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| Number | Title | Issue Date |
| 7910571 | Cystic fibrosis treatment methods The invention relates to the use of compounds to ameliorate or treat an condition such as a cystic fibrosis, neutropenia or other exemplified conditions. Exemplary compounds that can be used include 3β-hydroxy-17β-aminoandrost-5-ene, 3β-hydroxy-16α-fluoro-17β-a... | 03/22/2011 |
| 7846917 | 18-Methyl-19-norandrost-4-ene 17, 17-spiro ether (18-methyl-19-nor-20-spirox-4-en-3-one), and pharmaceutical products comprising the same The present invention describes the novel 18-methyl-19-norandrost-4-ene 17,17-spiro ethers of the general formula I in which Z is an oxygen atom, two hydrogen atoms, a group ═NOR or ═NNHSO2R, whe... | 12/07/2010 |
| 7842680 | Diene and triene compounds and formulations The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by an... | 11/30/2010 |
| 7678781 | 11-phosphorous steroid derivatives useful as progesterone receptor modulators The present invention is directed to novel 11-phosphorous steroid derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by a progesterone or glucocorticoid receptor. ... | 03/16/2010 |
| 7550450 | Prostate cancer treatment The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by an... | 06/23/2009 |
| 7514420 | Steroids having 1,8-unsaturation and formulations comprising same The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by an... | 04/07/2009 |
| 7462610 | Prostate cancer treatment The instant invention provides potent antiandrogen compounds, such as 3β-acetoxyandrost-1,5-diene-17-ethylene ketal and 3β-hydroxyandrost-1,5-diene-17-ethylene ketal, and methods for their use in the prevention and treatment of biological conditions mediated by an... | 12/09/2008 |
| 7417038 | Methods of treating cachexia A method of treating weight loss due to underlying disease in a patient the method comprising administering to the patient an effective amount of an agent which reduces sympathetic nervous system activity. A method of treating weight loss due to underlying disease i... | 08/26/2008 |
| 7405207 | Nebulizer formulations of dehydroepiandrosterone and methods of treating asthma or chronic obstructive pulmonary disease using compositions thereof This invention relates to a sealed container containing a powder formulation comprising a dehydroepiandrosterone, its analogue(s) or salt(s) by itself or with a pharmaceutically or veterinarily acceptable carrier or diluent, and having a particle size of about 0.1 ... | 07/29/2008 |
| 7348320 | Platinum complexes containing chemically modified bile acids, having antitumor activity The present invention relates to platinum complexes containing bile acid derivatives having antitumor activity ... | 03/25/2008 |
| 7138427 | 5-β-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia The invention discloses the use of sapogenin derivatives in the treatment of cognitive disfunction and similar conditions. Methods of treatment and pharmaceutical compositions are also disclosed ... | 11/21/2006 |
| 7112670 | Crystal form The present invention involves a novel crystal form of 17β-hydroxy-7α-(5′-methyl-2′-furyl)-pregna-4,9(11)-dien-3-one-21-carboxylic acid, γ-lactone, having the formula which is an intermediate useful in pre... | 09/26/2006 |
| 7053091 | 17 β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases In its many embodiments, the present invention provides a novel class of compounds as inhibitors of type 3 17β-hydroxysteroid dehydrogenase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing... | 05/30/2006 |
| 7053074 | Prevention of ovarian cancer by administration of a Vitamin D compound The present invention relates to methods for preventing the development of epithelial ovarian cancer by administering a Vitamin D compound in an amount capable of increasing apoptosis in non-neoplastic ovarian epithelial cells of the female subject. ... | 05/30/2006 |
| 7018991 | 17β-amino and hydroxylamino-11 β-arylsteroids and their derivatives having agonist or antagonist hormonal properties The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity. ... | 03/28/2006 |
| 7015210 | Methods of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists A method for treating or preventing ophthalmic disorders comprising the administration of one or more aldosterone receptor antagonists that contain a 9,11-epoxy moiety, such as eplerenone is disclosed. The method results in a reduction of intraocular pressure which ... | 03/21/2006 |
| 6984633 | Method to treat cardiofibrosis with a combination therapy of an angiotensin II antagonist and epoxymexrenone A therapeutic method is described for treating cardiofibrosis or cardiac hypertrophy using a combination therapy comprising a therapeutically-effective amount of an angiotensin II receptor antagonist and a therapeutically-effective amount of expoxymexrenone. ... | 01/10/2006 |
| 6977250 | Prevention of ovarian cancer by administration of progestin products The present invention relates to methods for preventing the development of epithelial ovarian cancer by administering progestin products, either alone or in combination with other agents such as estrogen products. ... | 12/20/2005 |
| 6759399 | Use of antimineralocorticoid compounds against narcotic withdrawal syndrome The method of treating narcotic withdrawal symptoms in warm-blooded animals comprising administering to warm-blooded animals in need thereof an amount of a compound having anti-mineralocorticoid activity sufficient to treat narcotic withdrawal symptoms. ... | 07/06/2004 |
| 6716829 | Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders Combinations of aldosterone blockers and Cyclooxygenase-2 inhibitors useful in the treatment of inflammation are disclosed. ... | 04/06/2004 |
| 6653306 | Epoxy-steroidal aldosterone antagonist and angiotensin II antagonist combination therapy A combination comprising therapeutically-effective amount of an epoxy-steroidal aldosterone receptor antagonist and a therapeutically-effective amount of an angiotensin II receptor antagonist is described for treatment of circulatory disorders.... | 11/25/2003 |
