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| Number | Title | Issue Date |
| 8173624 | Methods of using substituted tetracycline compounds to modulate RNA A method for modulating RNA with tetracycline compounds is described. ... | 05/08/2012 |
| 8101591 | 9-aminoacyl tetracycline compounds and methods of use thereof A compound of formula (I): ... | 01/24/2012 |
| 8101590 | 9-aminocarbonylsubstituted derivatives of glycylcyclines This invention provides compounds of Formula I having the structure where R1, R2, R3 and A are defined in the specification or a pharmaceutically acceptable salt thereof useful as antibacter... | 01/24/2012 |
| 8088755 | 11a, 12-derivatives of tetracycline compounds 11a,12-dehydrotetracycline compounds are described. ... | 01/03/2012 |
| 8067397 | Transdiscal administration of cycline compounds The present invention relates to administering a doxycycline compound into a diseased intervertebral disc. ... | 11/29/2011 |
| 8048867 | 9-substituted minocycline compounds The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known appl... | 11/01/2011 |
| 8012950 | Method to diagnose and treat degenerative joint disease Disclosed are methods for detecting and treating joint disease. The methods of diagnosis include determining increased expression of enzymes that are upregulated during the progress of joint and ligament inflammation and degeneration. In addition, disclosed are meth... | 09/06/2011 |
| 8012951 | 7-N-substituted phenyl tetracycline compounds 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described. ... | 09/06/2011 |
| 7943600 | Antimicrobial combination therapy This invention provides methods and pharmaceutical compositions for treating a subject having a condition associated with an antibiotic resistant bacterial infection. The invention includes administering to a subject a therapeutically effective combination of an ant... | 05/17/2011 |
| 7939513 | Tetracycline derivatives as antibacterial agents In accordance with one aspect, the present invention provides a compound of general formula (I), its stereoisomers thereof and/or its pharmaceutically acceptable salts thereof, which have antibacterial activity; with methods of treating infectious diseases in warm b... | 05/10/2011 |
| 7935687 | Methods for treating spinal muscular atrophy using tetracycline compounds Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described. ... | 05/03/2011 |
| 7919483 | Method for the treatment of acne A method for treatment of acne with tetracyclines is provided. A lower sustained dose and no loading dose is employed, with an optional once-a-day dosing regimen. ... | 04/05/2011 |
| 7871993 | Tigecycline crystalline forms and processes for preparation thereof The present invention relates to solid crystalline Tigecycline, and crystalline forms thereof. ... | 01/18/2011 |
| 7858601 | 4-substituted tetracyclines and methods of use thereof The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known appl... | 12/28/2010 |
| 7858600 | 7- and 9- carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline compounds are also included.... | 12/28/2010 |
| 7851460 | 7-phenyl-substituted tetracycline compounds 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described. ... | 12/14/2010 |
| 7825105 | 3, 10, and 12a substituted tetracycline compounds The present invention pertains to novel 3, 10, and/or 12a-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known appli... | 11/02/2010 |
| 7820641 | Substituted tetracycline compounds The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known appl... | 10/26/2010 |
| 7812008 | 9-substituted tetracyclines This invention provides compounds of Formula (I); or a tautomer or pharmaceutically acceptable salts thereof useful as antibacterial agents. ... | 10/12/2010 |
| 7807660 | Tetracycline compounds for treatment of related disorders Methods and compositions for treating Cryptosporidium parvum related disorders in a mammal are discussed. Several novel tetracycline compounds useful for treating Cryptosporidium parvum related disorders are also included. ... | 10/05/2010 |
| 7790705 | Minocycline oral dosage forms for the treatment of acne Minocycline oral dosage forms containing a controlled release carrier are useful for the treatment of acne. ... | 09/07/2010 |
| 7786099 | Aromatic a-ring derivatives of tetracycline compounds Aromatized A-ring derivatives of tetracycline compounds are described. ... | 08/31/2010 |
| 7696188 | 7,8 and 9-substituted tetracycline compounds 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described. ... | 04/13/2010 |
| 7696186 | 7,9-substituted tetracycline compounds The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for mi... | 04/13/2010 |
| 7696187 | Methods of preparing substituted tetracyclines with transition metal-based chemistries The present invention relates to 9-substituted tetracycline derivatives as well as compositions and use thereof. ... | 04/13/2010 |
| 7691831 | Pharmaceutical combination and method for treatment of reactive arthritis or bursitis A method for treatment for conditions in human beings associated with either or both reactive arthritis or bursitis comprising administering a combination of a member from each of the following groups of medications: (1) synthetic purine nucleoside analog antiviral ... | 04/06/2010 |
| 7652002 | 9-aminoacyl tetracycline compounds and methods of use thereof A compound of formula (I): ... | 01/26/2010 |
| 7612053 | 7-Substituted fused ring tetracycline compounds 7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds are described. ... | 11/03/2009 |
| 7595309 | 7-substituted tetracycline compounds The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known ap... | 09/29/2009 |
| 7553828 | 9-aminomethyl substituted minocycline compounds The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known appl... | 06/30/2009 |
| 7553827 | Transdiscal administration of cycline compounds The present invention relates to injecting a cycline compound into a diseased intervertebral disc. ... | 06/30/2009 |
| 7541347 | Minocycline oral dosage forms for the treatment of acne Minocycline oral dosage forms containing a controlled release carrier are useful for the treatment of acne. ... | 06/02/2009 |
| 7521437 | 7-phenyl-substituted tetracycline compounds 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described. ... | 04/21/2009 |
| 7456158 | 4-dedimethylaminotetracycline derivatives The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted with aryl, alkenyl, or alkynyl groups. The 7, 8, and/or 9 positions and methods for preparing such compounds. Other tetracycline compounds include ... | 11/25/2008 |
| 7435408 | Porous particles comprising excipients for deep lung delivery Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm... | 10/14/2008 |
| 7404964 | Injectable compositions for the controlled delivery of pharmacologically active compound The present invention provides compositions and methods for extending the release times and lowering the toxicity of pharmacologically active compounds. The compounds comprise a salt of the pharmacologically active compound with a lipophilic counterion and a pharmac... | 07/29/2008 |
| 7361335 | Methods for using an elastase The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzy... | 04/22/2008 |
| 7354928 | Small molecule inhibitors targeted at Bcl-2 The present invention relates to small molecule antagonists of Bcl-2 family proteins such as Bcl-2 and/or Bcl-XL. In particular, the present invention provides non-peptide cell permeable small molecules (e.g., tricyclo-dibenzo-diazocine-dioxides) that bin... | 04/08/2008 |
| RE40183 | 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines The invention is drawn to 7-substituted-9-(substituted amino)-6-demethyl-6-deoxytetracycline compounds of the formula wherein R, X, R5 and R6 are defined in the specification. The compounds of the invention ... | 03/25/2008 |
| 7345024 | Pharmaceutical preparation, method for its production as well as its use The invention relates to hardly soluble antiphlogistic salts and antiphlogistic-antibiotic pharmaceutical preparations and their use. The hardly water soluble antiphlogistic antibiotics salts have as their cationic component one of the antibiotics gentamicin, clinda... | 03/18/2008 |
