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| Number | Title | Issue Date |
| 7879792 | Synthetic peptide inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4 The invention relates to synthetic peptide analogs of D-Arg-Oic-Pro-Gly-Phe and methods of their use to inhibit human platelet aggregation, thrombosis and cell activation mediated by PAR1 and PAR4. ... | 02/01/2011 |
| 7838497 | Pro-angiogenic peptides This present invention generally relates to peptides, compositions, treatment methods, and devices useful for the medical diagnosis and treatment of pathogenic disorders. More specifically, the invention relates to immunostimulatory peptides which can stimulate the ... | 11/23/2010 |
| 7833984 | Peptide inhibitors of protein kinase C PKC V5 isozyme-specific peptides are described. The sequences and compositions comprising the sequences are useful for treating disease states associated with the PKC isozyme from which they are respectively derived. Methods of treatment, pharmaceutical formulations... | 11/16/2010 |
| 7820625 | UV-induced dermatitis inhibitor and atopic dermatitis inhibitor At least one substance selected from the group consisting of a water-soluble peptide comprising at least one unit selected from the group consisting of an isoleucylglycylseryl unit, a prolylisoleucylglycylseryl [SEQ ID NO: 2] unit, a glycylprolylisoleucylglycylseryl... | 10/26/2010 |
| 7820624 | Peptide ligands A peptide consisting of or comprising an amino acid sequence selected from a) PX1X2X3T [SEQ.ID.NO.:1]; b) PSX4S [SEQ.ID.NO.:2]; c) QX5X6 | 10/26/2010 |
| 7803775 | Protein kinase C peptides for use in withdrawal A method for managing withdrawal from an addictive substance is described. The method involves administering one or more peptides having specific activity for the ε and/or γ isozyme of protein kinase C (PKC). The peptide(s) can be administered prior to, concurrent... | 09/28/2010 |
| 7803774 | Modulators of β-amyloid peptide aggregation Compounds that modulate natural β amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a β amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid... | 09/28/2010 |
| 7795225 | Anti-chrondrosarcoma compounds The invention provides inhibitors of chondrosarcoma cell growth that are useful as anti-cancer and anti-tumor agents. The inhibitors are peptides having sequences related to cleavage regions of the proenzyme forms of matrix metalloproteinases and that can inhibit th... | 09/14/2010 |
| 7727960 | C5a receptor antagonists The invention relates to a C5a receptor antagonist of structure (I), wherein X1 is a radical having a mass of about 1-300 and stands for R5-, R5-CO—, R5-N(R6)-CO—, R5-O—CO—, R5-SO2—, R5-N(R6)-SO2—, R5-N(R6)-, R5-N(R6)-CS—, R5-N(R6... | 06/01/2010 |
| 7723305 | Abuse-resistant amphetamine prodrugs The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds ... | 05/25/2010 |
| 7718619 | Abuse-resistant amphetamine prodrugs The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds ... | 05/18/2010 |
| 7713936 | Abuse-resistant amphetamine prodrugs The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds ... | 05/11/2010 |
| 7700561 | Abuse-resistant amphetamine prodrugs The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds ... | 04/20/2010 |
| 7700560 | Inactivators and bivalent inhibitors of glyoxalase I and methods of inhibiting tumor growth Compounds comprising two human GlxI inhibitors covalently linked via a chemical linker are provided, wherein each of said two human GlxI inhibitors, which may be the same or different, is an S-substituted glutathione or an S-substituted glutathione prodrug, wherein ... | 04/20/2010 |
| 7691818 | Peptidomimetic inhibitors of retroviral proteases and their use as antivirals New peptidomimetic inhibitors of retroviral proteases are in particular for human immunodeficiency virus (HIV) protease. These inhibitors include as the core structure a new diamiriodiol isostere of the dipeptide Phe-Pro having four stereogenic centers. The inhibito... | 04/06/2010 |
| 7687467 | Abuse-resistant amphetamine prodrugs The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds ... | 03/30/2010 |
| 7687466 | Abuse-resistant amphetamine prodrugs The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds ... | 03/30/2010 |
| 7678770 | Abuse-resistant amphetamine prodrugs The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds ... | 03/16/2010 |
| 7678771 | Abuse-resistant amphetamine prodrugs The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds ... | 03/16/2010 |
| 7674774 | Abuse-resistant amphetamine prodrugs The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds ... | 03/09/2010 |
