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| Number | Title | Issue Date |
| 8138151 | Peptides This invention relates to novel peptides, discovered by using phage display technique, that bind to VAP-1 (Vascular Adhesion Protein-1). The invention concerns also peptides useful as VAP-1 ligands. Such peptides constitute a portion of natural proteins that are pre... | 03/20/2012 |
| 8093211 | Methods and pharmaceutical compositions for healing wounds A pharmaceutical composition and method for inducing or accelerating a healing process of a skin wound are described. The pharmaceutical composition contains, as an active ingredient, a therapeutically effective amount of at least one agent for modulating PKC produc... | 01/10/2012 |
| 8003610 | Bradykinin Breceptor antagonist peptide from amphibian skin A bradykinin B2-receptor antagonist peptide, kinestatin, isolated from toad (Bombina maxima) defensive skin secretion, and analogs thereof, is disclosed. The structure of kinestatin is pGlu-Leu/Ile-Pro-Gly-Leu/Ile-Gly-Pro-Leu/Ile-Arg-NH2. Also disc... | 08/23/2011 |
| 7943577 | Alpha-fetoprotein peptides and uses thereof Therapeutic compounds which are cell proliferation modulators, preferably inhibitors. These modulators contain amino acid structures that are arranged as a hydrophilic analog of an alpha-fetoprotein. The modulator may be a peptide itself, e.g., an octapeptide like t... | 05/17/2011 |
| 7910551 | Gene differentially expressed in breast and bladder cancer and encoded polypeptides The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to methods of treating or preventing a disorder in a subject. The invention further relates to uses of C35 polyp... | 03/22/2011 |
| 7884076 | Multipeptide regimen for the treatment of autistic spectrum, behavioral, emotional and visceral inflammation/autoimmune disorders The present invention provides compositions and methods for preventing and treating gastrointestinal disorders by administering to a subject an effective amount of secretin either alone or in combination with an effective amount of oxytocin. The invention also provi... | 02/08/2011 |
| 7867977 | Immunogenic peptides and methods of use for treating and preventing cancer Disclosed are immunogenic peptides, related fusion proteins, nucleic acids encoding the peptides or fusion proteins, conjugates, expression vectors, host cells, and antibodies. Also, disclosed are pharmaceutical compositions, vaccines for use in the treatment or pre... | 01/11/2011 |
| 7846901 | Method for inhibiting or treating intestinal damage caused by radiotherapy or chemotherapy comprising administering substance-P Disclosed herein are a composition for prevention or treatment of gastrointestinal damage comprising Substance-P as an active ingredient, a use of Substance-P for the preparation of a medicament for prevention or treatment of gastrointestinal damage, and a method fo... | 12/07/2010 |
| 7811994 | Phage display selection of anti fungal peptides A method for the identification of peptides having an affinity for the surface of fungi is provided as is a method for the identification of peptides capable of affecting the development of a fungus. Also provided are compositions containing peptides identified usin... | 10/12/2010 |
| 7795224 | Tumor associated antigen peptides and use of same as anti-tumor vaccines The present invention relates to tumor associated antigen (TAA) peptides and to use of same, of polynucleotides encoding same and of cells presenting same as anti-tumor vaccines. More particularly, the present invention relates to tumor associated antigen peptides d... | 09/14/2010 |
| 7795223 | Treatment of inflammatory airway disease This invention relates to methods of treatment of inflammatory airway disease, and in particular to methods of treatment of asthma and chronic obstructive pulmonary disease. The invention is applicable to both allergic (atopic) and non-allergic (intrinsic) asthma. I... | 09/14/2010 |
| 7786083 | Metastin derivatives and use thereof The present invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, a gonadotropic hormone secretion stimulating activity, sex hormone secretion stimulatin... | 08/31/2010 |
| 7776827 | Method of using substance P analogs for treatment amelioration of myelodysplastic syndrome Myelodysplastic syndromes can be treated or ameliorated by the administration of substance P analogs as disclosed herein. ... | 08/17/2010 |
| 7745410 | Bladder tumor-targeting peptide and use thereof The present invention relates to a bladder tumor-targeting peptide and use thereof. More particularly, the present invention relates to a bladder tumor-targeting peptide having an amino acid sequence represented by SEQ ID NO: 7 and use thereof. The peptide according... | 06/29/2010 |
| 7741289 | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of the substituents is as sp... | 06/22/2010 |
| 7737120 | Methods for the specific preparation of lysobactin fragments The invention relates to methods for the targeted production of lysobactin derivatives by combined chemical and enzymatic modifications. In particular, the invention relates to method for preparing lysobactin fragment 4-11 by chemical reduction and cleavage of the r... | 06/15/2010 |
| 7732412 | Methods of treatment using novel LHRH antagonists having improved solubility properties The invention relates to peptides which contain N-methylated amino acid units and have improved water solubility. The invention also relates methods for treating a hormone-dependent tumor or a non-malignant indication that is treatable by LH-RH suppression, the meth... | 06/08/2010 |
| 7732413 | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof The present invention provides compounds represented by the structural formula (I): or pharmaceutically acceptable isomers, salts, solvates or esters of the compound of Formula (I), wherein each of the substituents is as sp... | 06/08/2010 |
| 7727959 | Use of substances with oxytocin activity against climacteric disorders The present invention relates to the use of substances with oxytocin activity against climacteric disorders or similar symptoms due to dysfunction in the ovaries. It also relates to a pharmaceutical composition comprising at least one substance with oxytocin activit... | 06/01/2010 |
