...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 7829552 | Phosphorus-containing thyromimetics The present invention relates to compounds of phosphonic acid containing T3 mimetics, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparat... | 11/09/2010 |
| 7514419 | Phosphorus-containing thyromimetics The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as... | 04/07/2009 |
| 7109181 | Joint lubrication with P2Y purinergic receptor agonists The present invention is directed to a method of altering the amount or composition of synovial fluids secreted from joints in a subject in need of such treatment. The method comprises administering to a subject a pharmaceutical composition comprising a P2Y purinerg... | 09/19/2006 |
| 6803057 | Hydrogen peroxide disinfectant with increased activity An acidic aqueous hydrogen peroxide solution is provided with improved disinfectant activity. Concentrated solutions preferably contain up to about 8 wt./wt. % H2O2 and as-used concentrations contain about 0.5% wt./wt. % H2O2. The solution also contains from 0.05 to... | 10/12/2004 |
| 6762183 | Active substance combinations having insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties. ... | 07/13/2004 |
| 6649646 | Insecticidal and miticidal compositions The invention relates to an insecticidal and miticidal composition which contains as active ingredients chlorfenapyr in combination with one or more organophosphoric acid ester-type compounds and to a method for controlling insecticidal or miticidal pests... | 11/18/2003 |
| 6627660 | Stabilized thyroxine compounds Throxinyldimethylphosphinate was invented as a prodrug to stabilize thyroxine, a drug widely used to treat hypothyroidism. The presence of the dimethylphosphinate group at the phenolic hydroxyl of thyroxine is key to preventing thyroxine from decomposing ... | 09/30/2003 |
| 6569899 | 4-aminobutanoic acid derivatives and drugs containing these derivatives as the active ingredient Aminobutylic acid derivatives of the formula (I) ##STR1## wherein the symbols are as defined in specification; and non-toxic salts thereof. Because of inhibiting matrix metalloproteinase, the compounds of the formula (I) are useful for prevention and/or t... | 05/27/2003 |
| 6566304 | Biogenic control and limitation of the reproduction of parasitic earth nematodes in stock culture The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a) to (b) as a soil additive for biologically controlling pla... | 05/20/2003 |
| 6506739 | Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates, pharmaceutical compositions containing them, methods of treatment using them, and processes for their preparation. The compounds possess anti-tumor activities or are capable of being modified to have anti... | 01/14/2003 |
| 6372730 | 2-decarboxy-2-phosphinico Prostaglandin F analogs The invention provides novel Prostaglandin F analogs. In particular, the present invention is directed to compounds having a structure according to the following formula: ##STR1## wherein R1, R2, X, Y, V, a, b, W, and Z are defined b... | 04/16/2002 |
| 6200961 | Concentrates of organophosphorous insecticides A low volatile organic compound co-solvent system is disclosed for preparing emulsion concentrates of low melting organophosphorous insecticides wherein the bioefficacy of the insecticide active is significantly enhanced. The co-solvent system comprises a... | 03/13/2001 |
| 6162825 | High fructose insecticide bait compositions This invention relates to the discovery that in many strains of the German cockroach [Blattella, germanica (L.)], feeding is inhibited by high glucose levels, while conversely, feeding of this strain of cockroach is stimulated by high or ultra high levels... | 12/19/2000 |
| 6114340 | Fungicidal compositions An improved fungicidal composition is a mixture of (a) fungicide used to combat phytopathogenic fungi and (b) at least one phosphonate or phosphinate of formula R1 R2 P(O)OR3 where R1 is C6-20 alkyl, ... | 09/05/2000 |
| 6114285 | Compositions and methods for use in cropping bananas and plantain trees A method of chemically suckering trees of the families Musaceae (banana) and Plantaginaceae (plantains) which comprises introducing into a mother tree an amount of a composition effective to arrest apical dominance in the mother tree. A method of protecti... | 09/05/2000 |
| 6054448 | 2-amino-2-(3-substituted cyclobutyl) acetic acid derivatives Compounds of the formula ##STR1## in which R1 is Y or Y--C1-6 alkyl, where Y is carboxy, tetrazolyl, --SO2 H, --SO3 H, --OSO3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OP(OH)OR' or --OPO(OH)OR' ... | 04/25/2000 |
| 5969017 | Methods of treating or preventing cardiac arrhythmia This application discloses a method of treating or preventing atrial arrhythmias which utilizes compounds which are blockers of the ultra-rapidly-activating delayed rectifier K+ current (IKur) of the human atrium in a use-dependent ... | 10/19/1999 |
| 5958918 | Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-(aminominomethyl)phenylalkyl!-azaheterocyclylamide compounds The compounds of formula I exhibit useful pharmacological activity and accordingly are incorporated into pharmaceutical compositions and used in the treatment of patients suffering from certain medical disorders. More especially, they are inhibitors of th... | 09/28/1999 |
| 5955501 | Protein kinase C modulators O Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from phorboids of the diterpene- and benzolactam-classes.... | 09/21/1999 |
