peak positions and intensities as set forth in Table 1 herein, halobet... | 04/24/2007 |
| 7172752 | Combination particles for the treatment of asthma Inhalation particles incorporating, in an individual particle, a combination of a βhd 2-agonist and a glucocorticosteroid in a predetermined and constant ratio, a process for the preparation thereof and pharmaceutical compositions comprising the inhalation particle... | 02/06/2007 |
| 7163923 | Peptide deformylase activated prodrugs This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting the microorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gram-nega... | 01/16/2007 |
| 7160920 | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders Disclosed are (i) compounds of a steroid, a β-agonist, an anticholinergic, a mast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linked to a NO or NO2 group or a group which stimulates endogenous production of NO or EDRF i... | 01/09/2007 |
| 7128897 | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis Pharmaceutical compositions are described that contain one agent for treatment of sinusitis and a surfactant. The compositions are prepared to have a surface tension that renders the composition effective for treatment of sinusitis. ... | 10/31/2006 |
| 7119082 | 11β-long-chain-substituted 19-nor-17α-pregna-1,3,5(10)-trien-17β-ols with a 21,16α-lactone ring This invention relates to new 19-nor-17α-pregna-1,3,5(10)-trien-17β-ols with a 21,16α-lactone ring with a long-chain substituent in 11β-position of general formula II in which R11 means a straight-... | 10/10/2006 |
| 7112580 | 3-nitrogen-6, 7-dioxygen steroids and uses related thereto A compound of the formula: and pharmaceutically acceptable salts, solvates, stereoisomers and prodrugs thereof, in isolation or in mixture, wherein R groups are as defined by the present specification. The compou... | 09/26/2006 |
| 7108867 | Process for preparing particles A process for preparing particles of a substance, such as a protein or polypeptide, comprising: (a) preparing a first liquid comprising water, the substance and a modulator, wherein the modulator has a solubility in water which decreases with increasing temperature;... | 09/19/2006 |
| 7105151 | Oxygen delivery agents and uses for the same The present invention describes, inter alia, oxygen delivery agents or blood substitutes comprising a fluorinated gas and a stabilizing material, uses for the oxygen delivery agents or blood substitutes, and apparatus for making and delivering the oxygen delivery ag... | 09/12/2006 |
| 7087590 | 19-norbufalin derivatives, their preparation and pharmaceutical compositions containing them A 19-norbufalin derivative compound of formula (I): wherein the R groups are as defined by the present specification. The compounds are Na+K−-ATPase inhibitors and can be used in the treat... | 08/08/2006 |
| 7083572 | Therapeutic delivery systems Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Targeted therapeutic d... | 08/01/2006 |
| 7078015 | Ultrasound imaging and treatment Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly usefull for example, in ultrasonic imaging applications and in therapeutic dr... | 07/18/2006 |
| 7067682 | 6,7-Oxygenated steroids and uses related thereto Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have oxygen substitution at C6 an... | 06/27/2006 |
| 7056905 | Nitrate esters of corticoid compounds and pharmaceutical applications thereof Compounds of the formula and use of the compounds as medicaments. ... | 06/06/2006 |
| 7056949 | Oil/fat composition An oil/fat composition comprising 5 to 99.9 wt. % of a monoglyccride having, as fatty acid constituents thereof, 15 to 90 wt % of an ω 3-unsaturated fatty acid having less than 20 carbon atoms, 1 to 80 wt. % of an ω 9-unsaturated fatty acid and 2 to 50 wt. % of an... | 06/06/2006 |
| 7045152 | Treating pulmonary disorders with gaseous agent causing repletion of GSNO Pulmonary disorders in which the GSNO pool or glutathione pool in the lung is depleted and where reactive oxygen species in lung are increased, are treated by delivering into the lung as a gas, agent causing repletion or increase of the GSNO pool or protection again... | 05/16/2006 |
| 7041651 | Cellular uptake of bioactive agents Provided is a composition and a method for increasing cellular uptake of bioactive agents, particularly those compounds termed “small molecules” into the cells of mammalian tissue, such as the epithelial cells of the mucosa. ... | 05/09/2006 |
| 7015210 | Methods of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists A method for treating or preventing ophthalmic disorders comprising the administration of one or more aldosterone receptor antagonists that contain a 9,11-epoxy moiety, such as eplerenone is disclosed. The method results in a reduction of intraocular pressure which ... | 03/21/2006 |
| 6998107 | Composition comprising low density microspheres Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void having a volume that comprises at least about 75% of the total volume of the microspheres, and which contains a gas or the vapor of a... | 02/14/2006 |
| 6986904 | Formulation A new metered unit dose comprising 40 μg or less of budesonide is disclosed as well as a formulation thereof and the use thereof for the treatment of conditions in the nose. ... | 01/17/2006 |
| 6974807 | Tazarotene and corticosteroid treatment for psoriasis The present invention provides a method for treating proliferative skin diseases comprising the administration of an effective amount of tazarotene and an effective amount of a corticosteroid. This invention is especially useful for treating psoriasis. ... | 12/13/2005 |
| 6956031 | 11β-Substituted 19-nor-17-α-pregna-1,3,5(10)-trien-17β-ols with a 21,16α-lactone ring This invention relates to new 19-nor-17α-pregna-1,3,5(10)-trien-17β-ols with a 21,16α-lactone ring with a long-chain substituent in 11β-position of general formula II in which R11 is a long-chain alkyl r... | 10/18/2005 |
| 6949533 | 6,7-Oxygenated steroids and uses related thereto Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have oxygen substitution at C6 an... | 09/27/2005 |
| 6930113 | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donate, transfer... | 08/16/2005 |
| 6921531 | Administering bifunctional molecules containing a drug moiety and presenter protein ligand for therapy Bifunctional molecules and methods for their use in the production of binary or tripartite complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein ligand. The molecular weight of the bifunctional molecule i... | 07/26/2005 |
| 6921757 | Organic compounds Compounds of formula (I), where R is a monovalent cyclic organic group having from 3 to 15 atoms in the ring system, useful as pharmaceuticals ... | 07/26/2005 |
| 6884794 | Pharmaceutical formulations for dry powder inhalers in the form of hard-pellets The invention provides a formulation to be administered as dry powder for inhalation suitable for efficacious delivery of active ingredients into the low respiratory tract of patients suffering of pulmonary diseases such as asthma. In particular, the invention provi... | 04/26/2005 |
| 6787533 | Process for R-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregna,4-dien-11.beta., 16.alpha., 17.alpha.-triol-3,20-dione derivatives R-epimer enrichment of 16,17-acetal derivatives of 21-acyloxy pregna-1,4-dien-11beta,16alpha,17alpha-triol-3,20-dione derivatives is effected by fractional crystallization. ... | 09/07/2004 |
| 6767901 | Ciclesonide contained pharmaceutical composition for application to mucosa The present invention provides a pharmaceutical composition for application to the mucosa to be used in drug therapy comprising a water-insoluble and/or water-low soluble substance, ciclesonide, and an aqueous medium, and having an osmotic pressure of less than 290 ... | 07/27/2004 |
