Did You Know...
...that Robert Adler has the dubious distinction of being the Father of the Couch Potato? Back in 1955 Adler was employed by what was then Zenith Radio Corp., where he was charged to invent something that would allow viewers to turn down the TV volume without leaving their chairs. After a series of flops (such as a wired contraption that people tripped over), Adler hit on the idea of using sound waves. Thus the Remote Control was born...
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| Number | Title | Issue Date |
| 8106034 | Angiotensin II receptor antagonists A compound having the structure wherein R is an angiotensin receptor blocking group Y is —(CR1R20)1-7R5, or —C(O)(CR1R | 01/31/2012 |
| 8101589 | Nitric oxide-releasing molecules This invention relates to compositions comprising carbon-based diazeniumdiolates that release nitric oxide (NO). The carbon-based diazeniumdiolated molecules release NO spontaneously under physiological conditions without subsequent nitrosamine formation. The presen... | 01/24/2012 |
| 7829553 | Nitric oxide-releasing polymers This invention relates to compositions comprising carbon-based diazeniumdiolates attached to hydrophobic polymers that releases nitric oxide (NO). The carbon-based diazeniumdiolated polymers release NO spontaneously under physiological conditions without subsequent ... | 11/09/2010 |
| 7625884 | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives A method of increasing the bioavailability of balsalazide by administration of an oral dosage form with food is provided, as well as an article of manufacture comprising an oral dosage form of balsalazide in a suitable container and associated with printed labeling ... | 12/01/2009 |
| 7569559 | Nitric oxide-releasing molecules This invention relates to compositions comprising carbon-based diazeniumdiolates that release nitric oxide (NO). The carbon-based diazeniumdiolated molecules release NO spontaneously under physiological conditions without subsequent nitrosamine formation. The presen... | 08/04/2009 |
| 7511029 | Pesticidal diazene oxide carboxylates Pesticidal compounds having the structural formula wherein: R2 is C1-C6 branched or straight chain alkyl; C1-C4 branched or straight-... | 03/31/2009 |
| 7452872 | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives A method of increasing the bioavailability of balsalazide by administration of an oral dosage form with food is provided, as well as an article of manufacture comprising an oral dosage form of balsalazide in a suitable container and associated with printed labeling ... | 11/18/2008 |
| 7435408 | Porous particles comprising excipients for deep lung delivery Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm... | 10/14/2008 |
| 7399757 | Pesticidal diazene oxide carboxylates Pesticidal compounds having the structural formula wherein R1 and R2 are each, independently, C1-6 alkyl, compositions comprising the compounds and methods... | 07/15/2008 |
| 7348319 | Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same The present invention relates to nitric oxide-releasing amidine diazeniundiolates, compositions comprising same, methods of using same, and a method for preparing same from imidate diazeniumdiolates and primary or secondary amines. ... | 03/25/2008 |
| 7285533 | Apo-2 ligand A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to... | 10/23/2007 |
| 7122529 | Compounds that release nitric oxide at controlled rates upon photolysis Chemical compounds which release nitric oxide in a controlled manner upon photolysis with light are provided. These compounds are O2-benzyl, O2-naphthylmethyl and O2-naphthylallyl substituted diazeniumdiolates. Also provided are meth... | 10/17/2006 |
| 7105502 | Nitric oxide-releasing imidate and thioimidate diazeniumdiolates The invention provides NO- or NO−-releasing imidate; and thioimidate, diazeniumdiolates, in which the N2O2− functional group is bonded to a carbon atom. The imidate and thioimidate diazeniumdiolates are bound to a poly... | 09/12/2006 |
| 7081524 | O-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates The present invention provides O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates (1-[(2-carboxylato)pyrrolidin-1-yl]diazeniumdiolates) of the formula in which R and R22 | 07/25/2006 |
| 6964955 | Pharmaceutical compositions and uses for androst-5-ene-3β, 17β-diol Androst-5-ene-3β,17βdiol is used to treat or reduce the likelihood of acquiring osteoporosis or menopausal symptoms, or other diseases affected by estrogen receptor activity, and for conditions which respond well to DHEA treatment, but where a higher ratio of estr... | 11/15/2005 |
| 6949530 | Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same The present invention relates to nitric oxide-releasing amidine diazeniumdiolates, compositions comprising same, methods of using same, and a method for preparing same from imidate diazeniumdiolates and primary or secondary amines. ... | 09/27/2005 |
| 6825181 | Aminoisoquinoline derivatives Aminoisoquinoline derivatives of the following formulae or analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an excellent effect of inhibiting activated blood-coagulation factor X, and they are useful as anticoagulants ... | 11/30/2004 |
| 6780854 | Orally active androgens Novel, orally active androgens are 7α-substituted Δ14-nandrolone derivatives. The compounds satisfy the general formula: wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1... | 08/24/2004 |
| 6746668 | Apo-2 ligand A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to... | 06/08/2004 |
