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| Number | Title | Issue Date |
| 7964585 | Composition and method of treating peripheral neuropathy A method of treating diabetic neuropathy in a subject includes administering to a subject having diabetes or at risk of diabetes a therapeutically effective amount of a pharmaceutical composition comprising at least one of sulfasalazine or a composition including 5-... | 06/21/2011 |
| 7435408 | Porous particles comprising excipients for deep lung delivery Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm... | 10/14/2008 |
| 7232811 | Furosemide modulators of HM74 Host cells expressing HM74 were used to obtain furosemide-like molecules with agonist activity having the following structure formula: ... | 06/19/2007 |
| 7232812 | Substituted azetidine compounds, their preparation and use as medicaments The present invention relates to substituted Azetidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals. ... | 06/19/2007 |
| 7135465 | Sustained release beadlets containing stavudine Extended dosage forms of stavudine are provided comprising beadlets formed by extrusion-spheronization and coated with a seal coating. The beadlets are also coated with a modified release coating such that a hard gelatin capsule containing such beadlets will provide... | 11/14/2006 |
| 7132294 | Functionalized small molecules for use in chemical sensors The invention provides a device for selective molecular recognition, the device comprising a sensing portion, wherein said sensing portion includes a substrate having coated thereon a layer comprising a non-volatile, small molecule compound having at least two penda... | 11/07/2006 |
| 7071177 | P-(sulfonyl) aryl and heteroarylamines as anti-inflammatory agents This invention relates to anti-inflammatory and analgesic compounds, especially to certain p-(sulfonyl)phenyl amino derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds. ... | 07/04/2006 |
| 7067556 | Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use Topical compositions which include urea and an antimicrobial agent, particularly sulfacetamide, are described. Sulfacetamide compositions further including sulfur are also described. Methods for treating dermatological disorders using the compositions are also descr... | 06/27/2006 |
| 6753298 | Agents for combating Neospora spec Compositions for controlling diseases caused by protozoans of the genus Neospora, which are characterized in that they comprise one or more active compounds which inhibit the microtubulin system of plants. ... | 06/22/2004 |
| 6342510 | Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitors and a leukotriene B4 receptor antagonist Combinations of a cyclooxygenase-2 inhibitor and a leukotriene B4 receptor antagonist are described for treatment of inflammation and inflammation-related disorders.... | 01/29/2002 |
| 6291442 | Pharmacological modulators of voltage-gated potassium ion channels Disclosed herein is the discovery that an allosteric receptor site exists on the intracellular surface of Shaker class voltage-gated potassium ion channels that is distinct from the pore and is involved in regulating gating of the pore. A class of compoun... | 09/18/2001 |
| 6211185 | Concentrate comprising a sulfonamide in solution, a 2,4-diaminopyrimidine in stable suspension within said solution, and a suspending agent A palatable antimicrobial drug concentrate comprising: (a) a sulfonamide and/or sulfonamide salt in aqueous solution; (b) a 2,4-diaminopyrimidine in stable suspension within said solution; and (c) a suspending agent. The invention has a long room temperat... | 04/03/2001 |
| 6194399 | Aryldiamine derivatives useful as antibacterial agents Disclosed are pharmaceutical compositions and formulations comprising the compound: ##STR1## wherein: (a) R1, R2, R3, and R4 are independently selected from the group consisting of hydrogen, or optionally substi... | 02/27/2001 |
| 6165483 | Peroxy acid treatment to control pathogenic organisms on growing plants Both a process and a method of using peracid compositions, especially mixed peracid systems, to treat field or greenhouse grown plant tissue, seeds, fruits, and growing media and containers. The peracid can lower the natural, plant pathogen and human path... | 12/26/2000 |