| 7700559 | Gonadotropin releasing hormone analogues conjugates with steroid hormones A compound comprising a gonadotrophin releasing hormone analogue conjugated to a hormone moiety, or a derivative thereof, which is able to bind to a plasma hormone binding protein. The compounds may be used to treat hormone-dependent disorders such as cancer, or as ... | 04/20/2010 |
| 7696174 | Short bio-active peptides for cellular and immunological modulation Peptides having four to fourteen residues are disclosed that possess biological activity. These peptides constitute short fragments of the peptide HB-107 (SEQ ID NO:1), which itself is a fragment of the antimicrobial protein cecropin B, and exhibit cell stimulatory,... | 04/13/2010 |
| 7691817 | System and method for inhibiting cellular proliferation with tachykinins Systems and methods are described providing therapeutic preparations of tachykinins, and more specifically sialokinins, for treating various types of abnormal cellular proliferation conditions in regions of tissue associated with the body of a patient. The sialokini... | 04/06/2010 |
| 7687464 | Method for activating T cell protein tyrosine phosphatase for therapeutic applications This invention relates to methods for activation of T cell protein tyrosine phosphatase (TCPTP) and for inhibiting tyrosine kinase signalling in an individual. The invention concerns a method for preventing or treating a disease or disorder in an individual, wherein... | 03/30/2010 |
| 7671027 | Use of GnRH agonists to support the luteal phase during infertility treatment The present invention concerns the use of an agonist of an hypothalamic hormone for the preparation of a pharmaceutical agent to support the luteal phase during infertility treatment of female mammals and more specifically of woman. According to this invention, the ... | 03/02/2010 |
| 7671026 | Cytomodulating peptides for treating interstitial cystitis The methods and compositions relate to treatment of disorders of the bladder. In particular, the methods provide for treatment of interstitial cystitis and related disorders. The methods further comprise treatment to affect various manifestations associated with int... | 03/02/2010 |
| 7662783 | CLK-peptide and SLK-peptide The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen type-IV with substantially greater affinity than to the native triple helical form of collagen type-... | 02/16/2010 |
| 7659252 | Transdermal delivery peptides and method of use thereof Transdermal delivery peptides for the treatment of skin diseases and/or facilitation or enhancement of transdermal delivery of pharmaceutically active agents are provided. Compositions comprising the transdermal delivery peptides and methods of therapeutic use, incl... | 02/09/2010 |
| 7645741 | IAP BIR domain binding compounds Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I or II or a salt thereof, in which R1, R2, R3, R100, R200, R3... | 01/12/2010 |
| 7638494 | G-type peptides to ameliorate atherosclerosis This invention provides novel peptides that ameliorate one or more symptoms of atherosclerosis and/or other pathologies characterized by an inflammatory response. In certain embodiment, the peptides resemble a G* amphipathic helix of apolipoprotein J. The peptides a... | 12/29/2009 |
| 7625869 | Metastin derivatives and use thereof The invention provides stable metastin derivatives having excellent biological activities (a cancer metastasis suppressing activity, a cancer growth suppressing activity, etc.). By modifying the constituent amino acids of metastin with specific modifying groups, met... | 12/01/2009 |
| 7605132 | Protective factors against inflammation, burns and noxious stimuli Peptide factors isolated from skin following exposure to chemical or thermal injury and treatment with iodine preparations are capable of reducing or ameliorating the extent of injury when administered to other animals. Specific peptides, including fragments of hist... | 10/20/2009 |
| 7601694 | CLK-peptide and SLK-peptide The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen type-IV with substantially greater affinity than to the native triple helical form of collagen type-... | 10/13/2009 |
| 7598223 | Methods for producing target cell reactive lymphocytes Methods and compositions for producing target cell reactive lymphocytes, e.g., cytolytic T-lymphocytes, in a subject are provided. In practicing the subject methods, a lymphocyte population is contacted with an effective amount of a target cell peptide mixture of ac... | 10/06/2009 |
| 7585844 | Myosin light chain kinase inhibitors and methods of use Disclosed are inhibitors of myosin light chain kinase, pharmaceutical compositions and kits comprising the inhibitors and methods of use. ... | 09/08/2009 |
| 7579320 | IAP BIR domain binding compounds Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I or II or a salt thereof, in which R1, R2, R3, R100, R200, R3... | 08/25/2009 |
| 7566697 | Carboxy protection strategies for acidic C-terminal amino acids in chemical ligation of oligopeptides The present invention provides methods of assembling oligopeptides or polypeptides in a native chemical ligation reaction that eliminates the formation of unwanted side products resulting from the presence of an unprotected acidic C-terminal oligopeptide thioester. ... | 07/28/2009 |
| 7557086 | Method and peptide for regulating cellular activity Method and peptide for regulating cellular activity includes a panel of synthesized peptides that have biological effects on inhibiting or enhancing cellular activity. Selected peptides can be used as therapy to reduce and/or inhibit, or initiate and/or enhance, an ... | 07/07/2009 |
| 7553815 | Therapeutic use A method of chemoprevention of the onset of invasive breast cancer in a high risk patient comprises administering to the patient an effective amount of an EGFR tyrosine kinase inhibitor. ... | 06/30/2009 |
| 7544666 | NAP derivatives An oligopeptide comprises formulae (I) or (II) the oligopeptide derivative thereof, and a pharmaceutical composition comprising the same are provided. ... | 06/09/2009 |
| 7528112 | Small survival-promoting/immunomodulatory peptide for treatment of brain damage, neurodegenerative disorders, and inflammatory disorders A synthetic peptide sequence demonstrating neuroprotective and anti-inflammatory functions is disclosed. Methods of use for the synthetic peptide are also provided. ... | 05/05/2009 |