| 5948776 | Compositions and methods for treating bone deficit conditions Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or "linker" defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15Å, are effective in treating condit... | 09/07/1999 |
| 5925670 | High fructose insecticide bait compositions This invention relates to the discovered that in many strains of the German cockroach Blattella germanica (L.)!, feeding is inhibited by high glucose levels, conversely, feeding of this strain of cockroach is stimulated by high or ultra high levels of f... | 07/20/1999 |
| 5910492 | Osteogenic promoting pharmaceutical composition This invention provides a pharmaceutical composition comprising a non-peptide osteogenic promoting substance and a biodegradable polymer, which can be safely used as a prophylactic/therapeutic agent for various bone diseases (e.g., bone fractures).... | 06/08/1999 |
| 5861385 | Substituted triols Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments.... | 01/19/1999 |
| 5709890 | Polyaspartic acid and its analogues in combination with insecticides An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small amount of a water soluble non-aromatic polyorganic acid or... | 01/20/1998 |
| 5646133 | Polyaspartic acid and its analogues in combination with insecticides An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small amount of a water soluble non-aromatic polyorganic acid or... | 07/08/1997 |
| 5627174 | Fluoroalkenyl compounds and their use as pest control agents Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops, these compounds having the general structure: ##STR1## These Polar compounds are particularly useful for systemic cont... | 05/06/1997 |
| 5569671 | Fungicidally active compounds Novel compounds of formula I ##STR1## wherein R1 is independently hydrogen, hydroxy, alkyl with 1 to 6 carbon atoms, acyloxy groups with 1 to 6 carbon atoms, alkyloxy with 1 to 6 carbon atoms or from 1 to 5 sugar moieties; and R2 | 10/29/1996 |
| 5541221 | Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss 3 and 4-substituted 2(5H)-furanone compounds influence the balance between bone production and bone resorption in mammals, including humans. The active compounds are administered to mammals, including humans, in an effective dose which ranges between 0.05... | 07/30/1996 |
| 5468747 | Fungicidal compositions and methods of use employing pyrimidine derivatives Compounds having the formula (I): ##STR1## in which any two of K, L and M are nitrogen and the other is CE; X and Y are independently hydrogen, halogen, C1-4 alkyl, C3-6 cycloalkyl, C2-4 alkenyl, C2-4 alkyn... | 11/21/1995 |
| 5143539 | Method and composition for protecting plants against injury from the interaction of an organophosphate insecticide-nematicide and an AHAS inhibiting herbicide There is provided a method for inhibiting or preventing injury to a plant caused by the synergistic interaction of an organophosphate compound employed for the protection of the plant against attack by insects and nematodes and the use of an acetohydroxac... | 09/01/1992 |
| 4933167 | Pesticide compositions Toxicant, especially pesticide compositions, having lowered dermal toxicity are provided. The compositions include a microencapsulated lipophilicpesticide, a hydrophilic surfactant and water. Methods for reducing the dermal toxicity of microencapsulated l... | 06/12/1990 |
| 4618604 | Composition and method for improving feed utilization or tissue production in animals A composition and method for improving feed utilization or tissue production in animals are disclosed. At least one substituted phenylphosphinic acid derivative or pharmaceutically acceptable salts thereof is administered as a feed supplement at a daily d... | 10/21/1986 |
| 4598092 | -Hydroxy-ଲ-haloethylphosphinic acids and their salts, and their production and use A compound of the formula: ##STR1## wherein X is a chlorine atom or a bromine atom, or its salt, which is useful as a fungicide.... | 07/01/1986 |
| 4507284 | Soil disinfectant A soil disinfectant composition for preventing and controlling diseases caused by pathogenic fungi living in soil, which comprises an effective amount of at least one of phenylphosphinic acid and its salts as an active ingredient, and at least one inert c... | 03/26/1985 |
| 4304587 | Formulations for improved pesticide-fertilizer compositions A novel composition is disclosed, comprising (a) an aqueous solution of an N-P or N-P-K fertilizer and (b) an attapulgite clay. The composition provides improved emulsion stability when combined with an emulsifiable concentrate of an organophosphorus compound ... | 12/08/1981 |
| 4167568 | 8-Azapurin-6-one derivatives 8-Azapurin-6-one derivatives of the formula: ##STR1## wherein R8 represents alkoxy of from 1 to 6 carbon atoms, and R9 represents cyano, or a group of the formula V, VI, VII, VIII or IX indicated below: ##STR2## wherei... | 09/11/1979 |
| 4119715 | Pesticidally active O-(1-fluoro-2-halogeno-ethyl)-thionophosphoric (phosphonic) acid esters O-(1-Fluoro-2-halogeno-ethyl)-thionophosphoric (phosphonic) acid esters of the formula ##STR1## in which R is alkyl, phenyl or phenyl carrying at least one substituent selected from the group consisting of halogen, alkyl, alkylthio and nitro, R1... | 10/10/1978 |
| 3983227 | Dry mixture containing diphosphonates and a stannous salt useful in the preparation of Tc99M containing bone scanning agents A composition and method for the preparation of a technetium-99m based scintigraphic scanning agent are disclosed. The agent is prepared by the addition of a pertechnetate-99m solution to an anhydrous salt composition comprising a phosphonic acid or a pha... | 09/28/1976 |