| 6004948 | Derivatives of benzosulphonamides as inhibitors of the enzyme cyclooxygenase II Compounds of the formula (I) in which A is oxygen, sulphur or NH; B is a group of the formula (IIa) or (IIb); and the other variables have the meaning given in claim 1, may be used as inhibitors of the enzyme cyclooxygenase II ##STR1##... | 12/21/1999 |
| 5955458 | Penicillin glycolate New solvates of penicillin, in particular amoxycillin glycolate has been provided for together with a simple one-step process to prepare the same.... | 09/21/1999 |
| 5824661 | Sulfur-containing phosphonate compounds, pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism Compounds of the formula ##STR1## where m and n are integers 0 to 10 and m+n equals 0 to 10, (a) X is O or S (b) Z is a covalent bond; a monocyclic or polycyclic carbocycle ring moiety; or a monocyclic or polycyclic heterocyclic ring moiety containing ... | 10/20/1998 |
| 5814623 | Parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl-6-quinazoline sulfonamides Disclosed herein are parenteral solutions containing 7-halo-1,2,3, 4-tetrahydro-3-aryl-6-quinazoline sulfonamide in Tris or Bis-Tris or Tris buffer useful in the treatment of hypertension, heart disease and heart failure and renal disease. Also disclosed ... | 09/29/1998 |
| 5723452 | Therapeutic benzonitriles The present invention relates to novel compounds of formula (I): ##STR1## or a physiologically functional derivative thereof, pharmaceutical formulations containing them, processes for their preparation and their use in therapy for the prophylaxis or... | 03/03/1998 |
| 5633240 | Parenteral solutions containing metolazone Disclosed herein are parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl-6-quinazoline sulfonamide in Tris or Bis-Tris or Tris buffer useful in the treatment of hypertension, heart disease and heart failure and renal disease. Also disclosed a... | 05/27/1997 |
| 5273970 | Treatment of protozoal diseases The antibacterial substance baquiloprim (2,4-diamino-5-[8-dimethylamino-7-methyl-5-quinolylmethyl]pyrimidine) is shown to be active against protozoal infections, e.g. toxoplasmosis. Preferably the baquiloprim is administered together with a sulphonamide.... | 12/28/1993 |
| 5189031 | Urea derivatives, compositions and use The invention concerns novel (oxamido- and ureido-phenylsulfonyl)nitromethane derivatives and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain per... | 02/23/1993 |
| 5110808 | Amide derivatives, compositions and use The invention concerns novel (oxamido- and ureido-phenylsulfonyl)nitromethane derivatives and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain per... | 05/05/1992 |
| 5084449 | Anti-bacterial compositions comprising a substituted bis-(4-aminophenyl)-sulfone and a dihydro-folic acid reductase Disclosed are substituted bis(4-aminophenyl-sulfonees of general formula ##STR1## wherein R1 is hydrogen, alkyl or cycloalkyl; group, R2 is hydrogen or C1 -C3 alkyl, R3 is nitrile, C1 -C3 | 01/28/1992 |
| 5075108 | Melphalan derivatives A compound of formula I ##STR1## wherein R1 is of formula II ##STR2## wherein R4 and R5, which may be the same or different, are bromo, chloro, iodo or alkylsulphonyl; R2 is of formula III ##STR3#... | 12/24/1991 |
| 5053228 | Polymeric temperature sensitive drug carrier The drug carrier of this invention provides a temperature-sensitive polymer chemically bonded to a drug. The drug carrier is capable of releasing a drug continuously in the body. The drug carrier is a liquid when administered and becomes solid in the body... | 10/01/1991 |
| 5026690 | Antiviral agent The present invention relates to the use of sulphonamide derivatives for the treatment of diseases caused by viruses, especially caused by enclosed viruses such as, e.g., herpes simplex, as well as to an antiviral agent having a content of these sulphonam... | 06/25/1991 |