| 7671030 | Abuse-resistant amphetamine prodrugs The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds ... | 03/02/2010 |
| 7671031 | Abuse-resistant amphetamine prodrugs The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds ... | 03/02/2010 |
| 7671029 | Compositions and methods for enhanced pharmacological activity of compositions comprising peptide drug substances Pharmaceutical agents, compositions containing the same and methods for their use for enhancing the bioavailability and pharmacological efficacy of therapeutic peptides. The pharmaceutical agents have the formula Carrier-Linker-Peptide Wherein Pe... | 03/02/2010 |
| 7671028 | Peptides that antagonize FPR class receptor mediated signaling The present application discloses W-rich peptide that is useful for inhibiting FPR class receptor activity. ... | 03/02/2010 |
| 7662785 | Selective high affinity polydentate ligands and methods of making such This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the... | 02/16/2010 |
| 7662787 | Abuse resistant lysine amphetamine compounds The present invention describes compounds, compositions and methods of using the same comprising lysine covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds and ... | 02/16/2010 |
| 7662788 | Abuse-resistant amphetamine prodrugs The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds ... | 02/16/2010 |
| 7662786 | Dolastatin 15 derivatives Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and... | 02/16/2010 |
| 7659253 | Abuse-resistant amphetamine prodrugs The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds ... | 02/09/2010 |
| 7659254 | Abuse-resistant amphetamine prodrugs The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds ... | 02/09/2010 |
| 7655630 | Abuse-resistant amphetamine prodrugs The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for reducing or preventing abuse and overdose of amphetamine. These compounds ... | 02/02/2010 |
| 7635682 | Tumor activated prodrugs The instant invention provides compositions comprising a prodrug, the prodrug comprising a therapeutically active drug; and a peptide selected from the group consisting of the sequences: Ser-Ser-Lys-Tyr-Gln (SEQ ID NO:1);Gly-Lys-Ser-Gln-Tyr-Gln (SEQ ID NO:2); and Gl... | 12/22/2009 |
| 7595299 | Peptides as NS3-serine protease inhibitors of hepatitis C virus The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as metho... | 09/29/2009 |
| 7579322 | Compositions and methods for promoting myocardial and peripheral angiogenesis Methods, compositions and devices are disclosed for use in growing new blood vessels to restore or improve blood flow to ischemic tissues and organs of the body. Compositions comprising IGD peptides, particularly GGIGDGG, are able to induce migration in human endoth... | 08/25/2009 |
| 7550438 | Methods for production of growth-promoting proteins and peptides for kidney epithelial cells Novel growth peptides derived from protein factors having molecular weights of about 22 and 45 kDa stimulate mitogenic activity of epithelial, but not fibroblastic cells, in particular, kidney epithelial cells. A source of the factors is scrape-wounded kidney epithe... | 06/23/2009 |
| 7550437 | Compositions for preventing and treating digestive organs diseases The present invention provides a composition for safely and effectively preventing and treating digestive organs diseases, particularly, gastric ulcer, duodenal ulcer, gastritis, diarrhea, enteritis and the like. There is also provided a composition having a novel m... | 06/23/2009 |
| 7541339 | Par-2-activating peptide derivative and pharmaceutical composition using the same The present invention relates to a peptide derivative represented by the general formula (I) or a salt thereof: Z-(CH2)n—CO—NH-Leu-Ile-Gly-AA1-AA2-CO—R (I) wherein Z represents an aryl group which may or may not have... | 06/02/2009 |
| 7517857 | Immune-modulating peptide Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds to formyl peptide receptor or formyl peptid... | 04/14/2009 |
| 7491702 | Polypeptides related to amyloid precursor protein, pharmaceutical compositions thereof, and methods of treatment using the same The invention provides compounds having formulae comprising X1-Ser-Met-Arg-Glu-Arg-X2 in which X1 and X2 are up to 30 amino acid residues and the formula represents a reverse-order sequence correspondin... | 02/17/2009 |
| 7439231 | Inhibitors of antigen presentation by MHC class II molecules and methods of use thereof The present invention relates to compounds, pharmaceutical compositions containing such compounds and methods for their use. In particular, the compounds of the invention are useful for the treatment or prevention of diseases associated with T cell proliferation suc... | 10/21/2008 |
