...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 7638506 | Granular agrochemical composition Provided is a granular agrochemical composition by which the problems accompanying the prior art granular agrochemical compositions can be overcome, which can be prepared in a simple formulation and by which sustained releasability of the agrochemically active ingre... | 12/29/2009 |
| 7347984 | Mammalian agmatinase inhibitory substance The present invention provides for methods and compounds for treating brain trauma and disorders such as: ischemia, stroke, neurodegenerative disorders, opioid addiction, idiopathic pain, epilepsy, and depression. More specifically, the invention provides methods fo... | 03/25/2008 |
| 7320967 | Cosmetic composition, method of cosmetic treatment and preparation of a composition for promoting the growth and/or preventing or delaying the loss of hair The invention relates to a cosmetic composition containing at least one 15-hydroxy-prostaglandin dehydrogenase inhibitor and cosmetically acceptable excipients. It also relates to a method of cosmetic treatment for promoting the growth and/or preventing or delaying ... | 01/22/2008 |
| 7211696 | Antileishmanial dinitroaniline sulfanomides with activity against parasite tubulin Dinitroaniline compounds useful for the treatment of diseases caused by parasitic protozoa in subjects in need of such treatment. The compounds are particularly useful in the treatment of leishmaniasis. The compounds are preferably less cytotoxic to normal cells tha... | 05/01/2007 |
| 7048937 | Methods and compositions for control of coccidiosis Feeding yeast cell wall-containing compositions, including those compositions comprising mannanoligosaccharide(s), to animals exposed to or infected with coccidia, especially poultry exposed to pathogenic species of Eimeria, results in improved livestock perf... | 05/23/2006 |
| 7001924 | Inhibitors of RNase P proteins as antibacterial compounds The present invention features compounds useful for inhibiting RNase P activity. These compounds can be used as therapeutics for treating or preventing a variety of bacterial infections. The compounds belong to several classes including mono- and bis-guanylhydrazone... | 02/21/2006 |
| 6974593 | Insoluble drug delivery Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercriti... | 12/13/2005 |
| 6974825 | Compounds with analgesic effect Compounds of general formula (I) wherein m is 0 or 1, and n is 1 or 2; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical compositions comp... | 12/13/2005 |
| 6777000 | In-situ gel formation of pectin In-situ gelation of a pectic substance. Composition, method of preparation, and method of use of a pectin in-situ gelling formulation for the delivery and sustained release of a physiologically active agent to the body of an animal. The pectin can be isolated from A... | 08/17/2004 |
| 6573254 | Method for the stimulation of sperm production and gonadal development in animals Disclosed is a method to stimulate or enhance sperm development in males and gonadal development in females by administration of an agent which results in a transiently level of a thyroid hormone such as T3 and increased gonadotropin levels in ... | 06/03/2003 |
| 6432935 | Pharmaceutical compositions, mainly vaginal suppository, containing many different active ingredients Compositions comprising an antibiotic, sulphonamide, at least one an antiquagul agent, e.g., clotrimazol (bis-phenyl-(2-chlorophenyl)-1-imidazolyl-methane), natamycin, or nystatin,and 5-nitro-metronidazol (5-nitro-inidazoles) e.g., (metronidazol or t... | 08/13/2002 |
| 6180633 | Drug resistance and multidrug resistance modulators Drug and multidrug resistant modulators of the formula: ##STR1## where R1 and R2 are independently hydrogen or halo; A is --CH2 --CH2 --, --CH2 --CHR4 --CH2 --, or --CH2 | 01/30/2001 |
| 5725875 | Protective skin composition A protective cream composition contains 15 to 40 wt % of an alkali metal fatty acid salt having from 8 to 18 carbon atoms, an effective amount of a topical agent such as an antimicrobial compound, 5 to 20 wt. % of a polyol effective as an emollient, 0.5 t... | 03/10/1998 |