| 5008255 | Method for enhancing solubility of trimethoprim with sodium sulfacetamide, and synergistic pharmaceutical compositions derived therefrom A method of preparing aqueous pharmaceutical compositions containing a synergistic combination of trimethoprim and sodium sulfacetamide is described. The method results in a significant improvement in the aqueous solubility of trimethoprim due to a favora... | 04/16/1991 |
| 4992430 | Anti-bacterial compositions comprising a substituted bis-(4-aminophenyl)-sulfone and a dihydro-folic acid reductase Disclosed are substituted bis(4-aminophenyl)-sulfones of general formula ##STR1## wherein R1 is hydrogen, alkyl or cycloalkyl; group, R2 is hydrogen or C1 -C3 alkyl, R3 is nitrile, C1 -C3 | 02/12/1991 |
| 4985417 | Treatment of glaucoma Method and formulation useful in treatment of glaucoma in a mammal wherein an effective amount of an active water soluble carbonic anhydrase inhibitor is administered, said inhibitor being a compound having the formula ##STR1## or a pharmaceutic... | 01/15/1991 |
| 4981873 | Substituted sulphonamides, pharmaceuticals thereof and methods of using them The present invention concerns compounds of the formula: ##STR1## where R1 is an alkyl or alkenyl radical containing up to 6 carbon atoms, a cycloalkyl radical containing 3 to 7 carbon atoms, an aralkyl, aralkenyl or aryl radical in which ... | 01/01/1991 |
| 4855289 | Combination of two active substances The invention concerns the use of a compound with diuretic properties and of a magnesium supplementation in the form of magnesium monoaspartate hydrochloride, magnesium oxide, magnesium hydroxide or magnesium carbonate, and optionally of a potassium suppl... | 08/08/1989 |
| 4849563 | Novel 1-alkyl-1-arenesulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity Compounds of the formula: ##STR1## wherein R1 s an alkyl of 1-6 carbon atoms, benzyl, phenyl, or phenyl substituted by halogen, alkoxy of 1 to 4 carbon atoms, alkyl of 1 to 4 carbon atoms, amino, or carbonyl substituents, or --RN(R')2... | 07/18/1989 |
| 4829058 | Substituted bis-(4-aminophenyl)-sulfones Disclosed are substituted bis(4-aminophenyl)-sulfones of general formula ##STR1## wherein R1 is hydrogen, alkyl or cycloalkyl; group, R2 is hydrogen or C1 -C3 alkyl, R3 is nitrile, C1 -C3 | 05/09/1989 |
| 4818753 | Synthesis and method of use for 2, 4 diaminoquinazoline Compounds of the formula ##STR1## wherein R1 is H, methyl, ethyl, or chloro and R2 is hydrocarbyl of 1-12 C are useful as antifungal agents. Compounds of this series wherein R2 is 7-12 C are novel. A new synthetic met... | 04/04/1989 |
| 4769447 | Gamma-Glutamyl-4-azoanilides The present invention provides gamma-glutamyl-4-azoanilides, processes for their preparation and their use as substrates for gamma-glutamyl transferase determination, of the formula ##STR1## wherein X is alkyl, --(CH2)m --COOH o... | 09/06/1988 |
| 4761430 | Arylbenzenesulfonamide containing pharmaceutical compositions The invention relates to new medicaments having lipid regulating properties nd processes for their preparation. The medicaments according to the invention contain as active principle at least one compound, (or its corresponding optical isomer) of the aryls... | 08/02/1988 |
| 4735959 | Carboxylic acid amides and pharmaceutical compositions containing them There are described novel carboxylic acid derivatives of the formula ##STR1## and derivatives of the formula ##STR2## and the addition salts thereof, which exhibit an effect on the intermediary metabolism. Furthermore, the compounds of Formula I... | 04/05/1988 |
| 4652556 | Fungicidal N-cyanoalkyl-N-haloalkylthio sulfonamides Compounds of the formula: ##STR1## wherein R is aryl of 6 to 12 carbon atoms or aralkyl of 7 to 14 carbon atoms either optionally substituted with 1 to 3 substituents independently selected from lower alkyl of 1 to 6 carbon atoms, lower alkoxy of 1 t... | 03/24/1987 |
| 4621100 | Treatment of osteoporosis with prostaglandins The present invention provides a novel method for treating osteoporoses, joint and dental diseases and increasing the rate of bone healing by orally administering certain prostaglandins. Further provided are novel compositions employing these prostaglandi... | 11/04/1986 |
