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| Number | Title | Issue Date |
| 7960366 | Substituted tetracycline compounds as synergistic antifungal agents Methods and compositions for treating for the synergistic treatment of fungal associated disorders are discussed. ... | 06/14/2011 |
| 7879828 | Tigecycline compositions and methods of preparation The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these compositions. These compositions comprise tigecycline, a suitable carbohydrate, and an acid or buffer. ... | 02/01/2011 |
| 7732429 | Reducing tetracycline resistance in living cells The present invention provides an improved methodology by which therapeutically to overcome resistance to tetracycline in living cells including bacteria, parasites, fungi, and rickettsiae. The methodology employs a blocking agent such as C5 ester derivatives, or 6-... | 06/08/2010 |
| 7435380 | Pseudo-plastic or thixotropic liquid deodorant product for ostomy pouches A pseudo-plastic or thixotropic carrier having anti-malodorous components dissolved or suspended therein is sprayed on the internal surfaces of an ostomy bag or pouch. The viscoelastic properties of the carrier allow the composition to be conveniently dispensed from... | 10/14/2008 |
| 7425573 | Use of annellated pyrrole compounds in the treatment of articular cartilage or subchondral bone degeneration Treating or preventing degeneration or destruction of articular cartilage and/or subchondral bone in the affected joint of a mammal is accomplished by administering a compound of formula (I), wherein the variables have the meanings given in the present description. ... | 09/16/2008 |
| 7414041 | Reducing tetracycline resistance in living cells The present invention provides an improved methodology by which therapeutically to overcome resistance to tetracycline in living cells including bacteria, parasites, fungi, and rickettsiae. The methodology employs a blocking agent such as C5 ester derivatives, or 6-... | 08/19/2008 |
| 7345024 | Pharmaceutical preparation, method for its production as well as its use The invention relates to hardly soluble antiphlogistic salts and antiphlogistic-antibiotic pharmaceutical preparations and their use. The hardly water soluble antiphlogistic antibiotics salts have as their cationic component one of the antibiotics gentamicin, clinda... | 03/18/2008 |
| 7253183 | Method of use of (imidazol-5-yl)methyl-2-quinolinone derivatives to inhibit smooth muscle cell proliferation This invention comprises the use of compounds of formula (I) wherein the dotted line represents an optional bond; X is oxygen or sulfur; R1 is hydrogen, C1-12alkyl, Ar1, Ar2 | 08/07/2007 |
| 7238342 | Irrigation solution and methods for use Methods and solutions are provided for removal of the smear layer on prepared tooth and bone surfaces, especially in endodontic environments. ... | 07/03/2007 |
| 7226937 | Methods for modulating phototoxicity The invention relates to methods for modulating photodamage via the use of collagen derived molecules which either enhance or inhibit damage caused by ultraviolet light. ... | 06/05/2007 |
| 7112578 | Methods and compositions for treatment of inflammatory disease Compositions useful for treating inflammatory diseases including arthritis are disclosed which comprise cetyl myristoleate compounds or related compounds and at least one compound useful for treatment of inflammatory disease, such as tetracycline compounds, Cox-2 in... | 09/26/2006 |
| 7053073 | Treatment for reactive arthritis or bursitis A treatment for conditions in human beings associated with either or both reactive arthritis or bursitis comprising a combination of valacyclovir hydrochloride, minocycline hydrochloride, and metronidazole. ... | 05/30/2006 |
| 7026136 | Methods of reducing microbial resistance to drugs The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of sc... | 04/11/2006 |
| 6765000 | Treatment for reactive arthritis or bursitis A treatment for conditions in human beings associated with either or both reactive arthritis or bursitis comprising a combination of acyclovir, minocycline hydrochloride, and metronidazole. An alternate treatment comprises the combination of valacyclovir hydrochlori... | 07/20/2004 |