| 6620801 | 17ଲ-amino and hydroxylamino-11ଲ-arylsteroids and their derivatives having agonist or antagonist hormonal properties The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.... | 09/16/2003 |
| 6605604 | Carboxylic and hydroxamic acid compounds inhibiting metalloproteases, method for preparing same and pharmaceutical compositions containing them The invention concerns a compound of formula (I) wherein: n is equal to 0 or 1; R1, R2, R3, R4 represent a hydrogen or an alkyl group, or R1 and R3 together form a cycloalkyl group; R5 | 08/12/2003 |
| 6569843 | Steroidal sapogenins for the control of coccidiosis in animals Steroidal sapogenins and pharmaceutically acceptable salts thereof, useful in the prevention of coccidiosis in animals and methods of administering an effective amount of steroidal sapogenin or pharmaceutically acceptable salts thereof in the diet or drin... | 05/27/2003 |
| 6541463 | Inhibitors of type 5 and type 3 17ଲ-hydroxysteroid dehydrogenase and methods for their use Novel methods of medical treatment and/or inhibition of development of diseases are disclosed for diseases that are sensitive to androgenic or estrogenic activity. The treatments utilize inhibitors of type 5 and/or type 3 17ଲ-hydroxysteroid dehydrog... | 04/01/2003 |
| 6534490 | Unsaturated 14, 15-cyclopropanoandrostanes, method for the production thereof and pharmaceutical preparations containing said compounds Described are new, unsaturated 14,15-cyclopropano-androstanes of general formula (I) and their pharmaceutically acceptable salts, a process for their production and pharmaceutical preparations that contain these compounds. The compounds are characterized ... | 03/18/2003 |
| 6365582 | S-substitute 11ଲ-benzaldoxime-estra-4, 9-diene-carbonic acid thiolesters, method for the production thereof and pharmaceutical preparations containing these compounds Thiol esters of S-substituted 11ଲ-benzaldoxime-estra-4,9-dien-carboxylic acids of the formula I ##STR1## their pharmaceutically acceptable salts, a method for their synthesis and pharmaceutical preparations containing these compounds are described. ... | 04/02/2002 |
| 6291516 | Regulators of the hedgehog pathway, compositions and uses related thereto The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting a cell with a compound, such as a polypept... | 09/18/2001 |
| 6262042 | 17ଲ-amino and hydroxylamino-11ଲ-arylsteroids and their derivatives having agonist or antagonist hormonal properties The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.... | 07/17/2001 |
| 6245755 | Use of aldosterone antagonists to inhibit myocardial fibrosis This invention discloses a method of inhibiting aldosterone-mediated myocardial, perivascular and interstitial fibrosis using epoxymexrenone and other aldosterone antagonists.... | 06/12/2001 |
| 6177418 | Tetracyclic triterpenes as cholesterol-lowering and anti-atherosclerosis agents The invention is directed to compounds, compositions and method of preparation of compounds of formulae I and II: ##STR1## wherein X, Q1, Q2, R1 and R2 are as defined by the specification. The compounds are disc... | 01/23/2001 |
| 6172056 | Pharmaceutical compositions and method for prophylaxis and therapy of radical-mediated cell damage The method of prophylaxis and therapy of radical-mediated cell damage includes administering an effective amount of at least one steroid and at least one pharmaceutical adjuvant to a human being. The at least one steroid is selected from the group consist... | 01/09/2001 |
| 6172054 | Combination therapy for lowering and controlling intraocular pressure Angiostatic agents and another IOP lowering compound are combined in ophthalmic compositions to treat glaucoma and ocular hypertension. Methods for treating glaucoma and ocular hypertension are also disclosed.... | 01/09/2001 |
| 6093708 | Use of aldosterone antagonists to inhibit myocardial fibrosis This invention discloses a method of using an aldosterone antagonist such as spironolactone, at a dosage which does not disrupt a patient's normal electrolyte and water-retention balance, to inhibit myocardial fibrosis, including left ventricular hypertro... | 07/25/2000 |
| 6083940 | Method and composition for effecting contraception in a mammalian male Novel antiandrogenic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R1 through R10, a and b are as defined herein. Pharmaceutical compositions and methods for using the compo... | 07/04/2000 |
| 6043235 | 11ଲ-aryl-17, 17-spirothiolane-substituted steroids The invention is directed to 11ଲ-aryl-17,17-spirothiolane substituted steroid compounds of formula (I) exhibiting binding to the progestin receptor. ##STR1## Also disclosed are methods of using and process of making the compounds.... | 03/28/2000 |
| 6008210 | Use of aldosterone antagonists to inhibit myocardial fibrosis This invention discloses a method of inhibiting myocardial fibrosis by administering epoxymexrenone at a dosage which does not substantially increase sodium excretion by the body.... | 12/28/1999 |
| 5990099 | Angiostatic agents and methods and compositions for controlling ocular hypertension Compositions of angiostatic agents for treating GLC1A glaucoma and methods for their use are disclosed.... | 11/23/1999 |
| 5980940 | Pharmaceutical combination preparation for hormonal contraception The invention provides a pharmaceutical combination preparation with two hormone components in a packaging unit and intended for time-sequential oral administration, comprising a number of daily dosage units physically separate and individually removable ... | 11/09/1999 |
| 5854230 | Antiandrogenic agents and related pharmaceutical compositions and methods of use Novel antiandrogenic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R1 through R10, a and b are as defined herein. Pharmaceutical compositions and methods for using the compo... | 12/29/1998 |