| 5370876 | Antimicrobial protective skin composition and method for protecting skin from body fluids A protective cream composition contains 15 to 40 wt. % of an alkali metal fatty acid salt having from 8 to 18 carbon atoms, an effective amount an antimicrobial compound, 5 to 20 wt. % of a polyol effective as an emollient, 0.5 to 8.0 wt. %, of an alkali ... | 12/06/1994 |
| 5335675 | Stress-softened elastomeric films, articles, and method and apparatus for making such films and articles A stress-softened thermoplastic elastomeric (TPE) film which has been subjected to tensional deformation comprising at least uniaxial strain, and having improved textural and thermal transmissivity characteristics, as compared to a native, unstretched mat... | 08/09/1994 |
| 5330980 | Medicament for the topical treatment of skin A medicament for the topical treatment of burned, irritated, ulcered, chafed, or infected, skin, a method of making the medicament, and a method of use of the medicament, the medicament comprising: about 70.6% by weight of Petrolatum U.S.P.(Vaseline); abo... | 07/19/1994 |
| 5273970 | Treatment of protozoal diseases The antibacterial substance baquiloprim (2,4-diamino-5-[8-dimethylamino-7-methyl-5-quinolylmethyl]pyrimidine) is shown to be active against protozoal infections, e.g. toxoplasmosis. Preferably the baquiloprim is administered together with a sulphonamide.... | 12/28/1993 |
| 5258373 | Anticoccidial compositions Compositions comprising a mixture of the antibiotic frenolicin B with a potentiated sulfonamide anticoccidial agent, useful for the treatment and prevention of coccidiosis in animals and methods of treating coccidiosis are disclosed.... | 11/02/1993 |
| 5179127 | Halopropargyl acyl compound, compositions, microbicidal uses and processes of preparation Compounds of the formula ##STR1## wherein A is selected from the group consisting of (1) phenyl, (2) naphthyl, (3) phenyl substituted with one or more halo, cyano, (C1 -C4)alkyl, nitro, (C1 -C4)haloalkyl, a... | 01/12/1993 |
| 5135924 | Therapeutic treatment of animals with oral administration of ormetoprim-potentiated sulfonamides Systemic bacterial infections caused by aerobic and anaerobic organisms in companion animals such as dogs can be treated effectively and conveniently by the oral administration on a once a day basis of an antibacterial combination of ormetoprim and a sulf... | 08/04/1992 |
| 5096896 | Sustained release compositions A non-crosslinked derivative formable by reacting at least one substituted or unsubstituted, saturated or unsaturated, mono-, di- or poly-carboxy, hydroxy or mercapto hydrocarbon with at least one cyclic unsaturated (thio)ether.... | 03/17/1992 |
| 5063219 | Anticoccidial composition Compositions comprising a mixture of a 2,4-diamino-5-(trisubstituted)benzyl-pyrimidine potentiated sulfonamide antibiotic with an ionophorous polyether anticoccidial agent are useful for the treatment and prevention of coccidiosis in animals.... | 11/05/1991 |
| 5013306 | Anti-infective and antithrombogenic medical articles and method for their preparation An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine permeated into the surface or it may be an antibiotic, antithr... | 05/07/1991 |
| 4999210 | Anti-infective and antithrombogenic medical articles and method for their preparation An anti-infective medical article has chlorhexidine bulk distributed throughout a polyurethane base layer and may have a coating layer on the base layer. The coating layer may be chlorhexidine, an antibiotic, or an antithrombogenic agent permeated into th... | 03/12/1991 |
| 4996198 | Anticoccidial composition Compositions comprising a mixture of a 2,4-diamino-5-(trisubstituted)benzyl-pyrimidine potentiated sulfonamide antibiotic with an ionophorous polyether anticoccidial agent are useful for the treatment and prevention of coccidiosis in animals.... | 02/26/1991 |
| 4956354 | Therapeutic preparation for use on skin A therapeutic preparation for the treatment of skin problems. More particularly, the preparation is a mixture including almond oil, sulfathiazole, water and paraffin wax.... | 09/11/1990 |
| 4931433 | Method for treating certain neoplastic diseases Compounds of formula I are formulated with a pharmaceutical carrier for the treatment of neoplastic disease sensitive to treatment with the compounds in animals including humans. ##STR1## wherein: Y is a substituent attached to any of the unsubstitut... | 06/05/1990 |