| 6407081 | Method for inhibiting cytokine production by cells The invention concerns a method for inhibiting cytokine production by cells, in particular animal or human cells, and their secretion, which consists in applying on said cells at least an azo compound derivatives corresponding to formula (I), in which A r... | 06/18/2002 |
| 6306841 | Treatment of female sexual dysfunction Methods and formulations for treating female sexual dysfunction are provided. A pharmaceutical composition formulated so as to contain a selected vasoactive agent is administered to the vagina, vulvar area or urethra of the individual undergoing treatment... | 10/23/2001 |
| 5952334 | Carbocyclic compounds A compound of formula ##STR1## wherein Z is a tetrahydro-pyrano group selected from ##STR2## having antifungal activity in combination with other antifungal agents.... | 09/14/1999 |
| 5840759 | Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric ox... | 11/24/1998 |
| 5837736 | Nitric oxide-releasing compounds to sensitive cancerous cells to chemotherapeutic agents The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric ox... | 11/17/1998 |
| 5814656 | Selective prevention of organ injury is sepsis and shock using selective release of nitric oxide vulnerable organs A method for the treatment of mammalian tissue injured or at risk of injury during sepsis or shock including the administration to a mammal a diazeniumdiolate which releases a therapeutically effective amount of nitric oxide sufficient to protect the tiss... | 09/29/1998 |
| 5814667 | Use of nitric oxide-releasing compounds as hypoxic cell radiation sensitizers The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric ox... | 09/29/1998 |
| 5795878 | Biocidal compounds their preparation and use A phenylazoxycyanide compound of formula I ##STR1## is useful as an antimicrobial and fungicidal composition. A method for using the antimicrobial and fungicidal compositions, and for manufacturing the compound is also disclosed.... | 08/18/1998 |
| 5714511 | Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs A method for the treatment of mammalian tissue injured or at risk of injury during sepsis or shock including the administration to a mammal a diazeniumdiolate which releases a therapeutically effective amount of nitric oxide sufficient to protect the tiss... | 02/03/1998 |
| 5700830 | Use of nitric oxide-releasing agents for reducing metastasis risk A method for inhibiting the adherence between cancerous cells and noncancerous structures in a mammal, comprising the administration to the mammal of a nitric oxide-releasing compound containing a nitric oxide-releasing N2 O2- | 12/23/1997 |
| 5670537 | Method for effecting tumor regression with a low dose, short infusion taxol regimen Taxol dosages of about 135 mg/m2 or greater are administered via infusions of less than 6 hours duration; the method makes it possible to provide taxol infusions on an out-patient basis to patients who do not otherwise require hospitalization. ... | 09/23/1997 |
| 5650442 | Use of nitric oxide releasing compounds as hypoxic cell radiation sensitizers The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric ox... | 07/22/1997 |
| 5627175 | Azoxycyanobenzene compounds The invention is directed to azoxycyanobenzene derivatives of the formula: ##STR1## wherein n is 0-3; each R represents halogen, nitro, cyano, alkyl, haloalkyl, alkoxy, or haloalkoxy; and each R1 and R2 represents an optionally ... | 05/06/1997 |
| 5541169 | Azoxy compound An azoxy compound represented by the following general formula ##STR1## wherein R1 denotes a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkoxy group, a lower alkoxy-lower alkoxy group or a group of the formula X1 -... | 07/30/1996 |
| 5439897 | Azoxycyanobenzene derivatives, compositions containing them and their use as fungicides This invention relates to certain azoxycyanobenzene derivatives of the general formula. ##STR1## in which R represents an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl or heterocyclyl group; R1 represents a... | 08/08/1995 |
| 5376679 | Bicyclic or tricyclic biocidal compounds Compounds of the general formula ##STR1## where R2 and R3 together, or R3 and R4 together, represent an optionally substituted hydrocarbyloxy chain; the ring is optionally substituted at any or each of the ... | 12/27/1994 |
| 5366997 | Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs There are disclosed cardiovascularly active compounds possessing antihypertensive properties, and pharmaceutical compositions containing these agents and a method of treating cardiovascular disorders with the compounds. The active components of the pharma... | 11/22/1994 |
| 5350744 | Phenylnaphthalene lactones as inhibitors of leukotriene biosynthesis Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, ... | 09/27/1994 |
| 5273997 | Biocidal compounds The invention provides compounds of general formula ##STR1## wherein m is 0 or 1; each of R1 and R2, and R3 and R4 if present, independently represents a hydrogen or halogen atom or an optionally substitute... | 12/28/1993 |
| 5089486 | Biocidal azophenyl compounds Compounds of the general formula R--N.dbd.NX (I) or N-oxides thereof, where R represents on amidophenyl group, and X represents a cyano group, a group --COOH or a salt, ester or amino derivative thereof; are fungi... | 02/18/1992 |
| 5089487 | Circulation-active dibenzo[1,5]dioxocin-5-ones Cardioactive compounds of the formula ##STR1## in which R1 and R8 and R14 and R15 can be hydrogen or various organic radicals.... | 02/18/1992 |