| 6756365 | Reducing tetracycline resistance in living cells The present invention provides an improved methodology by which therapeutically to overcome resistance to tetracycline in living cells including bacteria, parasites, fungi, and rickettsiae. The methodology employs a blocking agent such as C5 ester derivatives, or 6-... | 06/29/2004 |
| 6743805 | Method of use of (imidazol-5-yl)methyl-2-quinolinone derivatives to inhibit smooth muscle cell proliferation This invention comprises the use of compounds of formula (I) wherein the dotted line represents an optional bond; X is oxygen or sulfur; R1 is hydrogen, C1-12alkyl, Ar1, Ar2C | 06/01/2004 |
| 6733764 | Immunostimulator anti-cancer compounds and methods for their use in the treatment of cancer The present invention comprises a method for the treatment of cancerous tumors in mammals comprising the administration of an effective amount of an immunostimulator which enhances and potentiates the mammals own immune system to selectively attack and kill the canc... | 05/11/2004 |
| 6734194 | Method of use of (imidazol-5-yl)methyl-2-quinolinone derivatives to inhibit smooth muscle cell proliferation This invention comprises the use of compounds of formula (I) wherein the dotted line represents an optional bond; X is oxygen or sulfur; R1 is hydrogen, C1-12alkyl, Ar1, Ar2C | 05/11/2004 |
| 6677321 | Methods and compositions for treatment of inflammatory disease Compositions useful for treating inflammatory diseases including arthritis are disclosed which comprise cetyl myristoleate compounds or related compounds and at least one compound useful for treatment of inflammatory disease, such as tetracycline compound... | 01/13/2004 |
| 6602516 | Antibiotic/medicated gutta percha point The ability to incorporate iodoform, tetracycline and a combination of iodoform/tetracycline into root canal gutta percha points is described. The iodoform, tetracycline and iodoform/tetracycline combination are bound within the gutta percha points. They ... | 08/05/2003 |
| 6462025 | Antibiotic/benzoyl peroxide dispenser Two separate compositions, one containing an antibiotic and one containing benzoyl peroxide are packaged within and dispensed from a common dispenser. More particularly, a dual dispenser contains i) a first composition that is substantially anhydrous and ... | 10/08/2002 |
| 6432935 | Pharmaceutical compositions, mainly vaginal suppository, containing many different active ingredients Compositions comprising an antibiotic, sulphonamide, at least one an antiquagul agent, e.g., clotrimazol (bis-phenyl-(2-chlorophenyl)-1-imidazolyl-methane), natamycin, or nystatin,and 5-nitro-metronidazol (5-nitro-inidazoles) e.g., (metronidazol or t... | 08/13/2002 |
| 6365600 | (Imidazol-5-yl)methyl-2-quinolinone derivatives as inhibitors of smooth muscle cell proliferation This invention comprises the use of compounds of formula (I) ##STR1## wherein the dotted line represents an optional bond; X is oxygen or sulfur; R1 is hydrogen, C1-12 alkyl, Ar1, Ar2 C1-6 alkyl, quin... | 04/02/2002 |
| 6326364 | Use of 5-aminosalicylates as antimicrobial agents A method of inhibiting the growth of a bacterial species in a human or non-human vertebrate employs the antimicrobial (i.e., antibiotic) properties of 5-aminosalicylates. These antimicrobial properties are also employed in an antimicrobial method of inhib... | 12/04/2001 |
| 6277829 | Process for preparing of aqueous formulation for opthalmic use The present invention describes a process for the preparation of aqueous formulations containing azithromycin for ophthalmic use, as well any formulations obtained by this process and their topical use in the ocular bacterial infections, more preferably i... | 08/21/2001 |
| 6248730 | Enhancing the toxicity of warfarin in rodents The presence of a small amount of an antibiotic, such as tetracycline or a salt or derivative thereof, in warfarin-containing rodent baits enhances the toxicity of warfarin against rodents which have heretofore shown apparent resistance to warfarin.... | 06/19/2001 |
| 6114316 | Combination of bisphosphonate and tetracycline Tissue-destructive conditions related to excess protemase activity in a biological system are treated or prevented by administering to the system a composition which combines a tetracycline and a bisphosphonate in synergistic proteinase inhibiting amounts... | 09/05/2000 |