| 4871722 | Synergistic veterinary composition and/or fodder premix and process for preparing same The invention relates to a synergistic veterinary composition and/or a fodder premix useful for preventing or curing bacterial, fungal and protozoic infection particularly occurring at poultry species. Furthermore the invention relates to a process for pr... | 10/03/1989 |
| 4818753 | Synthesis and method of use for 2, 4 diaminoquinazoline Compounds of the formula ##STR1## wherein R1 is H, methyl, ethyl, or chloro and R2 is hydrocarbyl of 1-12 C are useful as antifungal agents. Compounds of this series wherein R2 is 7-12 C are novel. A new synthetic met... | 04/04/1989 |
| 4792551 | 9-anthryloxyaminoalkanes and related compounds as anti-inflammatory and analgetic agents Compounds useful for treating inflammation, pain and swelling, represented by the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: Y and Z are each independently halo, alkyl or alkoxy; l and m are each indep... | 12/20/1988 |
| 4781920 | Anthelmintic paste compositions containing resinates of d1-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole The invention provides physically stable anthelmintic paste compositions containing resinates of d1-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole and other anthelmintic compounds in combination with a wide variety of therapeutic agents such as an... | 11/01/1988 |
| 4735959 | Carboxylic acid amides and pharmaceutical compositions containing them There are described novel carboxylic acid derivatives of the formula ##STR1## and derivatives of the formula ##STR2## and the addition salts thereof, which exhibit an effect on the intermediary metabolism. Furthermore, the compounds of Formula I... | 04/05/1988 |
| 4696921 | Antimalarial pharmaceutical compositions Mixtures of active substances and pharmaceutical compositions useful in malaria therapy comprising a quinolinemethanol derivative of the formula ##STR1## wherein R1 is hydrogen, fluorine, chlorine, bromine, methyl or trifluoromethyl, R | 09/29/1987 |
| 4677143 | Antimicrobial compositions Antimicrobial compositions finding particular utility for coating access systems, lead devices including shunts, cannulae, catheters, catheter adapters, wires and other solid or hollow tubular devices used for a variety of medical purposes is provided. Th... | 06/30/1987 |
| 4654323 | Method and composition for the therapeutic and prophylactic treatment of trauma to the skin A novel method and composition are disclosed for the therapeutic and prophylatic treatment of trauma to the skin. In particular, burns, sunburn and frostbite are treated with compounds that have the ability to interfere with the action of calcium calmodul... | 03/31/1987 |
| 4612337 | Method for preparing infection-resistant materials An infection-resistant polymeric material, such as polytetrafluoroethylene, for use on or within a human or animal body, for example, in the form of a vascular graft, can be prepared by an improved method which comprises the following sequence of steps: (... | 09/16/1986 |
| 4599226 | Wound dressing comprising silver sulfadiazine incorporated in animal tissue and method of preparation Animal tissue and the like having silver sulfadiazine incorporated therein is useful as a covering for burns and/or wounds. The silver sulfadiazine is incorporated in the tissue by soaking the tissue in an ammoniacal silver sulfadiazine solution or suspen... | 07/08/1986 |
| 4581028 | Infection-resistant materials and method of making same through use of sulfonamides Infection-resistant materials, and methods of preparing same, suitable for use within the interior of a human or animal body in such forms as vascular grafts prostheses, or other implanted devices. The material is rendered infection-resistant by incorpora... | 04/08/1986 |
| 4579731 | Polymeric diffusion burn matrix and method of use A protective skin matrix is provided which is particularly suited for the protection of burned or wounded patients. The matrix may be either cured, applied in sheets, or painted or sprayed directly onto the burned or wounded patient. The protective skin m... | 04/01/1986 |
| 4562211 | Pharmaceutically active 2-substituted-1-(omega-aminoalkoxy)benzenes 2-Substituted-1-(omega-aminoalkoxy)benzenes are prepared and found useful as pharmaceutical agents, particularly as antidepressants.... | 12/31/1985 |