| 6100248 | Method of inhibiting cancer growth The invention is a method of inhibiting cancer growth, by inhibiting cellular proliferation, invasiveness, or metastasis, or by inducing cytotoxicity against cancer in mammals. The method employs 6-demethyl-6-deoxy-4-de(dimethylamino)tetracycline (CMT-3) ... | 08/08/2000 |
| 5998390 | Combination of bisphosphonate and tetracycline Tissue-destructive conditions related to excess proteinase activity in a biological system are treated or prevented by administering to the system a composition which combines a tetracycline and a bisphosphonate in synergistic proteinase inhibiting amount... | 12/07/1999 |
| 5989832 | Method for screening for non-tetracycline efflux pump inhibitors Methods are provided for screening for inhibitors of microbial efflux pumps including those which export antibiotics. The screening methods are based on the increase in the intracellular concentration of a compound, such as an antibiotic, when the bacteri... | 11/23/1999 |
| 5883074 | Potentiators of antibacterial agents Methods for screening for compounds which potentiate the activity of antibacterial agents against bacteria resistant to the antibacterial agent alone, pharmaceutical compositions including such potentiators, and methods of treating bacterial infections us... | 03/16/1999 |
| 5856315 | Methods for inhibiting proliferation of tumor cells and tumor growth The invention relates to a method for inhibiting angiogenesis and proliferation of endothelial cells by administering an inhibitory amount of 7-substituted amino!-9-(substituted glycyl)amido!-6-demethyl-6-deoxytetracycline of Formula I: ##STR1## ... | 01/05/1999 |
| 5843925 | Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth The invention relates to a method for inhibiting angiogenesis and proliferation of endothelial cells by administering an inhibitory amount of a 7-substituted amino!-9-(substituted glycyl)amido!-6-demethyl-6-deoxytetracycline of Formula I: ##STR1#... | 12/01/1998 |
| 5837696 | Method of inhibiting cancer growth The invention is a method of inhibiting cancer growth, including cellular proliferation, invasiveness, or metastasis in mammals. The method employs 6-demethyl-6-deoxy-4-dedimethylaminotetracycline (CMT-3) and other functionally related chemically modified... | 11/17/1998 |
| 5827543 | Methods and compositions for the prevention and treatment of urogenital disorders The subject invention encompasses methods for prevention and treatment of a human or lower animal subject having a urogenital disorder caused or mediated by one or more parasitic protozoa comprising administering to the subject bismuth and one or more ant... | 10/27/1998 |
| 5811412 | Reducing tetracycline resistance in living cells The present invention provides an improved methodology by which therapeutically to overcome resistance to tetracycline in living cells including bacteria, parasites, fungi, and rickettsiae. The methodology employs a blocking agent such as C5 ester derivat... | 09/22/1998 |
| 5744168 | Methods and compositions for the prevention and treatment of gastrointestinal disorders The subject invention encompasses methods for prevention and treatment of a human or lower animal subject having a gastrointestinal disorder caused or mediated by algae and/or cyanobacteria comprising administering to the subject bismuth and one or more a... | 04/28/1998 |
| 5674539 | Method of treating skin and composition A topical medication for the treatment of skin pathology including acne is comprised of tetracycline, minocycline, clindamycin, erythromycin, or doxicycline and selenium sulfide or sulfur in a pharmaceutically acceptable carrier. The lotion, cream or oint... | 10/07/1997 |
| 5674858 | Medicaments for treating gastrointestinal disorders The use is described of both (i) ranitidine bismuth citrate and (ii) one or more Helicobacter pylori-inhibiting antibiotics in treating or preventing gastrointestinal disorders. Pharmaceutical compositions containing both (i) and (ii) and methods for the ... | 10/07/1997 |
| 5618564 | Composition for the treatment of helicobacter pylori infection The present invention is directed to a method for the treatment of Helicobacter pylori infection wherein a composition containing protease and an antibacterial agent as active ingredients, which can remove Helicobacter pylori from a stomach at high probab... | 04/08/1997 |
